CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 23
Active chains: 2
Uniprot: SIK3_HUMAN
Kinase Domain Residues: 66 - 317
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 91.3% AF-Q9Y2K2-K1A
DFGin ABAminus 2 8.7% 8R4VB

Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SIK3 AF-Q9Y2K2-K1A Q9Y2K2 58 325 1321.0 No_ligand No_ligand Active DFGin 6.6942 14.4508 BLAminus -119.54, 177.21 54.68, 82.58 -91.15, 18.08 289.11, 79.8 -61.47, -33.93 in-in in 9.1751 Saltbr-in 2.727 HRD-in -84.96, -43.42 62.16, 5.21 in-in-in SNCiii in-in ActLoopNT-in 2.9847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.68, 160.29 APE9-dihe-na 96.56, 179.01 APE8-dihe-in -86.75, 128.22 APE8-rot-in 305.58 APE67-dihe-in -65.83, -21.44 -50.37, -40.61 APE12-dist-in 8.7004 APE11-dist-in 10.8874 APE10-dist-in 5.1234 APE9-dist-in 3.3519 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[66, 317]] 1.0 AF-Q9Y2K2-K1 CAMK_SIK3_HUMAN CAMK 5.7e-96 326.7 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 AF-Q9Y2K2-K3A Q9Y2K2 58 325 1321.0 No_ligand No_ligand Active DFGin 6.3302 14.4097 BLAminus -124.8, 175.92 53.15, 79.61 -83.53, 14.89 285.3, 85.28 -59.08, -30.53 in-in in 9.0295 Saltbr-in 2.7464 HRD-in -84.43, -45.63 65.16, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.9436 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.55, -178.04 APE9-dihe-na 100.22, 168.15 APE8-dihe-in -79.95, 124.93 APE8-rot-in 300.39 APE67-dihe-in -65.89, -18.74 -51.05, -39.95 APE12-dist-in 8.574 APE11-dist-in 11.03 APE10-dist-in 5.6074 APE9-dist-in 3.365 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[66, 317]] 1.0 AF-Q9Y2K2-K3 CAMK_SIK3_HUMAN CAMK 5.7e-96 326.7 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4VB Q9Y2K2 61 384 1321.0 XWA:401 Type1 Inactive DFGin 6.5114 15.4905 ABAminus -125.75, -41.1 -99.77, 106.18 -109.14, 28.86 285.94, 82.47 -67.81, -21.46 out-out out 10.8343 Saltbr-out 4.9423 HRD-in -78.88, -52.53 65.1, 22.1 out-in-out SNCoio in-out ActLoopNT-in 3.0033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.56, 147.3 APE9-dihe-na 102.07, -167.18 APE8-dihe-in -89.53, 132.88 APE8-rot-out 85.39 APE67-dihe-in -62.44, -20.96 -46.68, -40.42 APE12-dist-in 7.9628 APE11-dist-in 10.1301 APE10-dist-in 5.1496 APE9-dist-in 3.837 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 B 328.0 316.0 0 27 27 0 [[66, 317]] 1.0 8r4v CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4VC Q9Y2K2 61 385 1321.0 XWA:401 Type1 Inactive DFGin 6.3779 15.7756 ABAminus -123.53, -39.3 -101.32, 103.7 -110.55, 26.69 286.87, 81.88 -68.74, -19.29 out-out out 10.3583 Saltbr-out 4.177 HRD-in -78.2, -53.12 69.27, 14.93 out-in-out SNCoio in-out ActLoopNT-in 3.0006 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.72, 148.26 APE9-dihe-na 98.16, -163.75 APE8-dihe-in -96.72, 131.38 APE8-rot-out 83.48 APE67-dihe-in -61.15, -23.52 -48.53, -38.56 APE12-dist-in 8.0603 APE11-dist-in 10.2666 APE10-dist-in 5.0229 APE9-dist-in 3.8461 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 C 328.0 319.0 0 27 27 0 [[66, 317]] 1.0 8r4v CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4OA Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.7893 14.5188 BLAminus -125.71, 175.86 61.17, 85.12 -103.12, 32.38 284.88, 82.02 -69.13, -38.43 in-in in 9.2107 Saltbr-in 2.7071 HRD-in -68.78, -49.07 59.21, 16.18 in-in-out SNCiio in-out ActLoopNT-in 2.9696 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.95, 164.22 APE9-dihe-na 138.1, 167.3 APE8-dihe-in -77.26, 120.01 APE8-rot-out 188.49 APE67-dihe-in -63.99, -17.85 -45.41, -48.19 APE12-dist-in 7.6133 APE11-dist-in 11.0803 APE10-dist-in 5.4608 APE9-dist-in 3.3384 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 A 328.0 316.0 0 27 27 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4OC Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.8282 14.4465 BLAminus -129.55, 168.82 71.42, 83.09 -102.43, 31.89 286.31, 82.55 -67.62, -40.46 in-in in 9.1654 