CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 23
Active chains: 2
Family: CAMK
Uniprot: SIK3_HUMAN
Kinase Domain Residues: 66 - 317
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 91.3% AF-Q9Y2K2-K1A
DFGin ABAminus 2 8.7% 8R4VB

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q9Y2K2-K1A 58 325 1321.0 No_ligand No_ligand Active DFGin 6.694 14.451 BLAminus -119.54, 177.21 54.68, 82.58 -91.15, 18.08 289.11, 79.8 -61.47, -33.93 in-in in 9.175 Saltbr-in 2.727 HRD-in -84.96, -43.42 62.16, 5.21 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.68, 160.29 APE9-dihe-na 96.56, 179.01 APE8-dihe-in -86.75, 128.22 APE8-rot-in 305.58 APE67-dihe-in -65.83, -21.44 -50.37, -40.61 APE12-dist-in 8.7 APE11-dist-in 10.887 APE10-dist-in 5.123 APE9-dist-in 3.352 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[66, 317]] 1.0 AF-Q9Y2K2-K1 CAMK_SIK3_HUMAN CAMK 5.7e-96 326.7 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
AF-Q9Y2K2-K3A 58 325 1321.0 No_ligand No_ligand Active DFGin 6.33 14.41 BLAminus -124.8, 175.92 53.15, 79.61 -83.53, 14.89 285.3, 85.28 -59.08, -30.53 in-in in 9.03 Saltbr-in 2.746 HRD-in -84.43, -45.63 65.16, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.55, -178.04 APE9-dihe-na 100.22, 168.15 APE8-dihe-in -79.95, 124.93 APE8-rot-in 300.39 APE67-dihe-in -65.89, -18.74 -51.05, -39.95 APE12-dist-in 8.574 APE11-dist-in 11.03 APE10-dist-in 5.607 APE9-dist-in 3.365 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[66, 317]] 1.0 AF-Q9Y2K2-K3 CAMK_SIK3_HUMAN CAMK 5.7e-96 326.7 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4VB 61 384 1321.0 XWA:401 Type1 Inactive DFGin 6.511 15.491 ABAminus -125.75, -41.1 -99.77, 106.18 -109.14, 28.86 285.94, 82.47 -67.81, -21.46 out-out out 10.834 Saltbr-out 4.942 HRD-in -78.88, -52.53 65.1, 22.1 out-in-out SNCoio in-out ActLoopNT-in 3.003 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.56, 147.3 APE9-dihe-na 102.07, -167.18 APE8-dihe-in -89.53, 132.88 APE8-rot-out 85.39 APE67-dihe-in -62.44, -20.96 -46.68, -40.42 APE12-dist-in 7.963 APE11-dist-in 10.13 APE10-dist-in 5.15 APE9-dist-in 3.837 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 B 328 316 0 0 0 0 [[66, 317]] 1.0 8r4v CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4VC 61 385 1321.0 XWA:401 Type1 Inactive DFGin 6.378 15.776 ABAminus -123.53, -39.3 -101.32, 103.7 -110.55, 26.69 286.87, 81.88 -68.74, -19.29 out-out out 10.358 Saltbr-out 4.177 HRD-in -78.2, -53.12 69.27, 14.93 out-in-out SNCoio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.72, 148.26 APE9-dihe-na 98.16, -163.75 APE8-dihe-in -96.72, 131.38 APE8-rot-out 83.48 APE67-dihe-in -61.15, -23.52 -48.53, -38.56 APE12-dist-in 8.06 APE11-dist-in 10.267 APE10-dist-in 5.023 APE9-dist-in 3.846 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 C 328 319 0 0 0 0 [[66, 317]] 1.0 8r4v CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4OA 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.789 14.519 BLAminus -125.71, 175.86 61.17, 85.12 -103.12, 32.38 284.88, 82.02 -69.13, -38.43 in-in in 9.211 Saltbr-in 2.707 HRD-in -68.78, -49.07 59.21, 16.18 in-in-out SNCiio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.95, 164.22 APE9-dihe-na 138.1, 167.3 APE8-dihe-in -77.26, 120.01 APE8-rot-out 188.49 APE67-dihe-in -63.99, -17.85 -45.41, -48.19 APE12-dist-in 7.613 APE11-dist-in 11.08 APE10-dist-in 5.461 APE9-dist-in 3.338 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 A 328 316 0 0 0 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4OC 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.828 14.447 BLAminus -129.55, 168.82 71.42, 83.09 -102.43, 31.89 286.31, 82.55 -67.62, -40.46 in-in in 9.165 Saltbr-in 2.644 HRD-in -65.95, -51.63 61.3, 16.73 in-in-out SNCiio in-out ActLoopNT-in 2.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.01, 164.27 APE9-dihe-na 137.9, 165.52 APE8-dihe-in -76.91, 120.34 APE8-rot-out 188.4 APE67-dihe-in -64.71, -17.77 -46.15, -47.73 APE12-dist-in 7.591 APE11-dist-in 11.054 APE10-dist-in 5.442 APE9-dist-in 3.369 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4OE 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.939 14.597 BLAminus -125.14, 175.42 62.75, 84.83 -103.08, 31.64 285.5, 81.52 -67.98, -40.19 in-in in 9.121 Saltbr-in 2.636 HRD-in -67.61, -51.56 60.74, 18.57 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 164.3 APE9-dihe-na 136.57, 164.66 APE8-dihe-in -75.86, 119.82 APE8-rot-out 188.72 APE67-dihe-in -65.37, -17.85 -45.28, -48.13 APE12-dist-in 7.58 APE11-dist-in 11.062 APE10-dist-in 5.458 APE9-dist-in 3.39 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 E 328 315 0 0 0 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4OG 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.91 14.615 BLAminus -124.38, 176.33 61.69, 84.93 -103.28, 30.5 286.01, 80.88 -68.19, -39.92 in-in in 9.182 Saltbr-in 2.866 HRD-in -70.7, -46.33 56.28, 19.08 in-in-out SNCiio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 164.45 APE9-dihe-na 136.64, 161.97 APE8-dihe-in -75.05, 120.57 APE8-rot-out 189.09 APE67-dihe-in -63.53, -18.35 -45.81, -48.67 APE12-dist-in 7.52 APE11-dist-in 11.021 APE10-dist-in 5.45 APE9-dist-in 3.395 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 G 328 323 0 0 0 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4OI 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.899 14.565 BLAminus -132.68, 177.0 60.73, 84.44 -102.51, 32.39 285.22, 81.32 -69.52, -27.66 in-in in 9.194 Saltbr-in 2.714 HRD-in -82.53, -49.17 62.06, 18.27 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.98, 164.61 APE9-dihe-na 136.93, 163.75 APE8-dihe-in -76.2, 120.78 APE8-rot-out 188.08 APE67-dihe-in -64.67, -17.51 -46.63, -48.17 APE12-dist-in 7.587 APE11-dist-in 11.079 APE10-dist-in 5.471 APE9-dist-in 3.381 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 I 328 317 0 0 0 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4OK 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.973 14.783 BLAminus -128.99, 172.89 59.57, 78.9 -97.11, 33.89 284.36, 89.39 -70.96, -33.22 in-in in 9.212 Saltbr-in 2.733 HRD-in -72.38, -44.94 53.52, 24.05 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.55, 165.44 APE9-dihe-na 135.73, 162.63 APE8-dihe-in -74.63, 117.97 APE8-rot-out 178.94 APE67-dihe-in -64.29, -16.62 -46.32, -48.14 APE12-dist-in 7.41 APE11-dist-in 10.926 APE10-dist-in 5.392 APE9-dist-in 3.295 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 K 328 316 0 0 0 0 [[66, 317]] 1.0 8r4o CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4QA 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.27 14.887 BLAminus -139.01, 171.07 65.51, 84.49 -98.95, 35.4 290.76, 86.17 -67.45, -37.73 in-out in 9.482 Saltbr-out 4.139 HRD-in -65.82, -56.46 69.69, -0.35 out-in-out SNCoio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.28, 159.93 APE9-dihe-na 142.02, 171.32 APE8-dihe-in -81.41, 117.57 APE8-rot-out 188.89 APE67-dihe-in -62.69, -24.82 -43.74, -50.05 APE12-dist-in 7.634 APE11-dist-in 11.009 APE10-dist-in 5.294 APE9-dist-in 3.232 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 A 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4QC 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.293 14.764 BLAminus -135.25, 170.61 66.71, 84.0 -99.07, 36.48 291.2, 85.91 -69.03, -37.82 in-out in 9.499 Saltbr-out 4.06 HRD-in -75.57, -57.14 68.81, -4.17 out-in-out SNCoio in-out ActLoopNT-in 2.89 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.57, 158.49 APE9-dihe-na 142.55, 