STE_PAK4 (Serine/threonine-protein kinase PAK 4)

Total number of chains: 54
Active chains: 42
Uniprot: PAK4_HUMAN
Kinase Domain Residues: 321 - 572
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 52 96.3% AF-O96013-K1A
DFGin ABAminus 1 1.9% 4XBRA
DFGin None 1 1.9% 4FIGB

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
4FIFA 296 589 591.0 ANP:1000 ATPlike Active DFGin 6.132 13.879 BLAminus -134.27, -172.64 55.78, 65.69 -91.22, 11.11 299.57, 98.92 -61.37, -20.58 in-in in 7.046 Saltbr-in 3.112 HRD-in -73.18, -47.2 74.11, -8.39 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.08, 134.89 APE9-dihe-na 136.18, -173.61 APE8-dihe-in -102.98, 119.55 APE8-rot-in 312.46 APE67-dihe-in -69.75, -26.2 -30.93, -52.34 APE12-dist-in 9.318 APE11-dist-in 11.709 APE10-dist-in 5.875 APE9-dist-in 3.299 None SEP474 SEP474 XRAY 2.6 0.207 0.227 A 346 294 0 0 0 0 [[321, 572]] 1.0 4fif STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4FIFB 297 589 591.0 ANP:1000 ATPlike Active DFGin 5.899 13.85 BLAminus -129.09, -170.37 52.27, 68.51 -93.51, 10.45 301.97, 96.23 -63.09, -15.01 in-in in 7.007 Saltbr-in 3.167 HRD-in -65.39, -48.9 75.1, -7.5 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.88, 134.77 APE9-dihe-na 136.42, -174.06 APE8-dihe-in -101.96, 121.94 APE8-rot-in 314.36 APE67-dihe-in -72.79, -21.56 -33.03, -50.98 APE12-dist-in 9.238 APE11-dist-in 11.712 APE10-dist-in 5.886 APE9-dist-in 3.335 None SEP474 SEP474 XRAY 2.6 0.207 0.227 B 346 293 0 0 0 0 [[321, 572]] 1.0 4fif STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4JDIA 300 589 591.0 ANP:1000 ATPlike Active DFGin 6.291 14.47 BLAminus -134.26, 177.87 63.72, 71.58 -94.6, 13.78 289.77, 79.71 -54.15, -28.77 in-in in 6.959 Saltbr-in 2.737 HRD-in -72.82, -49.09 73.48, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 145.0 APE9-dihe-na 130.41, -160.49 APE8-dihe-in -120.53, 123.45 APE8-rot-in 305.94 APE67-dihe-in -63.49, -22.51 -36.89, -56.07 APE12-dist-in 8.769 APE11-dist-in 11.535 APE10-dist-in 5.874 APE9-dist-in 3.327 None SEP474 SEP474 XRAY 1.85 0.194 0.233 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdi STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5UPKB 300 588 591.0 ANP:60600 ATPlike Active DFGin 6.272 14.139 BLAminus -132.3, -169.35 61.71, 61.5 -87.86, 7.28 293.59, 93.96 -55.36, -28.3 in-in in 7.077 Saltbr-in 3.329 HRD-in -65.35, -49.16 70.36, 11.54 in-in-in SNCiii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.55, 149.52 APE9-dihe-na 120.09, -163.11 APE8-dihe-in -119.51, 121.87 APE8-rot-in 313.98 APE67-dihe-in -69.89, -18.98 -32.47, -57.41 APE12-dist-in 8.623 APE11-dist-in 11.267 APE10-dist-in 5.616 APE9-dist-in 3.426 None SEP474 SEP474 XRAY 2.4 0.22 0.264 B 346 289 0 0 0 0 [[321, 572]] 1.0 5upk STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
7S46A 300 589 591.0 ANP:600 ATPlike Active DFGin 9.021 14.349 BLAminus -133.61, -177.07 54.75, 76.68 -92.18, 14.46 286.49, 80.35 -59.04, -19.55 in-in in 7.534 Saltbr-in 2.867 HRD-in -69.43, -50.5 76.76, 2.96 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.73, 132.58 APE9-dihe-na 145.82, -167.86 APE8-dihe-in -110.13, 128.57 APE8-rot-in 305.26 APE67-dihe-in -70.79, -21.11 -38.41, -55.32 APE12-dist-in 9.02 APE11-dist-in 11.537 APE10-dist-in 5.793 APE9-dist-in 3.286 D440N,S474E None None XRAY 2.1 0.182 0.22 A 346 290 0 0 0 0 [[321, 572]] 1.0 7s46 STE_PAK4_HUMAN STE 5.5e-87 297.4 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
7S47A 300 589 591.0 ANP:600 ATPlike Active DFGin 9.217 14.646 BLAminus -126.8, -179.34 54.51, 73.91 -89.97, 15.41 285.81, 78.05 -59.21, -18.99 in-in in 7.79 Saltbr-in 2.931 HRD-in -66.64, -48.47 70.7, 6.89 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.53, 138.41 APE9-dihe-na 140.72, -164.27 APE8-dihe-in -114.61, 124.35 APE8-rot-in 304.9 APE67-dihe-in -66.22, -20.32 -36.39, -56.83 APE12-dist-in 9.039 APE11-dist-in 11.45 APE10-dist-in 5.747 APE9-dist-in 3.401 D440N,S474E None None XRAY 2.0 0.196 0.237 A 383 290 0 0 0 0 [[321, 572]] 1.0 7s47 STE_PAK4_HUMAN STE 7.5e-87 297.0 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
AF-O96013-K1A 313 580 591.0 No_ligand No_ligand Active DFGin 5.976 13.493 BLAminus -130.1, -176.91 63.02, 54.98 -77.11, 5.6 302.38, 102.83 -58.72, -35.23 in-in in 7.715 Saltbr-in 2.696 HRD-in -71.08, -49.97 65.46, 11.72 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.24, 162.55 APE9-dihe-na 107.8, 178.89 APE8-dihe-in -83.65, 126.03 APE8-rot-in 303.62 APE67-dihe-in -75.87, -21.96 -48.06, -42.55 APE12-dist-in 9.036 APE11-dist-in 11.639 APE10-dist-in 5.674 APE9-dist-in 3.243 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[321, 572]] 1.0 AF-O96013-K1 STE_PAK4_HUMAN STE 1.3e-88 302.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
AF-O96013-K3A 313 580 591.0 No_ligand No_ligand Active DFGin 6.981 14.976 BLAminus -136.02, -172.75 59.27, 53.41 -76.06, 16.58 290.59, 81.49 -60.1, -26.15 in-in in 8.179 Saltbr-in 2.79 HRD-in -73.8, -46.38 65.56, -0.51 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.08, 135.85 APE9-dihe-na 132.39, 173.54 APE8-dihe-in -86.18, 126.08 APE8-rot-in 300.1 APE67-dihe-in -76.89, -22.75 -42.41, -45.98 APE12-dist-in 9.021 APE11-dist-in 11.486 APE10-dist-in 5.617 APE9-dist-in 3.125 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[321, 572]] 1.0 AF-O96013-K3 STE_PAK4_HUMAN STE 1.3e-88 302.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4L67A 300 589 591.0 No_ligand No_ligand Active DFGin 10.27 14.486 BLAminus -151.61, -168.49 52.0, 67.37 -93.33, 11.41 289.19, 94.18 -58.57, -33.07 in-in in 8.3 Saltbr-in 3.226 HRD-in -102.14, -50.27 82.9, -7.13 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.16, 134.74 APE9-dihe-na 141.36, 174.48 APE8-dihe-in -84.97, 121.4 APE8-rot-in 323.69 APE67-dihe-in -44.13, -27.72 -31.92, -71.35 APE12-dist-in 9.29 APE11-dist-in 11.655 APE10-dist-in 5.803 APE9-dist-in 3.595 None SEP474 SEP474 XRAY 2.8 0.233 0.333 A 292 290 0 0 0 0 [[321, 572]] 1.0 4l67 STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
2Q0NA 298 591 591.0 No_ligand No_ligand Active DFGin 7.255 14.793 BLAminus -133.4, -177.0 60.04, 59.83 -83.03, 16.12 284.85, 75.64 -58.21, -18.8 in-in in 8.517 Saltbr-in 2.777 HRD-in -73.11, -49.29 75.99, 5.88 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.34, 142.4 APE9-dihe-na 146.55, -148.54 APE8-dihe-in -125.26, 117.52 APE8-rot-in 303.56 APE67-dihe-in -67.05, -21.65 -33.32, -56.61 APE12-dist-in 9.359 APE11-dist-in 11.992 APE10-dist-in 6.123 APE9-dist-in 3.566 None SEP474 SEP474 XRAY 1.75 0.185 0.228 A 301 294 0 0 0 0 [[321, 572]] 1.0 2q0n STE_PAK4_HUMAN STE 1.9e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
2J0IA 300 589 591.0 No_ligand No_ligand Active DFGin 7.46 14.626 BLAminus -134.36, -165.75 58.37, 60.67 -88.32, 13.39 279.76, 75.6 -62.32, -23.3 in-in in 9.455 Saltbr-in 2.627 HRD-in -73.73, -49.62 71.12, 2.68 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.96, 131.78 APE9-dihe-na 149.44, -163.72 APE8-dihe-in -114.93, 122.79 APE8-rot-in 303.47 APE67-dihe-in -68.35, -22.9 -35.96, -56.0 APE12-dist-in 9.0 APE11-dist-in 11.582 APE10-dist-in 5.776 APE9-dist-in 3.376 None SEP474 SEP474 XRAY 1.6 0.174 0.215 A 303 290 0 0 0 0 [[321, 572]] 1.0 2j0i STE_PAK4_HUMAN STE 2e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4JDJA 300 589 591.0 No_ligand No_ligand Active DFGin 9.358 14.486 BLAminus -135.05, -172.77 54.02, 73.82 -92.85, 18.9 284.15, 75.9 -56.84, -29.73 in-in in 7.485 Saltbr-in 2.745 HRD-in -72.69, -51.05 77.52, -2.59 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.69, 141.26 APE9-dihe-na 128.18, -160.28 APE8-dihe-in -117.23, 122.47 APE8-rot-in 309.77 APE67-dihe-in -61.22, -24.48 -35.06, -58.78 APE12-dist-in 8.557 APE11-dist-in 11.313 APE10-dist-in 5.753 APE9-dist-in 3.513 F461V SEP474,TPO562 SEP474,TPO562 XRAY 2.3 0.197 0.244 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdj STE_PAK4_HUMAN STE 1.4e-88 302.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4JDKA 300 589 591.0 No_ligand No_ligand Active DFGin 9.298 14.327 BLAminus -140.41, 175.97 54.41, 74.79 -91.36, 8.02 284.28, 75.16 -60.4, -13.24 in-in in 7.528 Saltbr-in 3.384 HRD-in -73.1, -44.55 68.62, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.09, 153.76 APE9-dihe-na 119.82, -165.82 APE8-dihe-in -116.32, 129.51 APE8-rot-in 313.3 APE67-dihe-in -59.03, -26.55 -44.4, -55.05 APE12-dist-in 8.726 APE11-dist-in 11.441 APE10-dist-in 5.89 APE9-dist-in 3.406 F461V SEP474,TPO562 SEP474,TPO562 XRAY 2.4 0.188 0.249 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdk STE_PAK4_HUMAN STE 1.4e-88 302.