Saltbr-in 2.6441 HRD-in -65.95, -51.63 61.3, 16.73 in-in-out SNCiio in-out ActLoopNT-in 2.9607 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.01, 164.27 APE9-dihe-na 137.9, 165.52 APE8-dihe-in -76.91, 120.34 APE8-rot-out 188.4 APE67-dihe-in -64.71, -17.77 -46.15, -47.73 APE12-dist-in 7.5906 APE11-dist-in 11.054 APE10-dist-in 5.4419 APE9-dist-in 3.3689 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 C 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4OE Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.9385 14.5972 BLAminus -125.14, 175.42 62.75, 84.83 -103.08, 31.64 285.5, 81.52 -67.98, -40.19 in-in in 9.1211 Saltbr-in 2.6363 HRD-in -67.61, -51.56 60.74, 18.57 in-in-out SNCiio in-out ActLoopNT-in 2.9839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 164.3 APE9-dihe-na 136.57, 164.66 APE8-dihe-in -75.86, 119.82 APE8-rot-out 188.72 APE67-dihe-in -65.37, -17.85 -45.28, -48.13 APE12-dist-in 7.5804 APE11-dist-in 11.0615 APE10-dist-in 5.4579 APE9-dist-in 3.3905 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 E 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4OG Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.9095 14.6146 BLAminus -124.38, 176.33 61.69, 84.93 -103.28, 30.5 286.01, 80.88 -68.19, -39.92 in-in in 9.1822 Saltbr-in 2.8664 HRD-in -70.7, -46.33 56.28, 19.08 in-in-out SNCiio in-out ActLoopNT-in 2.9815 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 164.45 APE9-dihe-na 136.64, 161.97 APE8-dihe-in -75.05, 120.57 APE8-rot-out 189.09 APE67-dihe-in -63.53, -18.35 -45.81, -48.67 APE12-dist-in 7.5201 APE11-dist-in 11.0215 APE10-dist-in 5.4497 APE9-dist-in 3.3949 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 G 328.0 323.0 0 27 27 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4OI Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.8991 14.5651 BLAminus -132.68, 177.0 60.73, 84.44 -102.51, 32.39 285.22, 81.32 -69.52, -27.66 in-in in 9.1945 Saltbr-in 2.7141 HRD-in -82.53, -49.17 62.06, 18.27 in-in-out SNCiio in-out ActLoopNT-in 2.9594 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.98, 164.61 APE9-dihe-na 136.93, 163.75 APE8-dihe-in -76.2, 120.78 APE8-rot-out 188.08 APE67-dihe-in -64.67, -17.51 -46.63, -48.17 APE12-dist-in 7.5868 APE11-dist-in 11.0794 APE10-dist-in 5.4714 APE9-dist-in 3.3811 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 I 328.0 317.0 0 27 27 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4OK Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.9732 14.7833 BLAminus -128.99, 172.89 59.57, 78.9 -97.11, 33.89 284.36, 89.39 -70.96, -33.22 in-in in 9.2122 Saltbr-in 2.7328 HRD-in -72.38, -44.94 53.52, 24.05 in-in-out SNCiio in-out ActLoopNT-in 3.0043 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.55, 165.44 APE9-dihe-na 135.73, 162.63 APE8-dihe-in -74.63, 117.97 APE8-rot-out 178.94 APE67-dihe-in -64.29, -16.62 -46.32, -48.14 APE12-dist-in 7.4101 APE11-dist-in 10.9261 APE10-dist-in 5.3919 APE9-dist-in 3.2952 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 K 328.0 316.0 0 27 27 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4QA Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.2696 14.8874 BLAminus -139.01, 171.07 65.51, 84.49 -98.95, 35.4 290.76, 86.17 -67.45, -37.73 in-out in 9.4825 Saltbr-out 4.139 HRD-in -65.82, -56.46 69.69, -0.35 out-in-out SNCoio in-out ActLoopNT-in 2.9584 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.28, 159.93 APE9-dihe-na 142.02, 171.32 APE8-dihe-in -81.41, 117.57 APE8-rot-out 188.89 APE67-dihe-in -62.69, -24.82 -43.74, -50.05 APE12-dist-in 7.634 APE11-dist-in 11.0094 APE10-dist-in 5.2938 APE9-dist-in 3.2322 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 A 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4QC Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.2926 14.7635 BLAminus -135.25, 170.61 66.71, 84.0 -99.07, 36.48 291.2, 85.91 -69.03, -37.82 in-out in 9.4987 Saltbr-out 4.06 HRD-in -75.57, -57.14 68.81, -4.17 out-in-out SNCoio in-out ActLoopNT-in 2.8901 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.57, 158.49 APE9-dihe-na 142.55, 170.52 APE8-dihe-in -81.5, 119.22 APE8-rot-out 55.54 APE67-dihe-in -62.66, -24.97 -44.86, -49.85 APE12-dist-in 7.6162 APE11-dist-in 10.9859 APE10-dist-in 5.2631 APE9-dist-in 3.2383 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 C 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4QE Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.3104 14.8014 BLAminus -139.98, 171.19 65.46, 83.84 -99.17, 35.86 291.35, 86.11 -68.1, -36.3 in-out in 9.5316 Saltbr-out 4.0961 HRD-in -73.14, -51.55 63.42, 1.74 out-in-out SNCoio in-out ActLoopNT-in 3.1013 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.33, 159.33 APE9-dihe-na 142.87, 171.07 APE8-dihe-in -80.24, 117.39 APE8-rot-out 190.21 APE67-dihe-in -61.05, -42.7 -42.39, -51.02 APE12-dist-in 7.5429 APE11-dist-in 10.9393 APE10-dist-in 5.2591 APE9-dist-in 3.3317 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 E 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4QG Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.3822 14.7874 BLAminus -136.43, 170.69 66.72, 83.62 -98.78, 33.02 291.62, 86.44 -67.7, -37.12 in-out in 9.5547 Saltbr-out 3.9739 HRD-in -68.39, -50.34 62.72, 11.29 out-in-out SNCoio in-out ActLoopNT-in 2.9253 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 159.76 APE9-dihe-na 140.64, 172.45 APE8-dihe-in -81.58, 117.44 APE8-rot-out 189.92 APE67-dihe-in -60.6, -25.5 -43.58, -51.63 APE12-dist-in 7.4333 APE11-dist-in 10.7908 APE10-dist-in 5.137 APE9-dist-in 3.2434 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 G 328.0 320.0 0 27 27 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4QI Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.2899 14.8565 BLAminus -140.96, 171.42 64.9, 84.12 -97.96, 35.72 290.26, 86.39 -67.95, -38.18 in-out in 9.5445 Saltbr-out 4.0834 HRD-in -66.19, -52.55 62.88, 16.03 out-in-out SNCoio in-out ActLoopNT-in 2.9347 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.02, 158.46 APE9-dihe-na 144.09, 168.25 APE8-dihe-in -80.55, 117.37 APE8-rot-out 188.41 APE67-dihe-in -62.44, -25.32 -44.55, -49.34 APE12-dist-in 7.633 APE11-dist-in 10.9702 APE10-dist-in 5.2476 APE9-dist-in 3.2922 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 I 328.0 316.0 0 27 27 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4QK Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.3028 14.8618 BLAminus -130.99, 169.6 63.77, 94.11 -108.55, 39.14 294.05, 89.24 -69.02, -37.64 in-out in 9.9212 Saltbr-out 5.2015 HRD-in -62.64, -54.81 63.03, 15.84 out-in-out SNCoio in-out ActLoopNT-in 2.9832 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.45, 159.5 APE9-dihe-na 141.76, 170.37 APE8-dihe-in -80.52, 118.54 APE8-rot-out 187.31 APE67-dihe-in -62.28, -24.73 -43.25, -51.12 APE12-dist-in 7.5208 APE11-dist-in 10.9604 APE10-dist-in 5.2231 APE9-dist-in 3.2543 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 K 328.0 318.0 0 27 27 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4VA Q9Y2K2 62 385 1321.0 XWA:401 Type1 Inactive DFGin 6.4376 15.6686 BLAminus -133.47, -152.71 20.2, 101.69 -106.78, 28.22 287.75, 80.74 -71.67, -19.17 out-out out 10.2955 Saltbr-out 4.3454 HRD-in -76.94, -52.41 69.39, 16.72 out-in-out SNCoio in-out ActLoopNT-in 2.9944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.92, 170.72 APE9-dihe-na 96.7, -174.65 APE8-dihe-in -92.88, 129.37 APE8-rot-out 202.49 APE67-dihe-in -60.61, -23.54 -48.56, -40.34 APE12-dist-in 8.0722 APE11-dist-in 11.0108 APE10-dist-in 5.3696 APE9-dist-in 3.813 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 A 328.0 318.0 0 27 27 0 [[66, 317]] 1.0 8r4v CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8OKUA Q9Y2K2 60 392 1321.0 VRU:60401 Type1 Inactive DFGin 6.7119 14.4057 BLAminus -144.16, 172.7 59.49, 74.79 -82.46, 31.48 289.44, 90.32 -64.16, -39.0 in-in in 9.4463 