170.52 APE8-dihe-in -81.5, 119.22 APE8-rot-out 55.54 APE67-dihe-in -62.66, -24.97 -44.86, -49.85 APE12-dist-in 7.616 APE11-dist-in 10.986 APE10-dist-in 5.263 APE9-dist-in 3.238 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4QE 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.31 14.801 BLAminus -139.98, 171.19 65.46, 83.84 -99.17, 35.86 291.35, 86.11 -68.1, -36.3 in-out in 9.532 Saltbr-out 4.096 HRD-in -73.14, -51.55 63.42, 1.74 out-in-out SNCoio in-out ActLoopNT-in 3.101 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.33, 159.33 APE9-dihe-na 142.87, 171.07 APE8-dihe-in -80.24, 117.39 APE8-rot-out 190.21 APE67-dihe-in -61.05, -42.7 -42.39, -51.02 APE12-dist-in 7.543 APE11-dist-in 10.939 APE10-dist-in 5.259 APE9-dist-in 3.332 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 E 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4QG 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.382 14.787 BLAminus -136.43, 170.69 66.72, 83.62 -98.78, 33.02 291.62, 86.44 -67.7, -37.12 in-out in 9.555 Saltbr-out 3.974 HRD-in -68.39, -50.34 62.72, 11.29 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 159.76 APE9-dihe-na 140.64, 172.45 APE8-dihe-in -81.58, 117.44 APE8-rot-out 189.92 APE67-dihe-in -60.6, -25.5 -43.58, -51.63 APE12-dist-in 7.433 APE11-dist-in 10.791 APE10-dist-in 5.137 APE9-dist-in 3.243 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 G 328 320 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4QI 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.29 14.857 BLAminus -140.96, 171.42 64.9, 84.12 -97.96, 35.72 290.26, 86.39 -67.95, -38.18 in-out in 9.544 Saltbr-out 4.083 HRD-in -66.19, -52.55 62.88, 16.03 out-in-out SNCoio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.02, 158.46 APE9-dihe-na 144.09, 168.25 APE8-dihe-in -80.55, 117.37 APE8-rot-out 188.41 APE67-dihe-in -62.44, -25.32 -44.55, -49.34 APE12-dist-in 7.633 APE11-dist-in 10.97 APE10-dist-in 5.248 APE9-dist-in 3.292 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 I 328 316 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4QK 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.303 14.862 BLAminus -130.99, 169.6 63.77, 94.11 -108.55, 39.14 294.05, 89.24 -69.02, -37.64 in-out in 9.921 Saltbr-out 5.202 HRD-in -62.64, -54.81 63.03, 15.84 out-in-out SNCoio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.45, 159.5 APE9-dihe-na 141.76, 170.37 APE8-dihe-in -80.52, 118.54 APE8-rot-out 187.31 APE67-dihe-in -62.28, -24.73 -43.25, -51.12 APE12-dist-in 7.521 APE11-dist-in 10.96 APE10-dist-in 5.223 APE9-dist-in 3.254 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 K 328 318 0 0 0 0 [[66, 317]] 1.0 8r4q CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4VA 62 385 1321.0 XWA:401 Type1 Inactive DFGin 6.438 15.669 BLAminus -133.47, -152.71 20.2, 101.69 -106.78, 28.22 287.75, 80.74 -71.67, -19.17 out-out out 10.296 Saltbr-out 4.345 HRD-in -76.94, -52.41 69.39, 16.72 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.92, 170.72 APE9-dihe-na 96.7, -174.65 APE8-dihe-in -92.88, 129.37 APE8-rot-out 202.49 APE67-dihe-in -60.61, -23.54 -48.56, -40.34 APE12-dist-in 8.072 APE11-dist-in 11.011 APE10-dist-in 5.37 APE9-dist-in 3.813 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 A 328 318 0 0 0 0 [[66, 317]] 1.0 8r4v CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8OKUA 60 392 1321.0 VRU:60401 Type1 Inactive DFGin 6.712 14.406 BLAminus -144.16, 172.7 59.49, 74.79 -82.46, 31.48 289.44, 90.32 -64.16, -39.0 in-in in 9.446 Saltbr-in 2.814 HRD-in -72.62, -48.95 73.83, -7.19 in-in-out SNCiio in-out ActLoopNT-in 3.129 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.95, 144.32 APE9-dihe-na 81.38, -176.13 APE8-dihe-in -76.3, 137.88 APE8-rot-out 189.72 APE67-dihe-in -58.75, -30.34 -63.13, -44.14 APE12-dist-in 8.832 APE11-dist-in 9.894 APE10-dist-in 5.622 APE9-dist-in 3.852 T221D None None XRAY 3.1 0.216 0.259 A 348 325 0 0 0 0 [[66, 317]] 1.0 8oku CAMK_SIK3_HUMAN CAMK 3.3e-95 324.3 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8OKUB 60 390 1321.0 VRU:60401 Type1 Inactive DFGin 6.79 14.354 BLAminus -143.9, 172.45 56.62, 70.69 -81.92, 38.26 289.12, 72.35 -63.62, -37.79 in-in in 9.537 Saltbr-in 2.75 HRD-in -70.0, -53.73 73.61, -1.25 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.8, 146.67 APE9-dihe-na 84.59, -177.19 APE8-dihe-in -73.13, 140.61 APE8-rot-out 190.14 APE67-dihe-in -59.97, -33.38 -64.26, -41.58 APE12-dist-in 9.094 APE11-dist-in 10.176 APE10-dist-in 5.552 APE9-dist-in 3.707 T221D None None XRAY 3.1 0.216 0.259 B 348 323 0 0 0 0 [[66, 317]] 1.0 8oku CAMK_SIK3_HUMAN CAMK 3.3e-95 324.3 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4UA 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.114 15.718 BLAminus -120.83, 177.32 64.3, 69.36 -86.61, 37.32 285.42, 81.6 -68.75, -48.12 in-out in 9.71 Saltbr-out 5.071 HRD-in -73.95, -43.89 60.54, 13.54 out-in-out SNCoio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.63, 154.75 APE9-dihe-na 133.28, 148.28 APE8-dihe-in -72.97, 134.97 APE8-rot-out 76.69 APE67-dihe-in -59.48, -14.9 -51.66, -49.91 APE12-dist-in 7.575 APE11-dist-in 10.839 APE10-dist-in 5.2 APE9-dist-in 3.515 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 A 328 318 0 0 0 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4UC 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.064 15.726 BLAminus -119.63, 172.69 64.17, 70.56 -86.48, 38.17 284.47, 81.48 -70.51, -47.65 in-out in 9.634 Saltbr-out 5.218 HRD-in -70.11, -42.03 58.34, 19.25 out-in-out SNCoio in-out ActLoopNT-in 3.013 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.85, 155.41 APE9-dihe-na 132.79, 146.25 APE8-dihe-in -71.49, 134.8 APE8-rot-out 77.5 APE67-dihe-in -59.35, -15.04 -52.25, -50.26 APE12-dist-in 7.6 APE11-dist-in 10.767 APE10-dist-in 5.18 APE9-dist-in 3.513 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4UE 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.17 15.536 BLAminus -122.53, 178.95 58.14, 68.61 -86.97, 38.51 288.49, 78.31 -70.04, -45.62 in-out in 9.651 Saltbr-out 5.131 HRD-in -79.06, -42.81 63.53, 7.96 out-in-out SNCoio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.09, 155.41 APE9-dihe-na 133.64, 148.35 APE8-dihe-in -71.93, 135.03 APE8-rot-out 77.26 APE67-dihe-in -66.32, -2.94 -52.54, -46.56 APE12-dist-in 7.534 APE11-dist-in 10.767 APE10-dist-in 5.184 APE9-dist-in 3.511 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 E 328 317 0 0 0 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
8R4UG 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.045 15.697 BLAminus -121.26, 171.88 69.65, 69.3 -86.44, 37.16 284.67, 80.88 -69.89, -46.82 in-out in 9.772 Saltbr-out 5.165 HRD-in -83.11, -45.53 61.6, 18.33 out-in-out SNCoio in-out ActLoopNT-in 3.011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.64, 153.34 APE9-dihe-na 134.79, 145.88 APE8-dihe-in -70.55, 134.45 APE8-rot-out 77.43 APE67-dihe-in -59.64, -15.18 -51.77, -50.04 APE12-dist-in 7.656 APE11-dist-in 10.813 APE10-dist-in 5.192 APE9-dist-in 3.424 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 G 328 315 0 0 0 0 [[66, 317]] 1.0 8r4u CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3

CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 23
Active chains: 2
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 91.3% AF-Q9Y2K2-K1A
DFGin ABAminus 2 8.7% 8R4VB