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4FIHA 298 589 591.0 No_ligand No_ligand Active DFGin 9.206 14.407 BLAminus -135.98, -177.2 57.56, 65.31 -90.69, 14.94 285.62, 76.78 -54.76, -25.38 in-in in 7.578 Saltbr-in 2.892 HRD-in -76.81, -47.61 70.56, 6.55 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 153.53 APE9-dihe-na 122.35, -158.41 APE8-dihe-in -122.77, 125.62 APE8-rot-in 308.66 APE67-dihe-in -66.29, -20.2 -45.47, -47.52 APE12-dist-in 8.616 APE11-dist-in 11.303 APE10-dist-in 5.566 APE9-dist-in 3.307 None SEP474 SEP474 XRAY 1.97 0.181 0.225 A 346 292 0 0 0 0 [[321, 572]] 1.0 4fih STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4FIIA 299 590 591.0 No_ligand No_ligand Active DFGin 9.073 14.201 BLAminus -132.45, 178.79 60.3, 61.71 -80.38, 12.79 288.68, 79.5 -61.8, -21.84 in-in in 7.306 Saltbr-in 2.72 HRD-in -76.29, -44.67 66.21, 4.67 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.33, 143.29 APE9-dihe-na 138.12, -155.84 APE8-dihe-in -121.98, 122.0 APE8-rot-in 307.09 APE67-dihe-in -73.04, -19.21 -34.75, -51.15 APE12-dist-in 8.727 APE11-dist-in 11.467 APE10-dist-in 5.694 APE9-dist-in 3.357 None SEP474 SEP474 XRAY 2.0 0.203 0.24 A 346 292 0 0 0 0 [[321, 572]] 1.0 4fii STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4FIJA 299 590 591.0 No_ligand No_ligand Active DFGin 9.292 14.118 BLAminus -121.84, -176.7 65.31, 67.51 -99.57, 14.75 281.79, 80.65 -61.33, -22.97 in-in in 7.674 Saltbr-in 3.269 HRD-in -67.47, -53.79 82.69, -7.78 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.15, 145.87 APE9-dihe-na 132.39, -161.12 APE8-dihe-in -117.16, 124.28 APE8-rot-in 306.73 APE67-dihe-in -60.5, -24.88 -30.89, -62.08 APE12-dist-in 8.634 APE11-dist-in 11.233 APE10-dist-in 5.492 APE9-dist-in 3.441 None SEP474 SEP474 XRAY 2.3 0.21 0.271 A 346 292 0 0 0 0 [[321, 572]] 1.0 4fij STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4JDHA 300 589 591.0 No_ligand No_ligand Active DFGin 9.213 14.456 BLAminus -133.94, -173.46 58.56, 59.99 -88.47, 17.74 285.35, 78.93 -64.25, -20.67 in-in in 7.641 Saltbr-in 3.319 HRD-in -69.0, -48.43 71.31, 1.52 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.94, 132.78 APE9-dihe-na 145.26, -171.34 APE8-dihe-in -107.31, 123.45 APE8-rot-in 307.6 APE67-dihe-in -61.34, -23.1 -36.34, -56.17 APE12-dist-in 8.85 APE11-dist-in 11.633 APE10-dist-in 5.92 APE9-dist-in 3.451 None SEP474 SEP474 XRAY 2.0 0.185 0.224 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdh STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
6WLXA 299 590 591.0 No_ligand No_ligand Active DFGin 9.201 14.18 BLAminus -131.59, -176.89 52.24, 74.82 -93.47, 12.81 286.48, 76.04 -60.21, -15.65 in-in in 7.465 Saltbr-in 3.141 HRD-in -75.87, -52.52 76.84, 4.64 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.58, 142.68 APE9-dihe-na 133.42, -162.48 APE8-dihe-in -119.0, 127.34 APE8-rot-in 308.13 APE67-dihe-in -62.55, -20.45 -37.98, -61.18 APE12-dist-in 8.684 APE11-dist-in 11.422 APE10-dist-in 5.762 APE9-dist-in 3.399 None SEP474 SEP474 XRAY 2.2 0.198 0.229 A 346 292 0 0 0 0 [[321, 572]] 1.0 6wlx STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
6WLYA 299 590 591.0 No_ligand No_ligand Active DFGin 9.224 14.295 BLAminus -137.23, -173.74 57.81, 67.07 -89.26, 13.37 287.97, 80.51 -62.01, -15.87 in-in in 7.533 Saltbr-in 3.048 HRD-in -73.43, -48.63 72.76, 3.97 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.41, 131.81 APE9-dihe-na 146.78, -170.14 APE8-dihe-in -112.43, 122.77 APE8-rot-in 308.27 APE67-dihe-in -64.63, -20.86 -40.07, -54.5 APE12-dist-in 9.032 APE11-dist-in 11.625 APE10-dist-in 5.893 APE9-dist-in 3.458 None SEP474 SEP474 XRAY 1.9 0.187 0.205 A 346 292 0 0 0 0 [[321, 572]] 1.0 6wly STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
7S48A 300 589 591.0 No_ligand No_ligand Active DFGin 9.263 14.359 BLAminus -132.18, -176.07 57.15, 66.61 -90.62, 13.14 283.96, 77.99 -58.72, -23.33 in-in in 7.568 Saltbr-in 3.013 HRD-in -68.6, -50.0 72.97, 5.97 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.95, 147.83 APE9-dihe-na 129.62, -155.85 APE8-dihe-in -124.91, 120.05 APE8-rot-in 304.0 APE67-dihe-in -65.8, -21.35 -34.95, -54.24 APE12-dist-in 8.739 APE11-dist-in 11.41 APE10-dist-in 5.72 APE9-dist-in 3.359 None SEP474 SEP474 XRAY 1.9 0.182 0.222 A 346 290 0 0 0 0 [[321, 572]] 1.0 7s48 STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5UPLA 299 589 591.0 No_ligand No_ligand Active DFGin 6.912 14.21 BLAminus -163.39, -166.4 59.78, 65.71 -85.27, 8.4 284.5, 105.17 -65.55, -24.21 in-in in 7.153 Saltbr-in 3.45 HRD-in -74.32, -54.24 91.8, -11.6 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.47, 142.27 APE9-dihe-na 127.52, -177.54 APE8-dihe-in -94.03, 129.74 APE8-rot-in 310.33 APE67-dihe-in -74.72, -26.02 -36.97, -49.73 APE12-dist-in 9.097 APE11-dist-in 11.606 APE10-dist-in 5.991 APE9-dist-in 3.47 None SEP474 SEP474 XRAY 3.003 0.259 0.31 A 453 291 0 0 0 0 [[321, 572]] 1.0 5upl STE_PAK4_HUMAN STE 6.8e-88 300.4 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5XVFA 300 588 591.0 8FR:60601 Type1 Active DFGin 6.41 13.597 BLAminus -139.57, -167.28 48.68, 69.67 -90.45, 14.2 300.76, 102.19 -49.74, -29.58 in-in in 6.835 Saltbr-in 2.694 HRD-in -68.54, -55.23 77.68, 6.31 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.25, 148.38 APE9-dihe-na 130.46, 176.96 APE8-dihe-in -94.44, 129.78 APE8-rot-in 311.81 APE67-dihe-in -56.47, -21.8 -39.65, -64.54 APE12-dist-in 9.78 APE11-dist-in 11.712 APE10-dist-in 6.021 APE9-dist-in 3.115 None SEP474 SEP474 XRAY 2.655 0.197 0.251 A 290 289 0 0 0 0 [[321, 572]] 1.0 5xvf STE_PAK4_HUMAN STE 1.7e-88 302.3 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5XVAA 300 591 591.0 8FU:60601 Type1 Active DFGin 7.292 14.678 BLAminus -136.68, -167.04 56.18, 61.77 -88.8, 17.56 283.16, 73.25 -67.91, -15.71 in-in in 9.132 Saltbr-in 3.092 HRD-in -72.82, -52.08 71.15, 6.91 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.16, 135.82 APE9-dihe-na 145.24, -159.73 APE8-dihe-in -113.25, 122.53 APE8-rot-in 304.59 APE67-dihe-in -66.13, -21.23 -41.05, -53.04 APE12-dist-in 9.038 APE11-dist-in 11.494 APE10-dist-in 5.663 APE9-dist-in 3.454 None SEP474 SEP474 XRAY 1.847 0.17 0.209 A 293 292 0 0 0 0 [[321, 572]] 1.0 5xva STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5XVGA 300 591 591.0 8FX:60601 Type1 Active DFGin 7.024 14.57 BLAminus -144.25, -166.15 65.18, 60.23 -89.33, 20.04 283.56, 74.99 -67.07, -12.05 in-in in 8.826 Saltbr-in 2.764 HRD-in -73.13, -52.27 72.69, 11.49 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.8, 143.35 APE9-dihe-na 134.84, -159.43 APE8-dihe-in -114.76, 122.91 APE8-rot-in 304.21 APE67-dihe-in -67.25, -18.32 -47.47, -47.2 APE12-dist-in 8.974 APE11-dist-in 11.481 APE10-dist-in 5.603 APE9-dist-in 3.372 None SEP474 SEP474 XRAY 2.1 0.184 0.235 A 293 292 0 0 0 0 [[321, 572]] 1.0 5xvg STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5ZJWA 300 591 591.0 9EO:60601 Type1 Active DFGin 7.467 14.64 BLAminus -132.98, -163.71 63.14, 51.92 -88.51, 14.85 280.26, 75.04 -63.71, -21.2 in-in in 8.86 Saltbr-in 2.964 HRD-in -75.73, -49.33 70.25, 5.64 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.08, 137.6 APE9-dihe-na 143.8, -159.07 APE8-dihe-in -117.35, 122.21 APE8-rot-in 300.48 APE67-dihe-in -67.39, -19.86 -42.33, -52.03 APE12-dist-in 8.996 APE11-dist-in 11.569 APE10-dist-in 5.792 APE9-dist-in 3.463 None SEP474 SEP474 XRAY 1.798 0.171 0.215 A 293 292 0 0 0 0 [[321, 572]] 1.0 5zjw STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
9D52A 300 589 591.0 A1A2R:601 Type1 Active DFGin 5.845 13.851 BLAminus -137.59, -174.27 58.3, 72.52 -97.57, 11.47 297.67, 101.1 -60.39, -21.88 in-in in 7.298 Saltbr-in 3.091 HRD-in -68.35, -60.99 83.79, -1.35 in-in-in SNCiii in-in ActLoopNT-in 2.766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.19, 138.88 APE9-dihe-na 146.77, -167.01 APE8-dihe-in -103.22, 122.41 APE8-rot-in 308.06 APE67-dihe-in -66.75, -19.09 -36.2, -56.16 APE12-dist-in 9.053 APE11-dist-in 11.768 APE10-dist-in 5.918 APE9-dist-in 3.302 None SEP474 SEP474 XRAY 2.449 0.205 0.287 A 293 290 0 0 0 0 [[321, 572]] 1.0 9d52 STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
9D53A 300 591 591.0 A1A2P:601 Type1 Active DFGin 7.419 14.388 BLAminus -130.46, -168.1 66.3, 64.12 -97.32, 16.28 284.99, 83.03 -56.88, -20.45 in-in in 8.429 Saltbr-in 3.039 HRD-in -68.67, -55.34 70.78, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.701 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.76, 128.71 APE9-dihe-na 154.97, -168.87 APE8-dihe-in -101.14, 120.06 APE8-rot-in 318.43 APE67-dihe-in -66.45, -26.26 -33.54, -52.96 APE12-dist-in 9.874 APE11-dist-in 11.678 APE10-dist-in 5.88 APE9-dist-in 3.4 None SEP474 SEP474 XRAY 2.468 0.19 0.263 A 293 292 0 0 0 0 [[321, 572]] 1.0 9d53 STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5BMSA 300 589 591.0 4T6:60601 Type1 Active DFGin 5.882 13.769 BLAminus -127.85, -156.82 35.49, 78.34 -98.96, 8.42 299.27, 100.83 -63.09, -11.52 in-in in 7.312 Saltbr-in 3.075 HRD-in -77.22, -46.32 67.96, 4.24 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.5, 139.88 APE9-dihe-na 129.41, -167.55 APE8-dihe-in -107.17, 120.88 APE8-rot-in 315.49 APE67-dihe-in -62.73, -29.26 -33.47, -61.67 APE12-dist-in 9.996 APE11-dist-in 11.617 APE10-dist-in 5.891 APE9-dist-in 3.222 None SEP474 SEP474 XRAY 2.903 0.176 0.23 A 293 290 0 0 0 0 [[321, 572]] 1.0 5bms STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
