CAMK_MARK3 (MAP/microtubule affinity-regulating kinase 3)

Total number of chains: 25
Active chains: 2
Family: CAMK
Uniprot: MARK3_HUMAN
Kinase Domain Residues: 56 - 307
Spatial label Dihedral label Number of Chains Percent Representative
None None 9 36.0% 3FE3A
DFGin BLBtrans 8 32.0% 8UOJA
DFGin BLAminus 5 20.0% AF-P27448-K1A
DFGinter None 2 8.0% 9YR9B
DFGin BLBminus 1 4.0% 7P1LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P27448-K1A 48 315 753.0 No_ligand No_ligand Active DFGin 6.694 14.512 BLAminus DFGAsp-rot-in -123.88, 177.15 57.0, 72.45 200.85, 30.97 -81.46, 16.88 287.16, 80.97 -62.01, -29.4 in-in in 9.364 Saltbr-in 2.679 HRD-in -80.04, -47.96 63.78, 10.71 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 161.82 APE9-dihe-na 91.81, 172.25 APE8-dihe-in -69.14, 129.83 APE8-rot-in 285.11 APE67-dihe-in -65.12, -21.71 -52.38, -39.59 APE12-dist-in 8.617 APE11-dist-in 10.927 APE10-dist-in 5.122 APE9-dist-in 3.471 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[56, 307]] 1.0 AF-P27448-K1 CAMK_MARK3_HUMAN CAMK 2.3e-96 328.0 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
AF-P27448-K3A 48 315 753.0 No_ligand No_ligand Active DFGin 6.352 14.451 BLAminus DFGAsp-rot-in -124.45, 174.68 54.69, 73.48 201.69, 17.66 -76.92, 15.34 286.64, 84.94 -60.36, -27.19 in-in in 9.376 Saltbr-in 2.708 HRD-in -82.76, -46.83 65.47, 2.4 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.79, 176.51 APE9-dihe-na 104.72, 167.44 APE8-dihe-in -77.75, 123.61 APE8-rot-in 298.54 APE67-dihe-in -65.05, -21.7 -51.25, -39.58 APE12-dist-in 8.275 APE11-dist-in 11.243 APE10-dist-in 5.714 APE9-dist-in 3.266 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[56, 307]] 1.0 AF-P27448-K3 CAMK_MARK3_HUMAN CAMK 2.3e-96 328.0 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
8UOIA 51 368 753.0 X3Q:401 Type1 Inactive DFGin 7.165 15.033 BLAminus DFGAsp-rot-in -130.95, 170.74 60.36, 85.55 202.08, -22.57 -95.67, 24.7 289.31, 72.53 -63.79, -23.52 in-out in 9.531 Saltbr-out 4.173 HRD-in -74.46, -45.16 72.45, -5.81 out-in-out SNCoio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -143.96, 119.86 APE9-dihe-na -75.09, -153.48 APE8-dihe-in -55.48, 118.18 APE8-rot-out 181.77 APE67-dihe-in -60.92, -18.44 -53.9, -40.75 APE12-dist-in 12.166 APE11-dist-out 6.363 APE10-dist-out 10.669 APE9-dist-in 4.316 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None None XRAY 1.8 0.166 0.198 A 328 313 5 0 0 5 [[56, 307]] 1.0 8uoi CAMK_MARK3_HUMAN CAMK 1.6e-96 328.6 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
8UOKA 51 369 753.0 X5N:401 Type1 Inactive DFGin 7.201 14.589 BLAminus DFGAsp-rot-in -128.0, 174.4 56.61, 82.91 195.08, -0.07 -94.21, 21.07 288.64, 73.92 -62.72, -25.03 in-in in 9.084 Saltbr-in 3.263 HRD-in -74.87, -48.84 75.44, -4.0 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -114.94, 111.38 APE9-dihe-na -71.46, -165.83 APE8-dihe-in -59.52, 119.0 APE8-rot-out 186.09 APE67-dihe-in -59.81, -22.83 -52.2, -42.6 APE12-dist-in 11.786 APE11-dist-out 6.654 APE10-dist-out 10.502 APE9-dist-in 4.075 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None None XRAY 1.85 0.16 0.192 A 328 319 0 0 0 0 [[56, 307]] 1.0 8uok CAMK_MARK3_HUMAN CAMK 1.6e-96 328.6 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
8UOKB 51 369 753.0 X5N:401 Type1 Inactive DFGin 7.333 14.708 BLAminus DFGAsp-rot-in -129.56, 174.78 57.0, 81.41 193.48, -0.95 -92.91, 22.49 290.44, 74.44 -63.54, -22.2 in-in in 9.269 Saltbr-in 3.437 HRD-in -77.83, -48.31 76.0, -3.21 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -120.7, 120.48 APE9-dihe-na -72.58, -134.96 APE8-dihe-in -74.88, 122.89 APE8-rot-out 173.55 APE67-dihe-in -58.62, -25.28 -54.54, -40.65 APE12-dist-in 12.082 APE11-dist-out 7.015 APE10-dist-out 10.908 APE9-dist-in 4.068 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None None XRAY 1.85 0.16 0.192 B 328 319 0 0 0 0 [[56, 307]] 1.0 8uok CAMK_MARK3_HUMAN CAMK 1.6e-96 328.6 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
