AGC_RPS6KB1 (Ribosomal protein S6 kinase beta-1)

Total number of chains: 26
Active chains: 2
Family: AGC
Uniprot: KS6B1_HUMAN
Kinase Domain Residues: 91 - 352
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 14 53.8% 4L3JA
DFGin BLAminus 6 23.1% AF-P23443-K1A
DFGin None 4 15.4% 3WF7A
None None 2 7.7% 3A60B

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P23443-K1A 83 360 525.0 No_ligand No_ligand Active DFGin 6.85 14.148 BLAminus -124.31, -166.39 38.73, 66.43 -77.66, 13.72 288.38, 76.88 -63.66, -21.1 in-in in 8.764 Saltbr-in 2.612 HRD-in -85.2, -47.45 63.14, 5.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.51, 166.53 APE9-dihe-na 111.13, -177.37 APE8-dihe-in -97.94, 129.35 APE8-rot-in 304.6 APE67-dihe-in -59.86, -23.05 -60.69, -41.68 APE12-dist-in 8.424 APE11-dist-in 11.405 APE10-dist-in 5.675 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[91, 352]] 1.0 AF-P23443-K1 AGC_RPS6KB1_HUMAN AGC 2.5e-96 327.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
AF-P23443-K3A 83 360 525.0 No_ligand No_ligand Active DFGin 6.499 13.931 BLAminus -128.06, -173.88 44.57, 66.94 -75.34, 10.89 293.5, 80.29 -60.23, -27.79 in-in in 8.905 Saltbr-in 2.613 HRD-in -82.97, -50.48 68.32, 8.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.49, 169.69 APE9-dihe-na 107.2, 177.16 APE8-dihe-in -89.35, 135.4 APE8-rot-in 302.12 APE67-dihe-in -65.67, -26.41 -68.11, -34.82 APE12-dist-in 8.273 APE11-dist-in 11.346 APE10-dist-in 5.632 APE9-dist-in 3.355 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[91, 352]] 1.0 AF-P23443-K3 AGC_RPS6KB1_HUMAN AGC 2.5e-96 327.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4RLPA 85 372 525.0 72B:401 Type1 Inactive DFGin 6.13 13.245 ABAminus -108.51, -71.08 -84.78, 124.37 -121.68, 51.98 300.45, 37.52 -105.22, -52.67 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.77, -44.5 76.33, -53.54 none-in-out SNCnio in-out ActLoopNT-in 3.593 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -96.35 APE8-dihe-in -67.86, 138.97 APE8-rot-in 298.2 APE67-dihe-in -61.94, -34.86 -96.61, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 31.433 None None None XRAY 2.79 0.207 0.23 A 288 261 27 0 0 11 [[91, 352]] 1.0 4rlp AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4L3JA 85 375 525.0 5FI:60401 Type1 Inactive DFGin 6.957 14.984 ABAminus -135.63, -1.08 -98.35, 100.89 -120.85, -4.41 289.16, 86.77 -115.51, -149.17 in-in in 8.79 Saltbr-in 2.601 HRD-in -66.03, -51.33 68.42, -9.91 in-out-out SNCioo out-out ActLoopNT-out 14.56 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -70.58, -47.41 APE9-dihe-na -102.14, -165.34 APE8-dihe-in -61.42, 141.56 APE8-rot-out 181.9 APE67-dihe-in -64.17, -15.6 -103.7, 4.9 APE12-dist-in 12.365 APE11-dist-out 14.466 APE10-dist-out 9.751 APE9-dist-out 10.642 None None None XRAY 2.1 0.212 0.255 A 304 291 0 0 0 0 [[91, 352]] 1.0 4l3j AGC_RPS6KB1_HUMAN AGC 3.5e-96 327.2 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4L3LA 85 375 525.0 5FI:60401 Type1 Inactive DFGin 7.001 14.882 ABAminus -133.75, -15.34 -92.17, 82.26 -113.96, -4.44 296.95, 94.97 -108.02, -151.72 in-in in 9.02 Saltbr-in 2.698 HRD-in -63.02, -41.25 83.64, -56.35 in-out-out SNCioo out-out ActLoopNT-out 14.107 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.55, -38.47 APE9-dihe-na -103.09, -167.43 APE8-dihe-in -63.57, 145.34 APE8-rot-out 180.21 APE67-dihe-in -64.07, -18.64 -108.56, 8.72 APE12-dist-in 12.289 APE11-dist-out 14.487 APE10-dist-out 9.846 APE9-dist-out 11.496 None None None XRAY 2.1 0.208 0.247 A 304 291 0 0 0 0 [[91, 352]] 1.0 4l3l AGC_RPS6KB1_HUMAN AGC 3.5e-96 327.2 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
7N91A 85 418 525.0 1RJ:501 Type1 Inactive DFGin 6.745 14.303 ABAminus -137.24, 0.52 -126.06, 92.82 -120.47, 16.13 313.15, 88.79 -107.87, -160.91 in-in in 9.435 Saltbr-in 3.535 HRD-in -82.25, -17.04 69.01, -55.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -145.04 APE8-dihe-in -82.16, 156.45 APE8-rot-out 182.85 APE67-dihe-in -47.49, -22.81 -116.45, -13.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.069 T412E TPO390,SEP394 TPO390,SEP394 XRAY 3.0 0.212 0.272 A 340 307 18 0 0 15 [[91, 352]] 1.0 7n91 AGC_RPS6KB1_HUMAN AGC 5.2e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