2X4ZA 299 590 591.0 7KC:1593 Type1 Active DFGin 7.175 15.683 BLAminus -132.06, -173.98 55.27, 65.86 -89.03, 22.48 286.31, 71.15 -56.55, -18.72 out-in out 10.093 Saltbr-in 3.353 HRD-in -64.34, -55.81 75.26, 4.96 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.15, 164.59 APE9-dihe-na 116.46, -153.03 APE8-dihe-in -123.41, 117.02 APE8-rot-in 305.72 APE67-dihe-in -61.08, -22.54 -22.19, -62.41 APE12-dist-in 8.425 APE11-dist-in 11.116 APE10-dist-in 5.211 APE9-dist-in 3.362 P296G,Q297S,R298H,V299M SEP474 SEP474 XRAY 2.1 0.2 0.262 A 296 292 0 0 0 0 [[321, 572]] 1.0 2x4z STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4APPA 300 591 591.0 N53:60601 Type1 Active DFGin 7.373 15.543 BLAminus -133.61, -169.75 57.81, 63.69 -88.94, 22.51 284.15, 66.92 -58.72, -20.97 out-in out 10.218 Saltbr-in 2.879 HRD-in -73.06, -52.18 73.4, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.88, 162.5 APE9-dihe-na 116.5, -157.47 APE8-dihe-in -119.99, 123.77 APE8-rot-in 310.26 APE67-dihe-in -55.32, -22.24 -23.87, -72.11 APE12-dist-in 8.564 APE11-dist-in 11.028 APE10-dist-in 5.227 APE9-dist-in 3.3 None SEP474 SEP474 XRAY 2.2 0.188 0.229 A 296 292 0 0 0 0 [[321, 572]] 1.0 4app STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4NJDA 300 589 591.0 NJD:60600 Type1 Active DFGin 7.55 14.534 BLAminus -137.61, -170.79 59.81, 63.86 -89.24, 10.26 288.33, 68.78 -51.39, -35.62 in-in in 8.832 Saltbr-in 2.774 HRD-in -64.48, -51.46 71.88, -2.14 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.47, 156.67 APE9-dihe-na 134.13, -165.38 APE8-dihe-in -113.07, 115.38 APE8-rot-in 315.39 APE67-dihe-in -65.56, -7.99 -27.21, -63.29 APE12-dist-in 9.033 APE11-dist-in 11.457 APE10-dist-in 5.589 APE9-dist-in 3.292 None SEP474 SEP474 XRAY 2.5 0.239 0.321 A 296 290 0 0 0 0 [[321, 572]] 1.0 4njd STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5I0BA 301 589 591.0 67U:601 Type1 Active DFGin 7.442 14.009 BLAminus -124.94, -168.52 59.76, 54.09 -85.49, 7.58 290.32, 78.2 -49.18, -28.77 in-in in 8.386 Saltbr-in 2.784 HRD-in -62.72, -43.63 65.0, -1.19 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.17, -174.46 APE9-dihe-na 97.06, -178.26 APE8-dihe-in -118.11, 136.57 APE8-rot-in 266.84 APE67-dihe-in -62.52, -33.2 -59.08, -48.11 APE12-dist-in 9.53 APE11-dist-in 11.272 APE10-dist-in 5.32 APE9-dist-in 2.849 None SEP474 SEP474 XRAY 3.09 0.199 0.269 A 296 289 0 0 0 0 [[321, 572]] 1.0 5i0b STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
8AHGA 300 591 591.0 M4I:60601 Type1 Active DFGin 9.274 14.621 BLAminus -140.7, -178.52 59.09, 59.79 -84.52, 9.62 282.61, 76.91 -57.19, -25.15 in-in in 7.783 Saltbr-in 3.0 HRD-in -68.05, -53.29 75.32, 3.61 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.99, 144.76 APE9-dihe-na 133.62, -152.42 APE8-dihe-in -126.55, 119.92 APE8-rot-in 307.01 APE67-dihe-in -70.16, -19.98 -38.25, -51.28 APE12-dist-in 8.713 APE11-dist-in 11.311 APE10-dist-in 5.642 APE9-dist-in 3.378 L310A SEP474 SEP474 XRAY 1.885 0.181 0.227 A 297 292 0 0 0 0 [[321, 572]] 1.0 8ahg STE_PAK4_HUMAN STE 1.8e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
8AHHA 300 591 591.0 M4X:60601 Type1 Active DFGin 9.202 14.302 BLAminus -140.1, -178.26 56.12, 62.98 -87.16, 10.59 287.77, 78.02 -51.14, -27.59 in-in in 7.613 Saltbr-in 3.166 HRD-in -71.92, -49.28 69.03, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.71, 139.6 APE9-dihe-na 140.63, -152.77 APE8-dihe-in -124.55, 121.97 APE8-rot-in 311.5 APE67-dihe-in -69.72, -19.91 -39.05, -51.53 APE12-dist-in 8.885 APE11-dist-in 11.313 APE10-dist-in 5.683 APE9-dist-in 3.346 L310A SEP474 SEP474 XRAY 2.037 0.188 0.25 A 297 292 0 0 0 0 [[321, 572]] 1.0 8ahh STE_PAK4_HUMAN STE 1.8e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
2CDZA 299 590 591.0 23D:1591 Type1 Active DFGin 6.851 14.239 BLAminus -131.93, -172.68 60.56, 61.36 -89.92, 17.05 286.34, 82.19 -67.68, -14.12 in-in in 8.413 Saltbr-in 2.548 HRD-in -67.95, -51.01 69.05, 1.71 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.41, 141.72 APE9-dihe-na 145.87, -158.12 APE8-dihe-in -124.24, 119.58 APE8-rot-in 305.81 APE67-dihe-in -67.53, -21.67 -30.06, -59.48 APE12-dist-in 9.103 APE11-dist-in 11.374 APE10-dist-in 5.44 APE9-dist-in 3.375 None SEP474 SEP474 XRAY 2.3 0.202 0.248 A 303 290 2 0 0 0 [[321, 572]] 1.0 2cdz STE_PAK4_HUMAN STE 2e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5VEFA 300 589 591.0 M77:601 Type1 Active DFGin 9.346 14.591 BLAminus -136.52, -176.88 59.47, 65.15 -89.64, 13.99 283.23, 80.94 -61.13, -20.52 in-in in 7.74 Saltbr-in 3.421 HRD-in -69.98, -53.91 75.95, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.13, 146.51 APE9-dihe-na 127.95, -160.54 APE8-dihe-in -118.96, 120.95 APE8-rot-in 302.31 APE67-dihe-in -69.34, -18.53 -36.63, -52.05 APE12-dist-in 8.781 APE11-dist-in 11.284 APE10-dist-in 5.646 APE9-dist-in 3.383 None SEP474 SEP474 XRAY 1.752 0.202 0.239 A 319 290 0 0 0 0 [[321, 572]] 1.0 5vef STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
7CP3A 300 589 591.0 GC6:601 Type1.5_Back Active DFGin 7.425 14.516 BLAminus -143.23, -161.44 54.49, 56.58 -84.68, 17.45 283.38, 69.37 -57.63, -18.5 in-in in 8.25 Saltbr-in 2.97 HRD-in -75.52, -44.49 67.1, 5.14 in-in-in SNCiii in-in ActLoopNT-in 3.046 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 132.66 APE9-dihe-na 144.26, -150.95 APE8-dihe-in -112.54, 134.18 APE8-rot-in 306.62 APE67-dihe-in -71.08, -11.39 -57.8, -50.41 APE12-dist-in 8.889 APE11-dist-in 11.521 APE10-dist-in 5.733 APE9-dist-in 3.741 None SEP474 SEP474 XRAY 2.9 0.245 0.267 A 292 290 0 0 0 0 [[321, 572]] 1.0 7cp3 STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
7CP4A 300 591 591.0 GCC:601 Type1.5_Back Active DFGin 7.635 14.952 BLAminus -133.21, 179.04 59.99, 67.29 -90.26, 23.6 285.11, 67.74 -63.22, -23.85 in-in in 9.553 Saltbr-in 3.29 HRD-in -66.61, -55.01 72.71, 4.31 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.28, 137.07 APE9-dihe-na 140.56, -171.81 APE8-dihe-in -103.14, 125.77 APE8-rot-in 309.43 APE67-dihe-in -72.75, -28.29 -48.05, -39.75 APE12-dist-in 8.651 APE11-dist-in 11.228 APE10-dist-in 5.429 APE9-dist-in 3.361 None SEP474 SEP474 XRAY 2.5 0.199 0.252 A 292 292 0 0 0 0 [[321, 572]] 1.0 7cp4 STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
7CMBA 300 589 591.0 G5X:60601 Type1.5_Back Active DFGin 7.29 14.864 BLAminus -144.05, 179.08 58.57, 70.68 -90.04, 21.82 285.98, 71.77 -65.95, -9.86 in-in in 8.729 Saltbr-in 2.802 HRD-in -64.8, -46.41 64.06, 19.25 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.38, 168.28 APE9-dihe-na 114.24, -179.32 APE8-dihe-in -97.31, 129.92 APE8-rot-in 316.69 APE67-dihe-in -69.15, -20.09 -50.08, -47.79 APE12-dist-in 8.971 APE11-dist-in 11.233 APE10-dist-in 5.229 APE9-dist-in 3.486 None SEP474 SEP474 XRAY 2.592 0.208 0.251 A 293 290 0 0 0 0 [[321, 572]] 1.0 7cmb STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4O0VA 300 589 591.0 2OL:60601 Type1.5_Back Active DFGin 7.72 14.855 BLAminus -129.91, -179.13 52.93, 70.48 -91.0, 31.77 289.31, 80.54 -68.79, -11.49 in-in in 9.386 Saltbr-in 2.715 HRD-in -63.47, -48.3 66.54, 12.64 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.31, 136.62 APE9-dihe-na 128.1, -161.84 APE8-dihe-in -105.46, 125.26 APE8-rot-in 314.65 APE67-dihe-in -70.36, -25.33 -37.86, -50.41 APE12-dist-in 9.483 APE11-dist-in 11.399 APE10-dist-in 5.692 APE9-dist-in 3.35 None SEP474 SEP474 XRAY 2.8 0.204 0.253 A 293 290 0 0 0 0 [[321, 572]] 1.0 4o0v STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4O0XA 300 589 591.0 2OQ:60601 Type1.5_Back Active DFGin 7.686 14.42 BLAminus -143.48, 175.23 50.73, 80.07 -96.8, 29.16 288.57, 62.64 -65.03, -22.79 in-in in 7.841 Saltbr-in 2.524 HRD-in -64.27, -54.17 74.62, 7.89 in-in-in SNCiii in-in ActLoopNT-in 3.044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.91, 146.7 APE9-dihe-na 131.01, -164.91 APE8-dihe-in -110.0, 119.08 APE8-rot-in 309.56 APE67-dihe-in -57.87, -20.38 -32.76, -63.35 APE12-dist-in 9.115 APE11-dist-in 11.502 APE10-dist-in 5.674 APE9-dist-in 3.39 None SEP474 SEP474 XRAY 2.483 0.242 0.242 A 293 290 0 0 0 0 [[321, 572]] 1.0 4o0x STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4O0YA 300 589 591.0 2OO:60601 Type1.5_Back Active DFGin 7.439 13.922 BLAminus -135.18, 176.5 49.39, 78.85 -92.46, 20.76 288.83, 77.11 -54.08, -29.88 in-in in 7.462 Saltbr-in 2.628 HRD-in -74.32, -48.56 73.38, 6.1 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.29, 136.66 APE9-dihe-na 144.79, -161.28 APE8-dihe-in -119.15, 122.67 APE8-rot-in 309.1 APE67-dihe-in -63.4, -19.31 -38.26, -57.11 APE12-dist-in 9.651 APE11-dist-in 11.689 APE10-dist-in 5.96 APE9-dist-in 3.34 None SEP474 SEP474 XRAY 2.2 0.2 0.238 A 293 290 0 0 0 0 [[321, 572]] 1.0 4o0y STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4XBRA 177 589 591.0 ATP:60601 ATPlike Inactive DFGin 5.852 14.061 ABAminus -142.04, -22.23 -111.42, 72.59 -86.56, 10.51 310.81, 99.4 -46.84, -40.66 in-in in 7.009 Saltbr-in 3.158 HRD-in -84.11, -33.57 58.48, -1.88 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.96, 132.02 APE9-dihe-na 150.85, -176.82 APE8-dihe-in -102.34, 122.5 APE8-rot-in 312.14 APE67-dihe-in -59.91, -25.15 -35.82, -60.88 APE12-dist-in 9.335 APE11-dist-in 11.927 APE10-dist-in 6.05 APE9-dist-in 3.396 None SEP474 SEP474 XRAY 2.94 0.191 0.23 A 366 293 0 0 0 0 [[321, 572]] 1.0 4xbr STE_PAK4_HUMAN STE 3.7e-88 301.