7P1LA 50 365 753.0 V5E:401 Type1 Inactive DFGin 10.927 18.403 BLBminus DFGAsp-rot-out -100.8, 158.72 76.59, 15.2 289.64, -30.9 -55.33, 127.82 250.42, 110.27 85.72, 1.76 out-out out 11.526 Saltbr-out 7.975 HRD-in -70.67, -54.0 80.04, -12.41 out-out-out SNCooo out-out ActLoopNT-out 9.396 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 112.03 APE8-rot-out 198.04 APE67-dihe-in -61.79, -25.58 -53.61, -42.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.211 0.242 A 326 301 15 0 0 9 [[56, 307]] 1.0 7p1l CAMK_MARK3_HUMAN CAMK 4.7e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9YR9A 49 366 753.0 A1CZY:401 Type1 Inactive DFGin 10.64 18.553 BLBtrans DFGAsp-rot-out -113.0228, 161.8508 65.2376, 33.5975 298.5247, -11.9297 -87.41, 128.8067 222.5778, 131.0864 83.3448, 8.519 out-out out 11.019 Saltbr-out 7.653 HRD-in -69.1956, -46.674 71.5716, -7.0487 out-out-out SNCooo out-out ActLoopNT-out 9.49 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na -128.0691, 9.3707 APE9-dihe-na 80.4474, -159.9696 APE8-dihe-in -74.8969, 119.1274 APE8-rot-out 181.8154 APE67-dihe-in -63.3765, -22.0552 -58.423, -38.8233 APE12-dist-out 14.47 APE11-dist-out 17.145 APE10-dist-out 16.744 APE9-dist-in 5.543 None None None XRAY 2.402 0.209 0.253 A 325 311 7 0 0 3 [[56, 307]] 1.0 9yr9 CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9ZZWA 49 366 753.0 A1C86:401 Type1 Inactive DFGin 10.595 18.426 BLBtrans DFGAsp-rot-out -112.6726, 166.506 59.2021, 32.826 297.746, -28.4904 -83.1556, 128.6442 222.6559, 132.196 79.7001, 15.059 out-out out 11.177 Saltbr-out 6.941 HRD-in -70.4253, -49.0932 66.0948, 3.9004 out-out-out SNCooo out-out ActLoopNT-out 9.159 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 114.3595 APE8-rot-out 186.0707 APE67-dihe-in -59.5877, -38.6919 -58.0398, -43.8432 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.76 0.259 0.286 A 325 303 15 0 0 9 [[56, 307]] 1.0 9zzw CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9VFOA 51 368 753.0 A1ER0:401 Type1 Inactive DFGin 10.488 18.388 BLBtrans DFGAsp-rot-out -99.8719, 155.4335 66.861, 23.9367 296.7615, -31.6532 -70.0012, 120.1134 225.6909, 129.2838 97.7644, -1.85 out-out out 11.309 Saltbr-out 7.931 HRD-in -67.1087, -54.1928 74.9975, -9.3844 out-out-out SNCooo out-out ActLoopNT-out 9.447 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na 64.468, 38.5903 APE9-dihe-na 178.5391, -177.9125 APE8-dihe-in -97.0964, 108.7977 APE8-rot-out 179.6603 APE67-dihe-in -67.9531, -12.7532 -49.9137, -38.5113 APE12-dist-out 17.394 APE11-dist-out 15.64 APE10-dist-out 10.477 APE9-dist-in 5.601 None None None XRAY 2.5 0.188 0.237 A 326 318 0 0 0 0 [[56, 307]] 1.0 9vfo CAMK_MARK3_HUMAN CAMK 6e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9VGRA 51 368 753.0 A1ER9:401 Type1 Inactive DFGin 10.569 18.333 BLBtrans DFGAsp-rot-out -97.2113, 157.0679 68.0278, 16.3575 290.6527, -28.0213 -64.4008, 120.219 227.2131, 119.9102 101.937, -18.1157 out-out out 11.24 Saltbr-out 7.927 HRD-in -69.3466, -54.2864 76.9584, -10.8416 out-out-out SNCooo out-out ActLoopNT-out 9.452 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na 65.1561, 28.888 APE9-dihe-na -168.1428, -179.8852 APE8-dihe-in -92.9423, 110.7551 APE8-rot-out 175.8639 APE67-dihe-in -62.282, -17.6974 -52.5191, -37.5518 APE12-dist-out 17.509 APE11-dist-out 15.628 APE10-dist-out 10.507 APE9-dist-in 5.634 None None None XRAY 2.0 0.165 0.197 A 326 318 0 0 0 0 [[56, 307]] 1.0 9vgr CAMK_MARK3_HUMAN CAMK 6e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9VIRA 51 368 753.0 A1ESF:401 Type1 Inactive DFGin 10.514 18.377 BLBtrans DFGAsp-rot-out -108.5718, 159.6163 66.9678, 22.4943 292.4824, -43.9319 -68.5211, 115.9009 228.0581, 132.2315 103.0984, -10.2136 out-out out 11.056 Saltbr-out 7.566 HRD-in -65.6517, -46.1692 69.7279, -8.1917 out-out-out SNCooo out-out ActLoopNT-out 9.724 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na 60.035, 36.75 APE9-dihe-na -177.917, 177.2756 APE8-dihe-in -88.8513, 110.2897 APE8-rot-out 185.7087 APE67-dihe-in -65.7838, -10.8676 -51.4656, -40.5205 APE12-dist-out 17.262 APE11-dist-out 15.491 APE10-dist-out 10.315 APE9-dist-in 5.589 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.8 0.269 0.316 A 326 318 0 0 0 0 [[56, 307]] 1.0 9vir CAMK_MARK3_HUMAN CAMK 6e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9YSQA 51 369 753.0 A1CZY:401 Type1 Inactive DFGin 10.756 18.263 BLBtrans DFGAsp-rot-out -108.8574, 160.6486 71.5581, 20.7186 280.6224, -20.6146 -67.5035, 127.2239 231.8482, 116.9566 84.9919, 0.8568 out-out out 11.178 Saltbr-out 7.545 HRD-in -66.5595, -49.2385 73.3681, -9.4169 out-out-out SNCooo out-out ActLoopNT-out 9.55 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 22.7544 APE8-dihe-out -78.2129, -42.3438 APE8-rot-out 127.0058 APE67-dihe-in -62.4047, -23.2895 -55.559, -41.1396 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.907 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.4 0.198 0.248 A 328 307 12 0 0 7 [[56, 307]] 1.0 9ysq CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9YSQB 