CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 23
Active chains: 2
Uniprot: SIK3_HUMAN
Kinase Domain Residues: 66 - 317
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 91.3% AF-Q9Y2K2-K1A
DFGin ABAminus 2 8.7% 8R4VB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q9Y2K2-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 58 - 325 0 None None Serine/threonine-protein kinase SIK3
AF-Q9Y2K2-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 58 - 325 0 None None Serine/threonine-protein kinase SIK3
8R4VB 1.9 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii XWA Type1 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4VC 1.9 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii XWA Type1 61 - 385 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4OA 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4OC 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4OE 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4OG 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4OI 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4OK 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4QA 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4QC 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4QE 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4QG 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4QI 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4QK 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4VA 1.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii XWA Type1 62 - 385 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8OKUA 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VRU Type1 60 - 392 0 None T221D Serine/threonine-protein kinase SIK3
8OKUB 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VRU Type1 60 - 390 0 None T221D Serine/threonine-protein kinase SIK3
8R4UA 2.416 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4UC 2.416 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4UE 2.416 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3
8R4UG 2.416 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3

CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 23
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 91.3% AF-Q9Y2K2-K1A
DFGin ABAminus 2 8.7% 8R4VB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
SIK3_HUMAN AF-Q9Y2K2-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 58 - 325 0 None None Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN AF-Q9Y2K2-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 58 - 325 0 None None Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4VB 1.9 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii XWA Type1 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4VC 1.9 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii XWA Type1 61 - 385 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4OA 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4OC 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4OE 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4OG 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4OI 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4OK 2.725 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii XVI Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4QA 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4QC 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4QE 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4QG 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4QI 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4QK 2.838 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii DB8 Type1 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4VA 1.9 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii XWA Type1 62 - 385 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8OKUA 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VRU Type1 60 - 392 0 None T221D Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8OKUB 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii VRU Type1 60 - 390 0 None T221D Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4UA 2.416 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4UC 2.416 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4UE 2.416 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 61 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens
SIK3_HUMAN 8R4UG 2.416 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii XW3 Type1.5_Front 62 - 384 0 TPO221 C121S,C181S,C333S Serine/threonine-protein kinase SIK3 Homo sapiens

CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism