CAMK_MAPKAPK2 (MAP kinase-activated protein kinase 2)

Total number of chains: 119
Active chains: 2
Family: CAMK
Uniprot: MAPK2_HUMAN
Kinase Domain Residues: 63 - 325
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 107 89.9% AF-P49137-K1A
DFGin ABAminus 12 10.1% 8XU4B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P49137-K1A 55 333 400.0 No_ligand No_ligand Active DFGin 4.546 13.824 BLAminus -134.44, -178.32 60.99, 73.02 -77.16, 14.94 284.91, 72.06 -61.19, -19.08 in-in in 9.222 Saltbr-in 2.655 HRD-in -73.97, -44.93 66.36, 6.92 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.85, 117.34 APE9-dihe-na -163.87, 158.43 APE8-dihe-in -103.05, 128.91 APE8-rot-in 302.59 APE67-dihe-in -76.17, -21.81 -42.87, -45.53 APE12-dist-in 8.406 APE11-dist-in 10.793 APE10-dist-in 5.107 APE9-dist-in 4.569 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[63, 325]] 1.0 AF-P49137-K1 CAMK_MAPKAPK2_HUMAN CAMK 2e-80 275.7 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
AF-P49137-K3A 55 333 400.0 No_ligand No_ligand Active DFGin 4.263 13.854 BLAminus -139.32, -176.01 59.17, 72.48 -74.28, 14.66 284.7, 72.91 -60.93, -20.2 in-in in 9.302 Saltbr-in 2.682 HRD-in -78.07, -45.55 66.87, 7.53 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 122.38 APE9-dihe-na -167.75, 155.99 APE8-dihe-in -92.86, 129.83 APE8-rot-in 298.63 APE67-dihe-in -72.76, -25.18 -45.14, -45.86 APE12-dist-in 8.677 APE11-dist-in 11.15 APE10-dist-in 5.293 APE9-dist-in 4.364 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[63, 325]] 1.0 AF-P49137-K3 CAMK_MAPKAPK2_HUMAN CAMK 2e-80 275.7 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4A 47 351 400.0 No_ligand No_ligand Inactive DFGin 4.949 13.716 ABAminus -128.52, -52.54 -97.2, 106.03 -93.21, 12.59 278.71, 77.09 -54.91, -37.99 in-in in 8.687 Saltbr-in 2.878 HRD-in -60.97, -46.53 67.55, 11.05 in-in-none SNCiin in-none ActLoopNT-in 3.047 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -43.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 A 318 288 17 0 0 12 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4B 47 351 400.0 No_ligand No_ligand Inactive DFGin 4.97 13.93 ABAminus -128.62, -52.37 -96.88, 106.3 -93.53, 12.94 278.79, 76.83 -53.86, -39.26 in-in in 8.877 Saltbr-in 2.85 HRD-in -61.06, -46.54 67.22, 10.97 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.67, -39.29 999.0, 159.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 B 318 289 16 0 0 11 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4C 48 351 400.0 No_ligand No_ligand Inactive DFGin 4.952 13.77 ABAminus -128.61, -52.83 -97.32, 105.87 -93.56, 12.92 278.25, 77.18 -54.04, -38.82 in-in in 8.715 Saltbr-in 2.884 HRD-in -60.6, -46.65 67.66, 11.02 in-in-none SNCiin in-none ActLoopNT-in 3.048 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -67.27, -39.02 999.0, 154.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 C 318 283 21 0 0 11 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4D 47 349 400.0 No_ligand No_ligand Inactive DFGin 5.016 13.978 ABAminus -128.47, -52.45 -96.79, 105.82 -93.86, 12.98 278.72, 76.7 -54.12, -38.62 in-in in 8.882 Saltbr-in 2.867 HRD-in -61.37, -46.37 68.02, 10.61 in-in-none SNCiin in-none ActLoopNT-in 3.054 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.98, -38.84 999.0, 155.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 D 318 284 19 0 0 11 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4E 47 353 400.0 No_ligand No_ligand Inactive DFGin 4.978 13.843 ABAminus -128.62, -52.59 -97.28, 106.12 -93.2, 12.43 279.18, 76.54 -53.59, -39.54 in-in in 8.74 Saltbr-in 2.872 HRD-in -60.42, -46.83 67.49, 11.2 in-in-none SNCiin in-none ActLoopNT-in 3.045 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.61, -38.51 999.0, 154.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 E 318 286 21 0 0 8 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4F 47 353 400.0 No_ligand No_ligand Inactive DFGin 4.992 13.962 ABAminus -128.58, -52.75 -97.13, 105.72 -93.36, 12.89 278.82, 76.86 -54.15, -39.31 in-in in 8.87 Saltbr-in 2.857 HRD-in -61.41, -46.48 67.82, 10.61 in-in-none SNCiin in-none ActLoopNT-in 3.049 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.63, -38.8 999.0, 158.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 F 318 279 28 0 0 11 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4G 47 348 400.0 No_ligand No_ligand Inactive DFGin 4.988 13.714 ABAminus -128.53, -52.31 -97.11, 106.65 -93.35, 12.39 279.0, 76.45 -52.45, -40.58 in-in in 8.706 Saltbr-in 2.882 HRD-in -60.9, -46.46 67.81, 10.73 in-in-none SNCiin in-none ActLoopNT-in 3.049 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.07, -38.86 999.0, 175.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 G 318 273 29 0 0 9 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4H 47 358 400.0 No_ligand No_ligand Inactive DFGin 5.014 13.981 ABAminus -128.09, -52.94 -96.6, 105.83 -93.09, 12.25 278.91, 76.39 -53.17, -39.42 in-in in 8.856 Saltbr-in 2.866 HRD-in -61.25, -46.49 67.38, 11.04 in-in-out SNCiio in-out ActLoopNT-in 3.051 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 68.07 APE8-rot-out 50.27 APE67-dihe-out -68.41, -38.92 -61.79, 156.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 H 318 281 31 0 0 10 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4I 47 347 400.0 No_ligand No_ligand Inactive DFGin 4.958 13.827 ABAminus -128.35, -52.14 -97.19, 106.4 -93.31, 12.69 278.76, 76.95 -54.36, -39.16 in-in in 8.826 Saltbr-in 2.858 HRD-in -61.27, -46.42 67.55, 10.91 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 I 318 266 35 0 0 14 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4J 47 350 400.0 No_ligand No_ligand Inactive DFGin 4.954 13.75 ABAminus -128.19, -52.94 -96.37, 106.17 -93.76, 12.19 278.77, 77.03 -53.29, -39.12 in-in in 8.654 Saltbr-in 2.886 HRD-in -61.27, -46.26 67.9, 10.69 in-in-none SNCiin in-none ActLoopNT-in 3.049 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 J 318 273 31 0 0 15 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4K 47 348 400.0 No_ligand No_ligand Inactive DFGin 4.982 13.855 ABAminus -127.78, -52.88 -96.21, 106.11 -93.51, 11.66 278.96, 76.54 -52.14, -40.11 in-in in 8.732 Saltbr-in 2.884 HRD-in -61.37, -46.53 68.05, 10.32 in-in-none SNCiin in-none ActLoopNT-in 3.049 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.32, -38.96 999.0, 154.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 K 318 269 33 0 0 11 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XU4L 47 354 400.0 No_ligand No_ligand Inactive DFGin 4.982 13.927 ABAminus -127.97, -52.82 -96.79, 105.64 -93.41, 12.6 279.02, 76.77 -54.27, -38.59 in-in in 8.812 Saltbr-in 2.872 HRD-in -61.34, -46.64 68.01, 10.51 in-in-none SNCiin in-none ActLoopNT-in 3.055 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 L 318 272 36 0 0 13 [[63, 325]] 1.0 8xu4 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