50 366 753.0 A1CZY:401 Type1 Inactive DFGin 10.8 18.04 BLBtrans DFGAsp-rot-out -110.683, 163.2965 66.0959, 28.7362 286.628, -12.3969 -71.2512, 129.8425 237.719, 117.8729 85.3793, -0.9151 out-out out 11.088 Saltbr-out 7.386 HRD-in -71.3003, -49.1304 72.8084, -7.5305 out-out-out SNCooo out-out ActLoopNT-out 9.787 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.9933 APE8-dihe-out -77.202, -37.249 APE8-rot-out 77.8007 APE67-dihe-in -61.731, -24.709 -55.6717, -41.3945 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.699 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.4 0.198 0.248 B 328 309 8 0 0 8 [[56, 307]] 1.0 9ysq CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
8UOJA 50 370 753.0 X5I:401,BEZ:408 Type1,Allosteric Inactive DFGin 10.58 18.071 BLBtrans DFGAsp-rot-out -101.05, 155.21 67.06, 21.18 289.1, -30.65 -66.94, 120.95 226.3, 128.46 101.28, -16.49 out-out out 11.058 Saltbr-out 8.28 HRD-in -69.51, -52.67 78.76, -9.16 out-out-out SNCooo out-out ActLoopNT-out 9.628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na 71.66, 19.37 APE9-dihe-na -168.75, -176.01 APE8-dihe-in -87.16, 114.56 APE8-rot-out 184.74 APE67-dihe-in -62.01, -17.38 -58.58, -38.0 APE12-dist-out 17.399 APE11-dist-out 15.69 APE10-dist-out 10.516 APE9-dist-in 5.602 I62L,L72R,V116I,G137K,F141Y,A146E None CME213 XRAY 1.6 0.16 0.186 A 328 321 0 0 0 0 [[56, 307]] 1.0 8uoj CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9YR9B 49 366 753.0 A1CZY:401 Type1 Inactive DFGinter 5.066 10.889 None DFGAsp-rot-in -108.7303, 7.4554 -91.0978, 121.7543 188.5188, 0.6861 -123.6064, 13.5626 296.6271, 91.5036 -86.8982, 110.869 out-out out 10.044 Saltbr-out 5.354 HRD-out -61.1308, 133.7274 -64.2942, -49.7121 out-out-none SNCoon out-none ActLoopNT-out 5.991 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.402 0.209 0.253 B 325 291 27 0 0 13 [[56, 307]] 1.0 9yr9 CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
9ZZWB 49 366 753.0 A1C86:401 Type1 Inactive DFGinter 5.343 10.891 None DFGAsp-rot-in -102.9518, 5.0161 -90.5833, 103.1997 175.2656, 56.9936 -103.5954, 16.8437 297.9676, 93.0842 -88.9928, 104.8868 in-none in 9.777 Saltbr-none 999.0 HRD-out -65.103, 137.748 -63.4929, -42.9642 none-out-none SNCnon out-none ActLoopNT-out 5.904 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.76 0.259 0.286 B 325 270 48 0 0 19 [[56, 307]] 1.0 9zzw CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
2QNJA 44 366 753.0 No_ligand No_ligand Inactive None 12.443 20.404 None DFGAsp-rot-out -114.95, 141.71 62.35, 27.74 299.47, -56.63 -77.88, 119.92 190.26, 103.4 97.66, -1.53 in-out in 9.799 Saltbr-out 5.098 HRD-in -83.78, -49.26 67.49, 21.12 out-out-out SNCooo out-out ActLoopNT-out 10.977 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -66.12, -53.64 APE9-dihe-na -105.01, -4.56 APE8-dihe-out -84.55, -35.12 APE8-rot-out 49.11 APE67-dihe-in -58.06, -23.61 -46.8, -51.15 APE12-dist-in 11.702 APE11-dist-out 15.169 APE10-dist-out 16.006 APE9-dist-out 11.098 None None None XRAY 2.7 0.219 0.279 A 328 314 5 0 0 5 [[56, 307]] 1.0 2qnj CAMK_MARK3_HUMAN CAMK 4.8e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
2QNJB 44 367 753.0 No_ligand No_ligand Inactive None 11.9 19.68 None DFGAsp-rot-out -123.92, 136.38 65.94, 22.42 294.67, -27.3 -72.85, 117.89 195.02, 108.74 84.86, 12.44 out-out out 11.081 Saltbr-out 8.063 HRD-in -97.8, -46.59 60.9, 23.45 out-out-out SNCooo out-out ActLoopNT-out 10.281 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -66.11, -54.15 APE9-dihe-na -76.62, -25.8 APE8-dihe-out -74.91, -46.82 APE8-rot-in 349.35 APE67-dihe-in -61.9, -19.31 -53.48, -45.06 APE12-dist-in 13.045 APE11-dist-out 16.738 APE10-dist-out 17.093 APE9-dist-out 10.963 None None None XRAY 2.7 0.219 0.279 B 328 318 3 0 0 3 [[56, 307]] 1.0 2qnj CAMK_MARK3_HUMAN CAMK 4.8e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
3FE3A 50 366 753.0 No_ligand No_ligand Inactive None 12.417 20.168 None DFGAsp-rot-out -116.9, 149.76 55.89, 28.12 299.71, -40.98 -81.71, 122.43 187.85, 98.18 86.91, 9.08 out-out out 10.941 Saltbr-out 9.421 HRD-in -91.88, -53.41 60.02, 25.41 out-out-out SNCooo out-out ActLoopNT-out 10.639 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_iooo APE10-dihe-na -49.63, -54.37 APE9-dihe-na -102.56, 2.54 APE8-dihe-out -81.58, -36.99 APE8-rot-none 999.0 APE67-dihe-in -64.07, -19.24 -56.84, -39.32 APE12-dist-in 12.506 APE11-dist-out 16.293 APE10-dist-out 16.833 APE9-dist-out 11.079 T211A,S215A None None XRAY 1.9 0.199 0.233 A 328 317 0 0 0 0 [[56, 307]] 1.0 3fe3 CAMK_MARK3_HUMAN CAMK 4.9e-95 323.8 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