7N91B 85 418 525.0 1RJ:501 Type1 Inactive DFGin 6.806 14.222 ABAminus -123.54, -0.19 -129.03, 100.45 -127.45, 15.05 313.89, 88.27 -106.37, -120.46 in-in in 9.03 Saltbr-in 3.09 HRD-in -90.84, -16.84 59.67, -54.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.82 APE8-rot-out 171.24 APE67-dihe-in -64.35, -34.0 -103.88, 13.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T412E TPO390,SEP394 TPO390,SEP394 XRAY 3.0 0.212 0.272 B 340 313 15 0 0 15 [[91, 352]] 1.0 7n91 AGC_RPS6KB1_HUMAN AGC 5.2e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
7N93A 87 418 525.0 1SK:501 Type1 Inactive DFGin 6.834 14.674 ABAminus -126.58, -26.86 -97.15, 99.04 -121.83, -4.26 300.71, 92.82 -113.66, -157.84 in-in in 9.738 Saltbr-in 2.673 HRD-in -101.78, -26.88 75.91, -55.07 in-out-out SNCioo out-out ActLoopNT-out 14.081 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 31.81 APE9-dihe-na 99.46, -176.13 APE8-dihe-in -58.12, 156.59 APE8-rot-out 175.34 APE67-dihe-in -46.11, -19.14 -107.34, -3.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.047 APE9-dist-out 11.464 T412E TPO390,SEP394 TPO390,SEP394 XRAY 2.74 0.215 0.29 A 340 312 11 0 0 11 [[91, 352]] 1.0 7n93 AGC_RPS6KB1_HUMAN AGC 5.2e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
7N93B 85 418 525.0 1SK:501 Type1 Inactive DFGin 6.843 14.993 ABAminus -125.38, -26.14 -102.53, 92.75 -112.09, -9.82 298.31, 100.51 -98.13, -140.14 in-in in 9.44 Saltbr-in 2.932 HRD-in -73.16, -34.65 78.65, -66.66 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.54 APE8-dihe-in -65.27, 128.55 APE8-rot-out 146.5 APE67-dihe-in -69.77, -24.05 -96.24, 7.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.005 T412E TPO390,SEP394 TPO390,SEP394 XRAY 2.74 0.215 0.29 B 340 309 14 0 0 14 [[91, 352]] 1.0 7n93 AGC_RPS6KB1_HUMAN AGC 5.2e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3A62A 85 372 525.0 STU:400 Type1 Inactive DFGin 6.524 14.117 ABAminus -137.83, -32.54 -98.98, 101.69 -111.0, 24.18 305.63, 93.27 -75.95, -178.42 in-in in 8.238 Saltbr-in 2.912 HRD-in -88.81, -24.52 69.43, -47.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.23, -49.64 APE9-dihe-na -102.67, -164.37 APE8-dihe-in -63.46, 142.22 APE8-rot-out 175.82 APE67-dihe-in -68.79, -14.76 -111.61, 8.72 APE12-dist-in 10.247 APE11-dist-in 13.136 APE10-dist-out 9.309 APE9-dist-out 11.608 None TPO252 TPO252 XRAY 2.35 0.229 0.272 A 327 264 24 0 0 10 [[91, 352]] 1.0 3a62 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3WE4A 85 374 525.0 5FI:402 Type1 Inactive DFGin 7.02 14.733 ABAminus -125.47, -18.75 -95.38, 90.84 -122.57, 0.96 296.46, 95.2 -120.64, -158.24 in-in in 8.983 Saltbr-in 2.795 HRD-in -79.06, -32.34 75.27, -49.87 in-out-out SNCioo out-out ActLoopNT-out 14.57 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -76.57, -30.69 APE9-dihe-na -111.67, -160.44 APE8-dihe-in -65.24, 142.31 APE8-rot-out 177.96 APE67-dihe-in -64.53, -17.87 -105.62, 6.77 APE12-dist-in 11.776 APE11-dist-out 14.019 APE10-dist-out 9.521 APE9-dist-out 11.659 None TPO252 TPO252 XRAY 1.995 0.177 0.231 A 329 287 3 0 0 3 [[91, 352]] 1.0 3we4 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3WF5A 85 374 525.0 FZ8:402 Type1 Inactive DFGin 6.865 14.371 ABAminus -129.76, -14.65 -92.38, 84.54 -117.05, 2.8 295.94, 106.35 -92.73, -179.05 in-in in 8.554 Saltbr-in 2.776 HRD-in -78.96, -34.1 73.1, -44.42 in-out-out SNCioo out-out ActLoopNT-out 13.995 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.34, -49.41 APE9-dihe-na -98.44, -161.28 APE8-dihe-in -64.31, 143.89 APE8-rot-out 179.68 APE67-dihe-in -62.79, -13.23 -110.77, 8.19 APE12-dist-in 10.641 APE11-dist-in 13.275 APE10-dist-out 9.24 APE9-dist-out 11.479 None TPO252 TPO252 XRAY 2.099 0.177 0.233 A 329 278 12 0 0 0 [[91, 352]] 1.0 3wf5 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3WF6A 85 374 525.0 FZ9:402 Type1 Inactive DFGin 6.703 14.371 ABAminus -133.23, -13.75 -102.6, 94.37 -125.05, 0.97 297.43, 101.06 -85.4, -167.64 in-in in 8.67 Saltbr-in 2.712 HRD-in -77.97, -32.15 71.46, -43.57 in-out-out SNCioo out-out ActLoopNT-out 13.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -69.93, -50.15 APE9-dihe-na -98.92, -163.08 APE8-dihe-in -59.61, 143.39 APE8-rot-out 176.13 APE67-dihe-in -64.45, -12.44 -111.84, 9.05 APE12-dist-in 10.459 APE11-dist-in 13.149 APE10-dist-out 9.115 APE9-dist-out 11.592 None TPO252 TPO252 XRAY 2.031 0.198 0.265 A 329 278 12 0 0 0 [[91, 352]] 1.0 3wf6 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4L45A 81 417 525.0 5FI:60401 Type1 Inactive DFGin 7.233 14.636 ABAminus -119.27, -13.93 -120.01, 100.8 -106.47, 0.67 296.17, 87.49 -106.81, -133.5 in-in in 8.727 Saltbr-in 2.849 HRD-out -61.14, 153.32 -124.12, -51.0 in-out-out SNCioo out-out ActLoopNT-out 15.823 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.41 APE8-dihe-in -80.83, 132.8 APE8-rot-in 322.12 APE67-dihe-in -68.02, -0.43 -92.13, -15.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.762 T412E None None XRAY 2.9 0.235 0.286 A 346 317 11 0 0 11 [[91, 352]] 1.0 4l45 AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.7 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4L42A 84 417 525.0 5FI:60401 Type1 Inactive DFGin 6.836 14.464 ABAminus -94.23, -38.55 -136.54, 108.38 -136.44, 3.89 300.67, 83.7 -99.18, -151.82 in-in in 9.122 Saltbr-in 2.49 HRD-in -62.75, -31.77 73.94, -56.14 in-out-out SNCioo out-out ActLoopNT-out 14.884 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -70.78, -35.44 APE9-dihe-na -101.55, -147.05 APE8-dihe-in -76.25, 145.76 APE8-rot-out 181.86 APE67-dihe-in -41.34, -45.47 -103.54, -6.14 APE12-dist-in 11.561 APE11-dist-in 13.893 APE10-dist-out 9.617 APE9-dist-out 11.006 S403E,A404E,N405Q,Q406E,V407M,L409R,G410D,T412E,V414I,P416D,S417W None None XRAY 2.8 0.23 0.263 A 346 299 0 0 0 0 [[91, 352]] 1.0 4l42 AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4L46A 80 417 525.0 5FI:60401 Type1 Inactive DFGin 7.241 14.444 ABAminus -128.62, -46.06 -107.19, 113.68 -124.45, -8.59 294.14, 89.1 -97.33, -135.09 in-in in 8.909 Saltbr-in 3.025 HRD-out -53.09, -17.17 51.06, -128.85 in-out-out SNCioo out-out ActLoopNT-out 15.252 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -88.19, -33.47 APE9-dihe-na -130.34, -153.74 APE8-dihe-in -66.16, 132.01 APE8-rot-out 141.11 APE67-dihe-in -64.11, -10.28 -108.34, -0.39 APE12-dist-in 12.109 APE11-dist-out 14.419 APE10-dist-out 9.81 APE9-dist-out 13.005 None TPO412 TPO412 XRAY 3.01 0.22 0.269 A 346 318 4 0 0 4 [[91, 352]] 1.0 4l46 AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3WF8A 85 372 525.0 F76:402 Type1 Inactive DFGin 7.102 14.978 BLAminus -129.9, -170.63 61.17, 70.04 -107.71, -0.62 293.51, 88.63 -118.48, -145.57 in-in in 9.295 Saltbr-in 2.652 HRD-in -77.55, -44.17 68.12, -42.54 in-out-out SNCioo out-out ActLoopNT-out 14.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.25, -35.51 APE9-dihe-na -76.92, -168.9 APE8-dihe-in -54.62, 141.74 APE8-rot-out 169.07 APE67-dihe-in -59.06, -20.42 -107.38, 7.1 APE12-dist-in 10.871 APE11-dist-in 13.619 APE10-dist-out 9.628 APE9-dist-out 10.039 None TPO252 TPO252 XRAY 1.975 0.203 0.241 A 329 288 0 0 0 0 [[91, 352]] 1.0 3wf8 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3WF9A 85 372 525.0 FS7:402 Type1 Inactive DFGin 7.076 14.804 BLAminus -128.9, -172.38 62.02, 66.77 -105.26, 3.14 300.18, 93.35 -120.0, -148.85 in-in in 9.088 Saltbr-in 2.718 HRD-in -75.59, -53.56 73.09, -41.71 in-out-out SNCioo out-out ActLoopNT-out 14.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -64.84, -25.92 APE9-dihe-na -80.51, -169.69 APE8-dihe-in -58.81, 141.58 APE8-rot-out 172.69 APE67-dihe-in -64.9, -25.53 -106.39, 16.05 APE12-dist-in 10.888 APE11-dist-in 13.536 APE10-dist-out 9.666 APE9-dist-out 9.704 None TPO252 TPO252 XRAY 2.035 0.217 0.265 A 329 288 0 0 0 0 [[91, 352]] 1.0 3wf9 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4L43A 81 417 525.0 5FI:60401 Type1 Inactive DFGin 7.503 14.59 BLAminus -152.19, 178.7 68.2, 63.89 -95.2, 1.23 292.21, 97.05 -112.42, -123.66 in-in in 9.238 Saltbr-in 3.303 HRD-in -82.62, -11.83 59.52, -90.37 in-out-out SNCioo out-out ActLoopNT-out 16.402 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -80.85 APE8-dihe-in -75.2, 157.68 APE8-rot-in 319.39 APE67-dihe-in -73.24, -5.47 -122.38, -12.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.069 T412A None None XRAY 3.0 0.229 0.279 A 346 316 11 0 0 11 [[91, 352]] 1.0 4l43 AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4L44A 81 417 525.0 5FI:60404 Type1 Inactive DFGin 7.589 14.631 BLAminus -133.78, 179.09 58.09, 63.64 -94.03, 8.12 300.2, 94.56 -89.28, -144.2 in-in in 9.078 Saltbr-in 2.827 HRD-in -51.83, -35.36 73.61, -57.08 in-out-out SNCioo out-out ActLoopNT-out 14.948 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -91.08, 128.5 APE9-dihe-na 94.25, -75.66 APE8-dihe-in -159.56, 138.01 APE8-rot-out 142.19 APE67-dihe-in -66.44, -10.43 -117.84, -6.33 APE12-dist-in 12.107 APE11-dist-out 14.059 APE10-dist-out 9.638 APE9-dist-out 12.9 T412A None None XRAY 2.9 0.246 0.298 A 346 321 5 0 0 5 [[91, 352]] 1.0 4l44 AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4RLOA 85 371 525.0 3T3:401 Type1 Inactive DFGin 5.27 12.747 None -131.54, -63.42 -88.2, 143.06 -127.47, 172.78 303.39, 172.08 126.01, -46.31 in-in in 7.698 Saltbr-in 2.3 HRD-in -57.89, -55.64 79.38, -25.61 in-in-out SNCiio in-out ActLoopNT-in 3.286 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.78 APE8-dihe-in -54.68, 162.27 APE8-rot-out 190.34 APE67-dihe-in -62.73, -12.73 -141.73, -3.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 30.222 None None None XRAY 2.527 0.193 0.222 A 288 259 28 0 0 12 [[91, 352]] 1.0 4rlo AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3A60A 85 371 525.0 STU:400 Type1 Inactive DFGin 6.157 13.694 None -106.91, -67.93 -78.35, 124.27 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.754 Saltbr-out 3.905 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327 263 24 0 0 13 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3A61A 87 371 525.0 STU:400 Type1 Inactive DFGin 5.812 13.405 None -134.05, -75.4 -81.48, 111.28 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.863 Saltbr-in 3.459 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.963 None None None XRAY 3.43 0.274 0.349 A 327 254 31 0 0 16 [[91, 352]] 1.0 3a61 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3WF7A 83 374 525.0 FS9:402 Type1 Inactive DFGin 6.662 14.99 None -128.93, -10.26 -99.96, 98.47 -129.8, 160.96 298.66, 90.56 73.54, -129.51 out-out out 14.17 Saltbr-out 10.14 HRD-in -80.11, -34.14 77.1, -48.65 out-out-out SNCooo out-out ActLoopNT-out 12.972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -70.88, 130.47 APE9-dihe-na 74.33, -175.83 APE8-dihe-in -68.5, 140.34 APE8-rot-out 182.72 APE67-dihe-in -64.92, -16.71 -105.43, 9.18 APE12-dist-in 11.961 APE11-dist-out 14.438 APE10-dist-out 10.015 APE9-dist-out 11.986 None TPO252 TPO252 XRAY 1.85 0.175 0.224 A 329 289 3 0 0 3 [[91, 352]] 1.0 3wf7 AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
4RLOB 85 372 525.0 STU:401 Type1 Inactive None 999.0 7.196 None -86.75, 160.35 -107.62, 22.98 -156.62, 162.78 69.29, 88.54 159.5, 162.01 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.31, -49.02 69.03, -42.5 none-out-out SNCnoo out-out ActLoopNT-out 4.816 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.17 APE8-rot-out 189.44 APE67-dihe-in -65.44, -8.07 -124.54, 4.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.527 0.193 0.222 B 288 254 34 0 0 11 [[91, 352]] 1.0 4rlo AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
3A60B 85 372 525.0 STU:401 Type1 Inactive None 999.0 9.181 None -122.3, -155.7 -144.9, 63.43 -46.62, 179.79 231.81, 121.03 -99.91, 37.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.46, -48.18 73.35, -54.05 none-in-out SNCnio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -2.69 APE9-dihe-na -82.95, -88.68 APE8-dihe-in -146.72, 128.75 APE8-rot-out 80.81 APE67-dihe-in -72.02, 1.17 -100.99, 0.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.777 APE9-dist-out 31.967 None None None XRAY 2.8 0.21 0.268 B 327 255 33 0 0 10 [[91, 352]] 1.0 3a60 AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1

AGC_RPS6KB1 (Ribosomal protein S6 kinase beta-1)

Total number of chains: 26
Active chains: 2
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 14 53.8% 4L3JA
DFGin BLAminus 6 23.1% AF-P23443-K1A
DFGin None 4 15.4% 3WF7A
None None 2 7.7% 3A60B

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KS6B1_HUMAN AF-P23443-K1A P23443 83 360 525.0 No_ligand No_ligand Active DFGin 6.85 14.148 BLAminus -124.31, -166.39 38.73, 66.43 -77.66, 13.72 288.38, 76.88 -63.66, -21.1 in-in in 8.764 Saltbr-in 2.612 HRD-in -85.2, -47.45 63.14, 5.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.51, 166.53 APE9-dihe-na 111.13, -177.37 APE8-dihe-in -97.94, 129.35 APE8-rot-in 304.6 APE67-dihe-in -59.86, -23.05 -60.69, -41.68 APE12-dist-in 8.424 APE11-dist-in 11.405 APE10-dist-in 5.675 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[91, 352]] 1.0 AF-P23443-K1 Homo sapiens AGC_RPS6KB1_HUMAN AGC 2.5e-96 327.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN AF-P23443-K3A P23443 83 360 525.0 No_ligand No_ligand Active DFGin 6.499 13.931 BLAminus -128.06, -173.88 44.57, 66.94 -75.34, 10.89 293.5, 80.29 -60.23, -27.79 in-in in 8.905 Saltbr-in 2.613 HRD-in -82.97, -50.48 68.32, 8.66 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.49, 169.69 APE9-dihe-na 107.2, 177.16 APE8-dihe-in -89.35, 135.4 APE8-rot-in 302.12 APE67-dihe-in -65.67, -26.41 -68.11, -34.82 APE12-dist-in 8.273 APE11-dist-in 11.346 APE10-dist-in 5.632 APE9-dist-in 3.355 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[91, 352]] 1.0 AF-P23443-K3 Homo sapiens AGC_RPS6KB1_HUMAN AGC 2.5e-96 327.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4RLPA P23443 85 372 525.0 72B:401 Type1 Inactive DFGin 6.13 13.245 ABAminus -108.51, -71.08 -84.78, 124.37 -121.68, 51.98 300.45, 37.52 -105.22, -52.67 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.77, -44.5 76.33, -53.54 none-in-out SNCnio in-out ActLoopNT-in 3.593 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -96.35 APE8-dihe-in -67.86, 138.97 APE8-rot-in 298.2 APE67-dihe-in -61.94, -34.86 -96.61, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 31.433 None None None XRAY 2.79 0.207 0.23 A 288 261 27 0 0 11 [[91, 352]] 1.0 4rlp Homo sapiens AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4L3JA P23443 85 375 525.0 5FI:60401 Type1 Inactive DFGin 6.957 14.984 ABAminus -135.63, -1.08 -98.35, 100.89 -120.85, -4.41 289.16, 86.77 -115.51, -149.17 in-in in 8.79 Saltbr-in 2.601 HRD-in -66.03, -51.33 68.42, -9.91 in-out-out SNCioo out-out ActLoopNT-out 14.56 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -70.58, -47.41 APE9-dihe-na -102.14, -165.34 APE8-dihe-in -61.42, 141.56 APE8-rot-out 181.9 APE67-dihe-in -64.17, -15.6 -103.7, 4.9 APE12-dist-in 12.365 APE11-dist-out 14.466 APE10-dist-out 9.751 APE9-dist-out 10.642 None None None XRAY 2.1 0.212 0.255 A 304 291 0 0 0 0 [[91, 352]] 1.0 4l3j Homo sapiens AGC_RPS6KB1_HUMAN AGC 3.5e-96 327.2 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4L3LA P23443 85 375 525.0 5FI:60401 Type1 Inactive DFGin 7.001 14.882 ABAminus -133.75, -15.34 -92.17, 82.26 -113.96, -4.44 296.95, 94.97 -108.02, -151.72 in-in in 9.02 Saltbr-in 2.698 HRD-in -63.02, -41.25 83.64, -56.35 in-out-out SNCioo out-out ActLoopNT-out 14.107 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.55, -38.47 APE9-dihe-na -103.09, -167.43 APE8-dihe-in -63.57, 145.34 APE8-rot-out 180.21 APE67-dihe-in -64.07, -18.64 -108.56, 8.72 APE12-dist-in 12.289 APE11-dist-out 14.487 APE10-dist-out 9.846 APE9-dist-out 11.496 None None None XRAY 2.1 0.208 0.247 A 304 291 0 0 0 0 [[91, 352]] 1.0 4l3l Homo sapiens AGC_RPS6KB1_HUMAN AGC 3.5e-96 327.2 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 7N91A P23443 85 418 525.0 1RJ:501 Type1 Inactive DFGin 6.745 14.303 ABAminus -137.24, 0.52 -126.06, 92.82 -120.47, 16.13 313.15, 88.79 -107.87, -160.91 in-in in 9.435 Saltbr-in 3.535 HRD-in -82.25, -17.04 69.01, -55.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -145.04 APE8-dihe-in -82.16, 156.45 APE8-rot-out 182.85 APE67-dihe-in -47.49, -22.81 -116.45, -13.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.069 T412E TPO390,SEP394 TPO390,SEP394 XRAY 3.0 0.212 0.272 A 340 307 18 0 0 15 [[91, 352]] 1.0 7n91 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.2e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 7N91B P23443 85 418 525.0 1RJ:501 Type1 Inactive DFGin 6.806 14.222 ABAminus -123.54, -0.19 -129.03, 100.45 -127.45, 15.05 313.89, 88.27 -106.37, -120.46 in-in in 9.03 Saltbr-in 3.09 HRD-in -90.84, -16.84 59.67, -54.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.82 APE8-rot-out 171.24 APE67-dihe-in -64.35, -34.0 -103.88, 13.