NEK_NEK1 (Serine/threonine-protein kinase Nek1)

Total number of chains: 6
Active chains: 2
Uniprot: NEK1_HUMAN
Kinase Domain Residues: 4 - 258
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter BABtrans 4 66.7% 4B9DB
DFGin BLAminus 2 33.3% AF-Q96PY6-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NEK1 AF-Q96PY6-K1A Q96PY6 1 266 1258.0 No_ligand No_ligand Active DFGin 6.3354 14.4945 BLAminus -134.89, -170.37 56.21, 76.6 -88.15, 17.38 287.19, 77.32 -63.06, -23.12 in-in in 8.8489 Saltbr-in 2.7035 HRD-in -74.84, -44.42 65.12, 4.26 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 150.58 APE9-dihe-na 123.75, 169.73 APE8-dihe-in -71.78, 127.34 APE8-rot-in 301.7 APE67-dihe-in -71.82, -21.68 -49.23, -41.12 APE12-dist-in 9.2555 APE11-dist-in 12.4856 APE10-dist-in 6.6965 APE9-dist-in 3.5642 None None None AF2 -1.0 1.0 1.0 A 266.0 266.0 0 28 28 0 [[4, 258]] 1.0 AF-Q96PY6-K1 NEK_NEK1_HUMAN NEK 1.7e-118 400.7 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 AF-Q96PY6-K3A Q96PY6 1 266 1258.0 No_ligand No_ligand Active DFGin 6.7665 14.4455 BLAminus -139.16, -171.33 53.91, 73.21 -83.79, 17.52 290.29, 79.37 -64.02, -21.09 in-in in 8.5958 Saltbr-in 2.72 HRD-in -73.82, -44.01 66.18, -13.05 in-in-in SNCiii in-in ActLoopNT-in 2.8427 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.99, 148.47 APE9-dihe-na 131.06, 169.83 APE8-dihe-in -74.74, 126.62 APE8-rot-in 298.85 APE67-dihe-in -66.5, -15.67 -48.65, -43.65 APE12-dist-in 9.1409 APE11-dist-in 12.3429 APE10-dist-in 6.576 APE9-dist-in 3.5677 None None None AF2 -1.0 1.0 1.0 A 266.0 266.0 0 28 28 0 [[4, 258]] 1.0 AF-Q96PY6-K3 NEK_NEK1_HUMAN NEK 1.7e-118 400.7 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 4APCA Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.6436 5.9989 BABtrans -56.67, 136.95 -74.99, -38.65 -62.93, 130.11 204.86, 72.11 112.63, -15.33 out-none out 11.4846 Saltbr-none 999.0 HRD-out -132.48, 108.44 -75.85, -8.05 none-out-out SNCnoo out-out ActLoopNT-out 5.3591 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.83, -42.36 APE9-dihe-na -95.57, -114.29 APE8-dihe-in -105.03, 125.23 APE8-rot-in 310.11 APE67-dihe-in -73.53, -9.9 -94.81, -5.15 APE12-dist-out 15.9707 APE11-dist-out 20.7331 APE10-dist-out 18.8674 APE9-dist-out 10.4316 T162A None None XRAY 2.1 0.216 0.248 A 350.0 278.0 6 28 28 0 [[4, 258]] 1.0 4apc NEK_NEK1_HUMAN NEK 2e-117 397.3 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 4APCB Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.5524 6.1025 BABtrans -57.58, 134.02 -75.98, -33.46 -60.99, 130.52 202.95, 70.38 110.42, -15.38 out-out out 11.7317 Saltbr-out 12.8771 HRD-out -131.41, 107.06 -74.49, -7.52 out-out-out SNCooo out-out ActLoopNT-out 5.3523 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.97, -42.82 APE9-dihe-na -96.64, -115.4 APE8-dihe-in -106.78, 122.56 APE8-rot-in 310.29 APE67-dihe-in -74.36, -7.84 -93.49, -5.36 APE12-dist-out 15.8766 APE11-dist-out 20.6288 APE10-dist-out 18.8135 APE9-dist-out 10.4107 T162A None None XRAY 2.1 0.216 0.248 B 350.0 279.0 5 28 28 0 [[4, 258]] 1.0 4apc NEK_NEK1_HUMAN NEK 2e-117 397.3 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 