3FE3B 50 366 753.0 No_ligand No_ligand Inactive None 11.932 20.119 None DFGAsp-rot-out -110.37, 144.31 56.67, 33.46 302.45, -39.5 -81.7, 126.13 189.03, 94.94 63.66, 33.94 out-out out 11.195 Saltbr-out 9.18 HRD-in -91.11, -44.92 54.79, 28.21 out-out-out SNCooo out-out ActLoopNT-out 10.813 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_iooo APE10-dihe-na -74.77, -44.14 APE9-dihe-na -104.98, -9.1 APE8-dihe-out -84.71, -31.68 APE8-rot-none 999.0 APE67-dihe-in -64.26, -21.73 -53.82, -39.54 APE12-dist-in 11.563 APE11-dist-out 16.666 APE10-dist-out 17.807 APE9-dist-out 11.207 T211A,S215A None None XRAY 1.9 0.199 0.233 B 328 317 0 0 0 0 [[56, 307]] 1.0 3fe3 CAMK_MARK3_HUMAN CAMK 4.9e-95 323.8 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
8UOHA 48 369 753.0 No_ligand No_ligand Inactive None 12.687 20.367 None DFGAsp-rot-out -117.13, 140.02 64.94, 24.85 287.51, -52.23 -74.21, 123.56 189.15, 94.71 85.26, 0.08 out-out out 10.78 Saltbr-out 5.975 HRD-in -94.8, -51.45 61.76, 22.1 out-out-out SNCooo out-out ActLoopNT-out 11.002 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -64.28, -34.94 APE9-dihe-na -115.45, -9.52 APE8-dihe-out -88.4, -31.62 APE8-rot-out 52.49 APE67-dihe-in -59.16, -26.98 -55.45, -40.3 APE12-dist-in 12.636 APE11-dist-out 15.976 APE10-dist-out 16.741 APE9-dist-out 11.01 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.15 0.177 0.22 A 328 322 0 0 0 0 [[56, 307]] 1.0 8uoh CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
7P1LB 50 365 753.0 V5E:401 Type1 Inactive None 11.167 18.575 None DFGAsp-rot-out -100.73, 158.59 71.61, 16.47 299.74, -34.86 -55.25, 125.09 249.8, 109.04 88.25, 0.28 out-out out 11.379 Saltbr-out 8.11 HRD-in -71.16, -56.55 81.07, -12.42 out-out-out SNCooo out-out ActLoopNT-out 9.551 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.99 APE8-rot-out 191.89 APE67-dihe-in -61.94, -25.0 -54.1, -40.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.211 0.242 B 326 300 16 0 0 9 [[56, 307]] 1.0 7p1l CAMK_MARK3_HUMAN CAMK 4.7e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
8UOHB 48 370 753.0 X4W:60401 Type1 Inactive None 12.44 20.578 None DFGAsp-rot-out -113.0, 147.72 64.6, 20.65 291.24, -43.4 -72.95, 123.81 193.03, 100.59 90.77, -4.48 in-out in 9.898 Saltbr-out 5.115 HRD-in -84.74, -56.67 67.83, 18.5 out-out-out SNCooo out-out ActLoopNT-out 11.639 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -60.37, -47.15 APE9-dihe-na -105.95, -4.56 APE8-dihe-out -87.05, -34.89 APE8-rot-out 51.08 APE67-dihe-in -64.72, -16.31 -57.64, -43.04 APE12-dist-in 10.314 APE11-dist-out 15.142 APE10-dist-out 16.314 APE9-dist-out 11.071 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.15 0.177 0.22 B 328 323 0 0 0 0 [[56, 307]] 1.0 8uoh CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
8UOLA 51 370 753.0 X4H:900 Type1 Inactive None 11.059 18.278 None DFGAsp-rot-out -97.77, 152.81 73.17, 19.08 279.7, -32.23 -54.78, 127.13 250.97, 109.53 89.53, -7.86 out-out out 11.178 Saltbr-out 7.987 HRD-in -68.6, -58.12 77.66, -6.9 out-out-out SNCooo out-out ActLoopNT-out 9.462 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 114.64 APE8-rot-out 188.33 APE67-dihe-in -59.03, -24.82 -53.83, -43.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 1.9 0.173 0.211 A 328 308 12 0 0 8 [[56, 307]] 1.0 8uol CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
8UOLB 50 367 753.0 X4H:900 Type1 Inactive None 11.037 18.283 None DFGAsp-rot-out -98.59, 152.62 74.43, 19.8 279.41, -33.94 -54.93, 131.38 250.37, 111.06 80.17, 2.41 out-out out 11.331 Saltbr-out 8.042 HRD-in -74.62, -54.02 79.17, -17.09 out-out-out SNCooo out-out ActLoopNT-out 9.475 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.85 APE8-dihe-out 53.01, 103.59 APE8-rot-out 198.67 APE67-dihe-in -66.99, -20.09 -53.62, -40.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.26 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 1.9 0.173 0.211 B 328 306 12 0 0 8 [[56, 307]] 1.0 8uol CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3

CAMK_MARK3 (MAP/microtubule affinity-regulating kinase 3)

Total number of chains: 25
Active chains: 2
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
None None 9 36.0% 3FE3A
DFGin BLBtrans 8 32.0% 8UOJA
DFGin BLAminus 5 20.0% AF-P27448-K1A
DFGinter None 2 8.0% 9YR9B