Saltbr-in 2.8143 HRD-in -72.62, -48.95 73.83, -7.19 in-in-out SNCiio in-out ActLoopNT-in 3.1287 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.95, 144.32 APE9-dihe-na 81.38, -176.13 APE8-dihe-in -76.3, 137.88 APE8-rot-out 189.72 APE67-dihe-in -58.75, -30.34 -63.13, -44.14 APE12-dist-in 8.8324 APE11-dist-in 9.8942 APE10-dist-in 5.6219 APE9-dist-in 3.8522 T221D None None XRAY 3.1 0.216 0.259 A 348.0 325.0 0 27 27 0 [[66, 317]] 1.0 8oku CAMK_SIK3_HUMAN CAMK 3.3e-95 324.3 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8OKUB Q9Y2K2 60 390 1321.0 VRU:60401 Type1 Inactive DFGin 6.7905 14.3538 BLAminus -143.9, 172.45 56.62, 70.69 -81.92, 38.26 289.12, 72.35 -63.62, -37.79 in-in in 9.5366 Saltbr-in 2.7501 HRD-in -70.0, -53.73 73.61, -1.25 in-in-out SNCiio in-out ActLoopNT-in 2.9714 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.8, 146.67 APE9-dihe-na 84.59, -177.19 APE8-dihe-in -73.13, 140.61 APE8-rot-out 190.14 APE67-dihe-in -59.97, -33.38 -64.26, -41.58 APE12-dist-in 9.0936 APE11-dist-in 10.176 APE10-dist-in 5.5521 APE9-dist-in 3.7066 T221D None None XRAY 3.1 0.216 0.259 B 348.0 323.0 0 27 27 0 [[66, 317]] 1.0 8oku CAMK_SIK3_HUMAN CAMK 3.3e-95 324.3 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4UA Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.1141 15.7176 BLAminus -120.83, 177.32 64.3, 69.36 -86.61, 37.32 285.42, 81.6 -68.75, -48.12 in-out in 9.7104 Saltbr-out 5.0707 HRD-in -73.95, -43.89 60.54, 13.54 out-in-out SNCoio in-out ActLoopNT-in 2.9903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.63, 154.75 APE9-dihe-na 133.28, 148.28 APE8-dihe-in -72.97, 134.97 APE8-rot-out 76.69 APE67-dihe-in -59.48, -14.9 -51.66, -49.91 APE12-dist-in 7.5753 APE11-dist-in 10.8389 APE10-dist-in 5.1999 APE9-dist-in 3.5147 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 A 328.0 318.0 0 27 27 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4UC Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.0638 15.7258 BLAminus -119.63, 172.69 64.17, 70.56 -86.48, 38.17 284.47, 81.48 -70.51, -47.65 in-out in 9.6342 Saltbr-out 5.2184 HRD-in -70.11, -42.03 58.34, 19.25 out-in-out SNCoio in-out ActLoopNT-in 3.0126 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.85, 155.41 APE9-dihe-na 132.79, 146.25 APE8-dihe-in -71.49, 134.8 APE8-rot-out 77.5 APE67-dihe-in -59.35, -15.04 -52.25, -50.26 APE12-dist-in 7.6004 APE11-dist-in 10.7673 APE10-dist-in 5.1799 APE9-dist-in 3.5129 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 C 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4UE Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.1697 15.5355 BLAminus -122.53, 178.95 58.14, 68.61 -86.97, 38.51 288.49, 78.31 -70.04, -45.62 in-out in 9.6508 Saltbr-out 5.1315 HRD-in -79.06, -42.81 63.53, 7.96 out-in-out SNCoio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.09, 155.41 APE9-dihe-na 133.64, 148.35 APE8-dihe-in -71.93, 135.03 APE8-rot-out 77.26 APE67-dihe-in -66.32, -2.94 -52.54, -46.56 APE12-dist-in 7.5335 APE11-dist-in 10.767 APE10-dist-in 5.1845 APE9-dist-in 3.511 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 E 328.0 317.0 0 27 27 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 8R4UG Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.0447 15.6968 BLAminus -121.26, 171.88 69.65, 69.3 -86.44, 37.16 284.67, 80.88 -69.89, -46.82 in-out in 9.7716 Saltbr-out 5.1648 HRD-in -83.11, -45.53 61.6, 18.33 out-in-out SNCoio in-out ActLoopNT-in 3.0109 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.64, 153.34 APE9-dihe-na 134.79, 145.88 APE8-dihe-in -70.55, 134.45 APE8-rot-out 77.43 APE67-dihe-in -59.64, -15.18 -51.77, -50.04 APE12-dist-in 7.656 APE11-dist-in 10.8127 APE10-dist-in 5.1921 APE9-dist-in 3.4242 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 G 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3

CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 23
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 91.3% AF-Q9Y2K2-K1A