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SIK3_HUMAN AF-Q9Y2K2-K1A Q9Y2K2 58 325 1321.0 No_ligand No_ligand Active DFGin 6.694 14.451 BLAminus -119.54, 177.21 54.68, 82.58 -91.15, 18.08 289.11, 79.8 -61.47, -33.93 in-in in 9.175 Saltbr-in 2.727 HRD-in -84.96, -43.42 62.16, 5.21 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.68, 160.29 APE9-dihe-na 96.56, 179.01 APE8-dihe-in -86.75, 128.22 APE8-rot-in 305.58 APE67-dihe-in -65.83, -21.44 -50.37, -40.61 APE12-dist-in 8.7 APE11-dist-in 10.887 APE10-dist-in 5.123 APE9-dist-in 3.352 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[66, 317]] 1.0 AF-Q9Y2K2-K1 Homo sapiens CAMK_SIK3_HUMAN CAMK 5.7e-96 326.7 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN AF-Q9Y2K2-K3A Q9Y2K2 58 325 1321.0 No_ligand No_ligand Active DFGin 6.33 14.41 BLAminus -124.8, 175.92 53.15, 79.61 -83.53, 14.89 285.3, 85.28 -59.08, -30.53 in-in in 9.03 Saltbr-in 2.746 HRD-in -84.43, -45.63 65.16, -2.37 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.55, -178.04 APE9-dihe-na 100.22, 168.15 APE8-dihe-in -79.95, 124.93 APE8-rot-in 300.39 APE67-dihe-in -65.89, -18.74 -51.05, -39.95 APE12-dist-in 8.574 APE11-dist-in 11.03 APE10-dist-in 5.607 APE9-dist-in 3.365 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[66, 317]] 1.0 AF-Q9Y2K2-K3 Homo sapiens CAMK_SIK3_HUMAN CAMK 5.7e-96 326.7 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4VB Q9Y2K2 61 384 1321.0 XWA:401 Type1 Inactive DFGin 6.511 15.491 ABAminus -125.75, -41.1 -99.77, 106.18 -109.14, 28.86 285.94, 82.47 -67.81, -21.46 out-out out 10.834 Saltbr-out 4.942 HRD-in -78.88, -52.53 65.1, 22.1 out-in-out SNCoio in-out ActLoopNT-in 3.003 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -141.56, 147.3 APE9-dihe-na 102.07, -167.18 APE8-dihe-in -89.53, 132.88 APE8-rot-out 85.39 APE67-dihe-in -62.44, -20.96 -46.68, -40.42 APE12-dist-in 7.963 APE11-dist-in 10.13 APE10-dist-in 5.15 APE9-dist-in 3.837 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 B 328 316 0 0 0 0 [[66, 317]] 1.0 8r4v Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4VC Q9Y2K2 61 385 1321.0 XWA:401 Type1 Inactive DFGin 6.378 15.776 ABAminus -123.53, -39.3 -101.32, 103.7 -110.55, 26.69 286.87, 81.88 -68.74, -19.29 out-out out 10.358 Saltbr-out 4.177 HRD-in -78.2, -53.12 69.27, 14.93 out-in-out SNCoio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -142.72, 148.26 APE9-dihe-na 98.16, -163.75 APE8-dihe-in -96.72, 131.38 APE8-rot-out 83.48 APE67-dihe-in -61.15, -23.52 -48.53, -38.56 APE12-dist-in 8.06 APE11-dist-in 10.267 APE10-dist-in 5.023 APE9-dist-in 3.846 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 C 328 319 0 0 0 0 [[66, 317]] 1.0 8r4v Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4OA Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.789 14.519 BLAminus -125.71, 175.86 61.17, 85.12 -103.12, 32.38 284.88, 82.02 -69.13, -38.43 in-in in 9.211 Saltbr-in 2.707 HRD-in -68.78, -49.07 59.21, 16.18 in-in-out SNCiio in-out ActLoopNT-in 2.97 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.95, 164.22 APE9-dihe-na 138.1, 167.3 APE8-dihe-in -77.26, 120.01 APE8-rot-out 188.49 APE67-dihe-in -63.99, -17.85 -45.41, -48.19 APE12-dist-in 7.613 APE11-dist-in 11.08 APE10-dist-in 5.461 APE9-dist-in 3.338 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 A 328 316 0 0 0 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4OC Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.828 14.447 BLAminus -129.55, 168.82 71.42, 83.09 -102.43, 31.89 286.31, 82.55 -67.62, -40.46 in-in in 9.165 Saltbr-in 2.644 HRD-in -65.95, -51.63 61.3, 16.73 in-in-out SNCiio in-out ActLoopNT-in 2.