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4FIGA 298 590 591.0 ANP:1001 ATPlike Inactive DFGin 5.976 13.995 BLAminus -134.45, -166.25 59.06, 57.3 -88.34, 9.13 298.9, 106.14 -61.58, -20.66 in-in in 7.133 Saltbr-in 3.168 HRD-in -77.25, -46.66 72.07, -3.1 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.47, 161.1 APE9-dihe-na 110.61, 163.55 APE8-dihe-in -79.54, 130.34 APE8-rot-out 29.96 APE67-dihe-in -76.38, -28.34 -35.31, -49.63 APE12-dist-in 9.418 APE11-dist-in 11.569 APE10-dist-in 5.635 APE9-dist-in 3.369 None SEP474 SEP474 XRAY 3.01 0.197 0.221 A 346 293 0 0 0 0 [[321, 572]] 1.0 4fig STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4FIEA 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.278 14.03 BLAminus -142.71, -177.86 63.75, 67.7 -92.97, 13.53 295.29, 98.36 -64.15, -7.0 in-out in 6.991 Saltbr-out 3.974 HRD-in -74.78, -36.69 67.65, -13.13 out-in-out SNCoio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.98, 139.97 APE9-dihe-na 123.6, -177.34 APE8-dihe-in -84.44, 139.76 APE8-rot-out 19.51 APE67-dihe-in -74.38, -37.99 -51.24, -48.18 APE12-dist-in 9.515 APE11-dist-in 11.685 APE10-dist-in 5.909 APE9-dist-in 3.508 None SEP474 SEP474 XRAY 3.11 0.257 0.276 A 423 301 0 0 0 0 [[321, 572]] 1.0 4fie STE_PAK4_HUMAN STE 5.6e-88 300.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4FIEB 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.278 14.031 BLAminus -142.24, -177.62 63.59, 67.55 -92.7, 13.49 295.33, 98.22 -64.04, -7.21 in-out in 6.989 Saltbr-out 3.957 HRD-in -74.95, -36.21 66.97, -12.74 out-in-out SNCoio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.0, 139.86 APE9-dihe-na 123.6, -177.41 APE8-dihe-in -84.57, 139.76 APE8-rot-out 19.62 APE67-dihe-in -74.42, -37.89 -51.19, -48.15 APE12-dist-in 9.515 APE11-dist-in 11.689 APE10-dist-in 5.912 APE9-dist-in 3.51 None SEP474 SEP474 XRAY 3.11 0.257 0.276 B 423 301 0 0 0 0 [[321, 572]] 1.0 4fie STE_PAK4_HUMAN STE 5.6e-88 300.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
2BVAA 300 587 591.0 No_ligand No_ligand Inactive DFGin 7.438 16.475 BLAminus -117.27, -176.72 56.65, 71.44 -91.27, 35.1 289.21, 80.8 -69.61, -2.94 out-out out 10.481 Saltbr-out 4.02 HRD-in -57.52, -60.13 72.86, 5.02 out-out-in SNCooi out-in ActLoopNT-out 3.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.79, 153.17 APE9-dihe-na 127.58, -141.52 APE8-dihe-in -136.11, 111.21 APE8-rot-in 333.57 APE67-dihe-in -60.96, -14.16 -40.33, -50.6 APE12-dist-in 8.848 APE11-dist-in 11.484 APE10-dist-in 5.83 APE9-dist-in 3.471 None SEP474 SEP474 XRAY 2.3 0.192 0.269 A 292 273 15 0 0 2 [[321, 572]] 1.0 2bva STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
2BVAB 301 587 591.0 No_ligand No_ligand Inactive DFGin 7.572 17.238 BLAminus -131.91, -158.23 65.58, 44.26 -84.57, 26.99 293.34, 56.33 -60.85, -21.66 out-out out 11.675 Saltbr-out 7.148 HRD-in -60.3, -59.82 75.14, 24.4 out-in-in SNCoii in-in ActLoopNT-in 2.499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.93, 163.72 APE9-dihe-na 104.79, -155.19 APE8-dihe-in -112.34, 124.37 APE8-rot-in 319.0 APE67-dihe-in -73.92, -14.55 -41.39, -45.76 APE12-dist-in 8.588 APE11-dist-in 11.399 APE10-dist-in 5.909 APE9-dist-in 3.197 None SEP474 SEP474 XRAY 2.3 0.192 0.269 B 292 275 12 0 0 2 [[321, 572]] 1.0 2bva STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
8YHKA 298 591 591.0 No_ligand No_ligand Inactive DFGin 6.394 13.95 BLAminus -144.78, -174.84 60.87, 52.46 -74.27, -7.16 291.41, 99.22 -44.42, -31.64 in-out in 7.212 Saltbr-out 5.663 HRD-out -76.82, 93.99 -85.26, 6.82 out-in-in SNCoii in-in ActLoopNT-in 2.734 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.02, 139.67 APE9-dihe-na 131.69, -172.38 APE8-dihe-in -96.54, 118.36 APE8-rot-in 308.12 APE67-dihe-in -79.25, -37.48 -34.17, -42.18 APE12-dist-in 9.944 APE11-dist-in 11.39 APE10-dist-in 5.545 APE9-dist-in 3.243 None None None XRAY 3.3 0.253 0.319 A 301 294 0 0 0 0 [[321, 572]] 1.0 8yhk STE_PAK4_HUMAN STE 1.9e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4XBUA 297 589 591.0 No_ligand No_ligand Inactive DFGin 7.426 14.345 BLAminus -134.76, -171.38 58.13, 68.14 -90.95, 10.75 282.43, 88.09 -57.4, -26.1 in-out in 8.875 Saltbr-out 4.505 HRD-in -80.19, -49.71 68.99, 2.54 out-in-in SNCoii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.64, 133.45 APE9-dihe-na 156.19, -154.61 APE8-dihe-in -123.57, 122.27 APE8-rot-in 305.74 APE67-dihe-in -70.59, -15.2 -40.43, -52.25 APE12-dist-in 8.806 APE11-dist-in 11.559 APE10-dist-in 5.875 APE9-dist-in 3.518 None SEP474 SEP474 XRAY 2.06 0.201 0.243 A 326 293 0 0 0 0 [[321, 572]] 1.0 4xbu STE_PAK4_HUMAN STE 2.5e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
8AHIA 300 591 591.0 M56:601 Type1 Inactive DFGin 9.181 14.38 BLAminus -137.45, -173.93 55.91, 63.31 -90.54, 16.67 287.37, 76.55 -61.73, -19.34 in-out in 7.694 Saltbr-out 3.645 HRD-in -78.82, -49.15 74.56, 0.81 out-in-in SNCoii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.24, 128.69 APE9-dihe-na 143.74, -151.59 APE8-dihe-in -115.17, 123.77 APE8-rot-in 313.27 APE67-dihe-in -68.11, -27.23 -45.23, -43.93 APE12-dist-in 8.803 APE11-dist-in 11.358 APE10-dist-in 5.796 APE9-dist-in 3.534 L310A SEP474 SEP474 XRAY 2.69 0.16 0.249 A 297 292 0 0 0 0 [[321, 572]] 1.0 8ahi STE_PAK4_HUMAN STE 1.8e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5VEDA 300 589 591.0 STU:601 Type1 Inactive DFGin 7.591 14.871 BLAminus -137.67, -169.84 57.61, 74.14 -100.29, 38.24 286.21, 78.54 -72.3, -31.74 in-out in 8.771 Saltbr-out 5.279 HRD-in -70.67, -47.26 60.82, 22.3 out-in-in SNCoii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 169.93 APE9-dihe-na 110.0, -167.24 APE8-dihe-in -107.4, 122.99 APE8-rot-in 313.49 APE67-dihe-in -72.02, -18.93 -37.81, -47.81 APE12-dist-in 8.493 APE11-dist-in 11.13 APE10-dist-in 5.271 APE9-dist-in 3.412 None SEP474 SEP474 XRAY 2.301 0.231 0.277 A 319 290 0 0 0 0 [[321, 572]] 1.0 5ved STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
5VEEA 300 589 591.0 981:601 Type1 Inactive DFGin 6.832 15.436 BLAminus -149.85, -166.61 63.61, 64.4 -91.35, 12.72 287.99, 79.38 -42.54, -35.66 in-out in 8.369 Saltbr-out 6.665 HRD-in -63.93, -45.62 68.7, 8.17 out-in-in SNCoii in-in ActLoopNT-in 3.12 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.59, 147.54 APE9-dihe-na 146.37, -170.93 APE8-dihe-in -104.03, 125.68 APE8-rot-in 311.71 APE67-dihe-in -46.67, -33.8 -40.96, -66.37 APE12-dist-in 9.09 APE11-dist-in 11.607 APE10-dist-in 5.815 APE9-dist-in 3.64 None SEP474 SEP474 XRAY 2.5 0.231 0.276 A 319 290 0 0 0 0 [[321, 572]] 1.0 5vee STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
4FIGB 298 590 591.0 ANP:602 ATPlike Inactive DFGin 5.979 13.845 None -136.1, -40.27 -82.41, 70.29 -85.54, 12.48 305.29, 106.7 -66.77, -24.27 in-in in 7.007 Saltbr-in 3.047 HRD-in -63.37, -48.9 73.21, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.8, 141.64 APE9-dihe-na 130.69, -165.45 APE8-dihe-in -110.43, 122.9 APE8-rot-in 324.7 APE67-dihe-in -77.33, -31.89 -29.23, -51.11 APE12-dist-in 9.706 APE11-dist-in 11.743 APE10-dist-in 5.92 APE9-dist-in 3.386 None SEP474 SEP474 XRAY 3.01 0.197 0.221 B 346 293 0 0 0 0 [[321, 572]] 1.0 4fig STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4

STE_PAK4 (Serine/threonine-protein kinase PAK 4)

Total number of chains: 54
Active chains: 42
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 52 96.3% AF-O96013-K1A
DFGin ABAminus 1 1.9% 4XBRA
DFGin None 1 1.9% 4FIGB