DFGin ABAminus 2 8.7% 8R4VB

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SIK3 SIK3_HUMAN AF-Q9Y2K2-K1A Q9Y2K2 58 325 1321.0 No_ligand No_ligand Active DFGin 6.6942 14.4508 BLAminus -119.54, 177.21 54.68, 82.58 -91.15, 18.08 289.11, 79.8 -61.47, -33.93 in-in in 9.1751 Saltbr-in 2.727 HRD-in -84.96, -43.42 62.16, 5.21 in-in-in SNCiii in-in ActLoopNT-in 2.9847 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.68, 160.29 APE9-dihe-na 96.56, 179.01 APE8-dihe-in -86.75, 128.22 APE8-rot-in 305.58 APE67-dihe-in -65.83, -21.44 -50.37, -40.61 APE12-dist-in 8.7004 APE11-dist-in 10.8874 APE10-dist-in 5.1234 APE9-dist-in 3.3519 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[66, 317]] 1.0 AF-Q9Y2K2-K1 Homo sapiens CAMK_SIK3_HUMAN CAMK 5.7e-96 326.7 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN AF-Q9Y2K2-K3A Q9Y2K2 58 325 1321.0 No_ligand No_ligand Active DFGin 6.3302 14.4097 BLAminus -124.8, 175.92 53.15, 79.61 -83.53, 14.89 285.3, 85.28 -59.08, -30.53 in-in in 9.0295 Saltbr-in 2.7464 HRD-in -84.43, -45.63 65.16, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.9436 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.55, -178.04 APE9-dihe-na 100.22, 168.15 APE8-dihe-in -79.95, 124.93 APE8-rot-in 300.39 APE67-dihe-in -65.89, -18.74 -51.05, -39.95 APE12-dist-in 8.574 APE11-dist-in 11.03 APE10-dist-in 5.6074 APE9-dist-in 3.365 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 27 27 0 [[66, 317]] 1.0 AF-Q9Y2K2-K3 Homo sapiens CAMK_SIK3_HUMAN CAMK 5.7e-96 326.7 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4VB Q9Y2K2 61 384 1321.0 XWA:401 Type1 Inactive DFGin 6.5114 15.4905 ABAminus -125.75, -41.1 -99.77, 106.18 -109.14, 28.86 285.94, 82.47 -67.81, -21.46 out-out out 10.8343 Saltbr-out 4.9423 HRD-in -78.88, -52.53 65.1, 22.1 out-in-out SNCoio in-out ActLoopNT-in 3.0033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.56, 147.3 APE9-dihe-na 102.07, -167.18 APE8-dihe-in -89.53, 132.88 APE8-rot-out 85.39 APE67-dihe-in -62.44, -20.96 -46.68, -40.42 APE12-dist-in 7.9628 APE11-dist-in 10.1301 APE10-dist-in 5.1496 APE9-dist-in 3.837 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 B 328.0 316.0 0 27 27 0 [[66, 317]] 1.0 8r4v Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4VC Q9Y2K2 61 385 1321.0 XWA:401 Type1 Inactive DFGin 6.3779 15.7756 ABAminus -123.53, -39.3 -101.32, 103.7 -110.55, 26.69 286.87, 81.88 -68.74, -19.29 out-out out 10.3583 Saltbr-out 4.177 HRD-in -78.2, -53.12 69.27, 14.93 out-in-out SNCoio in-out ActLoopNT-in 3.0006 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.72, 148.26 APE9-dihe-na 98.16, -163.75 APE8-dihe-in -96.72, 131.38 APE8-rot-out 83.48 APE67-dihe-in -61.15, -23.52 -48.53, -38.56 APE12-dist-in 8.0603 APE11-dist-in 10.2666 APE10-dist-in 5.0229 APE9-dist-in 3.8461 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 C 328.0 319.0 0 27 27 0 [[66, 317]] 1.0 8r4v Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4OA Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.7893 14.5188 BLAminus -125.71, 175.86 61.17, 85.12 -103.12, 32.38 284.88, 82.02 -69.13, -38.43 in-in in 9.2107 Saltbr-in 2.7071 HRD-in -68.78, -49.07 59.21, 16.18 in-in-out SNCiio in-out ActLoopNT-in 2.9696 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.95, 164.22 APE9-dihe-na 138.1, 167.3 APE8-dihe-in -77.26, 120.01 APE8-rot-out 188.49 APE67-dihe-in -63.99, -17.85 -45.41, -48.19 APE12-dist-in 7.6133 APE11-dist-in 11.0803 APE10-dist-in 5.4608 APE9-dist-in 3.3384 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 A 328.0 316.0 0 27 27 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4OC Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.8282 14.4465 BLAminus -129.55, 168.82 71.42, 83.09 -102.43, 31.89 286.31, 82.55 -67.62, -40.46 in-in in 9.1654 Saltbr-in 2.6441 HRD-in -65.95, -51.63 61.3, 16.73 in-in-out SNCiio in-out ActLoopNT-in 2.9607 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.01, 