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.01, 164.27 APE9-dihe-na 137.9, 165.52 APE8-dihe-in -76.91, 120.34 APE8-rot-out 188.4 APE67-dihe-in -64.71, -17.77 -46.15, -47.73 APE12-dist-in 7.591 APE11-dist-in 11.054 APE10-dist-in 5.442 APE9-dist-in 3.369 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4OE Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.939 14.597 BLAminus -125.14, 175.42 62.75, 84.83 -103.08, 31.64 285.5, 81.52 -67.98, -40.19 in-in in 9.121 Saltbr-in 2.636 HRD-in -67.61, -51.56 60.74, 18.57 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 164.3 APE9-dihe-na 136.57, 164.66 APE8-dihe-in -75.86, 119.82 APE8-rot-out 188.72 APE67-dihe-in -65.37, -17.85 -45.28, -48.13 APE12-dist-in 7.58 APE11-dist-in 11.062 APE10-dist-in 5.458 APE9-dist-in 3.39 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 E 328 315 0 0 0 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4OG Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.91 14.615 BLAminus -124.38, 176.33 61.69, 84.93 -103.28, 30.5 286.01, 80.88 -68.19, -39.92 in-in in 9.182 Saltbr-in 2.866 HRD-in -70.7, -46.33 56.28, 19.08 in-in-out SNCiio in-out ActLoopNT-in 2.982 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.89, 164.45 APE9-dihe-na 136.64, 161.97 APE8-dihe-in -75.05, 120.57 APE8-rot-out 189.09 APE67-dihe-in -63.53, -18.35 -45.81, -48.67 APE12-dist-in 7.52 APE11-dist-in 11.021 APE10-dist-in 5.45 APE9-dist-in 3.395 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 G 328 323 0 0 0 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4OI Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.899 14.565 BLAminus -132.68, 177.0 60.73, 84.44 -102.51, 32.39 285.22, 81.32 -69.52, -27.66 in-in in 9.194 Saltbr-in 2.714 HRD-in -82.53, -49.17 62.06, 18.27 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.98, 164.61 APE9-dihe-na 136.93, 163.75 APE8-dihe-in -76.2, 120.78 APE8-rot-out 188.08 APE67-dihe-in -64.67, -17.51 -46.63, -48.17 APE12-dist-in 7.587 APE11-dist-in 11.079 APE10-dist-in 5.471 APE9-dist-in 3.381 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 I 328 317 0 0 0 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4OK Q9Y2K2 62 384 1321.0 XVI:401 Type1 Inactive DFGin 6.973 14.783 BLAminus -128.99, 172.89 59.57, 78.9 -97.11, 33.89 284.36, 89.39 -70.96, -33.22 in-in in 9.212 Saltbr-in 2.733 HRD-in -72.38, -44.94 53.52, 24.05 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.55, 165.44 APE9-dihe-na 135.73, 162.63 APE8-dihe-in -74.63, 117.97 APE8-rot-out 178.94 APE67-dihe-in -64.29, -16.62 -46.32, -48.14 APE12-dist-in 7.41 APE11-dist-in 10.926 APE10-dist-in 5.392 APE9-dist-in 3.295 C121S,C181S,C333S TPO221 TPO221 XRAY 2.725 0.216 0.244 K 328 316 0 0 0 0 [[66, 317]] 1.0 8r4o Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4QA Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.27 14.887 BLAminus -139.01, 171.07 65.51, 84.49 -98.95, 35.4 290.76, 86.17 -67.45, -37.73 in-out in 9.482 Saltbr-out 4.139 HRD-in -65.82, -56.46 69.69, -0.35 out-in-out SNCoio in-out ActLoopNT-in 2.958 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.28, 159.93 APE9-dihe-na 142.02, 171.32 APE8-dihe-in -81.41, 117.57 APE8-rot-out 188.89 APE67-dihe-in -62.69, -24.82 -43.74, -50.05 APE12-dist-in 7.634 APE11-dist-in 11.009 APE10-dist-in 5.294 APE9-dist-in 3.232 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 A 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4QC Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.293 14.764 BLAminus -135.25, 170.61 66.71, 84.0 -99.07, 36.48 291.2, 85.91 -69.03, -37.82 in-out in 9.499 Saltbr-out 4.06 HRD-in -75.57, -57.14 68.81, -4.17 out-in-out SNCoio in-out ActLoopNT-in 2.89 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.57, 158.49 APE9-dihe-na 142.55, 170.52 APE8-dihe-in -81.5, 119.22 APE8-rot-out 55.54 APE67-dihe-in -62.66, -24.97 -44.86, -49.85 APE12-dist-in 7.616 APE11-dist-in 10.986 APE10-dist-in 5.263 APE9-dist-in 3.238 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4QE Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.31 