1NY3A 46 345 400.0 ADP:401 ATPlike Inactive DFGin 4.213 13.918 BLAminus -139.11, 173.49 82.65, 112.5 -121.18, 20.23 280.18, 65.28 -53.92, -18.87 out-out out 10.039 Saltbr-out 6.106 HRD-in -63.84, -48.41 55.55, 34.09 out-in-none SNCoin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -47.32, -19.47 999.0, 98.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.27 0.292 A 400 277 23 0 0 9 [[63, 325]] 1.0 1ny3 CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2PZYD 43 342 400.0 No_ligand No_ligand Inactive DFGin 4.062 13.922 BLAminus -152.15, 165.55 73.92, 95.4 -98.52, 24.64 286.52, 78.72 -40.74, -59.3 in-in in 8.771 Saltbr-in 2.73 HRD-in -82.11, -45.31 68.56, -1.03 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 58.75 APE9-dihe-na -176.76, -129.46 APE8-dihe-out 94.27, 109.95 APE8-rot-in 285.39 APE67-dihe-out -47.44, -18.99 -80.83, 132.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 31.238 APE9-dist-out 32.707 None None None XRAY 2.9 0.251 0.313 D 324 288 12 0 0 8 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
4TYHA 51 400 400.0 No_ligand No_ligand Inactive DFGin 4.441 14.325 BLAminus -142.08, 171.7 55.29, 109.24 -104.89, 23.52 273.51, 53.57 -64.22, -15.92 out-out out 11.187 Saltbr-out 3.993 HRD-out -83.42, 132.47 -122.22, 37.78 out-in-out SNCoio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -76.48, -33.25 APE9-dihe-na -107.91, 124.37 APE8-dihe-in -138.48, 156.89 APE8-rot-out 74.08 APE67-dihe-out -72.03, -25.61 -71.89, 168.09 APE12-dist-out 28.197 APE11-dist-out 33.461 APE10-dist-out 36.005 APE9-dist-out 33.065 None None None XRAY 3.0 0.232 0.313 A 350 339 11 0 0 0 [[63, 325]] 1.0 4tyh CAMK_MAPKAPK2_HUMAN CAMK 4.4e-80 274.8 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2OZAA 51 390 400.0 No_ligand No_ligand Inactive DFGin 4.518 14.471 BLAminus -123.6, 174.75 70.29, 93.68 -101.87, 20.63 281.37, 55.77 -53.13, -26.57 out-in out 10.386 Saltbr-in 3.436 HRD-in -72.68, -56.57 75.31, 21.22 in-in-out SNCiio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -78.43, -27.23 APE9-dihe-na -116.51, 130.73 APE8-dihe-in -149.24, 149.83 APE8-rot-out 53.32 APE67-dihe-out -67.3, -35.95 -56.79, 159.27 APE12-dist-out 27.346 APE11-dist-out 32.873 APE10-dist-out 35.564 APE9-dist-out 32.631 None None None XRAY 2.7 0.239 0.296 A 356 332 8 0 0 0 [[63, 325]] 1.0 2oza CAMK_MAPKAPK2_HUMAN CAMK 4.7e-80 274.8 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6TCAA 51 399 400.0 No_ligand No_ligand Inactive DFGin 4.808 14.709 BLAminus -135.67, -169.38 58.66, 66.44 -82.91, 21.97 272.01, 70.02 -62.4, -32.28 out-out out 10.543 Saltbr-out 4.578 HRD-out -51.48, 137.64 -139.83, 40.36 out-in-out SNCoio in-out ActLoopNT-in 2.542 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -76.04, -19.94 APE9-dihe-na -101.4, 109.34 APE8-dihe-in -124.3, 144.8 APE8-rot-out 81.9 APE67-dihe-out -65.78, -45.04 -67.31, 169.54 APE12-dist-out 27.566 APE11-dist-out 32.877 APE10-dist-out 34.713 APE9-dist-out 32.586 None None None XRAY 3.7 0.254 0.297 A 371 345 4 0 0 0 [[63, 325]] 1.0 6tca CAMK_MAPKAPK2_HUMAN CAMK 5.3e-80 274.6 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6TCAC 51 397 400.0 No_ligand No_ligand Inactive DFGin 4.398 14.006 BLAminus -137.3, -177.32 55.62, 70.05 -77.27, 20.32 283.21, 48.26 -39.45, -41.82 out-out out 10.681 Saltbr-out 5.209 HRD-out -67.04, 142.78 -136.57, 25.0 out-in-out SNCoio in-out ActLoopNT-in 3.096 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -62.01, -43.21 APE9-dihe-na -111.68, 156.05 APE8-dihe-in -156.69, 147.09 APE8-rot-out 176.79 APE67-dihe-out -79.69, -42.53 -75.02, -178.41 APE12-dist-out 29.503 APE11-dist-out 33.956 APE10-dist-out 37.358 APE9-dist-out 34.003 None None None XRAY 3.7 0.254 0.297 C 371 326 21 0 0 0 [[63, 325]] 1.0 6tca CAMK_MAPKAPK2_HUMAN CAMK 5.3e-80 274.6 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6TCAE 51 394 400.0 No_ligand No_ligand Inactive DFGin 4.64 15.205 BLAminus -127.42, -167.98 61.16, 68.59 -80.76, 21.11 276.97, 51.93 -62.95, -41.61 out-none out 10.928 Saltbr-none 999.0 HRD-out -75.87, 144.22 -136.93, 24.68 none-in-out SNCnio in-out ActLoopNT-in 2.748 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -91.5, -33.23 APE9-dihe-na -97.26, 70.28 APE8-dihe-in -92.3, 143.46 APE8-rot-out 73.64 APE67-dihe-out -74.99, -22.66 -65.33, 170.76 APE12-dist-out 27.729 APE11-dist-out 33.33 APE10-dist-out 35.098 APE9-dist-out 33.635 None None None XRAY 3.7 0.254 0.297 E 371 327 17 0 0 0 [[63, 325]] 1.0 6tca CAMK_MAPKAPK2_HUMAN CAMK 5.3e-80 274.6 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6TCAG 51 397 400.0 No_ligand No_ligand Inactive DFGin 5.283 14.452 BLAminus -126.97, -178.87 58.45, 67.91 -84.51, 24.35 287.29, 64.0 -66.48, -20.58 out-none out 10.942 Saltbr-none 999.0 HRD-out -70.0, 138.95 -123.96, 22.22 none-in-out SNCnio in-out ActLoopNT-in 3.329 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -79.36, -46.18 APE9-dihe-na -86.11, 115.37 APE8-dihe-in -128.35, 144.51 APE8-rot-out 165.31 APE67-dihe-out -65.52, -41.43 -66.57, 167.52 APE12-dist-out 28.221 APE11-dist-out 33.733 APE10-dist-out 35.943 APE9-dist-out 32.937 None None None XRAY 3.7 0.254 0.297 G 371 337 10 0 0 0 [[63, 325]] 1.0 6tca CAMK_MAPKAPK2_HUMAN CAMK 5.3e-80 274.6 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
1KWPA 46 385 400.0 No_ligand No_ligand Inactive DFGin 4.429 13.889 BLAminus -126.95, -164.58 53.05, 82.7 -89.43, 29.12 276.39, 66.04 -76.65, 13.1 out-out out 10.974 Saltbr-out 5.651 HRD-in -68.44, -51.49 60.45, 15.74 out-in-none SNCoin in-none ActLoopNT-in 2.707 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.233 0.245 A 400 319 21 0 0 17 [[63, 325]] 1.0 1kwp CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