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PAK4_HUMAN 4FIFA O96013 296 589 591.0 ANP:1000 ATPlike Active DFGin 6.132 13.879 BLAminus -134.27, -172.64 55.78, 65.69 -91.22, 11.11 299.57, 98.92 -61.37, -20.58 in-in in 7.046 Saltbr-in 3.112 HRD-in -73.18, -47.2 74.11, -8.39 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.08, 134.89 APE9-dihe-na 136.18, -173.61 APE8-dihe-in -102.98, 119.55 APE8-rot-in 312.46 APE67-dihe-in -69.75, -26.2 -30.93, -52.34 APE12-dist-in 9.318 APE11-dist-in 11.709 APE10-dist-in 5.875 APE9-dist-in 3.299 None SEP474 SEP474 XRAY 2.6 0.207 0.227 A 346 294 0 0 0 0 [[321, 572]] 1.0 4fif Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4FIFB O96013 297 589 591.0 ANP:1000 ATPlike Active DFGin 5.899 13.85 BLAminus -129.09, -170.37 52.27, 68.51 -93.51, 10.45 301.97, 96.23 -63.09, -15.01 in-in in 7.007 Saltbr-in 3.167 HRD-in -65.39, -48.9 75.1, -7.5 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.88, 134.77 APE9-dihe-na 136.42, -174.06 APE8-dihe-in -101.96, 121.94 APE8-rot-in 314.36 APE67-dihe-in -72.79, -21.56 -33.03, -50.98 APE12-dist-in 9.238 APE11-dist-in 11.712 APE10-dist-in 5.886 APE9-dist-in 3.335 None SEP474 SEP474 XRAY 2.6 0.207 0.227 B 346 293 0 0 0 0 [[321, 572]] 1.0 4fif Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4JDIA O96013 300 589 591.0 ANP:1000 ATPlike Active DFGin 6.291 14.47 BLAminus -134.26, 177.87 63.72, 71.58 -94.6, 13.78 289.77, 79.71 -54.15, -28.77 in-in in 6.959 Saltbr-in 2.737 HRD-in -72.82, -49.09 73.48, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 145.0 APE9-dihe-na 130.41, -160.49 APE8-dihe-in -120.53, 123.45 APE8-rot-in 305.94 APE67-dihe-in -63.49, -22.51 -36.89, -56.07 APE12-dist-in 8.769 APE11-dist-in 11.535 APE10-dist-in 5.874 APE9-dist-in 3.327 None SEP474 SEP474 XRAY 1.85 0.194 0.233 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdi Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5UPKB O96013 300 588 591.0 ANP:60600 ATPlike Active DFGin 6.272 14.139 BLAminus -132.3, -169.35 61.71, 61.5 -87.86, 7.28 293.59, 93.96 -55.36, -28.3 in-in in 7.077 Saltbr-in 3.329 HRD-in -65.35, -49.16 70.36, 11.54 in-in-in SNCiii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.55, 149.52 APE9-dihe-na 120.09, -163.11 APE8-dihe-in -119.51, 121.87 APE8-rot-in 313.98 APE67-dihe-in -69.89, -18.98 -32.47, -57.41 APE12-dist-in 8.623 APE11-dist-in 11.267 APE10-dist-in 5.616 APE9-dist-in 3.426 None SEP474 SEP474 XRAY 2.4 0.22 0.264 B 346 289 0 0 0 0 [[321, 572]] 1.0 5upk Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 7S46A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.021 14.349 BLAminus -133.61, -177.07 54.75, 76.68 -92.18, 14.46 286.49, 80.35 -59.04, -19.55 in-in in 7.534 Saltbr-in 2.867 HRD-in -69.43, -50.5 76.76, 2.96 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.73, 132.58 APE9-dihe-na 145.82, -167.86 APE8-dihe-in -110.13, 128.57 APE8-rot-in 305.26 APE67-dihe-in -70.79, -21.11 -38.41, -55.32 APE12-dist-in 9.02 APE11-dist-in 11.537 APE10-dist-in 5.793 APE9-dist-in 3.286 D440N,S474E None None XRAY 2.1 0.182 0.22 A 346 290 0 0 0 0 [[321, 572]] 1.0 7s46 Homo sapiens STE_PAK4_HUMAN STE 5.5e-87 297.4 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 7S47A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.217 14.646 BLAminus -126.8, -179.34 54.51, 73.91 -89.97, 15.41 285.81, 78.05 -59.21, -18.99 in-in in 7.79 Saltbr-in 2.931 HRD-in -66.64, -48.47 70.7, 6.89 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.53, 138.41 APE9-dihe-na 140.72, -164.27 APE8-dihe-in -114.61, 124.35 APE8-rot-in 304.9 APE67-dihe-in -66.22, -20.32 -36.39, -56.83 APE12-dist-in 9.039 APE11-dist-in 11.45 APE10-dist-in 5.747 APE9-dist-in 3.401 D440N,S474E None None XRAY 2.0 0.196 0.237 A 383 290 0 0 0 0 [[321, 572]] 1.0 7s47 Homo sapiens STE_PAK4_HUMAN STE 7.5e-87 297.0 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN AF-O96013-K1A O96013 313 580 591.0 No_ligand No_ligand Active DFGin 5.976 13.493 BLAminus -130.1, -176.91 63.02, 54.98 -77.11, 5.6 302.38, 102.83 -58.72, -35.23 in-in in 7.715 Saltbr-in 2.696 HRD-in -71.08, -49.97 65.46, 11.72 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.24, 162.55 APE9-dihe-na 107.8, 178.89 APE8-dihe-in -83.65, 126.03 APE8-rot-in 303.62 APE67-dihe-in -75.87, -21.96 -48.06, -42.55 APE12-dist-in 9.036 APE11-dist-in 11.639 APE10-dist-in 5.674 APE9-dist-in 3.243 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[321, 572]] 1.0 AF-O96013-K1 Homo sapiens STE_PAK4_HUMAN STE 1.3e-88 302.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN AF-O96013-K3A O96013 313 580 591.0 No_ligand No_ligand Active DFGin 6.981 14.976 BLAminus -136.02, -172.75 59.27, 53.41 -76.06, 16.58 290.59, 81.49 -60.1, -26.15 in-in in 8.179 Saltbr-in 2.79 HRD-in -73.8, -46.38 65.56, -0.51 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.08, 135.85 APE9-dihe-na 132.39, 173.54 APE8-dihe-in -86.18, 126.08 APE8-rot-in 300.1 APE67-dihe-in -76.89, -22.75 -42.41, -45.98 APE12-dist-in 9.021 APE11-dist-in 11.486 APE10-dist-in 5.617 APE9-dist-in 3.125 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[321, 572]] 1.0 AF-O96013-K3 Homo sapiens STE_PAK4_HUMAN STE 1.3e-88 302.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4L67A O96013 300 589 591.0 No_ligand No_ligand Active DFGin 10.27 14.486 BLAminus -151.61, -168.49 52.0, 67.37 -93.33, 11.41 289.19, 94.18 -58.57, -33.07 in-in in 8.3 Saltbr-in 3.226 HRD-in -102.14, -50.27 82.9, -7.13 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.16, 134.74 APE9-dihe-na 141.36, 174.48 APE8-dihe-in -84.97, 121.4 APE8-rot-in 323.69 APE67-dihe-in -44.13, -27.72 -31.92, -71.35 APE12-dist-in 9.29 APE11-dist-in 11.655 APE10-dist-in 5.803 APE9-dist-in 3.595 None SEP474 SEP474 XRAY 2.8 0.233 0.333 A 292 290 0 0 0 0 [[321, 572]] 1.0 4l67 Homo sapiens STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 2Q0NA O96013 298 591 591.0 No_ligand No_ligand Active DFGin 7.255 14.793 BLAminus -133.4, -177.0 60.04, 59.83 -83.03, 16.12 284.85, 75.64 -58.21, -18.8 in-in in 8.517 Saltbr-in 2.777 HRD-in -73.11, -49.29 75.99, 5.88 in-in-in SNCiii in-in ActLoopNT-in 2.867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.34, 142.4 APE9-dihe-na 146.55, -148.54 APE8-dihe-in -125.26, 117.52 APE8-rot-in 303.56 APE67-dihe-in -67.05, -21.65 -33.32, -56.61 APE12-dist-in 9.359 APE11-dist-in 11.992 APE10-dist-in 6.123 APE9-dist-in 3.566 None SEP474 SEP474 XRAY 1.75 0.185 0.228 A 301 294 0 0 0 0 [[321, 572]] 1.0 2q0n Homo sapiens STE_PAK4_HUMAN STE 1.9e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 2J0IA O96013 300 589 591.0 No_ligand No_ligand Active DFGin 7.46 14.626 BLAminus -134.36, -165.75 58.37, 60.67 -88.32, 13.39 279.76, 75.6 -62.32, -23.3 in-in in 9.455 Saltbr-in 2.627 HRD-in -73.73, -49.62 71.12, 2.68 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.96, 131.78 APE9-dihe-na 149.44, -163.72 APE8-dihe-in -114.93, 122.79 APE8-rot-in 303.47 APE67-dihe-in -68.35, -22.9 -35.96, -56.0 APE12-dist-in 9.0 APE11-dist-in 11.582 APE10-dist-in 5.776 APE9-dist-in 3.376 None SEP474 SEP474 XRAY 1.6 0.174 0.215 A 303 290 0 0 0 0 [[321, 572]] 1.0 2j0i Homo sapiens STE_PAK4_HUMAN STE 2e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4JDJA O96013 300 589 591.0 No_ligand No_ligand Active DFGin 9.358 14.486 BLAminus -135.05, -172.77 54.02, 73.82 -92.85, 18.9 284.15, 75.9 -56.84, -29.73 in-in in 7.485 Saltbr-in 2.745 HRD-in -72.69, -51.05 77.52, -2.59 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.69, 141.26 APE9-dihe-na 128.18, -160.28 APE8-dihe-in -117.23, 122.47 APE8-rot-in 309.77 APE67-dihe-in -61.22, -24.48 -35.06, -58.78 APE12-dist-in 8.557 APE11-dist-in 11.313 APE10-dist-in 5.753 APE9-dist-in 3.513 F461V SEP474,TPO562 SEP474,TPO562 XRAY 2.3 0.197 0.244 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdj Homo sapiens STE_PAK4_HUMAN STE 1.4e-88 302.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4JDKA O96013 300 589 591.0 No_ligand No_ligand Active DFGin 9.298 14.327 BLAminus -140.41, 175.97 54.41, 74.79 -91.36, 8.02 284.28, 75.16 -60.4, -13.24 in-in in 7.528 Saltbr-in 3.384 HRD-in -73.1, -44.55 68.62, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.09, 153.76 APE9-dihe-na 119.82, -165.82 APE8-dihe-in -116.32, 129.51 APE8-rot-in 313.3 APE67-dihe-in -59.03, -26.55 -44.4, -55.05 APE12-dist-in 8.726 APE11-dist-in 11.441 APE10-dist-in 5.89 APE9-dist-in 3.406 F461V SEP474,TPO562 SEP474,TPO562 XRAY 2.4 0.188 0.249 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdk Homo sapiens STE_PAK4_HUMAN STE 1.4e-88 302.