4B9DA Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.3047 6.0798 BABtrans -64.94, 139.98 -87.18, -44.3 -54.24, 126.06 193.16, 81.64 121.24, -18.42 out-none out 11.5396 Saltbr-none 999.0 HRD-out -117.2, 113.34 -81.68, 1.37 none-out-out SNCnoo out-out ActLoopNT-out 5.1643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -97.21, -40.86 APE9-dihe-na -102.37, -129.43 APE8-dihe-in -86.61, 121.95 APE8-rot-in 319.16 APE67-dihe-in -71.65, -10.17 -95.47, -0.6 APE12-dist-out 16.1509 APE11-dist-out 20.7765 APE10-dist-out 18.7739 APE9-dist-out 10.6781 T162A None None XRAY 1.9 0.196 0.222 A 350.0 278.0 6 28 28 0 [[4, 258]] 1.0 4b9d NEK_NEK1_HUMAN NEK 2e-117 397.3 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 4B9DB Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.476 6.1482 BABtrans -65.92, 139.98 -87.45, -46.22 -48.38, 128.7 190.39, 78.79 118.23, -19.27 out-out out 11.6653 Saltbr-out 11.6088 HRD-out -108.39, 113.36 -82.3, 1.28 out-out-out SNCooo out-out ActLoopNT-out 5.0611 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.88, -40.18 APE9-dihe-na -104.73, -128.22 APE8-dihe-in -88.79, 124.64 APE8-rot-in 318.31 APE67-dihe-in -72.39, -9.41 -95.66, -1.52 APE12-dist-out 16.1358 APE11-dist-out 20.6896 APE10-dist-out 18.6729 APE9-dist-out 10.7019 T162A None None XRAY 1.9 0.196 0.222 B 350.0 279.0 5 28 28 0 [[4, 258]] 1.0 4b9d NEK_NEK1_HUMAN NEK 2e-117 397.3 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1

NEK_NEK1 (Serine/threonine-protein kinase Nek1)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter BABtrans 4 66.7% 4B9DB
DFGin BLAminus 2 33.3% AF-Q96PY6-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NEK1 NEK1_HUMAN AF-Q96PY6-K1A Q96PY6 1 266 1258.0 No_ligand No_ligand Active DFGin 6.3354 14.4945 BLAminus -134.89, -170.37 56.21, 76.6 -88.15, 17.38 287.19, 77.32 -63.06, -23.12 in-in in 8.8489 Saltbr-in 2.7035 HRD-in -74.84, -44.42 65.12, 4.26 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 150.58 APE9-dihe-na 123.75, 169.73 APE8-dihe-in -71.78, 127.34 APE8-rot-in 301.7 APE67-dihe-in -71.82, -21.68 -49.23, -41.12 APE12-dist-in 9.2555 APE11-dist-in 12.4856 APE10-dist-in 6.6965 APE9-dist-in 3.5642 None None None AF2 -1.0 1.0 1.0 A 266.0 266.0 0 28 28 0 [[4, 258]] 1.0 AF-Q96PY6-K1 Homo sapiens NEK_NEK1_HUMAN NEK 1.7e-118 400.7 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 NEK1_HUMAN AF-Q96PY6-K3A Q96PY6 1 266 1258.0 No_ligand No_ligand Active DFGin 6.7665 14.4455 BLAminus -139.16, -171.33 53.91, 73.21 -83.79, 17.52 290.29, 79.37 -64.02, -21.09 in-in in 8.5958 Saltbr-in 2.72 HRD-in -73.82, -44.01 66.18, -13.05 in-in-in SNCiii in-in ActLoopNT-in 2.8427 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.99, 148.47 APE9-dihe-na 131.06, 169.83 APE8-dihe-in -74.74, 126.62 APE8-rot-in 298.85 APE67-dihe-in -66.5, -15.67 -48.65, -43.65 APE12-dist-in 9.1409 APE11-dist-in 12.3429 APE10-dist-in 6.576 APE9-dist-in 3.5677 None None None AF2 -1.0 1.0 1.0 A 266.0 266.0 0 28 28 0 [[4, 258]] 1.0 AF-Q96PY6-K3 Homo sapiens NEK_NEK1_HUMAN NEK 1.7e-118 400.7 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 NEK1_HUMAN 