1KWPB 44 378 400.0 No_ligand No_ligand Inactive DFGin 4.377 14.119 BLAminus -117.6, -155.6 68.63, 73.62 -94.92, 21.17 280.86, 68.81 -59.61, -28.18 out-out out 10.182 Saltbr-out 4.977 HRD-in -60.1, -56.36 69.04, 7.85 out-in-none SNCoin in-none ActLoopNT-in 2.762 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.233 0.245 B 400 313 22 0 0 17 [[63, 325]] 1.0 1kwp CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2ONLC 46 393 400.0 No_ligand No_ligand Inactive DFGin 5.372 13.877 BLAminus -144.71, 177.23 57.74, 79.95 -93.42, 20.24 283.94, 44.28 -42.17, -30.27 out-out out 10.482 Saltbr-out 5.159 HRD-in -63.93, -50.35 64.99, 1.87 out-in-out SNCoio in-out ActLoopNT-in 2.678 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.05, 148.13 APE9-dihe-na -79.09, -172.22 APE8-dihe-out -151.58, -163.46 APE8-rot-in 293.27 APE67-dihe-out -61.73, 102.69 -87.71, -35.23 APE12-dist-out 31.664 APE11-dist-out 35.028 APE10-dist-out 35.94 APE9-dist-out 30.146 None None None XRAY 4.0 0.315 0.331 C 406 317 31 0 0 0 [[63, 325]] 1.0 2onl CAMK_MAPKAPK2_HUMAN CAMK 7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2ONLD 46 393 400.0 No_ligand No_ligand Inactive DFGin 4.225 13.848 BLAminus -137.37, 177.77 67.14, 69.15 -84.34, 79.92 286.72, 38.57 -108.36, -19.15 out-out out 11.005 Saltbr-out 7.408 HRD-out -59.16, 114.42 -89.49, -17.7 out-in-out SNCoio in-out ActLoopNT-in 2.595 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -152.0, 123.99 APE9-dihe-na -67.05, 173.86 APE8-dihe-out -109.94, -76.7 APE8-rot-out 147.79 APE67-dihe-out -164.84, -165.18 -122.96, 14.75 APE12-dist-out 31.018 APE11-dist-out 34.196 APE10-dist-out 36.371 APE9-dist-out 29.902 None None None XRAY 4.0 0.315 0.331 D 406 313 35 0 0 0 [[63, 325]] 1.0 2onl CAMK_MAPKAPK2_HUMAN CAMK 7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3WI6A 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.536 13.832 BLAminus -135.2, -179.28 63.48, 87.85 -99.08, 27.55 280.11, 67.56 -72.5, -23.63 out-out out 10.624 Saltbr-out 6.333 HRD-in -70.73, -49.93 64.06, 23.09 out-in-none SNCoin in-none ActLoopNT-in 2.805 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -94.82, -2.38 999.0, 84.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 A 324 282 20 0 0 10 [[63, 325]] 1.0 3wi6 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3WI6B 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.515 13.714 BLAminus -134.59, 176.34 65.99, 87.98 -98.51, 25.22 282.93, 64.99 -67.04, -26.83 out-out out 10.562 Saltbr-out 6.423 HRD-in -66.95, -50.26 60.54, 21.62 out-in-none SNCoin in-none ActLoopNT-in 2.866 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.97, 0.01 999.0, 94.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 B 324 283 19 0 0 10 [[63, 325]] 1.0 3wi6 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3WI6C 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.504 13.721 BLAminus -134.82, 178.56 63.86, 88.03 -96.41, 23.84 282.48, 61.55 -65.28, -26.77 out-out out 10.611 Saltbr-out 6.149 HRD-in -68.02, -48.56 59.13, 24.29 out-in-none SNCoin in-none ActLoopNT-in 2.819 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -95.37, 0.55 999.0, 92.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 C 324 283 19 0 0 10 [[63, 325]] 1.0 3wi6 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3WI6D 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.584 13.811 BLAminus -134.2, 179.76 62.42, 89.36 -98.33, 27.39 283.59, 63.54 -69.5, -24.8 out-out out 10.711 Saltbr-out 6.248 HRD-in -69.08, -49.01 61.71, 22.88 out-in-none SNCoin in-none ActLoopNT-in 2.864 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -93.52, -6.37 999.0, 92.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 D 324 282 20 0 0 10 [[63, 325]] 1.0 3wi6 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3WI6E 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.572 13.765 BLAminus -140.29, 177.62 64.15, 87.56 -97.84, 28.21 283.48, 62.99 -68.98, -27.5 out-out out 10.68 Saltbr-out 6.68 HRD-in -69.93, -48.5 64.52, 21.01 out-in-none SNCoin in-none ActLoopNT-in 2.898 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -99.02, -1.95 999.0, 92.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 E 324 283 19 0 0 10 [[63, 325]] 1.0 3wi6 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3WI6F 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.55 13.75 BLAminus -134.82, 178.96 64.08, 87.79 -97.95, 26.96 281.15, 62.98 -67.35, -27.07 out-out out 10.599 Saltbr-out 6.064 HRD-in -71.75, -47.02 59.62, 20.27 out-in-none SNCoin in-none ActLoopNT-in 2.854 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -95.39, -0.45 999.0, 88.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 F 324 283 19 0 0 10 [[63, 325]] 1.0 3wi6 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3FPMA 44 345 400.0 793:1 Type1 Inactive DFGin 4.526 13.6 BLAminus -111.73, -179.28 68.06, 93.12 -104.74, 29.09 277.15, 66.6 -75.69, -5.19 out-out out 10.299 Saltbr-out 6.423 HRD-in -77.57, -45.45 63.38, 17.34 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.98 APE8-rot-in 312.19 APE67-dihe-out -94.66, 6.84 -102.2, 101.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.284 0.337 A 325 283 19 0 0 9 [[63, 325]] 1.0 3fpm CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2P3GX 45 364 400.0 F10:401 Type1 Inactive DFGin 4.636 13.497 BLAminus -126.99, -179.06 63.74, 79.6 -89.5, 29.28 285.47, 37.86 -65.44, -2.41 out-out out 10.049 Saltbr-out 5.912 HRD-in -79.61, -38.01 59.63, 23.28 out-in-none SNCoin in-none ActLoopNT-in 2.77 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.8 0.303 0.374 X 327 282 38 0 0 17 [[63, 325]] 1.0 2p3g CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3FYJX 45 364 400.0 B97:372 Type1 Inactive DFGin 4.808 12.764 BLAminus -143.93, -168.45 50.75, 86.11 -92.87, 22.38 289.04, 32.96 -62.16, -2.8 out-out out 10.249 Saltbr-out 6.285 HRD-in -79.69, -43.1 68.94, 27.85 out-in-none SNCoin in-none ActLoopNT-in 2.466 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.8 0.331 0.388 X 327 282 38 0 0 17 [[63, 325]] 1.0 3fyj CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3FYKX 45 364 400.0 B98:372 Type1 Inactive DFGin 4.312 13.507 BLAminus -134.88, -177.51 58.62, 91.5 -96.03, 29.83 280.37, 46.93 -66.4, -8.98 out-out out 10.374 Saltbr-out 6.291 HRD-in -78.77, -40.47 62.21, 24.85 out-in-none SNCoin in-none ActLoopNT-in 2.877 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.5 0.267 0.296 X 327 282 38 0 0 17 [[63, 325]] 1.0 3fyk CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
7NRYX 45 366 400.0 B97:401 Type1 Inactive DFGin 4.627 14.222 BLAminus -139.32, 169.04 60.45, 76.63 -78.82, 16.72 283.41, 68.06 -65.88, -11.72 out-out out 10.683 Saltbr-out 7.218 HRD-in -78.99, -50.58 73.3, 6.74 out-in-none SNCoin in-none ActLoopNT-in 3.137 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.8 0.235 0.275 X 327 283 39 0 0 17 [[63, 325]] 1.0 7nry CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBOA 44 347 400.0 P4O:1348 Type1 Inactive DFGin 4.522 13.443 BLAminus -128.45, 174.66 76.7, 105.07 -117.13, 15.66 280.46, 72.55 -57.97, -19.55 in-in in 9.062 Saltbr-in 2.814 HRD-in -85.59, -45.77 68.85, 12.78 in-in-out SNCiio in-out ActLoopNT-in 2.892 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 115.47 APE9-dihe-na -176.67, 6.0 APE8-dihe-in -119.96, 55.28 APE8-rot-out 175.51 APE67-dihe-in -48.92, -37.26 -101.11, -10.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 31.255 APE9-dist-out 36.058 None None None XRAY 3.1 0.232 0.274 A 326 296 8 0 0 8 [[63, 325]] 1.0 2jbo CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPL 44 345 400.0 P4O:1345 Type1 Inactive DFGin 4.327 13.69 BLAminus -115.16, -156.79 35.96, 109.78 -107.71, 6.88 277.06, 60.03 -55.27, -5.39 in-out in 8.636 Saltbr-out 3.699 HRD-in -78.67, -41.91 74.03, 10.39 out-in-none SNCoin in-none ActLoopNT-in 2.794 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 L 326 268 34 0 0 18 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