164.27 APE9-dihe-na 137.9, 165.52 APE8-dihe-in -76.91, 120.34 APE8-rot-out 188.4 APE67-dihe-in -64.71, -17.77 -46.15, -47.73 APE12-dist-in 7.5906 APE11-dist-in 11.054 APE10-dist-in 5.4419 APE9-dist-in 3.3689 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 C 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4OE Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.9385 14.5972 BLAminus -125.14, 175.42 62.75, 84.83 -103.08, 31.64 285.5, 81.52 -67.98, -40.19 in-in in 9.1211 Saltbr-in 2.6363 HRD-in -67.61, -51.56 60.74, 18.57 in-in-out SNCiio in-out ActLoopNT-in 2.9839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 164.3 APE9-dihe-na 136.57, 164.66 APE8-dihe-in -75.86, 119.82 APE8-rot-out 188.72 APE67-dihe-in -65.37, -17.85 -45.28, -48.13 APE12-dist-in 7.5804 APE11-dist-in 11.0615 APE10-dist-in 5.4579 APE9-dist-in 3.3905 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 E 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4OG Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.9095 14.6146 BLAminus -124.38, 176.33 61.69, 84.93 -103.28, 30.5 286.01, 80.88 -68.19, -39.92 in-in in 9.1822 Saltbr-in 2.8664 HRD-in -70.7, -46.33 56.28, 19.08 in-in-out SNCiio in-out ActLoopNT-in 2.9815 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 164.45 APE9-dihe-na 136.64, 161.97 APE8-dihe-in -75.05, 120.57 APE8-rot-out 189.09 APE67-dihe-in -63.53, -18.35 -45.81, -48.67 APE12-dist-in 7.5201 APE11-dist-in 11.0215 APE10-dist-in 5.4497 APE9-dist-in 3.3949 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 G 328.0 323.0 0 27 27 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4OI Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.8991 14.5651 BLAminus -132.68, 177.0 60.73, 84.44 -102.51, 32.39 285.22, 81.32 -69.52, -27.66 in-in in 9.1945 Saltbr-in 2.7141 HRD-in -82.53, -49.17 62.06, 18.27 in-in-out SNCiio in-out ActLoopNT-in 2.9594 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.98, 164.61 APE9-dihe-na 136.93, 163.75 APE8-dihe-in -76.2, 120.78 APE8-rot-out 188.08 APE67-dihe-in -64.67, -17.51 -46.63, -48.17 APE12-dist-in 7.5868 APE11-dist-in 11.0794 APE10-dist-in 5.4714 APE9-dist-in 3.3811 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 I 328.0 317.0 0 27 27 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4OK Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.9732 14.7833 BLAminus -128.99, 172.89 59.57, 78.9 -97.11, 33.89 284.36, 89.39 -70.96, -33.22 in-in in 9.2122 Saltbr-in 2.7328 HRD-in -72.38, -44.94 53.52, 24.05 in-in-out SNCiio in-out ActLoopNT-in 3.0043 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.55, 165.44 APE9-dihe-na 135.73, 162.63 APE8-dihe-in -74.63, 117.97 APE8-rot-out 178.94 APE67-dihe-in -64.29, -16.62 -46.32, -48.14 APE12-dist-in 7.4101 APE11-dist-in 10.9261 APE10-dist-in 5.3919 APE9-dist-in 3.2952 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 K 328.0 316.0 0 27 27 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4QA Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.2696 14.8874 BLAminus -139.01, 171.07 65.51, 84.49 -98.95, 35.4 290.76, 86.17 -67.45, -37.73 in-out in 9.4825 Saltbr-out 4.139 HRD-in -65.82, -56.46 69.69, -0.35 out-in-out SNCoio in-out ActLoopNT-in 2.9584 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.28, 159.93 APE9-dihe-na 142.02, 171.32 APE8-dihe-in -81.41, 117.57 APE8-rot-out 188.89 APE67-dihe-in -62.69, -24.82 -43.74, -50.05 APE12-dist-in 7.634 APE11-dist-in 11.0094 APE10-dist-in 5.2938 APE9-dist-in 3.2322 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 A 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4QC Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.2926 14.7635 BLAminus -135.25, 170.61 66.71, 84.0 -99.07, 36.48 291.2, 85.91 -69.03, -37.82 in-out in 9.4987 Saltbr-out 4.06 HRD-in -75.57, -57.14 68.81, -4.17 out-in-out SNCoio in-out ActLoopNT-in 2.8901 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.57, 158.49 