4APCA Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.6436 5.9989 BABtrans -56.67, 136.95 -74.99, -38.65 -62.93, 130.11 204.86, 72.11 112.63, -15.33 out-none out 11.4846 Saltbr-none 999.0 HRD-out -132.48, 108.44 -75.85, -8.05 none-out-out SNCnoo out-out ActLoopNT-out 5.3591 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.83, -42.36 APE9-dihe-na -95.57, -114.29 APE8-dihe-in -105.03, 125.23 APE8-rot-in 310.11 APE67-dihe-in -73.53, -9.9 -94.81, -5.15 APE12-dist-out 15.9707 APE11-dist-out 20.7331 APE10-dist-out 18.8674 APE9-dist-out 10.4316 T162A None None XRAY 2.1 0.216 0.248 A 350.0 278.0 6 28 28 0 [[4, 258]] 1.0 4apc Homo sapiens NEK_NEK1_HUMAN NEK 2e-117 397.3 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 NEK1_HUMAN 4APCB Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.5524 6.1025 BABtrans -57.58, 134.02 -75.98, -33.46 -60.99, 130.52 202.95, 70.38 110.42, -15.38 out-out out 11.7317 Saltbr-out 12.8771 HRD-out -131.41, 107.06 -74.49, -7.52 out-out-out SNCooo out-out ActLoopNT-out 5.3523 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.97, -42.82 APE9-dihe-na -96.64, -115.4 APE8-dihe-in -106.78, 122.56 APE8-rot-in 310.29 APE67-dihe-in -74.36, -7.84 -93.49, -5.36 APE12-dist-out 15.8766 APE11-dist-out 20.6288 APE10-dist-out 18.8135 APE9-dist-out 10.4107 T162A None None XRAY 2.1 0.216 0.248 B 350.0 279.0 5 28 28 0 [[4, 258]] 1.0 4apc Homo sapiens NEK_NEK1_HUMAN NEK 2e-117 397.3 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 NEK1_HUMAN 4B9DA Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.3047 6.0798 BABtrans -64.94, 139.98 -87.18, -44.3 -54.24, 126.06 193.16, 81.64 121.24, -18.42 out-none out 11.5396 Saltbr-none 999.0 HRD-out -117.2, 113.34 -81.68, 1.37 none-out-out SNCnoo out-out ActLoopNT-out 5.1643 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -97.21, -40.86 APE9-dihe-na -102.37, -129.43 APE8-dihe-in -86.61, 121.95 APE8-rot-in 319.16 APE67-dihe-in -71.65, -10.17 -95.47, -0.6 APE12-dist-out 16.1509 APE11-dist-out 20.7765 APE10-dist-out 18.7739 APE9-dist-out 10.6781 T162A None None XRAY 1.9 0.196 0.222 A 350.0 278.0 6 28 28 0 [[4, 258]] 1.0 4b9d Homo sapiens NEK_NEK1_HUMAN NEK 2e-117 397.3 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK1 NEK1_HUMAN 4B9DB Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.476 6.1482 BABtrans -65.92, 139.98 -87.45, -46.22 -48.38, 128.7 190.39, 78.79 118.23, -19.27 out-out out 11.6653 Saltbr-out 11.6088 HRD-out -108.39, 113.36 -82.3, 1.28 out-out-out SNCooo out-out ActLoopNT-out 5.0611 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.88, -40.18 APE9-dihe-na -104.73, -128.22 APE8-dihe-in -88.79, 124.64 APE8-rot-in 318.31 APE67-dihe-in -72.39, -9.41 -95.66, -1.52 APE12-dist-out 16.1358 APE11-dist-out 20.6896 APE10-dist-out 18.6729 APE9-dist-out 10.7019 T162A None None XRAY 1.9 0.196 0.222 B 350.0 279.0 5 28 28 0 [[4, 258]] 1.0 4b9d Homo sapiens NEK_NEK1_HUMAN NEK 2e-117 397.3 1.0 256.0 256.0 145 146 147 149 151 33 51 55 125 127 126 128.0 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1

NEK_NEK1 (Serine/threonine-protein kinase Nek1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name