9R59A 48 364 400.0 A1JH4:60401 Type1 Inactive DFGin 4.506 13.971 BLAminus -133.79, -179.1 58.15, 93.82 -95.19, 25.62 274.7, 64.62 -81.37, 7.19 out-none out 10.304 Saltbr-none 999.0 HRD-in -85.22, -50.74 73.31, 11.03 none-in-none SNCnin in-none ActLoopNT-in 2.927 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.202 0.229 A 320 280 37 0 0 18 [[63, 325]] 1.0 9r59 CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
1NXKD 43 342 400.0 STU:401 Type1 Inactive DFGin 4.831 13.91 BLAminus -136.01, 172.45 58.97, 96.18 -97.02, 30.62 280.59, 64.96 -55.97, -37.81 in-in in 8.803 Saltbr-in 2.649 HRD-in -61.55, -54.52 76.31, -8.43 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 21.79 APE9-dihe-na -95.93, -89.71 APE8-dihe-out 87.4, 89.72 APE8-rot-in 304.66 APE67-dihe-out -57.06, -12.13 -63.98, 136.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 30.487 APE9-dist-out 33.331 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 D 400 288 12 0 0 8 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CB 47 345 400.0 PDY:1,PDY:2 Type1,Allosteric Inactive DFGin 4.737 13.553 BLAminus -125.31, 179.32 62.03, 93.3 -105.16, 21.09 287.49, 59.11 -59.5, -21.99 in-out in 9.297 Saltbr-out 4.157 HRD-in -77.44, -36.26 59.31, 7.54 out-in-none SNCoin in-none ActLoopNT-in 3.019 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 B 324 277 22 0 0 13 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CI 48 343 400.0 PDY:1,PDY:2 Type1,Allosteric Inactive DFGin 4.809 13.72 BLAminus -125.53, 174.35 66.59, 96.73 -108.15, 23.97 284.55, 62.17 -70.07, 2.45 in-out in 9.281 Saltbr-out 4.752 HRD-in -79.24, -45.58 66.95, 0.2 out-in-none SNCoin in-none ActLoopNT-in 2.94 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 I 324 275 21 0 0 12 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6T8XA 44 330 400.0 B97:401,MW8:403 Type1,Allosteric Inactive DFGin 4.57 13.434 BLAminus -131.03, 170.9 67.7, 100.81 -106.86, 34.47 292.12, 79.14 -67.76, -27.73 in-in in 8.612 Saltbr-in 2.792 HRD-in -69.35, -49.87 72.11, 11.43 in-in-out SNCiio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.12 APE8-dihe-in -95.72, 126.31 APE8-rot-in 315.68 APE67-dihe-in -58.39, -33.83 -52.68, -49.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.841 T222E,T334E None None XRAY 2.81 0.229 0.247 A 319 279 8 0 0 8 [[63, 325]] 1.0 6t8x CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6T8XD 44 331 400.0 B97:401,MW8:403 Type1,Allosteric Inactive DFGin 4.483 13.55 BLAminus -130.63, 174.14 63.49, 94.3 -98.34, 31.83 289.68, 73.36 -61.87, -29.24 in-in in 8.601 Saltbr-in 2.791 HRD-in -63.87, -41.66 67.57, -0.14 in-in-out SNCiio in-out ActLoopNT-in 2.996 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 38.4 APE9-dihe-na -174.63, 165.43 APE8-dihe-in -95.48, 125.63 APE8-rot-in 314.21 APE67-dihe-in -57.53, -34.17 -53.38, -48.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 32.963 APE9-dist-out 33.763 T222E,T334E None None XRAY 2.81 0.229 0.247 D 319 280 8 0 0 8 [[63, 325]] 1.0 6t8x CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6T8XE 45 329 400.0 B97:401,MW8:403 Type1,Allosteric Inactive DFGin 4.527 13.597 BLAminus -130.92, 174.05 63.5, 95.58 -99.57, 31.94 289.7, 73.63 -62.69, -28.68 in-in in 8.618 Saltbr-in 2.792 HRD-in -71.65, -41.81 62.96, 8.53 in-in-out SNCiio in-out ActLoopNT-in 2.995 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 30.44 APE9-dihe-na -173.7, 165.91 APE8-dihe-in -95.92, 126.31 APE8-rot-in 315.63 APE67-dihe-in -58.29, -33.74 -53.7, -48.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 32.403 APE9-dist-out 33.801 T222E,T334E None None XRAY 2.81 0.229 0.247 E 319 277 8 0 0 8 [[63, 325]] 1.0 6t8x CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6T8XF 45 329 400.0 B97:401,MW8:403 Type1,Allosteric Inactive DFGin 4.489 13.68 BLAminus -127.96, 174.83 62.76, 90.11 -94.3, 29.64 283.77, 77.92 -65.54, -27.43 in-in in 8.611 Saltbr-in 2.786 HRD-in -71.8, -44.12 66.14, 4.48 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.56 APE8-dihe-in -95.39, 126.47 APE8-rot-in 315.37 APE67-dihe-in -57.73, -34.19 -54.15, -48.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.826 T222E,T334E None None XRAY 2.81 0.229 0.247 F 319 276 9 0 0 9 [[63, 325]] 1.0 6t8x CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BC 47 345 400.0 No_ligand No_ligand None DFGin 4.699 13.755 BLAminus -145.08, 171.25 61.11, 107.16 -112.51, 31.96 284.23, 68.66 -61.45, -37.77 in-in in 8.935 Saltbr-in 2.757 HRD-in -69.97, -44.39 78.89, -25.31 in-in-none SNCiin in-none ActLoopNT-in 3.064 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.67, -20.62 999.0, 173.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 C 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BD 47 345 400.0 No_ligand No_ligand None DFGin 4.711 13.906 BLAminus -145.79, 167.53 68.59, 102.7 -108.4, 30.91 282.62, 68.72 -66.3, -36.77 in-in in 8.983 Saltbr-in 3.408 HRD-in -69.48, -46.19 68.3, 18.38 in-in-none SNCiin in-none ActLoopNT-in 3.29 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -107.53, -10.82 999.0, -167.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 D 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BE 47 345 400.0 No_ligand No_ligand None DFGin 4.837 13.766 BLAminus -139.59, 169.54 69.21, 97.38 -104.17, 34.32 282.85, 67.94 -62.67, -38.94 in-in in 8.985 Saltbr-in 2.679 HRD-in -71.5, -45.64 70.77, 10.18 in-in-none SNCiin in-none ActLoopNT-in 3.092 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -99.43, -1.37 999.0, -172.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 E 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BF 47 345 400.0 No_ligand No_ligand None DFGin 4.621 13.688 BLAminus -142.07, 170.01 64.83, 98.1 -101.81, 30.72 282.18, 71.32 -65.73, -35.15 in-in in 8.992 Saltbr-in 2.702 HRD-in -80.67, -40.94 69.92, -1.27 in-in-none SNCiin in-none ActLoopNT-in 3.032 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -101.55, -20.21 999.0, -176.