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4FIHA O96013 298 589 591.0 No_ligand No_ligand Active DFGin 9.206 14.407 BLAminus -135.98, -177.2 57.56, 65.31 -90.69, 14.94 285.62, 76.78 -54.76, -25.38 in-in in 7.578 Saltbr-in 2.892 HRD-in -76.81, -47.61 70.56, 6.55 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 153.53 APE9-dihe-na 122.35, -158.41 APE8-dihe-in -122.77, 125.62 APE8-rot-in 308.66 APE67-dihe-in -66.29, -20.2 -45.47, -47.52 APE12-dist-in 8.616 APE11-dist-in 11.303 APE10-dist-in 5.566 APE9-dist-in 3.307 None SEP474 SEP474 XRAY 1.97 0.181 0.225 A 346 292 0 0 0 0 [[321, 572]] 1.0 4fih Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4FIIA O96013 299 590 591.0 No_ligand No_ligand Active DFGin 9.073 14.201 BLAminus -132.45, 178.79 60.3, 61.71 -80.38, 12.79 288.68, 79.5 -61.8, -21.84 in-in in 7.306 Saltbr-in 2.72 HRD-in -76.29, -44.67 66.21, 4.67 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.33, 143.29 APE9-dihe-na 138.12, -155.84 APE8-dihe-in -121.98, 122.0 APE8-rot-in 307.09 APE67-dihe-in -73.04, -19.21 -34.75, -51.15 APE12-dist-in 8.727 APE11-dist-in 11.467 APE10-dist-in 5.694 APE9-dist-in 3.357 None SEP474 SEP474 XRAY 2.0 0.203 0.24 A 346 292 0 0 0 0 [[321, 572]] 1.0 4fii Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4FIJA O96013 299 590 591.0 No_ligand No_ligand Active DFGin 9.292 14.118 BLAminus -121.84, -176.7 65.31, 67.51 -99.57, 14.75 281.79, 80.65 -61.33, -22.97 in-in in 7.674 Saltbr-in 3.269 HRD-in -67.47, -53.79 82.69, -7.78 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.15, 145.87 APE9-dihe-na 132.39, -161.12 APE8-dihe-in -117.16, 124.28 APE8-rot-in 306.73 APE67-dihe-in -60.5, -24.88 -30.89, -62.08 APE12-dist-in 8.634 APE11-dist-in 11.233 APE10-dist-in 5.492 APE9-dist-in 3.441 None SEP474 SEP474 XRAY 2.3 0.21 0.271 A 346 292 0 0 0 0 [[321, 572]] 1.0 4fij Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4JDHA O96013 300 589 591.0 No_ligand No_ligand Active DFGin 9.213 14.456 BLAminus -133.94, -173.46 58.56, 59.99 -88.47, 17.74 285.35, 78.93 -64.25, -20.67 in-in in 7.641 Saltbr-in 3.319 HRD-in -69.0, -48.43 71.31, 1.52 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.94, 132.78 APE9-dihe-na 145.26, -171.34 APE8-dihe-in -107.31, 123.45 APE8-rot-in 307.6 APE67-dihe-in -61.34, -23.1 -36.34, -56.17 APE12-dist-in 8.85 APE11-dist-in 11.633 APE10-dist-in 5.92 APE9-dist-in 3.451 None SEP474 SEP474 XRAY 2.0 0.185 0.224 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdh Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 6WLXA O96013 299 590 591.0 No_ligand No_ligand Active DFGin 9.201 14.18 BLAminus -131.59, -176.89 52.24, 74.82 -93.47, 12.81 286.48, 76.04 -60.21, -15.65 in-in in 7.465 Saltbr-in 3.141 HRD-in -75.87, -52.52 76.84, 4.64 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.58, 142.68 APE9-dihe-na 133.42, -162.48 APE8-dihe-in -119.0, 127.34 APE8-rot-in 308.13 APE67-dihe-in -62.55, -20.45 -37.98, -61.18 APE12-dist-in 8.684 APE11-dist-in 11.422 APE10-dist-in 5.762 APE9-dist-in 3.399 None SEP474 SEP474 XRAY 2.2 0.198 0.229 A 346 292 0 0 0 0 [[321, 572]] 1.0 6wlx Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 6WLYA O96013 299 590 591.0 No_ligand No_ligand Active DFGin 9.224 14.295 BLAminus -137.23, -173.74 57.81, 67.07 -89.26, 13.37 287.97, 80.51 -62.01, -15.87 in-in in 7.533 Saltbr-in 3.048 HRD-in -73.43, -48.63 72.76, 3.97 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.41, 131.81 APE9-dihe-na 146.78, -170.14 APE8-dihe-in -112.43, 122.77 APE8-rot-in 308.27 APE67-dihe-in -64.63, -20.86 -40.07, -54.5 APE12-dist-in 9.032 APE11-dist-in 11.625 APE10-dist-in 5.893 APE9-dist-in 3.458 None SEP474 SEP474 XRAY 1.9 0.187 0.205 A 346 292 0 0 0 0 [[321, 572]] 1.0 6wly Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 7S48A O96013 300 589 591.0 No_ligand No_ligand Active DFGin 9.263 14.359 BLAminus -132.18, -176.07 57.15, 66.61 -90.62, 13.14 283.96, 77.99 -58.72, -23.33 in-in in 7.568 Saltbr-in 3.013 HRD-in -68.6, -50.0 72.97, 5.97 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.95, 147.83 APE9-dihe-na 129.62, -155.85 APE8-dihe-in -124.91, 120.05 APE8-rot-in 304.0 APE67-dihe-in -65.8, -21.35 -34.95, -54.24 APE12-dist-in 8.739 APE11-dist-in 11.41 APE10-dist-in 5.72 APE9-dist-in 3.359 None SEP474 SEP474 XRAY 1.9 0.182 0.222 A 346 290 0 0 0 0 [[321, 572]] 1.0 7s48 Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5UPLA O96013 299 589 591.0 No_ligand No_ligand Active DFGin 6.912 14.21 BLAminus -163.39, -166.4 59.78, 65.71 -85.27, 8.4 284.5, 105.17 -65.55, -24.21 in-in in 7.153 Saltbr-in 3.45 HRD-in -74.32, -54.24 91.8, -11.6 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.47, 142.27 APE9-dihe-na 127.52, -177.54 APE8-dihe-in -94.03, 129.74 APE8-rot-in 310.33 APE67-dihe-in -74.72, -26.02 -36.97, -49.73 APE12-dist-in 9.097 APE11-dist-in 11.606 APE10-dist-in 5.991 APE9-dist-in 3.47 None SEP474 SEP474 XRAY 3.003 0.259 0.31 A 453 291 0 0 0 0 [[321, 572]] 1.0 5upl Homo sapiens STE_PAK4_HUMAN STE 6.8e-88 300.4 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5XVFA O96013 300 588 591.0 8FR:60601 Type1 Active DFGin 6.41 13.597 BLAminus -139.57, -167.28 48.68, 69.67 -90.45, 14.2 300.76, 102.19 -49.74, -29.58 in-in in 6.835 Saltbr-in 2.694 HRD-in -68.54, -55.23 77.68, 6.31 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.25, 148.38 APE9-dihe-na 130.46, 176.96 APE8-dihe-in -94.44, 129.78 APE8-rot-in 311.81 APE67-dihe-in -56.47, -21.8 -39.65, -64.54 APE12-dist-in 9.78 APE11-dist-in 11.712 APE10-dist-in 6.021 APE9-dist-in 3.115 None SEP474 SEP474 XRAY 2.655 0.197 0.251 A 290 289 0 0 0 0 [[321, 572]] 1.0 5xvf Homo sapiens STE_PAK4_HUMAN STE 1.7e-88 302.3 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5XVAA O96013 300 591 591.0 8FU:60601 Type1 Active DFGin 7.292 14.678 BLAminus -136.68, -167.04 56.18, 61.77 -88.8, 17.56 283.16, 73.25 -67.91, -15.71 in-in in 9.132 Saltbr-in 3.092 HRD-in -72.82, -52.08 71.15, 6.91 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.16, 135.82 APE9-dihe-na 145.24, -159.73 APE8-dihe-in -113.25, 122.53 APE8-rot-in 304.59 APE67-dihe-in -66.13, -21.23 -41.05, -53.04 APE12-dist-in 9.038 APE11-dist-in 11.494 APE10-dist-in 5.663 APE9-dist-in 3.454 None SEP474 SEP474 XRAY 1.847 0.17 0.209 A 293 292 0 0 0 0 [[321, 572]] 1.0 5xva Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5XVGA O96013 300 591 591.0 8FX:60601 Type1 Active DFGin 7.024 14.57 BLAminus -144.25, -166.15 65.18, 60.23 -89.33, 20.04 283.56, 74.99 -67.07, -12.05 in-in in 8.826 Saltbr-in 2.764 HRD-in -73.13, -52.27 72.69, 11.49 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.8, 143.35 APE9-dihe-na 134.84, -159.43 APE8-dihe-in -114.76, 122.91 APE8-rot-in 304.21 APE67-dihe-in -67.25, -18.32 -47.47, -47.2 APE12-dist-in 8.974 APE11-dist-in 11.481 APE10-dist-in 5.603 APE9-dist-in 3.372 None SEP474 SEP474 XRAY 2.1 0.184 0.235 A 293 292 0 0 0 0 [[321, 572]] 1.0 5xvg Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5ZJWA O96013 300 591 591.0 9EO:60601 Type1 Active DFGin 7.467 14.64 BLAminus -132.98, -163.71 63.14, 51.92 -88.51, 14.85 280.26, 75.04 -63.71, -21.2 in-in in 8.86 Saltbr-in 2.964 HRD-in -75.73, -49.33 70.25, 5.64 in-in-in SNCiii in-in ActLoopNT-in 2.833 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.08, 137.6 APE9-dihe-na 143.8, -159.07 APE8-dihe-in -117.35, 122.21 APE8-rot-in 300.48 APE67-dihe-in -67.39, -19.86 -42.33, -52.03 APE12-dist-in 8.996 APE11-dist-in 11.569 APE10-dist-in 5.792 APE9-dist-in 3.463 None SEP474 SEP474 XRAY 1.798 0.171 0.215 A 293 292 0 0 0 0 [[321, 572]] 1.0 5zjw Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 9D52A O96013 300 589 591.0 A1A2R:601 Type1 Active DFGin 5.845 13.851 BLAminus -137.59, -174.27 58.3, 72.52 -97.57, 11.47 297.67, 101.1 -60.39, -21.88 in-in in 7.298 Saltbr-in 3.091 HRD-in -68.35, -60.99 83.79, -1.35 in-in-in SNCiii in-in ActLoopNT-in 2.766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.19, 138.88 APE9-dihe-na 146.77, -167.01 APE8-dihe-in -103.22, 122.41 APE8-rot-in 308.06 APE67-dihe-in -66.75, -19.09 -36.2, -56.16 APE12-dist-in 9.053 APE11-dist-in 11.768 APE10-dist-in 5.918 APE9-dist-in 3.302 None SEP474 SEP474 XRAY 2.449 0.205 0.287 A 293 290 0 0 0 0 [[321, 572]] 1.0 9d52 Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 9D53A O96013 300 591 591.0 A1A2P:601 Type1 Active DFGin 7.419 14.388 BLAminus -130.46, -168.1 66.3, 64.12 -97.32, 16.28 284.99, 83.03 -56.88, -20.45 in-in in 8.429 Saltbr-in 3.039 HRD-in -68.67, -55.34 70.78, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.701 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.76, 128.71 APE9-dihe-na 154.97, -168.87 APE8-dihe-in -101.14, 120.06 APE8-rot-in 318.43 APE67-dihe-in -66.45, -26.26 -33.54, -52.96 APE12-dist-in 9.874 APE11-dist-in 11.678 APE10-dist-in 5.88 APE9-dist-in 3.4 None SEP474 SEP474 XRAY 2.468 0.19 0.263 A 293 292 0 0 0 0 [[321, 572]] 1.0 9d53 Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5BMSA O96013 300 589 591.0 4T6:60601 Type1 Active DFGin 5.882 13.769 BLAminus -127.85, -156.82 35.49, 78.34 -98.96, 8.42 299.27, 100.83 -63.09, -11.52 in-in in 7.312 Saltbr-in 3.075 HRD-in -77.22, -46.32 67.96, 4.24 in-in-in SNCiii in-in ActLoopNT-in 