14.801 BLAminus -139.98, 171.19 65.46, 83.84 -99.17, 35.86 291.35, 86.11 -68.1, -36.3 in-out in 9.532 Saltbr-out 4.096 HRD-in -73.14, -51.55 63.42, 1.74 out-in-out SNCoio in-out ActLoopNT-in 3.101 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.33, 159.33 APE9-dihe-na 142.87, 171.07 APE8-dihe-in -80.24, 117.39 APE8-rot-out 190.21 APE67-dihe-in -61.05, -42.7 -42.39, -51.02 APE12-dist-in 7.543 APE11-dist-in 10.939 APE10-dist-in 5.259 APE9-dist-in 3.332 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 E 328 315 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4QG Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.382 14.787 BLAminus -136.43, 170.69 66.72, 83.62 -98.78, 33.02 291.62, 86.44 -67.7, -37.12 in-out in 9.555 Saltbr-out 3.974 HRD-in -68.39, -50.34 62.72, 11.29 out-in-out SNCoio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 159.76 APE9-dihe-na 140.64, 172.45 APE8-dihe-in -81.58, 117.44 APE8-rot-out 189.92 APE67-dihe-in -60.6, -25.5 -43.58, -51.63 APE12-dist-in 7.433 APE11-dist-in 10.791 APE10-dist-in 5.137 APE9-dist-in 3.243 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 G 328 320 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4QI Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.29 14.857 BLAminus -140.96, 171.42 64.9, 84.12 -97.96, 35.72 290.26, 86.39 -67.95, -38.18 in-out in 9.544 Saltbr-out 4.083 HRD-in -66.19, -52.55 62.88, 16.03 out-in-out SNCoio in-out ActLoopNT-in 2.935 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -130.02, 158.46 APE9-dihe-na 144.09, 168.25 APE8-dihe-in -80.55, 117.37 APE8-rot-out 188.41 APE67-dihe-in -62.44, -25.32 -44.55, -49.34 APE12-dist-in 7.633 APE11-dist-in 10.97 APE10-dist-in 5.248 APE9-dist-in 3.292 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 I 328 316 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4QK Q9Y2K2 62 384 1321.0 DB8:401 Type1 Inactive DFGin 6.303 14.862 BLAminus -130.99, 169.6 63.77, 94.11 -108.55, 39.14 294.05, 89.24 -69.02, -37.64 in-out in 9.921 Saltbr-out 5.202 HRD-in -62.64, -54.81 63.03, 15.84 out-in-out SNCoio in-out ActLoopNT-in 2.983 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.45, 159.5 APE9-dihe-na 141.76, 170.37 APE8-dihe-in -80.52, 118.54 APE8-rot-out 187.31 APE67-dihe-in -62.28, -24.73 -43.25, -51.12 APE12-dist-in 7.521 APE11-dist-in 10.96 APE10-dist-in 5.223 APE9-dist-in 3.254 C121S,C181S,C333S TPO221 TPO221 XRAY 2.838 0.214 0.244 K 328 318 0 0 0 0 [[66, 317]] 1.0 8r4q Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4VA Q9Y2K2 62 385 1321.0 XWA:401 Type1 Inactive DFGin 6.438 15.669 BLAminus -133.47, -152.71 20.2, 101.69 -106.78, 28.22 287.75, 80.74 -71.67, -19.17 out-out out 10.296 Saltbr-out 4.345 HRD-in -76.94, -52.41 69.39, 16.72 out-in-out SNCoio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.92, 170.72 APE9-dihe-na 96.7, -174.65 APE8-dihe-in -92.88, 129.37 APE8-rot-out 202.49 APE67-dihe-in -60.61, -23.54 -48.56, -40.34 APE12-dist-in 8.072 APE11-dist-in 11.011 APE10-dist-in 5.37 APE9-dist-in 3.813 C121S,C181S,C333S TPO221 TPO221 XRAY 1.9 0.206 0.24 A 328 318 0 0 0 0 [[66, 317]] 1.0 8r4v Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8OKUA Q9Y2K2 60 392 1321.0 VRU:60401 Type1 Inactive DFGin 6.712 14.406 BLAminus -144.16, 172.7 59.49, 74.79 -82.46, 31.48 289.44, 90.32 -64.16, -39.0 in-in in 9.446 Saltbr-in 2.814 HRD-in -72.62, -48.95 73.83, -7.19 in-in-out SNCiio in-out ActLoopNT-in 3.129 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.95, 144.32 APE9-dihe-na 81.38, -176.13 APE8-dihe-in -76.3, 137.88 APE8-rot-out 189.72 APE67-dihe-in -58.75, -30.34 -63.13, -44.14 APE12-dist-in 8.832 APE11-dist-in 9.894 APE10-dist-in 5.622 APE9-dist-in 3.852 T221D None None XRAY 