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 F 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BG 47 345 400.0 No_ligand No_ligand None DFGin 4.714 14.011 BLAminus -137.77, 173.07 72.09, 96.81 -108.03, 29.22 281.02, 70.25 -63.92, -39.04 in-in in 9.1 Saltbr-in 2.657 HRD-in -83.07, -38.78 69.53, -15.76 in-in-none SNCiin in-none ActLoopNT-in 2.998 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -92.27, -2.06 999.0, -177.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 G 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BH 47 345 400.0 No_ligand No_ligand None DFGin 4.783 13.684 BLAminus -141.56, 171.1 67.42, 98.81 -106.45, 32.94 281.72, 69.09 -63.41, -39.6 in-in in 8.81 Saltbr-in 2.638 HRD-in -69.99, -38.96 66.77, 4.24 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -98.5, -19.42 999.0, -171.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 H 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BI 47 345 400.0 No_ligand No_ligand None DFGin 4.832 13.615 BLAminus -144.83, 172.47 66.99, 98.69 -105.77, 31.32 281.48, 70.34 -64.97, -40.42 in-none in 8.902 Saltbr-none 999.0 HRD-in -71.72, -44.4 66.46, 8.73 none-in-none SNCnin in-none ActLoopNT-in 2.992 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -89.48, -16.84 999.0, -178.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 I 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BJ 47 345 400.0 No_ligand No_ligand None DFGin 4.585 13.726 BLAminus -139.73, 172.93 64.33, 98.73 -104.15, 24.81 279.87, 69.77 -58.59, -39.13 in-in in 8.829 Saltbr-in 2.742 HRD-in -76.49, -44.95 70.08, 8.99 in-in-none SNCiin in-none ActLoopNT-in 3.006 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -95.9, -9.71 999.0, -177.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 J 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BK 47 345 400.0 No_ligand No_ligand None DFGin 4.649 13.886 BLAminus -142.88, 173.31 64.15, 96.21 -100.21, 30.51 279.28, 69.33 -63.22, -35.24 in-in in 8.951 Saltbr-in 2.645 HRD-in -75.63, -40.1 74.89, -28.49 in-in-none SNCiin in-none ActLoopNT-in 3.055 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -102.3, -6.38 999.0, -170.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 K 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BL 47 345 400.0 No_ligand No_ligand None DFGin 4.754 13.811 BLAminus -149.62, 172.88 62.04, 95.8 -100.2, 29.15 282.37, 69.48 -62.27, -33.8 in-in in 8.809 Saltbr-in 2.54 HRD-in -71.4, -42.73 71.32, 3.36 in-in-none SNCiin in-none ActLoopNT-in 3.086 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -93.48, -10.45 999.0, 179.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 L 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3G 43 342 400.0 No_ligand No_ligand None DFGin 4.403 12.831 BLAminus -153.55, -179.38 55.29, 116.19 -117.23, 10.89 291.13, 75.69 -43.5, -24.71 in-in in 8.551 Saltbr-in 3.076 HRD-in -68.58, -34.89 71.69, -26.95 in-in-none SNCiin in-none ActLoopNT-in 3.413 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 G 324 276 24 0 0 14 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPJ 48 328 400.0 No_ligand No_ligand None DFGin 4.458 13.647 BLAminus -143.07, -174.18 50.09, 100.81 -101.05, 31.78 269.94, 23.78 -83.21, -13.12 in-in in 8.094 Saltbr-in 3.175 HRD-in -63.4, -41.75 72.41, 26.69 in-in-none SNCiin in-none ActLoopNT-in 3.026 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 J 326 225 56 0 0 18 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
8XX1A 47 364 400.0 No_ligand No_ligand None DFGin 4.495 14.22 BLAminus -125.96, 176.04 66.8, 91.73 -96.65, 23.36 281.49, 65.79 -64.79, -14.16 in-in in 9.722 Saltbr-in 2.918 HRD-in -77.76, -52.02 68.77, 17.81 in-in-none SNCiin in-none ActLoopNT-in 2.956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.55 0.17 0.245 A 318 293 25 0 0 17 [[63, 325]] 1.0 8xx1 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BA 47 345 400.0 05B:1000 Type1 None DFGin 4.793 14.039 BLAminus -133.6, 172.77 62.95, 100.31 -104.2, 34.41 278.04, 66.12 -71.39, -34.54 in-in in 9.008 Saltbr-in 2.409 HRD-in -83.09, -47.43 74.93, -6.02 in-in-none SNCiin in-none ActLoopNT-in 3.112 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.52, -24.55 999.0, -179.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 A 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2BB 47 345 400.0 05B:1000 Type1 None DFGin 4.54 13.845 BLAminus -142.13, 174.13 65.41, 93.56 -99.51, 29.64 280.69, 67.08 -63.86, -41.52 in-in in 9.102 Saltbr-in 2.593 HRD-in -69.44, -43.13 63.83, 12.28 in-in-none SNCiin in-none ActLoopNT-in 3.017 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.51, -10.75 999.0, -173.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 B 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R2YA 46 345 400.0 P4O:3 Type1 None DFGin 4.51 13.529 BLAminus -139.75, 177.52 74.44, 98.73 -113.49, 19.9 276.17, 64.33 -51.78, -25.44 in-in in 8.652 Saltbr-in 2.551 HRD-in -79.45, -34.37 67.58, -79.89 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.294 0.334 A 319 259 41 0 0 18 [[63, 325]] 1.0 3r2y CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3R30A 46 345 400.0 CD2:1 Type1 None DFGin 4.276 13.617 BLAminus -134.32, 174.77 70.14, 102.44 -110.03, 21.6 275.81, 65.59 -62.22, -28.91 in-in in 8.733 Saltbr-in 2.951 HRD-in -89.69, -43.87 75.38, -83.52 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.284 0.332 A 319 264 36 0 0 16 [[63, 325]] 1.0 3r30 CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2PZYA 42 346 400.0 B18:1 Type1 None DFGin 4.58 13.976 BLAminus -104.95, 167.84 71.31, 102.38 -102.76, 24.4 284.1, 63.71 -59.24, -43.49 in-in in 8.6 Saltbr-in 2.624 HRD-in -76.66, -46.66 68.5, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.747 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -117.11, -34.75 999.0, -126.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 A 324 291 14 0 0 11 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2PZYB 44 345 400.0 B18:2 Type1 None DFGin 4.541 13.833 BLAminus -135.83, 172.16 61.22, 108.34 -113.0, 27.32 291.58, 57.74 -68.8, -9.66 in-in in 8.917 Saltbr-in 2.953 HRD-in -74.89, -51.86 41.3, 40.89 in-in-none SNCiin in-none ActLoopNT-in 2.826 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.0, -7.36 999.0, 151.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 B 324 283 19 0 0 11 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2PZYC 42 359 400.0 STU:3 Type1 None DFGin 4.742 13.584 BLAminus -137.32, 155.33 89.76, 83.85 -93.67, 22.39 287.9, 52.26 -71.67, 3.21 in-in in 8.899 Saltbr-in 2.479 HRD-in -82.26, -44.82 71.63, -15.61 in-in-none SNCiin in-none ActLoopNT-in 2.823 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.01, -7.47 999.0, -140.