APE9-dihe-na 142.55, 170.52 APE8-dihe-in -81.5, 119.22 APE8-rot-out 55.54 APE67-dihe-in -62.66, -24.97 -44.86, -49.85 APE12-dist-in 7.6162 APE11-dist-in 10.9859 APE10-dist-in 5.2631 APE9-dist-in 3.2383 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 C 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4QE Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.3104 14.8014 BLAminus -139.98, 171.19 65.46, 83.84 -99.17, 35.86 291.35, 86.11 -68.1, -36.3 in-out in 9.5316 Saltbr-out 4.0961 HRD-in -73.14, -51.55 63.42, 1.74 out-in-out SNCoio in-out ActLoopNT-in 3.1013 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.33, 159.33 APE9-dihe-na 142.87, 171.07 APE8-dihe-in -80.24, 117.39 APE8-rot-out 190.21 APE67-dihe-in -61.05, -42.7 -42.39, -51.02 APE12-dist-in 7.5429 APE11-dist-in 10.9393 APE10-dist-in 5.2591 APE9-dist-in 3.3317 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 E 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4QG Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.3822 14.7874 BLAminus -136.43, 170.69 66.72, 83.62 -98.78, 33.02 291.62, 86.44 -67.7, -37.12 in-out in 9.5547 Saltbr-out 3.9739 HRD-in -68.39, -50.34 62.72, 11.29 out-in-out SNCoio in-out ActLoopNT-in 2.9253 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 159.76 APE9-dihe-na 140.64, 172.45 APE8-dihe-in -81.58, 117.44 APE8-rot-out 189.92 APE67-dihe-in -60.6, -25.5 -43.58, -51.63 APE12-dist-in 7.4333 APE11-dist-in 10.7908 APE10-dist-in 5.137 APE9-dist-in 3.2434 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 G 328.0 320.0 0 27 27 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4QI Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.2899 14.8565 BLAminus -140.96, 171.42 64.9, 84.12 -97.96, 35.72 290.26, 86.39 -67.95, -38.18 in-out in 9.5445 Saltbr-out 4.0834 HRD-in -66.19, -52.55 62.88, 16.03 out-in-out SNCoio in-out ActLoopNT-in 2.9347 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.02, 158.46 APE9-dihe-na 144.09, 168.25 APE8-dihe-in -80.55, 117.37 APE8-rot-out 188.41 APE67-dihe-in -62.44, -25.32 -44.55, -49.34 APE12-dist-in 7.633 APE11-dist-in 10.9702 APE10-dist-in 5.2476 APE9-dist-in 3.2922 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 I 328.0 316.0 0 27 27 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4QK Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.3028 14.8618 BLAminus -130.99, 169.6 63.77, 94.11 -108.55, 39.14 294.05, 89.24 -69.02, -37.64 in-out in 9.9212 Saltbr-out 5.2015 HRD-in -62.64, -54.81 63.03, 15.84 out-in-out SNCoio in-out ActLoopNT-in 2.9832 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.45, 159.5 APE9-dihe-na 141.76, 170.37 APE8-dihe-in -80.52, 118.54 APE8-rot-out 187.31 APE67-dihe-in -62.28, -24.73 -43.25, -51.12 APE12-dist-in 7.5208 APE11-dist-in 10.9604 APE10-dist-in 5.2231 APE9-dist-in 3.2543 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 K 328.0 318.0 0 27 27 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4VA Q9Y2K2 62 385 1321.0 XWA:401 Type1 Inactive DFGin 6.4376 15.6686 BLAminus -133.47, -152.71 20.2, 101.69 -106.78, 28.22 287.75, 80.74 -71.67, -19.17 out-out out 10.2955 Saltbr-out 4.3454 HRD-in -76.94, -52.41 69.39, 16.72 out-in-out SNCoio in-out ActLoopNT-in 2.9944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.92, 170.72 APE9-dihe-na 96.7, -174.65 APE8-dihe-in -92.88, 129.37 APE8-rot-out 202.49 APE67-dihe-in -60.61, -23.54 -48.56, -40.34 APE12-dist-in 8.0722 APE11-dist-in 11.0108 APE10-dist-in 5.3696 APE9-dist-in 3.813 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 A 328.0 318.0 0 27 27 0 [[66, 317]] 1.0 8r4v Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8OKUA Q9Y2K2 60 392 1321.0 VRU:60401 Type1 Inactive DFGin 6.7119 14.4057 BLAminus -144.16, 172.7 59.49, 74.79 -82.46, 31.48 289.44, 90.32 -64.16, -39.0 in-in in 9.4463 Saltbr-in 2.8143 HRD-in -72.62, -48.95 73.83, -7.19 in-in-out SNCiio in-out ActLoopNT-in 3.1287 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.95, 