3.1 0.216 0.259 A 348 325 0 0 0 0 [[66, 317]] 1.0 8oku Homo sapiens CAMK_SIK3_HUMAN CAMK 3.3e-95 324.3 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8OKUB Q9Y2K2 60 390 1321.0 VRU:60401 Type1 Inactive DFGin 6.79 14.354 BLAminus -143.9, 172.45 56.62, 70.69 -81.92, 38.26 289.12, 72.35 -63.62, -37.79 in-in in 9.537 Saltbr-in 2.75 HRD-in -70.0, -53.73 73.61, -1.25 in-in-out SNCiio in-out ActLoopNT-in 2.971 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -146.8, 146.67 APE9-dihe-na 84.59, -177.19 APE8-dihe-in -73.13, 140.61 APE8-rot-out 190.14 APE67-dihe-in -59.97, -33.38 -64.26, -41.58 APE12-dist-in 9.094 APE11-dist-in 10.176 APE10-dist-in 5.552 APE9-dist-in 3.707 T221D None None XRAY 3.1 0.216 0.259 B 348 323 0 0 0 0 [[66, 317]] 1.0 8oku Homo sapiens CAMK_SIK3_HUMAN CAMK 3.3e-95 324.3 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4UA Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.114 15.718 BLAminus -120.83, 177.32 64.3, 69.36 -86.61, 37.32 285.42, 81.6 -68.75, -48.12 in-out in 9.71 Saltbr-out 5.071 HRD-in -73.95, -43.89 60.54, 13.54 out-in-out SNCoio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.63, 154.75 APE9-dihe-na 133.28, 148.28 APE8-dihe-in -72.97, 134.97 APE8-rot-out 76.69 APE67-dihe-in -59.48, -14.9 -51.66, -49.91 APE12-dist-in 7.575 APE11-dist-in 10.839 APE10-dist-in 5.2 APE9-dist-in 3.515 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 A 328 318 0 0 0 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4UC Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.064 15.726 BLAminus -119.63, 172.69 64.17, 70.56 -86.48, 38.17 284.47, 81.48 -70.51, -47.65 in-out in 9.634 Saltbr-out 5.218 HRD-in -70.11, -42.03 58.34, 19.25 out-in-out SNCoio in-out ActLoopNT-in 3.013 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.85, 155.41 APE9-dihe-na 132.79, 146.25 APE8-dihe-in -71.49, 134.8 APE8-rot-out 77.5 APE67-dihe-in -59.35, -15.04 -52.25, -50.26 APE12-dist-in 7.6 APE11-dist-in 10.767 APE10-dist-in 5.18 APE9-dist-in 3.513 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 C 328 315 0 0 0 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4UE Q9Y2K2 61 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.17 15.536 BLAminus -122.53, 178.95 58.14, 68.61 -86.97, 38.51 288.49, 78.31 -70.04, -45.62 in-out in 9.651 Saltbr-out 5.131 HRD-in -79.06, -42.81 63.53, 7.96 out-in-out SNCoio in-out ActLoopNT-in 3.05 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -149.09, 155.41 APE9-dihe-na 133.64, 148.35 APE8-dihe-in -71.93, 135.03 APE8-rot-out 77.26 APE67-dihe-in -66.32, -2.94 -52.54, -46.56 APE12-dist-in 7.534 APE11-dist-in 10.767 APE10-dist-in 5.184 APE9-dist-in 3.511 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 E 328 317 0 0 0 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3
SIK3_HUMAN 8R4UG Q9Y2K2 62 384 1321.0 XW3:401 Type1.5_Front Inactive DFGin 7.045 15.697 BLAminus -121.26, 171.88 69.65, 69.3 -86.44, 37.16 284.67, 80.88 -69.89, -46.82 in-out in 9.772 Saltbr-out 5.165 HRD-in -83.11, -45.53 61.6, 18.33 out-in-out SNCoio in-out ActLoopNT-in 3.011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -148.64, 153.34 APE9-dihe-na 134.79, 145.88 APE8-dihe-in -70.55, 134.45 APE8-rot-out 77.43 APE67-dihe-in -59.64, -15.18 -51.77, -50.04 APE12-dist-in 7.656 APE11-dist-in 10.813 APE10-dist-in 5.192 APE9-dist-in 3.424 C121S,C181S,C333S TPO221 TPO221 XRAY 2.416 0.23 0.265 G 328 315 0 0 0 0 [[66, 317]] 1.0 8r4u Homo sapiens CAMK_SIK3_HUMAN CAMK 1.8e-96 328.4 1 256 256 205 206 207 209 211 95 113 117 185 187 186 188 245 232 227 226 225 224 223 222 221 143 Serine/threonine-protein kinase SIK3

CAMK_SIK3 (Serine/threonine-protein kinase SIK3)

Total number of chains: 0
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name