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 C 324 307 11 0 0 11 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3A 43 347 400.0 MK2:500 Type1 None DFGin 4.557 13.885 BLAminus -135.8, -176.83 67.41, 90.4 -94.59, 16.73 291.73, 73.07 -43.87, -36.09 in-in in 9.109 Saltbr-in 2.597 HRD-in -79.47, -55.59 75.47, 16.47 in-in-none SNCiin in-none ActLoopNT-in 3.09 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.87, 1.13 999.0, 124.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 A 324 288 17 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3B 44 349 400.0 MK2:500 Type1 None DFGin 4.882 13.792 BLAminus -132.93, 176.5 69.16, 89.86 -95.19, 24.7 286.31, 75.82 -62.52, -14.87 in-in in 8.556 Saltbr-in 2.527 HRD-in -84.62, -39.61 65.84, 1.69 in-in-none SNCiin in-none ActLoopNT-in 3.033 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -67.96, -17.69 999.0, 172.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 B 324 290 16 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3C 41 345 400.0 MK2:500 Type1 None DFGin 4.718 13.596 BLAminus -138.58, -178.81 60.4, 102.94 -104.46, 17.28 285.49, 73.29 -64.82, -5.96 in-in in 8.931 Saltbr-in 2.774 HRD-in -72.28, -46.2 69.4, 2.58 in-in-none SNCiin in-none ActLoopNT-in 2.986 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.35, -6.27 999.0, 125.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 C 324 281 24 0 0 12 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3D 46 342 400.0 MK2:500 Type1 None DFGin 4.505 13.916 BLAminus -137.86, 175.26 61.96, 98.93 -99.81, 17.41 286.59, 67.21 -44.85, -25.56 in-in in 8.851 Saltbr-in 2.546 HRD-in -66.46, -43.69 66.23, -1.99 in-in-none SNCiin in-none ActLoopNT-in 2.83 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 D 324 269 28 0 0 15 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3E 44 345 400.0 MK2:500 Type1 None DFGin 4.773 13.965 BLAminus -128.92, -178.83 60.96, 110.53 -118.06, 18.13 288.23, 69.3 -53.96, -31.23 in-in in 9.094 Saltbr-in 2.496 HRD-in -67.96, -46.81 65.87, -10.72 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -176.66, -15.58 999.0, -104.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 E 324 287 15 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3F 44 350 400.0 MK2:500 Type1 None DFGin 4.917 13.869 BLAminus -134.88, 179.04 76.75, 94.93 -104.84, 22.2 282.85, 74.6 -64.74, -17.47 in-in in 8.995 Saltbr-in 2.731 HRD-in -79.49, -56.77 86.68, 2.72 in-in-none SNCiin in-none ActLoopNT-in 2.94 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.34, 144.53 999.0, 179.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 F 324 293 14 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3H 44 350 400.0 MK2:500 Type1 None DFGin 4.607 13.429 BLAminus -138.19, -172.17 57.05, 102.0 -106.68, 27.15 292.81, 72.2 -57.13, -29.31 in-in in 8.726 Saltbr-in 2.696 HRD-in -74.06, -45.37 69.29, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.761 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.73, -8.44 999.0, 98.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 H 324 290 17 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3I 45 356 400.0 MK2:500 Type1 None DFGin 4.689 13.646 BLAminus -127.79, 171.26 71.85, 103.11 -106.85, 28.41 284.17, 74.69 -57.35, -27.49 in-in in 8.555 Saltbr-in 2.402 HRD-in -93.72, -30.87 60.32, -1.04 in-in-none SNCiin in-none ActLoopNT-in 2.894 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 I 324 295 17 0 0 13 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3J 43 348 400.0 MK2:500 Type1 None DFGin 4.718 13.802 BLAminus -125.72, -175.9 62.46, 84.05 -88.35, 25.1 281.01, 81.77 -82.54, 2.25 in-in in 9.128 Saltbr-in 3.314 HRD-in -78.38, -40.95 69.7, 4.74 in-in-none SNCiin in-none ActLoopNT-in 3.075 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.62, -14.39 999.0, 120.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 J 324 288 18 0 0 9 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3K 44 345 400.0 MK2:500 Type1 None DFGin 4.468 13.615 BLAminus -140.04, -177.82 52.3, 117.47 -116.32, 11.78 277.13, 82.36 -69.91, 0.72 in-in in 8.958 Saltbr-in 2.78 HRD-in -74.88, -50.37 73.49, 9.77 in-in-none SNCiin in-none ActLoopNT-in 3.333 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 K 324 280 22 0 0 14 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KC3L 42 348 400.0 MK2:500 Type1 None DFGin 4.821 13.855 BLAminus -130.63, 174.42 78.71, 90.78 -100.08, 26.64 282.13, 65.04 -59.13, -39.73 in-in in 9.255 Saltbr-in 2.663 HRD-in -90.63, -50.0 65.8, 13.75 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.39, -28.9 999.0, 127.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 L 324 291 16 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPA 46 350 400.0 P4O:1351 Type1 None DFGin 4.478 13.85 BLAminus -133.98, 174.95 70.89, 89.1 -93.56, 24.83 287.0, 65.27 -55.43, -29.01 in-in in 8.726 Saltbr-in 2.604 HRD-in -85.33, -35.83 65.16, 16.45 in-in-none SNCiin in-none ActLoopNT-in 3.057 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 A 326 283 22 0 0 15 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPB 46 350 400.0 P4O:1351 Type1 None DFGin 4.579 13.852 BLAminus -138.34, 174.48 73.85, 84.83 -88.84, 30.16 284.72, 60.62 -64.51, -26.86 in-in in 8.707 Saltbr-in 2.535 HRD-in -85.86, -36.04 69.02, 7.05 in-in-none SNCiin in-none ActLoopNT-in 3.061 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -40.26, -29.78 999.0, 121.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 B 326 290 15 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPC 46 350 400.0 P4O:1351 Type1 None DFGin 4.503 13.831 BLAminus -133.29, -179.58 64.71, 93.56 -95.15, 25.62 283.97, 64.1 -59.22, -26.85 in-in in 8.767 Saltbr-in 2.926 HRD-in -80.25, -42.98 69.55, 17.83 in-in-none SNCiin in-none ActLoopNT-in 3.088 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.2, -7.86 999.0, 175.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 C 326 284 21 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPD 47 350 400.0 P4O:1351 Type1 None DFGin 4.523 13.952 BLAminus -137.03, -179.33 64.04, 94.44 -97.23, 21.04 282.65, 66.88 -48.31, -30.44 in-in in 8.832 Saltbr-in 2.714 HRD-in -81.64, -32.5 57.25, 21.38 in-in-none SNCiin in-none ActLoopNT-in 2.967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -148.58, -26.73 999.0, -145.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 D 326 286 18 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPE 44 345 400.0 P4O:1345 Type1 None DFGin 4.724 13.859 BLAminus -136.12, 175.35 73.31, 80.12 -82.5, 33.85 283.92, 48.58 -62.96, -45.19 in-in in 8.59 Saltbr-in 2.959 HRD-in -104.14, -29.02 60.75, 18.27 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -151.62, -21.91 999.0, -152.