2.832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.5, 139.88 APE9-dihe-na 129.41, -167.55 APE8-dihe-in -107.17, 120.88 APE8-rot-in 315.49 APE67-dihe-in -62.73, -29.26 -33.47, -61.67 APE12-dist-in 9.996 APE11-dist-in 11.617 APE10-dist-in 5.891 APE9-dist-in 3.222 None SEP474 SEP474 XRAY 2.903 0.176 0.23 A 293 290 0 0 0 0 [[321, 572]] 1.0 5bms Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 2X4ZA O96013 299 590 591.0 7KC:1593 Type1 Active DFGin 7.175 15.683 BLAminus -132.06, -173.98 55.27, 65.86 -89.03, 22.48 286.31, 71.15 -56.55, -18.72 out-in out 10.093 Saltbr-in 3.353 HRD-in -64.34, -55.81 75.26, 4.96 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.15, 164.59 APE9-dihe-na 116.46, -153.03 APE8-dihe-in -123.41, 117.02 APE8-rot-in 305.72 APE67-dihe-in -61.08, -22.54 -22.19, -62.41 APE12-dist-in 8.425 APE11-dist-in 11.116 APE10-dist-in 5.211 APE9-dist-in 3.362 P296G,Q297S,R298H,V299M SEP474 SEP474 XRAY 2.1 0.2 0.262 A 296 292 0 0 0 0 [[321, 572]] 1.0 2x4z Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4APPA O96013 300 591 591.0 N53:60601 Type1 Active DFGin 7.373 15.543 BLAminus -133.61, -169.75 57.81, 63.69 -88.94, 22.51 284.15, 66.92 -58.72, -20.97 out-in out 10.218 Saltbr-in 2.879 HRD-in -73.06, -52.18 73.4, 4.77 in-in-in SNCiii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.88, 162.5 APE9-dihe-na 116.5, -157.47 APE8-dihe-in -119.99, 123.77 APE8-rot-in 310.26 APE67-dihe-in -55.32, -22.24 -23.87, -72.11 APE12-dist-in 8.564 APE11-dist-in 11.028 APE10-dist-in 5.227 APE9-dist-in 3.3 None SEP474 SEP474 XRAY 2.2 0.188 0.229 A 296 292 0 0 0 0 [[321, 572]] 1.0 4app Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4NJDA O96013 300 589 591.0 NJD:60600 Type1 Active DFGin 7.55 14.534 BLAminus -137.61, -170.79 59.81, 63.86 -89.24, 10.26 288.33, 68.78 -51.39, -35.62 in-in in 8.832 Saltbr-in 2.774 HRD-in -64.48, -51.46 71.88, -2.14 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.47, 156.67 APE9-dihe-na 134.13, -165.38 APE8-dihe-in -113.07, 115.38 APE8-rot-in 315.39 APE67-dihe-in -65.56, -7.99 -27.21, -63.29 APE12-dist-in 9.033 APE11-dist-in 11.457 APE10-dist-in 5.589 APE9-dist-in 3.292 None SEP474 SEP474 XRAY 2.5 0.239 0.321 A 296 290 0 0 0 0 [[321, 572]] 1.0 4njd Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5I0BA O96013 301 589 591.0 67U:601 Type1 Active DFGin 7.442 14.009 BLAminus -124.94, -168.52 59.76, 54.09 -85.49, 7.58 290.32, 78.2 -49.18, -28.77 in-in in 8.386 Saltbr-in 2.784 HRD-in -62.72, -43.63 65.0, -1.19 in-in-in SNCiii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.17, -174.46 APE9-dihe-na 97.06, -178.26 APE8-dihe-in -118.11, 136.57 APE8-rot-in 266.84 APE67-dihe-in -62.52, -33.2 -59.08, -48.11 APE12-dist-in 9.53 APE11-dist-in 11.272 APE10-dist-in 5.32 APE9-dist-in 2.849 None SEP474 SEP474 XRAY 3.09 0.199 0.269 A 296 289 0 0 0 0 [[321, 572]] 1.0 5i0b Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 8AHGA O96013 300 591 591.0 M4I:60601 Type1 Active DFGin 9.274 14.621 BLAminus -140.7, -178.52 59.09, 59.79 -84.52, 9.62 282.61, 76.91 -57.19, -25.15 in-in in 7.783 Saltbr-in 3.0 HRD-in -68.05, -53.29 75.32, 3.61 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.99, 144.76 APE9-dihe-na 133.62, -152.42 APE8-dihe-in -126.55, 119.92 APE8-rot-in 307.01 APE67-dihe-in -70.16, -19.98 -38.25, -51.28 APE12-dist-in 8.713 APE11-dist-in 11.311 APE10-dist-in 5.642 APE9-dist-in 3.378 L310A SEP474 SEP474 XRAY 1.885 0.181 0.227 A 297 292 0 0 0 0 [[321, 572]] 1.0 8ahg Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 8AHHA O96013 300 591 591.0 M4X:60601 Type1 Active DFGin 9.202 14.302 BLAminus -140.1, -178.26 56.12, 62.98 -87.16, 10.59 287.77, 78.02 -51.14, -27.59 in-in in 7.613 Saltbr-in 3.166 HRD-in -71.92, -49.28 69.03, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.71, 139.6 APE9-dihe-na 140.63, -152.77 APE8-dihe-in -124.55, 121.97 APE8-rot-in 311.5 APE67-dihe-in -69.72, -19.91 -39.05, -51.53 APE12-dist-in 8.885 APE11-dist-in 11.313 APE10-dist-in 5.683 APE9-dist-in 3.346 L310A SEP474 SEP474 XRAY 2.037 0.188 0.25 A 297 292 0 0 0 0 [[321, 572]] 1.0 8ahh Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 2CDZA O96013 299 590 591.0 23D:1591 Type1 Active DFGin 6.851 14.239 BLAminus -131.93, -172.68 60.56, 61.36 -89.92, 17.05 286.34, 82.19 -67.68, -14.12 in-in in 8.413 Saltbr-in 2.548 HRD-in -67.95, -51.01 69.05, 1.71 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.41, 141.72 APE9-dihe-na 145.87, -158.12 APE8-dihe-in -124.24, 119.58 APE8-rot-in 305.81 APE67-dihe-in -67.53, -21.67 -30.06, -59.48 APE12-dist-in 9.103 APE11-dist-in 11.374 APE10-dist-in 5.44 APE9-dist-in 3.375 None SEP474 SEP474 XRAY 2.3 0.202 0.248 A 303 290 2 0 0 0 [[321, 572]] 1.0 2cdz Homo sapiens STE_PAK4_HUMAN STE 2e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5VEFA O96013 300 589 591.0 M77:601 Type1 Active DFGin 9.346 14.591 BLAminus -136.52, -176.88 59.47, 65.15 -89.64, 13.99 283.23, 80.94 -61.13, -20.52 in-in in 7.74 Saltbr-in 3.421 HRD-in -69.98, -53.91 75.95, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.13, 146.51 APE9-dihe-na 127.95, -160.54 APE8-dihe-in -118.96, 120.95 APE8-rot-in 302.31 APE67-dihe-in -69.34, -18.53 -36.63, -52.05 APE12-dist-in 8.781 APE11-dist-in 11.284 APE10-dist-in 5.646 APE9-dist-in 3.383 None SEP474 SEP474 XRAY 1.752 0.202 0.239 A 319 290 0 0 0 0 [[321, 572]] 1.0 5vef Homo sapiens STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 7CP3A O96013 300 589 591.0 GC6:601 Type1.5_Back Active DFGin 7.425 14.516 BLAminus -143.23, -161.44 54.49, 56.58 -84.68, 17.45 283.38, 69.37 -57.63, -18.5 in-in in 8.25 Saltbr-in 2.97 HRD-in -75.52, -44.49 67.1, 5.14 in-in-in SNCiii in-in ActLoopNT-in 3.046 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 132.66 APE9-dihe-na 144.26, -150.95 APE8-dihe-in -112.54, 134.18 APE8-rot-in 306.62 APE67-dihe-in -71.08, -11.39 -57.8, -50.41 APE12-dist-in 8.889 APE11-dist-in 11.521 APE10-dist-in 5.733 APE9-dist-in 3.741 None SEP474 SEP474 XRAY 2.9 0.245 0.267 A 292 290 0 0 0 0 [[321, 572]] 1.0 7cp3 Homo sapiens STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 7CP4A O96013 300 591 591.0 GCC:601 Type1.5_Back Active DFGin 7.635 14.952 BLAminus -133.21, 179.04 59.99, 67.29 -90.26, 23.6 285.11, 67.74 -63.22, -23.85 in-in in 9.553 Saltbr-in 3.29 HRD-in -66.61, -55.01 72.71, 4.31 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.28, 137.07 APE9-dihe-na 140.56, -171.81 APE8-dihe-in -103.14, 125.77 APE8-rot-in 309.43 APE67-dihe-in -72.75, -28.29 -48.05, -39.75 APE12-dist-in 8.651 APE11-dist-in 11.228 APE10-dist-in 5.429 APE9-dist-in 3.361 None SEP474 SEP474 XRAY 2.5 0.199 0.252 A 292 292 0 0 0 0 [[321, 572]] 1.0 7cp4 Homo sapiens STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 7CMBA O96013 300 589 591.0 G5X:60601 Type1.5_Back Active DFGin 7.29 14.864 BLAminus -144.05, 179.08 58.57, 70.68 -90.04, 21.82 285.98, 71.77 -65.95, -9.86 in-in in 8.729 Saltbr-in 2.802 HRD-in -64.8, -46.41 64.06, 19.25 in-in-in SNCiii in-in ActLoopNT-in 2.943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.38, 168.28 APE9-dihe-na 114.24, -179.32 APE8-dihe-in -97.31, 129.92 APE8-rot-in 316.69 APE67-dihe-in -69.15, -20.09 -50.08, -47.79 APE12-dist-in 8.971 APE11-dist-in 11.233 APE10-dist-in 5.229 APE9-dist-in 3.486 None SEP474 SEP474 XRAY 2.592 0.208 0.251 A 293 290 0 0 0 0 [[321, 572]] 1.0 7cmb Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4O0VA O96013 300 589 591.0 2OL:60601 Type1.5_Back Active DFGin 7.72 14.855 BLAminus -129.91, -179.13 52.93, 70.48 -91.0, 31.77 289.31, 80.54 -68.79, -11.49 in-in in 9.386 Saltbr-in 2.715 HRD-in -63.47, -48.3 66.54, 12.64 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.31, 136.62 APE9-dihe-na 128.1, -161.84 APE8-dihe-in -105.46, 125.26 APE8-rot-in 314.65 APE67-dihe-in -70.36, -25.33 -37.86, -50.41 APE12-dist-in 9.483 APE11-dist-in 11.399 APE10-dist-in 5.692 APE9-dist-in 3.35 None SEP474 SEP474 XRAY 2.8 0.204 0.253 A 293 290 0 0 0 0 [[321, 572]] 1.0 4o0v Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4O0XA O96013 300 589 591.0 2OQ:60601 Type1.5_Back Active DFGin 7.686 14.42 BLAminus -143.48, 175.23 50.73, 80.07 -96.8, 29.16 288.57, 62.64 -65.03, -22.79 in-in in 7.841 Saltbr-in 2.524 HRD-in -64.27, -54.17 74.62, 7.89 in-in-in SNCiii in-in ActLoopNT-in 3.044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.91, 146.7 APE9-dihe-na 131.01, -164.91 APE8-dihe-in -110.0, 119.08 APE8-rot-in 309.56 APE67-dihe-in -57.87, -20.38 -32.76, -63.35 APE12-dist-in 9.115 APE11-dist-in 11.502 APE10-dist-in 5.674 APE9-dist-in 3.39 None SEP474 SEP474 XRAY 2.483 0.242 0.242 A 293 290 0 0 0 0 [[321, 572]] 1.0 4o0x Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4O0YA O96013 300 589 591.0 2OO:60601 Type1.5_Back Active DFGin 7.439 13.922 BLAminus -135.18, 176.5 49.39, 78.85 -92.46, 20.76 288.83, 77.11 -54.08, -29.88 in-in in 7.462 Saltbr-in 2.628 HRD-in -74.32, -48.56 73.38, 6.1 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.29, 136.66 APE9-dihe-na 144.79, -161.28 APE8-dihe-in -119.15, 122.67 APE8-rot-in 309.1 APE67-dihe-in -63.4, -19.31 -38.26, -57.11 APE12-dist-in 9.651 APE11-dist-in 11.689 APE10-dist-in 5.96 APE9-dist-in 3.34 None SEP474 SEP474 XRAY 2.2 0.2 0.238 A 293 290 0 0 0 0 [[321, 572]] 1.0 4o0y Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4XBRA O96013 177 589 591.0 ATP:60601 ATPlike Inactive DFGin 5.852 14.061 ABAminus -142.04, -22.23 -111.42, 72.59 -86.56, 10.51 310.81, 99.4 -46.84, -40.66 in-in in 7.009 Saltbr-in 3.158 HRD-in -84.11, -33.57 58.48, -1.88 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.96, 132.02 APE9-dihe-na 150.85, -176.82 APE8-dihe-in -102.34, 122.5 APE8-rot-in 312.14 APE67-dihe-in -59.91, -25.15 -35.82, -60.88 APE12-dist-in 9.335 APE11-dist-in 11.927 APE10-dist-in 6.05 APE9-dist-in 3.396 None SEP474 SEP474 XRAY 2.94 0.191 0.23 A 366 293 0 0 0 0 [[321, 572]] 1.0 4xbr Homo sapiens STE_PAK4_HUMAN STE 3.7e-88 301.