DFGin BLBminus 1 4.0% 7P1LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MARK3_HUMAN AF-P27448-K1A P27448 48 315 753.0 No_ligand No_ligand Active DFGin 6.694 14.512 BLAminus DFGAsp-rot-in -123.88, 177.15 57.0, 72.45 200.85, 30.97 -81.46, 16.88 287.16, 80.97 -62.01, -29.4 in-in in 9.364 Saltbr-in 2.679 HRD-in -80.04, -47.96 63.78, 10.71 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 161.82 APE9-dihe-na 91.81, 172.25 APE8-dihe-in -69.14, 129.83 APE8-rot-in 285.11 APE67-dihe-in -65.12, -21.71 -52.38, -39.59 APE12-dist-in 8.617 APE11-dist-in 10.927 APE10-dist-in 5.122 APE9-dist-in 3.471 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[56, 307]] 1.0 AF-P27448-K1 Homo sapiens CAMK_MARK3_HUMAN CAMK 2.3e-96 328.0 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN AF-P27448-K3A P27448 48 315 753.0 No_ligand No_ligand Active DFGin 6.352 14.451 BLAminus DFGAsp-rot-in -124.45, 174.68 54.69, 73.48 201.69, 17.66 -76.92, 15.34 286.64, 84.94 -60.36, -27.19 in-in in 9.376 Saltbr-in 2.708 HRD-in -82.76, -46.83 65.47, 2.4 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.79, 176.51 APE9-dihe-na 104.72, 167.44 APE8-dihe-in -77.75, 123.61 APE8-rot-in 298.54 APE67-dihe-in -65.05, -21.7 -51.25, -39.58 APE12-dist-in 8.275 APE11-dist-in 11.243 APE10-dist-in 5.714 APE9-dist-in 3.266 None None None AF2 -1.0 1.0 1.0 A 268 268 0 0 0 0 [[56, 307]] 1.0 AF-P27448-K3 Homo sapiens CAMK_MARK3_HUMAN CAMK 2.3e-96 328.0 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 8UOIA P27448 51 368 753.0 X3Q:401 Type1 Inactive DFGin 7.165 15.033 BLAminus DFGAsp-rot-in -130.95, 170.74 60.36, 85.55 202.08, -22.57 -95.67, 24.7 289.31, 72.53 -63.79, -23.52 in-out in 9.531 Saltbr-out 4.173 HRD-in -74.46, -45.16 72.45, -5.81 out-in-out SNCoio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -143.96, 119.86 APE9-dihe-na -75.09, -153.48 APE8-dihe-in -55.48, 118.18 APE8-rot-out 181.77 APE67-dihe-in -60.92, -18.44 -53.9, -40.75 APE12-dist-in 12.166 APE11-dist-out 6.363 APE10-dist-out 10.669 APE9-dist-in 4.316 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None None XRAY 1.8 0.166 0.198 A 328 313 5 0 0 5 [[56, 307]] 1.0 8uoi Homo sapiens CAMK_MARK3_HUMAN CAMK 1.6e-96 328.6 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 8UOKA P27448 51 369 753.0 X5N:401 Type1 Inactive DFGin 7.201 14.589 BLAminus DFGAsp-rot-in -128.0, 174.4 56.61, 82.91 195.08, -0.07 -94.21, 21.07 288.64, 73.92 -62.72, -25.03 in-in in 9.084 Saltbr-in 3.263 HRD-in -74.87, -48.84 75.44, -4.0 in-in-out SNCiio in-out ActLoopNT-in 2.984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -114.94, 111.38 APE9-dihe-na -71.46, -165.83 APE8-dihe-in -59.52, 119.0 APE8-rot-out 186.09 APE67-dihe-in -59.81, -22.83 -52.2, -42.6 APE12-dist-in 11.786 APE11-dist-out 6.654 APE10-dist-out 10.502 APE9-dist-in 4.075 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None None XRAY 1.85 0.16 0.192 A 328 319 0 0 0 0 [[56, 307]] 1.0 8uok Homo sapiens CAMK_MARK3_HUMAN CAMK 1.6e-96 328.6 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 8UOKB P27448 51 369 753.0 X5N:401 Type1 Inactive DFGin 7.333 14.708 BLAminus DFGAsp-rot-in -129.56, 174.78 57.0, 81.41 193.48, -0.95 -92.91, 22.49 290.44, 74.44 -63.54, -22.2 in-in in 9.269 Saltbr-in 3.437 HRD-in -77.83, -48.31 76.0, -3.21 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -120.7, 120.48 APE9-dihe-na -72.58, -134.96 APE8-dihe-in -74.88, 122.89 APE8-rot-out 173.55 APE67-dihe-in -58.62, -25.28 -54.54, -40.65 APE12-dist-in 12.082 APE11-dist-out 7.015 APE10-dist-out 10.908 APE9-dist-in 4.068 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None None XRAY 1.85 0.16 0.192 B 328 319 0 0 0 0 [[56, 307]] 1.0 8uok Homo sapiens CAMK_MARK3_HUMAN CAMK 1.6e-96 328.6 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 7P1LA P27448 50 365 753.0 V5E:401 Type1 Inactive DFGin 10.927 18.403 BLBminus DFGAsp-rot-out -100.8, 158.72 76.59, 15.2 289.64, -30.9 -55.33, 127.82 250.42, 110.27 85.72, 1.76 out-out out 11.526 Saltbr-out 7.975 HRD-in -70.67, -54.0 80.04, -12.41 out-out-out SNCooo out-out ActLoopNT-out 9.396 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 112.03 APE8-rot-out 198.04 APE67-dihe-in -61.79, -25.58 -53.61, -42.