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 E 326 283 19 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPF 45 350 400.0 P4O:1350 Type1 None DFGin 4.595 13.837 BLAminus -132.13, 175.04 70.48, 88.46 -92.2, 24.44 284.08, 67.86 -58.09, -29.79 in-in in 8.685 Saltbr-in 2.569 HRD-in -92.78, -39.0 72.25, 8.97 in-in-none SNCiin in-none ActLoopNT-in 3.082 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -131.16, 4.71 999.0, 165.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 F 326 288 18 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPG 45 350 400.0 P4O:1350 Type1 None DFGin 4.58 13.726 BLAminus -138.34, 174.28 71.04, 87.0 -92.84, 24.64 284.29, 71.24 -62.44, -18.91 in-in in 8.739 Saltbr-in 2.523 HRD-in -84.59, -34.64 66.84, 14.57 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.82, -9.25 999.0, -129.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 G 326 288 18 0 0 10 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPH 46 347 400.0 P4O:1347 Type1 None DFGin 4.207 13.746 BLAminus -134.88, 173.26 70.14, 89.63 -96.59, 27.77 281.47, 58.87 -55.42, -35.35 in-in in 8.808 Saltbr-in 2.548 HRD-in -90.46, -32.76 68.86, 13.14 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 H 326 283 19 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPI 45 350 400.0 P4O:1351 Type1 None DFGin 4.558 13.813 BLAminus -140.96, 171.77 69.8, 89.64 -96.08, 24.27 287.29, 67.6 -46.64, -33.04 in-in in 8.736 Saltbr-in 2.735 HRD-in -89.03, -36.29 66.61, 16.32 in-in-none SNCiin in-none ActLoopNT-in 3.06 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -162.11, 79.7 999.0, -145.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 I 326 289 17 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
2JBPK 47 345 400.0 P4O:1345 Type1 None DFGin 4.452 13.779 BLAminus -134.43, 174.45 70.58, 87.87 -93.92, 23.8 282.34, 69.99 -55.95, -30.42 in-in in 8.751 Saltbr-in 2.364 HRD-in -80.27, -34.62 66.03, 15.08 in-in-none SNCiin in-none ActLoopNT-in 3.168 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 K 326 265 34 0 0 19 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKA 46 350 400.0 P4O:1 Type1 None DFGin 4.589 13.771 BLAminus -126.65, 173.47 71.0, 100.22 -103.09, 25.12 288.21, 68.89 -63.74, -22.07 in-in in 8.808 Saltbr-in 2.833 HRD-in -83.14, -45.68 70.24, 10.29 in-in-none SNCiin in-none ActLoopNT-in 2.999 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 A 334 285 20 0 0 13 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKB 46 350 400.0 P4O:1 Type1 None DFGin 4.574 13.71 BLAminus -126.17, 171.53 76.59, 101.21 -106.82, 28.17 283.51, 70.31 -69.3, -20.78 in-in in 8.8 Saltbr-in 2.767 HRD-in -83.32, -42.01 66.8, 9.77 in-in-none SNCiin in-none ActLoopNT-in 2.956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -76.35, -4.83 999.0, -139.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 B 334 290 15 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKC 46 350 400.0 P4O:1 Type1 None DFGin 4.542 13.708 BLAminus -127.95, 171.63 72.32, 100.54 -105.36, 27.99 284.77, 68.66 -70.12, -18.04 in-in in 8.818 Saltbr-in 2.76 HRD-in -83.09, -44.86 72.76, 6.72 in-in-none SNCiin in-none ActLoopNT-in 3.021 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -151.92, 3.8 999.0, -64.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 C 334 285 20 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKD 46 350 400.0 P4O:1 Type1 None DFGin 4.552 13.762 BLAminus -126.6, 170.16 75.93, 99.4 -106.12, 27.5 286.71, 67.62 -64.49, -22.4 in-in in 8.826 Saltbr-in 2.7 HRD-in -78.53, -45.63 70.0, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 D 334 283 22 0 0 15 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKE 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.694 BLAminus -126.73, 170.86 73.31, 97.65 -100.72, 25.15 284.53, 70.5 -65.36, -19.29 in-in in 8.823 Saltbr-in 2.816 HRD-in -80.98, -44.08 70.38, 5.75 in-in-none SNCiin in-none ActLoopNT-in 3.006 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -110.91, 12.45 999.0, 143.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 E 334 290 15 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKF 46 350 400.0 P4O:1 Type1 None DFGin 4.474 13.706 BLAminus -127.85, 174.17 70.83, 96.56 -99.93, 26.89 286.07, 67.62 -67.09, -18.68 in-in in 8.833 Saltbr-in 2.795 HRD-in -80.56, -45.1 72.92, 6.47 in-in-none SNCiin in-none ActLoopNT-in 3.015 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -140.44, 23.91 999.0, -39.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 F 334 284 21 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKG 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.723 BLAminus -127.83, 169.9 76.58, 97.3 -103.07, 31.55 285.98, 70.31 -69.86, -24.12 in-in in 8.832 Saltbr-in 2.773 HRD-in -83.6, -42.88 70.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.958 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.46 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 G 334 286 19 0 0 12 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKH 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.701 BLAminus -127.46, 173.5 71.38, 99.68 -106.67, 28.02 284.54, 69.36 -65.15, -20.54 in-in in 8.87 Saltbr-in 2.758 HRD-in -82.45, -44.8 70.18, 5.58 in-in-none SNCiin in-none ActLoopNT-in 2.987 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.35, 40.25 999.0, -116.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 H 334 290 15 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKI 46 350 400.0 P4O:1 Type1 None DFGin 4.446 13.686 BLAminus -127.75, 172.18 73.28, 98.61 -103.78, 25.37 284.35, 71.35 -64.93, -20.35 in-in in 8.771 Saltbr-in 2.738 HRD-in -82.7, -44.15 67.61, 9.58 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -120.54, 0.33 999.0, -77.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 I 334 284 21 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKJ 46 350 400.0 P4O:1 Type1 None DFGin 4.516 13.696 BLAminus -125.94, 171.03 73.59, 99.21 -101.22, 24.36 288.17, 72.78 -63.96, -20.62 in-in in 8.837 Saltbr-in 2.841 HRD-in -84.33, -42.62 69.41, 8.71 in-in-none SNCiin in-none ActLoopNT-in 3.076 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 J 334 283 22 0 0 15 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKK 46 350 400.0 P4O:1 Type1 None DFGin 4.495 13.74 BLAminus -127.59, 167.14 77.13, 99.42 -103.98, 27.43 284.8, 74.73 -67.14, -17.07 in-in in 8.865 Saltbr-in 2.825 HRD-in -83.96, -44.73 69.47, 7.73 in-in-none SNCiin in-none ActLoopNT-in 3.043 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.78, -37.53 999.0, -135.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 K 334 290 15 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3GOKL 46 350 400.0 P4O:1 Type1 None DFGin 4.548 13.687 BLAminus -128.35, 173.4 71.1, 97.91 -103.12, 25.34 286.16, 67.54 -60.79, -25.02 in-in in 8.821 Saltbr-in 2.744 HRD-in -84.04, -41.11 66.0, 8.07 in-in-none SNCiin in-none ActLoopNT-in 3.03 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -106.57, 23.19 999.0, 177.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 L 334 284 21 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KA0A 47 364 400.0 MK3:500 Type1 None DFGin 4.835 13.747 BLAminus -134.09, 176.23 64.42, 97.77 -108.27, 26.09 291.3, 65.21 -54.85, -29.31 in-in in 9.224 Saltbr-in 2.84 HRD-in -80.5, -45.65 65.5, 4.98 in-in-none SNCiin in-none ActLoopNT-in 2.817 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E None None XRAY 2.9 0.232 0.265 A 320 279 39 0 0 19 [[63, 325]] 1.0 3ka0 CAMK_MAPKAPK2_HUMAN CAMK 7.7e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