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4FIGA O96013 298 590 591.0 ANP:1001 ATPlike Inactive DFGin 5.976 13.995 BLAminus -134.45, -166.25 59.06, 57.3 -88.34, 9.13 298.9, 106.14 -61.58, -20.66 in-in in 7.133 Saltbr-in 3.168 HRD-in -77.25, -46.66 72.07, -3.1 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.47, 161.1 APE9-dihe-na 110.61, 163.55 APE8-dihe-in -79.54, 130.34 APE8-rot-out 29.96 APE67-dihe-in -76.38, -28.34 -35.31, -49.63 APE12-dist-in 9.418 APE11-dist-in 11.569 APE10-dist-in 5.635 APE9-dist-in 3.369 None SEP474 SEP474 XRAY 3.01 0.197 0.221 A 346 293 0 0 0 0 [[321, 572]] 1.0 4fig Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4FIEA O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.278 14.03 BLAminus -142.71, -177.86 63.75, 67.7 -92.97, 13.53 295.29, 98.36 -64.15, -7.0 in-out in 6.991 Saltbr-out 3.974 HRD-in -74.78, -36.69 67.65, -13.13 out-in-out SNCoio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.98, 139.97 APE9-dihe-na 123.6, -177.34 APE8-dihe-in -84.44, 139.76 APE8-rot-out 19.51 APE67-dihe-in -74.38, -37.99 -51.24, -48.18 APE12-dist-in 9.515 APE11-dist-in 11.685 APE10-dist-in 5.909 APE9-dist-in 3.508 None SEP474 SEP474 XRAY 3.11 0.257 0.276 A 423 301 0 0 0 0 [[321, 572]] 1.0 4fie Homo sapiens STE_PAK4_HUMAN STE 5.6e-88 300.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4FIEB O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.278 14.031 BLAminus -142.24, -177.62 63.59, 67.55 -92.7, 13.49 295.33, 98.22 -64.04, -7.21 in-out in 6.989 Saltbr-out 3.957 HRD-in -74.95, -36.21 66.97, -12.74 out-in-out SNCoio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.0, 139.86 APE9-dihe-na 123.6, -177.41 APE8-dihe-in -84.57, 139.76 APE8-rot-out 19.62 APE67-dihe-in -74.42, -37.89 -51.19, -48.15 APE12-dist-in 9.515 APE11-dist-in 11.689 APE10-dist-in 5.912 APE9-dist-in 3.51 None SEP474 SEP474 XRAY 3.11 0.257 0.276 B 423 301 0 0 0 0 [[321, 572]] 1.0 4fie Homo sapiens STE_PAK4_HUMAN STE 5.6e-88 300.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 2BVAA O96013 300 587 591.0 No_ligand No_ligand Inactive DFGin 7.438 16.475 BLAminus -117.27, -176.72 56.65, 71.44 -91.27, 35.1 289.21, 80.8 -69.61, -2.94 out-out out 10.481 Saltbr-out 4.02 HRD-in -57.52, -60.13 72.86, 5.02 out-out-in SNCooi out-in ActLoopNT-out 3.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.79, 153.17 APE9-dihe-na 127.58, -141.52 APE8-dihe-in -136.11, 111.21 APE8-rot-in 333.57 APE67-dihe-in -60.96, -14.16 -40.33, -50.6 APE12-dist-in 8.848 APE11-dist-in 11.484 APE10-dist-in 5.83 APE9-dist-in 3.471 None SEP474 SEP474 XRAY 2.3 0.192 0.269 A 292 273 15 0 0 2 [[321, 572]] 1.0 2bva Homo sapiens STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 2BVAB O96013 301 587 591.0 No_ligand No_ligand Inactive DFGin 7.572 17.238 BLAminus -131.91, -158.23 65.58, 44.26 -84.57, 26.99 293.34, 56.33 -60.85, -21.66 out-out out 11.675 Saltbr-out 7.148 HRD-in -60.3, -59.82 75.14, 24.4 out-in-in SNCoii in-in ActLoopNT-in 2.499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.93, 163.72 APE9-dihe-na 104.79, -155.19 APE8-dihe-in -112.34, 124.37 APE8-rot-in 319.0 APE67-dihe-in -73.92, -14.55 -41.39, -45.76 APE12-dist-in 8.588 APE11-dist-in 11.399 APE10-dist-in 5.909 APE9-dist-in 3.197 None SEP474 SEP474 XRAY 2.3 0.192 0.269 B 292 275 12 0 0 2 [[321, 572]] 1.0 2bva Homo sapiens STE_PAK4_HUMAN STE 1.7e-88 302.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 8YHKA O96013 298 591 591.0 No_ligand No_ligand Inactive DFGin 6.394 13.95 BLAminus -144.78, -174.84 60.87, 52.46 -74.27, -7.16 291.41, 99.22 -44.42, -31.64 in-out in 7.212 Saltbr-out 5.663 HRD-out -76.82, 93.99 -85.26, 6.82 out-in-in SNCoii in-in ActLoopNT-in 2.734 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.02, 139.67 APE9-dihe-na 131.69, -172.38 APE8-dihe-in -96.54, 118.36 APE8-rot-in 308.12 APE67-dihe-in -79.25, -37.48 -34.17, -42.18 APE12-dist-in 9.944 APE11-dist-in 11.39 APE10-dist-in 5.545 APE9-dist-in 3.243 None None None XRAY 3.3 0.253 0.319 A 301 294 0 0 0 0 [[321, 572]] 1.0 8yhk Homo sapiens STE_PAK4_HUMAN STE 1.9e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4XBUA O96013 297 589 591.0 No_ligand No_ligand Inactive DFGin 7.426 14.345 BLAminus -134.76, -171.38 58.13, 68.14 -90.95, 10.75 282.43, 88.09 -57.4, -26.1 in-out in 8.875 Saltbr-out 4.505 HRD-in -80.19, -49.71 68.99, 2.54 out-in-in SNCoii in-in ActLoopNT-in 2.842 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.64, 133.45 APE9-dihe-na 156.19, -154.61 APE8-dihe-in -123.57, 122.27 APE8-rot-in 305.74 APE67-dihe-in -70.59, -15.2 -40.43, -52.25 APE12-dist-in 8.806 APE11-dist-in 11.559 APE10-dist-in 5.875 APE9-dist-in 3.518 None SEP474 SEP474 XRAY 2.06 0.201 0.243 A 326 293 0 0 0 0 [[321, 572]] 1.0 4xbu Homo sapiens STE_PAK4_HUMAN STE 2.5e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 8AHIA O96013 300 591 591.0 M56:601 Type1 Inactive DFGin 9.181 14.38 BLAminus -137.45, -173.93 55.91, 63.31 -90.54, 16.67 287.37, 76.55 -61.73, -19.34 in-out in 7.694 Saltbr-out 3.645 HRD-in -78.82, -49.15 74.56, 0.81 out-in-in SNCoii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.24, 128.69 APE9-dihe-na 143.74, -151.59 APE8-dihe-in -115.17, 123.77 APE8-rot-in 313.27 APE67-dihe-in -68.11, -27.23 -45.23, -43.93 APE12-dist-in 8.803 APE11-dist-in 11.358 APE10-dist-in 5.796 APE9-dist-in 3.534 L310A SEP474 SEP474 XRAY 2.69 0.16 0.249 A 297 292 0 0 0 0 [[321, 572]] 1.0 8ahi Homo sapiens STE_PAK4_HUMAN STE 1.8e-88 302.1 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5VEDA O96013 300 589 591.0 STU:601 Type1 Inactive DFGin 7.591 14.871 BLAminus -137.67, -169.84 57.61, 74.14 -100.29, 38.24 286.21, 78.54 -72.3, -31.74 in-out in 8.771 Saltbr-out 5.279 HRD-in -70.67, -47.26 60.82, 22.3 out-in-in SNCoii in-in ActLoopNT-in 2.978 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.74, 169.93 APE9-dihe-na 110.0, -167.24 APE8-dihe-in -107.4, 122.99 APE8-rot-in 313.49 APE67-dihe-in -72.02, -18.93 -37.81, -47.81 APE12-dist-in 8.493 APE11-dist-in 11.13 APE10-dist-in 5.271 APE9-dist-in 3.412 None SEP474 SEP474 XRAY 2.301 0.231 0.277 A 319 290 0 0 0 0 [[321, 572]] 1.0 5ved Homo sapiens STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 5VEEA O96013 300 589 591.0 981:601 Type1 Inactive DFGin 6.832 15.436 BLAminus -149.85, -166.61 63.61, 64.4 -91.35, 12.72 287.99, 79.38 -42.54, -35.66 in-out in 8.369 Saltbr-out 6.665 HRD-in -63.93, -45.62 68.7, 8.17 out-in-in SNCoii in-in ActLoopNT-in 3.12 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.59, 147.54 APE9-dihe-na 146.37, -170.93 APE8-dihe-in -104.03, 125.68 APE8-rot-in 311.71 APE67-dihe-in -46.67, -33.8 -40.96, -66.37 APE12-dist-in 9.09 APE11-dist-in 11.607 APE10-dist-in 5.815 APE9-dist-in 3.64 None SEP474 SEP474 XRAY 2.5 0.231 0.276 A 319 290 0 0 0 0 [[321, 572]] 1.0 5vee Homo sapiens STE_PAK4_HUMAN STE 2.4e-88 301.8 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
PAK4_HUMAN 4FIGB O96013 298 590 591.0 ANP:602 ATPlike Inactive DFGin 5.979 13.845 None -136.1, -40.27 -82.41, 70.29 -85.54, 12.48 305.29, 106.7 -66.77, -24.27 in-in in 7.007 Saltbr-in 3.047 HRD-in -63.37, -48.9 73.21, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.8, 141.64 APE9-dihe-na 130.69, -165.45 APE8-dihe-in -110.43, 122.9 APE8-rot-in 324.7 APE67-dihe-in -77.33, -31.89 -29.23, -51.11 APE12-dist-in 9.706 APE11-dist-in 11.743 APE10-dist-in 5.92 APE9-dist-in 3.386 None SEP474 SEP474 XRAY 3.01 0.197 0.221 B 346 293 0 0 0 0 [[321, 572]] 1.0 4fig Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4

STE_PAK4 (Serine/threonine-protein kinase PAK 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name