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.211 0.242 A 326 301 15 0 0 9 [[56, 307]] 1.0 7p1l Homo sapiens CAMK_MARK3_HUMAN CAMK 4.7e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9YR9A P27448 49 366 753.0 A1CZY:401 Type1 Inactive DFGin 10.64 18.553 BLBtrans DFGAsp-rot-out -113.0228, 161.8508 65.2376, 33.5975 298.5247, -11.9297 -87.41, 128.8067 222.5778, 131.0864 83.3448, 8.519 out-out out 11.019 Saltbr-out 7.653 HRD-in -69.1956, -46.674 71.5716, -7.0487 out-out-out SNCooo out-out ActLoopNT-out 9.49 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na -128.0691, 9.3707 APE9-dihe-na 80.4474, -159.9696 APE8-dihe-in -74.8969, 119.1274 APE8-rot-out 181.8154 APE67-dihe-in -63.3765, -22.0552 -58.423, -38.8233 APE12-dist-out 14.47 APE11-dist-out 17.145 APE10-dist-out 16.744 APE9-dist-in 5.543 None None None XRAY 2.402 0.209 0.253 A 325 311 7 0 0 3 [[56, 307]] 1.0 9yr9 Homo sapiens CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9ZZWA P27448 49 366 753.0 A1C86:401 Type1 Inactive DFGin 10.595 18.426 BLBtrans DFGAsp-rot-out -112.6726, 166.506 59.2021, 32.826 297.746, -28.4904 -83.1556, 128.6442 222.6559, 132.196 79.7001, 15.059 out-out out 11.177 Saltbr-out 6.941 HRD-in -70.4253, -49.0932 66.0948, 3.9004 out-out-out SNCooo out-out ActLoopNT-out 9.159 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 114.3595 APE8-rot-out 186.0707 APE67-dihe-in -59.5877, -38.6919 -58.0398, -43.8432 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.76 0.259 0.286 A 325 303 15 0 0 9 [[56, 307]] 1.0 9zzw Homo sapiens CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9VFOA P27448 51 368 753.0 A1ER0:401 Type1 Inactive DFGin 10.488 18.388 BLBtrans DFGAsp-rot-out -99.8719, 155.4335 66.861, 23.9367 296.7615, -31.6532 -70.0012, 120.1134 225.6909, 129.2838 97.7644, -1.85 out-out out 11.309 Saltbr-out 7.931 HRD-in -67.1087, -54.1928 74.9975, -9.3844 out-out-out SNCooo out-out ActLoopNT-out 9.447 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na 64.468, 38.5903 APE9-dihe-na 178.5391, -177.9125 APE8-dihe-in -97.0964, 108.7977 APE8-rot-out 179.6603 APE67-dihe-in -67.9531, -12.7532 -49.9137, -38.5113 APE12-dist-out 17.394 APE11-dist-out 15.64 APE10-dist-out 10.477 APE9-dist-in 5.601 None None None XRAY 2.5 0.188 0.237 A 326 318 0 0 0 0 [[56, 307]] 1.0 9vfo Homo sapiens CAMK_MARK3_HUMAN CAMK 6e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9VGRA P27448 51 368 753.0 A1ER9:401 Type1 Inactive DFGin 10.569 18.333 BLBtrans DFGAsp-rot-out -97.2113, 157.0679 68.0278, 16.3575 290.6527, -28.0213 -64.4008, 120.219 227.2131, 119.9102 101.937, -18.1157 out-out out 11.24 Saltbr-out 7.927 HRD-in -69.3466, -54.2864 76.9584, -10.8416 out-out-out SNCooo out-out ActLoopNT-out 9.452 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na 65.1561, 28.888 APE9-dihe-na -168.1428, -179.8852 APE8-dihe-in -92.9423, 110.7551 APE8-rot-out 175.8639 APE67-dihe-in -62.282, -17.6974 -52.5191, -37.5518 APE12-dist-out 17.509 APE11-dist-out 15.628 APE10-dist-out 10.507 APE9-dist-in 5.634 None None None XRAY 2.0 0.165 0.197 A 326 318 0 0 0 0 [[56, 307]] 1.0 9vgr Homo sapiens CAMK_MARK3_HUMAN CAMK 6e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9VIRA P27448 51 368 753.0 A1ESF:401 Type1 Inactive DFGin 10.514 18.377 BLBtrans DFGAsp-rot-out -108.5718, 159.6163 66.9678, 22.4943 292.4824, -43.9319 -68.5211, 115.9009 228.0581, 132.2315 103.0984, -10.2136 out-out out 11.056 Saltbr-out 7.566 HRD-in -65.6517, -46.1692 69.7279, -8.1917 out-out-out SNCooo out-out ActLoopNT-out 9.724 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na 60.035, 36.75 APE9-dihe-na -177.917, 177.2756 APE8-dihe-in -88.8513, 110.2897 APE8-rot-out 185.7087 APE67-dihe-in -65.7838, -10.8676 -51.4656, -40.5205 APE12-dist-out 17.262 APE11-dist-out 15.491 APE10-dist-out 10.315 APE9-dist-in 5.589 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.8 0.269 0.316 A 326 318 0 0 0 0 [[56, 307]] 1.0 9vir Homo sapiens CAMK_MARK3_HUMAN CAMK 6e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9YSQA P27448 51 369 753.0 A1CZY:401 Type1 Inactive DFGin 10.756 18.263 BLBtrans DFGAsp-rot-out -108.8574, 160.6486 71.5581, 20.7186 280.6224, -20.6146 -67.5035, 127.2239 231.8482, 116.9566 84.9919, 0.8568 out-out out 11.178 Saltbr-out 7.545 HRD-in -66.5595, -49.2385 73.3681, -9.4169 out-out-out SNCooo out-out ActLoopNT-out 9.55 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 22.7544 APE8-dihe-out -78.2129, -42.3438 APE8-rot-out 127.0058 APE67-dihe-in -62.4047, -23.2895 -55.559, -41.1396 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.907 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.4 0.198 0.248 A 328 307 12 0 0 7 [[56, 307]] 1.0 9ysq Homo sapiens CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9YSQB P27448 50 366 753.0 A1CZY:401 Type1 Inactive DFGin 10.8 18.04 BLBtrans DFGAsp-rot-out -110.683, 163.2965 66.0959, 