144.32 APE9-dihe-na 81.38, -176.13 APE8-dihe-in -76.3, 137.88 APE8-rot-out 189.72 APE67-dihe-in -58.75, -30.34 -63.13, -44.14 APE12-dist-in 8.8324 APE11-dist-in 9.8942 APE10-dist-in 5.6219 APE9-dist-in 3.8522 T221D None None XRAY 3.1 0.216 0.259 A 348.0 325.0 0 27 27 0 [[66, 317]] 1.0 8oku Homo sapiens CAMK_SIK3_HUMAN CAMK 3.3e-95 324.3 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8OKUB Q9Y2K2 60 390 1321.0 VRU:60401 Type1 Inactive DFGin 6.7905 14.3538 BLAminus -143.9, 172.45 56.62, 70.69 -81.92, 38.26 289.12, 72.35 -63.62, -37.79 in-in in 9.5366 Saltbr-in 2.7501 HRD-in -70.0, -53.73 73.61, -1.25 in-in-out SNCiio in-out ActLoopNT-in 2.9714 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.8, 146.67 APE9-dihe-na 84.59, -177.19 APE8-dihe-in -73.13, 140.61 APE8-rot-out 190.14 APE67-dihe-in -59.97, -33.38 -64.26, -41.58 APE12-dist-in 9.0936 APE11-dist-in 10.176 APE10-dist-in 5.5521 APE9-dist-in 3.7066 T221D None None XRAY 3.1 0.216 0.259 B 348.0 323.0 0 27 27 0 [[66, 317]] 1.0 8oku Homo sapiens CAMK_SIK3_HUMAN CAMK 3.3e-95 324.3 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4UA Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.1141 15.7176 BLAminus -120.83, 177.32 64.3, 69.36 -86.61, 37.32 285.42, 81.6 -68.75, -48.12 in-out in 9.7104 Saltbr-out 5.0707 HRD-in -73.95, -43.89 60.54, 13.54 out-in-out SNCoio in-out ActLoopNT-in 2.9903 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.63, 154.75 APE9-dihe-na 133.28, 148.28 APE8-dihe-in -72.97, 134.97 APE8-rot-out 76.69 APE67-dihe-in -59.48, -14.9 -51.66, -49.91 APE12-dist-in 7.5753 APE11-dist-in 10.8389 APE10-dist-in 5.1999 APE9-dist-in 3.5147 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 A 328.0 318.0 0 27 27 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4UC Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.0638 15.7258 BLAminus -119.63, 172.69 64.17, 70.56 -86.48, 38.17 284.47, 81.48 -70.51, -47.65 in-out in 9.6342 Saltbr-out 5.2184 HRD-in -70.11, -42.03 58.34, 19.25 out-in-out SNCoio in-out ActLoopNT-in 3.0126 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.85, 155.41 APE9-dihe-na 132.79, 146.25 APE8-dihe-in -71.49, 134.8 APE8-rot-out 77.5 APE67-dihe-in -59.35, -15.04 -52.25, -50.26 APE12-dist-in 7.6004 APE11-dist-in 10.7673 APE10-dist-in 5.1799 APE9-dist-in 3.5129 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 C 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4UE Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.1697 15.5355 BLAminus -122.53, 178.95 58.14, 68.61 -86.97, 38.51 288.49, 78.31 -70.04, -45.62 in-out in 9.6508 Saltbr-out 5.1315 HRD-in -79.06, -42.81 63.53, 7.96 out-in-out SNCoio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.09, 155.41 APE9-dihe-na 133.64, 148.35 APE8-dihe-in -71.93, 135.03 APE8-rot-out 77.26 APE67-dihe-in -66.32, -2.94 -52.54, -46.56 APE12-dist-in 7.5335 APE11-dist-in 10.767 APE10-dist-in 5.1845 APE9-dist-in 3.511 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 E 328.0 317.0 0 27 27 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3 SIK3_HUMAN 8R4UG Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.0447 15.6968 BLAminus -121.26, 171.88 69.65, 69.3 -86.44, 37.16 284.67, 80.88 -69.89, -46.82 in-out in 9.7716 Saltbr-out 5.1648 HRD-in -83.11, -45.53 61.6, 18.33 out-in-out SNCoio in-out ActLoopNT-in 3.0109 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.64, 153.34 APE9-dihe-na 134.79, 145.88 APE8-dihe-in -70.55, 134.45 APE8-rot-out 77.43 APE67-dihe-in -59.64, -15.18 -51.77, -50.04 APE12-dist-in 7.656 APE11-dist-in 10.8127 APE10-dist-in 5.1921 APE9-dist-in 3.4242 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 G 328.0 315.0 0 27 27 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1.0 256.0 256.0 205 206 207 209 211 95 113 117 185 187 186 188.0 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3

CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name