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T412E TPO390,SEP394 TPO390,SEP394 XRAY 3.0 0.212 0.272 B 340 313 15 0 0 15 [[91, 352]] 1.0 7n91 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.2e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 7N93A P23443 87 418 525.0 1SK:501 Type1 Inactive DFGin 6.834 14.674 ABAminus -126.58, -26.86 -97.15, 99.04 -121.83, -4.26 300.71, 92.82 -113.66, -157.84 in-in in 9.738 Saltbr-in 2.673 HRD-in -101.78, -26.88 75.91, -55.07 in-out-out SNCioo out-out ActLoopNT-out 14.081 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 31.81 APE9-dihe-na 99.46, -176.13 APE8-dihe-in -58.12, 156.59 APE8-rot-out 175.34 APE67-dihe-in -46.11, -19.14 -107.34, -3.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.047 APE9-dist-out 11.464 T412E TPO390,SEP394 TPO390,SEP394 XRAY 2.74 0.215 0.29 A 340 312 11 0 0 11 [[91, 352]] 1.0 7n93 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.2e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 7N93B P23443 85 418 525.0 1SK:501 Type1 Inactive DFGin 6.843 14.993 ABAminus -125.38, -26.14 -102.53, 92.75 -112.09, -9.82 298.31, 100.51 -98.13, -140.14 in-in in 9.44 Saltbr-in 2.932 HRD-in -73.16, -34.65 78.65, -66.66 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.54 APE8-dihe-in -65.27, 128.55 APE8-rot-out 146.5 APE67-dihe-in -69.77, -24.05 -96.24, 7.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.005 T412E TPO390,SEP394 TPO390,SEP394 XRAY 2.74 0.215 0.29 B 340 309 14 0 0 14 [[91, 352]] 1.0 7n93 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.2e-96 327.1 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3A62A P23443 85 372 525.0 STU:400 Type1 Inactive DFGin 6.524 14.117 ABAminus -137.83, -32.54 -98.98, 101.69 -111.0, 24.18 305.63, 93.27 -75.95, -178.42 in-in in 8.238 Saltbr-in 2.912 HRD-in -88.81, -24.52 69.43, -47.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.23, -49.64 APE9-dihe-na -102.67, -164.37 APE8-dihe-in -63.46, 142.22 APE8-rot-out 175.82 APE67-dihe-in -68.79, -14.76 -111.61, 8.72 APE12-dist-in 10.247 APE11-dist-in 13.136 APE10-dist-out 9.309 APE9-dist-out 11.608 None TPO252 TPO252 XRAY 2.35 0.229 0.272 A 327 264 24 0 0 10 [[91, 352]] 1.0 3a62 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3WE4A P23443 85 374 525.0 5FI:402 Type1 Inactive DFGin 7.02 14.733 ABAminus -125.47, -18.75 -95.38, 90.84 -122.57, 0.96 296.46, 95.2 -120.64, -158.24 in-in in 8.983 Saltbr-in 2.795 HRD-in -79.06, -32.34 75.27, -49.87 in-out-out SNCioo out-out ActLoopNT-out 14.57 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -76.57, -30.69 APE9-dihe-na -111.67, -160.44 APE8-dihe-in -65.24, 142.31 APE8-rot-out 177.96 APE67-dihe-in -64.53, -17.87 -105.62, 6.77 APE12-dist-in 11.776 APE11-dist-out 14.019 APE10-dist-out 9.521 APE9-dist-out 11.659 None TPO252 TPO252 XRAY 1.995 0.177 0.231 A 329 287 3 0 0 3 [[91, 352]] 1.0 3we4 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3WF5A P23443 85 374 525.0 FZ8:402 Type1 Inactive DFGin 6.865 14.371 ABAminus -129.76, -14.65 -92.38, 84.54 -117.05, 2.8 295.94, 106.35 -92.73, -179.05 in-in in 8.554 Saltbr-in 2.776 HRD-in -78.96, -34.1 73.1, -44.42 in-out-out SNCioo out-out ActLoopNT-out 13.995 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.34, -49.41 APE9-dihe-na -98.44, -161.28 APE8-dihe-in -64.31, 143.89 APE8-rot-out 179.68 APE67-dihe-in -62.79, -13.23 -110.77, 8.19 APE12-dist-in 10.641 APE11-dist-in 13.275 APE10-dist-out 9.24 APE9-dist-out 11.479 None TPO252 TPO252 XRAY 2.099 0.177 0.233 A 329 278 12 0 0 0 [[91, 352]] 1.0 3wf5 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3WF6A P23443 85 374 525.0 FZ9:402 Type1 Inactive DFGin 6.703 14.371 ABAminus -133.23, -13.75 -102.6, 94.37 -125.05, 0.97 297.43, 101.06 -85.4, -167.64 in-in in 8.67 Saltbr-in 2.712 HRD-in -77.97, -32.15 71.46, -43.57 in-out-out SNCioo out-out ActLoopNT-out 13.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -69.93, -50.15 APE9-dihe-na -98.92, -163.08 APE8-dihe-in -59.61, 143.39 APE8-rot-out 176.13 APE67-dihe-in -64.45, -12.44 -111.84, 9.05 APE12-dist-in 10.459 APE11-dist-in 13.149 APE10-dist-out 9.115 APE9-dist-out 11.592 None TPO252 TPO252 XRAY 2.031 0.198 0.265 A 329 278 12 0 0 0 [[91, 352]] 1.0 3wf6 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4L45A P23443 81 417 525.0 5FI:60401 Type1 Inactive DFGin 7.233 14.636 ABAminus -119.27, -13.93 -120.01, 100.8 -106.47, 0.67 296.17, 87.49 -106.81, -133.5 in-in in 8.727 Saltbr-in 2.849 HRD-out -61.14, 153.32 -124.12, -51.0 in-out-out SNCioo out-out ActLoopNT-out 15.823 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -86.41 APE8-dihe-in -80.83, 132.8 APE8-rot-in 322.12 APE67-dihe-in -68.02, -0.43 -92.13, -15.