28.7362 286.628, -12.3969 -71.2512, 129.8425 237.719, 117.8729 85.3793, -0.9151 out-out out 11.088 Saltbr-out 7.386 HRD-in -71.3003, -49.1304 72.8084, -7.5305 out-out-out SNCooo out-out ActLoopNT-out 9.787 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.9933 APE8-dihe-out -77.202, -37.249 APE8-rot-out 77.8007 APE67-dihe-in -61.731, -24.709 -55.6717, -41.3945 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.699 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.4 0.198 0.248 B 328 309 8 0 0 8 [[56, 307]] 1.0 9ysq Homo sapiens CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 8UOJA P27448 50 370 753.0 X5I:401,BEZ:408 Type1,Allosteric Inactive DFGin 10.58 18.071 BLBtrans DFGAsp-rot-out -101.05, 155.21 67.06, 21.18 289.1, -30.65 -66.94, 120.95 226.3, 128.46 101.28, -16.49 out-out out 11.058 Saltbr-out 8.28 HRD-in -69.51, -52.67 78.76, -9.16 out-out-out SNCooo out-out ActLoopNT-out 9.628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooi APE10-dihe-na 71.66, 19.37 APE9-dihe-na -168.75, -176.01 APE8-dihe-in -87.16, 114.56 APE8-rot-out 184.74 APE67-dihe-in -62.01, -17.38 -58.58, -38.0 APE12-dist-out 17.399 APE11-dist-out 15.69 APE10-dist-out 10.516 APE9-dist-in 5.602 I62L,L72R,V116I,G137K,F141Y,A146E None CME213 XRAY 1.6 0.16 0.186 A 328 321 0 0 0 0 [[56, 307]] 1.0 8uoj Homo sapiens CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9YR9B P27448 49 366 753.0 A1CZY:401 Type1 Inactive DFGinter 5.066 10.889 None DFGAsp-rot-in -108.7303, 7.4554 -91.0978, 121.7543 188.5188, 0.6861 -123.6064, 13.5626 296.6271, 91.5036 -86.8982, 110.869 out-out out 10.044 Saltbr-out 5.354 HRD-out -61.1308, 133.7274 -64.2942, -49.7121 out-out-none SNCoon out-none ActLoopNT-out 5.991 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.402 0.209 0.253 B 325 291 27 0 0 13 [[56, 307]] 1.0 9yr9 Homo sapiens CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 9ZZWB P27448 49 366 753.0 A1C86:401 Type1 Inactive DFGinter 5.343 10.891 None DFGAsp-rot-in -102.9518, 5.0161 -90.5833, 103.1997 175.2656, 56.9936 -103.5954, 16.8437 297.9676, 93.0842 -88.9928, 104.8868 in-none in 9.777 Saltbr-none 999.0 HRD-out -65.103, 137.748 -63.4929, -42.9642 none-out-none SNCnon out-none ActLoopNT-out 5.904 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.76 0.259 0.286 B 325 270 48 0 0 19 [[56, 307]] 1.0 9zzw Homo sapiens CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 2QNJA P27448 44 366 753.0 No_ligand No_ligand Inactive None 12.443 20.404 None DFGAsp-rot-out -114.95, 141.71 62.35, 27.74 299.47, -56.63 -77.88, 119.92 190.26, 103.4 97.66, -1.53 in-out in 9.799 Saltbr-out 5.098 HRD-in -83.78, -49.26 67.49, 21.12 out-out-out SNCooo out-out ActLoopNT-out 10.977 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -66.12, -53.64 APE9-dihe-na -105.01, -4.56 APE8-dihe-out -84.55, -35.12 APE8-rot-out 49.11 APE67-dihe-in -58.06, -23.61 -46.8, -51.15 APE12-dist-in 11.702 APE11-dist-out 15.169 APE10-dist-out 16.006 APE9-dist-out 11.098 None None None XRAY 2.7 0.219 0.279 A 328 314 5 0 0 5 [[56, 307]] 1.0 2qnj Homo sapiens CAMK_MARK3_HUMAN CAMK 4.8e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 2QNJB P27448 44 367 753.0 No_ligand No_ligand Inactive None 11.9 19.68 None DFGAsp-rot-out -123.92, 136.38 65.94, 22.42 294.67, -27.3 -72.85, 117.89 195.02, 108.74 84.86, 12.44 out-out out 11.081 Saltbr-out 8.063 HRD-in -97.8, -46.59 60.9, 23.45 out-out-out SNCooo out-out ActLoopNT-out 10.281 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -66.11, -54.15 APE9-dihe-na -76.62, -25.8 APE8-dihe-out -74.91, -46.82 APE8-rot-in 349.35 APE67-dihe-in -61.9, -19.31 -53.48, -45.06 APE12-dist-in 13.045 APE11-dist-out 16.738 APE10-dist-out 17.093 APE9-dist-out 10.963 None None None XRAY 2.7 0.219 0.279 B 328 318 3 0 0 3 [[56, 307]] 1.0 2qnj Homo sapiens CAMK_MARK3_HUMAN CAMK 4.8e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 3FE3A P27448 50 366 753.0 No_ligand No_ligand Inactive None 12.417 20.168 None DFGAsp-rot-out -116.9, 149.76 55.89, 28.12 299.71, -40.98 -81.71, 122.43 187.85, 98.18 86.91, 9.08 out-out out 10.941 Saltbr-out 9.421 HRD-in -91.88, -53.41 60.02, 25.41 out-out-out SNCooo out-out ActLoopNT-out 10.639 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_iooo APE10-dihe-na -49.63, -54.37 APE9-dihe-na -102.56, 2.54 APE8-dihe-out -81.58, -36.99 APE8-rot-none 999.0 APE67-dihe-in -64.07, -19.24 -56.84, -39.32 APE12-dist-in 12.506 APE11-dist-out 16.293 APE10-dist-out 16.833 APE9-dist-out 11.079 T211A,S215A None