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.762 T412E None None XRAY 2.9 0.235 0.286 A 346 317 11 0 0 11 [[91, 352]] 1.0 4l45 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.7 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4L42A P23443 84 417 525.0 5FI:60401 Type1 Inactive DFGin 6.836 14.464 ABAminus -94.23, -38.55 -136.54, 108.38 -136.44, 3.89 300.67, 83.7 -99.18, -151.82 in-in in 9.122 Saltbr-in 2.49 HRD-in -62.75, -31.77 73.94, -56.14 in-out-out SNCioo out-out ActLoopNT-out 14.884 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -70.78, -35.44 APE9-dihe-na -101.55, -147.05 APE8-dihe-in -76.25, 145.76 APE8-rot-out 181.86 APE67-dihe-in -41.34, -45.47 -103.54, -6.14 APE12-dist-in 11.561 APE11-dist-in 13.893 APE10-dist-out 9.617 APE9-dist-out 11.006 S403E,A404E,N405Q,Q406E,V407M,L409R,G410D,T412E,V414I,P416D,S417W None None XRAY 2.8 0.23 0.263 A 346 299 0 0 0 0 [[91, 352]] 1.0 4l42 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4L46A P23443 80 417 525.0 5FI:60401 Type1 Inactive DFGin 7.241 14.444 ABAminus -128.62, -46.06 -107.19, 113.68 -124.45, -8.59 294.14, 89.1 -97.33, -135.09 in-in in 8.909 Saltbr-in 3.025 HRD-out -53.09, -17.17 51.06, -128.85 in-out-out SNCioo out-out ActLoopNT-out 15.252 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -88.19, -33.47 APE9-dihe-na -130.34, -153.74 APE8-dihe-in -66.16, 132.01 APE8-rot-out 141.11 APE67-dihe-in -64.11, -10.28 -108.34, -0.39 APE12-dist-in 12.109 APE11-dist-out 14.419 APE10-dist-out 9.81 APE9-dist-out 13.005 None TPO412 TPO412 XRAY 3.01 0.22 0.269 A 346 318 4 0 0 4 [[91, 352]] 1.0 4l46 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3WF8A P23443 85 372 525.0 F76:402 Type1 Inactive DFGin 7.102 14.978 BLAminus -129.9, -170.63 61.17, 70.04 -107.71, -0.62 293.51, 88.63 -118.48, -145.57 in-in in 9.295 Saltbr-in 2.652 HRD-in -77.55, -44.17 68.12, -42.54 in-out-out SNCioo out-out ActLoopNT-out 14.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -65.25, -35.51 APE9-dihe-na -76.92, -168.9 APE8-dihe-in -54.62, 141.74 APE8-rot-out 169.07 APE67-dihe-in -59.06, -20.42 -107.38, 7.1 APE12-dist-in 10.871 APE11-dist-in 13.619 APE10-dist-out 9.628 APE9-dist-out 10.039 None TPO252 TPO252 XRAY 1.975 0.203 0.241 A 329 288 0 0 0 0 [[91, 352]] 1.0 3wf8 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3WF9A P23443 85 372 525.0 FS7:402 Type1 Inactive DFGin 7.076 14.804 BLAminus -128.9, -172.38 62.02, 66.77 -105.26, 3.14 300.18, 93.35 -120.0, -148.85 in-in in 9.088 Saltbr-in 2.718 HRD-in -75.59, -53.56 73.09, -41.71 in-out-out SNCioo out-out ActLoopNT-out 14.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -64.84, -25.92 APE9-dihe-na -80.51, -169.69 APE8-dihe-in -58.81, 141.58 APE8-rot-out 172.69 APE67-dihe-in -64.9, -25.53 -106.39, 16.05 APE12-dist-in 10.888 APE11-dist-in 13.536 APE10-dist-out 9.666 APE9-dist-out 9.704 None TPO252 TPO252 XRAY 2.035 0.217 0.265 A 329 288 0 0 0 0 [[91, 352]] 1.0 3wf9 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4L43A P23443 81 417 525.0 5FI:60401 Type1 Inactive DFGin 7.503 14.59 BLAminus -152.19, 178.7 68.2, 63.89 -95.2, 1.23 292.21, 97.05 -112.42, -123.66 in-in in 9.238 Saltbr-in 3.303 HRD-in -82.62, -11.83 59.52, -90.37 in-out-out SNCioo out-out ActLoopNT-out 16.402 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -80.85 APE8-dihe-in -75.2, 157.68 APE8-rot-in 319.39 APE67-dihe-in -73.24, -5.47 -122.38, -12.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.069 T412A None None XRAY 3.0 0.229 0.279 A 346 316 11 0 0 11 [[91, 352]] 1.0 4l43 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4L44A P23443 81 417 525.0 5FI:60404 Type1 Inactive DFGin 7.589 14.631 BLAminus -133.78, 179.09 58.09, 63.64 -94.03, 8.12 300.2, 94.56 -89.28, -144.2 in-in in 9.078 Saltbr-in 2.827 HRD-in -51.83, -35.36 73.61, -57.08 in-out-out SNCioo out-out ActLoopNT-out 14.948 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -91.08, 128.5 APE9-dihe-na 94.25, -75.66 APE8-dihe-in -159.56, 138.01 APE8-rot-out 142.19 APE67-dihe-in -66.44, -10.43 -117.84, -6.33 APE12-dist-in 12.107 APE11-dist-out 14.059 APE10-dist-out 9.638 APE9-dist-out 12.9 T412A None None XRAY 2.9 0.246 0.298 A 346 321 5 0 0 5 [[91, 352]] 1.0 4l44 Homo sapiens AGC_RPS6KB1_HUMAN AGC 5.5e-96 326.6 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4RLOA P23443 85 371 525.0 3T3:401 Type1 Inactive DFGin 5.27 12.747 None -131.54, -63.42 -88.2, 143.06 -127.47, 172.78 303.39, 172.08 126.01, -46.31 in-in in 7.698 Saltbr-in 2.3 HRD-in -57.89, -55.64 79.38, -25.61 in-in-out SNCiio in-out ActLoopNT-in 3.286 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.78 APE8-dihe-in -54.68, 162.27 APE8-rot-out 190.34 APE67-dihe-in -62.73, -12.73 -141.73, -3.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 30.222 None None None XRAY 2.527 0.193 0.222 A 288 259 28 0 0 12 [[91, 352]] 1.0 4rlo Homo sapiens AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3A60A P23443 85 371 525.0 STU:400 Type1 Inactive DFGin 6.157 13.694 None -106.91, -67.93 -78.35, 124.27 -119.68, -133.11 293.51, 79.75 162.78, -54.12 in-out in 7.754 Saltbr-out 3.905 HRD-in -63.83, -43.18 73.78, -30.83 out-out-none SNCoon out-none ActLoopNT-out 3.673 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -74.9 APE8-rot-in 297.46 APE67-dihe-in -54.54, -22.69 -86.47, -11.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.268 A 327 263 24 0 0 13 [[91, 352]] 1.0 3a60 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3A61A P23443 87 371 525.0 STU:400 Type1 Inactive DFGin 5.812 13.405 None -134.05, -75.4 -81.48, 111.28 -98.21, -179.91 302.65, 80.45 -119.91, 999.0 in-in in 7.863 Saltbr-in 3.459 HRD-in -91.01, -26.19 64.38, -56.51 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -70.31 APE8-dihe-in -167.04, 106.84 APE8-rot-out 166.31 APE67-dihe-in -54.66, 20.97 -86.85, -22.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.963 None None None XRAY 3.43 0.274 0.349 A 327 254 31 0 0 16 [[91, 352]] 1.0 3a61 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3WF7A P23443 83 374 525.0 FS9:402 Type1 Inactive DFGin 6.662 14.99 None -128.93, -10.26 -99.96, 98.47 -129.8, 160.96 298.66, 90.56 73.54, -129.51 out-out out 14.17 Saltbr-out 10.14 HRD-in -80.11, -34.14 77.1, -48.65 out-out-out SNCooo out-out ActLoopNT-out 12.972 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -70.88, 130.47 APE9-dihe-na 74.33, -175.83 APE8-dihe-in -68.5, 140.34 APE8-rot-out 182.72 APE67-dihe-in -64.92, -16.71 -105.43, 9.18 APE12-dist-in 11.961 APE11-dist-out 14.438 APE10-dist-out 10.015 APE9-dist-out 11.986 None TPO252 TPO252 XRAY 1.85 0.175 0.224 A 329 289 3 0 0 3 [[91, 352]] 1.0 3wf7 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.7e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 4RLOB P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 7.196 None -86.75, 160.35 -107.62, 22.98 -156.62, 162.78 69.29, 88.54 159.5, 162.01 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.31, -49.02 69.03, -42.5 none-out-out SNCnoo out-out ActLoopNT-out 4.816 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 152.17 APE8-rot-out 189.44 APE67-dihe-in -65.44, -8.07 -124.54, 4.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.527 0.193 0.222 B 288 254 34 0 0 11 [[91, 352]] 1.0 4rlo Homo sapiens AGC_RPS6KB1_HUMAN AGC 2.9e-96 327.5 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1
KS6B1_HUMAN 3A60B P23443 85 372 525.0 STU:401 Type1 Inactive None 999.0 9.181 None -122.3, -155.7 -144.9, 63.43 -46.62, 179.79 231.81, 121.03 -99.91, 37.09 none-none none 999.0 Saltbr-none 999.0 HRD-in -85.46, -48.18 73.35, -54.05 none-in-out SNCnio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -2.69 APE9-dihe-na -82.95, -88.68 APE8-dihe-in -146.72, 128.75 APE8-rot-out 80.81 APE67-dihe-in -72.02, 1.17 -100.99, 0.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.777 APE9-dist-out 31.967 None None None XRAY 2.8 0.21 0.268 B 327 255 33 0 0 10 [[91, 352]] 1.0 3a60 Homo sapiens AGC_RPS6KB1_HUMAN AGC 4.6e-96 326.8 1 260 260 235 236 237 239 241 123 143 147 215 217 216 218 275 263 258 257 256 255 254 253 252 173 Ribosomal protein S6 kinase beta-1

AGC_RPS6KB1 (Ribosomal protein S6 kinase beta-1)

Total number of chains: 0
Active chains: 0
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name