None XRAY 1.9 0.199 0.233 A 328 317 0 0 0 0 [[56, 307]] 1.0 3fe3 Homo sapiens CAMK_MARK3_HUMAN CAMK 4.9e-95 323.8 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 3FE3B P27448 50 366 753.0 No_ligand No_ligand Inactive None 11.932 20.119 None DFGAsp-rot-out -110.37, 144.31 56.67, 33.46 302.45, -39.5 -81.7, 126.13 189.03, 94.94 63.66, 33.94 out-out out 11.195 Saltbr-out 9.18 HRD-in -91.11, -44.92 54.79, 28.21 out-out-out SNCooo out-out ActLoopNT-out 10.813 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_iooo APE10-dihe-na -74.77, -44.14 APE9-dihe-na -104.98, -9.1 APE8-dihe-out -84.71, -31.68 APE8-rot-none 999.0 APE67-dihe-in -64.26, -21.73 -53.82, -39.54 APE12-dist-in 11.563 APE11-dist-out 16.666 APE10-dist-out 17.807 APE9-dist-out 11.207 T211A,S215A None None XRAY 1.9 0.199 0.233 B 328 317 0 0 0 0 [[56, 307]] 1.0 3fe3 Homo sapiens CAMK_MARK3_HUMAN CAMK 4.9e-95 323.8 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 8UOHA P27448 48 369 753.0 No_ligand No_ligand Inactive None 12.687 20.367 None DFGAsp-rot-out -117.13, 140.02 64.94, 24.85 287.51, -52.23 -74.21, 123.56 189.15, 94.71 85.26, 0.08 out-out out 10.78 Saltbr-out 5.975 HRD-in -94.8, -51.45 61.76, 22.1 out-out-out SNCooo out-out ActLoopNT-out 11.002 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -64.28, -34.94 APE9-dihe-na -115.45, -9.52 APE8-dihe-out -88.4, -31.62 APE8-rot-out 52.49 APE67-dihe-in -59.16, -26.98 -55.45, -40.3 APE12-dist-in 12.636 APE11-dist-out 15.976 APE10-dist-out 16.741 APE9-dist-out 11.01 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.15 0.177 0.22 A 328 322 0 0 0 0 [[56, 307]] 1.0 8uoh Homo sapiens CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 7P1LB P27448 50 365 753.0 V5E:401 Type1 Inactive None 11.167 18.575 None DFGAsp-rot-out -100.73, 158.59 71.61, 16.47 299.74, -34.86 -55.25, 125.09 249.8, 109.04 88.25, 0.28 out-out out 11.379 Saltbr-out 8.11 HRD-in -71.16, -56.55 81.07, -12.42 out-out-out SNCooo out-out ActLoopNT-out 9.551 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 110.99 APE8-rot-out 191.89 APE67-dihe-in -61.94, -25.0 -54.1, -40.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.95 0.211 0.242 B 326 300 16 0 0 9 [[56, 307]] 1.0 7p1l Homo sapiens CAMK_MARK3_HUMAN CAMK 4.7e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 8UOHB P27448 48 370 753.0 X4W:60401 Type1 Inactive None 12.44 20.578 None DFGAsp-rot-out -113.0, 147.72 64.6, 20.65 291.24, -43.4 -72.95, 123.81 193.03, 100.59 90.77, -4.48 in-out in 9.898 Saltbr-out 5.115 HRD-in -84.74, -56.67 67.83, 18.5 out-out-out SNCooo out-out ActLoopNT-out 11.639 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -60.37, -47.15 APE9-dihe-na -105.95, -4.56 APE8-dihe-out -87.05, -34.89 APE8-rot-out 51.08 APE67-dihe-in -64.72, -16.31 -57.64, -43.04 APE12-dist-in 10.314 APE11-dist-out 15.142 APE10-dist-out 16.314 APE9-dist-out 11.071 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 2.15 0.177 0.22 B 328 323 0 0 0 0 [[56, 307]] 1.0 8uoh Homo sapiens CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 8UOLA P27448 51 370 753.0 X4H:900 Type1 Inactive None 11.059 18.278 None DFGAsp-rot-out -97.77, 152.81 73.17, 19.08 279.7, -32.23 -54.78, 127.13 250.97, 109.53 89.53, -7.86 out-out out 11.178 Saltbr-out 7.987 HRD-in -68.6, -58.12 77.66, -6.9 out-out-out SNCooo out-out ActLoopNT-out 9.462 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 114.64 APE8-rot-out 188.33 APE67-dihe-in -59.03, -24.82 -53.83, -43.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 1.9 0.173 0.211 A 328 308 12 0 0 8 [[56, 307]] 1.0 8uol Homo sapiens CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
MARK3_HUMAN 8UOLB P27448 50 367 753.0 X4H:900 Type1 Inactive None 11.037 18.283 None DFGAsp-rot-out -98.59, 152.62 74.43, 19.8 279.41, -33.94 -54.93, 131.38 250.37, 111.06 80.17, 2.41 out-out out 11.331 Saltbr-out 8.042 HRD-in -74.62, -54.02 79.17, -17.09 out-out-out SNCooo out-out ActLoopNT-out 9.475 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.85 APE8-dihe-out 53.01, 103.59 APE8-rot-out 198.67 APE67-dihe-in -66.99, -20.09 -53.62, -40.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.26 I62L,L72R,V116I,G137K,F141Y,A146E None None XRAY 1.9 0.173 0.211 B 328 306 12 0 0 8 [[56, 307]] 1.0 8uol Homo sapiens CAMK_MARK3_HUMAN CAMK 6.1e-96 326.7 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3

CAMK_MARK3 (MAP/microtubule affinity-regulating kinase 3)

Total number of chains: 0
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name