1NXKA 42 345 400.0 STU:401 Type1 None DFGin 4.829 13.428 BLAminus -122.05, -170.73 42.15, 101.84 -103.58, 19.28 282.18, 65.24 -58.03, -23.15 in-in in 8.716 Saltbr-in 2.473 HRD-in -79.4, -39.47 62.13, 0.83 in-in-none SNCiin in-none ActLoopNT-in 2.683 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.16, 3.04 999.0, 148.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 A 400 290 14 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
1NXKB 44 345 400.0 STU:403 Type1 None DFGin 4.577 13.822 BLAminus -128.27, 177.79 53.09, 103.0 -104.87, 20.3 276.49, 67.38 -57.0, -14.43 in-in in 8.647 Saltbr-in 2.563 HRD-in -64.22, -46.2 66.47, 1.25 in-in-none SNCiin in-none ActLoopNT-in 2.82 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.0, -19.87 999.0, 111.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 B 400 283 19 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
1NXKC 41 357 400.0 STU:401 Type1 None DFGin 4.963 13.774 BLAminus -132.89, 178.15 57.47, 93.76 -100.34, 25.49 283.43, 65.32 -70.88, 11.4 in-in in 8.684 Saltbr-in 2.34 HRD-in -75.36, -47.72 65.17, 8.17 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.28, 2.34 999.0, 115.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 C 400 306 11 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3KGAA 47 364 400.0 LX9:365 Type1 None DFGin 4.446 13.678 BLAminus -124.87, 174.18 69.13, 92.77 -95.92, 21.23 282.6, 67.95 -62.32, -18.3 in-in in 8.84 Saltbr-in 2.692 HRD-in -73.16, -55.01 73.82, 13.46 in-in-none SNCiin in-none ActLoopNT-in 3.001 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.55 0.183 0.235 A 299 290 7 0 0 0 [[63, 325]] 1.0 3kga CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
3M2WA 47 364 400.0 L8I:1 Type1 None DFGin 4.422 13.673 BLAminus -122.16, 170.83 75.18, 88.88 -90.88, 16.66 279.1, 67.47 -57.47, -17.13 in-in in 8.951 Saltbr-in 2.544 HRD-in -74.98, -51.41 69.8, 12.51 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.41 0.187 0.227 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m2w CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
3M42A 47 364 400.0 HGF:365 Type1 None DFGin 4.265 13.765 BLAminus -127.28, 170.7 71.87, 101.44 -103.87, 20.75 277.01, 69.5 -61.92, -8.22 in-in in 9.26 Saltbr-in 3.091 HRD-in -73.72, -58.45 76.25, 11.76 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.68 0.186 0.232 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m42 CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
3A2CA 47 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 5.014 14.198 BLAminus -114.29, 177.7 65.08, 82.59 -97.76, 30.04 283.71, 62.65 -83.2, 2.17 in-in in 9.603 Saltbr-in 2.896 HRD-in -71.23, -50.47 72.84, 4.07 in-in-none SNCiin in-none ActLoopNT-in 2.824 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 A 324 274 24 0 0 13 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CC 48 342 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.716 14.256 BLAminus -128.21, 173.02 63.81, 82.24 -94.68, 28.25 283.43, 68.99 -82.34, 1.06 in-in in 9.591 Saltbr-in 3.278 HRD-in -77.67, -40.68 59.71, 0.01 in-in-none SNCiin in-none ActLoopNT-in 2.721 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 C 324 273 22 0 0 12 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CD 48 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.807 14.05 BLAminus -134.61, 177.48 60.17, 88.04 -99.2, 27.01 287.17, 57.58 -68.85, -16.25 in-in in 9.516 Saltbr-in 3.391 HRD-in -71.25, -48.29 67.38, -0.24 in-in-none SNCiin in-none ActLoopNT-in 2.893 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 D 324 277 20 0 0 13 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CE 48 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.811 14.494 BLAminus -118.71, 175.79 66.97, 85.41 -100.83, 39.75 283.04, 64.41 -78.69, -21.27 in-in in 9.883 Saltbr-in 3.247 HRD-in -75.69, -51.67 70.77, 11.52 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 E 324 276 21 0 0 12 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CF 47 345 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.629 13.803 BLAminus -127.88, 179.32 59.24, 93.48 -106.61, 16.66 278.85, 67.85 -68.32, 3.18 in-in in 9.127 Saltbr-in 2.699 HRD-in -69.45, -47.69 65.57, 9.98 in-in-none SNCiin in-none ActLoopNT-in 2.945 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 F 324 287 12 0 0 12 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CG 48 342 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.876 13.836 BLAminus -119.34, 176.47 66.35, 96.55 -109.04, 20.64 281.55, 64.63 -61.28, -15.4 in-in in 9.181 Saltbr-in 2.837 HRD-in -65.24, -45.15 65.73, 3.99 in-in-none SNCiin in-none ActLoopNT-in 3.16 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 G 324 273 22 0 0 12 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CH 47 343 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.744 14.093 BLAminus -121.63, 176.48 63.37, 90.03 -101.58, 35.19 280.13, 69.73 -76.98, -23.87 in-in in 9.443 Saltbr-in 2.813 HRD-in -82.97, -49.71 72.47, 4.66 in-in-none SNCiin in-none ActLoopNT-in 2.875 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 H 324 275 22 0 0 12 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CJ 48 343 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 5.134 14.239 BLAminus -131.68, 169.07 71.74, 90.49 -103.64, 47.99 277.77, 64.09 -101.18, 2.5 in-in in 9.268 Saltbr-in 2.955 HRD-in -70.85, -53.4 79.34, -2.41 in-in-none SNCiin in-none ActLoopNT-in 3.233 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 J 324 275 21 0 0 12 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CK 48 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.784 13.688 BLAminus -132.3, 173.04 63.29, 100.11 -111.51, 35.65 282.7, 65.16 -83.49, -1.19 in-in in 9.392 Saltbr-in 2.78 HRD-in -81.49, -46.78 68.74, 4.82 in-in-none SNCiin in-none ActLoopNT-in 2.939 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 K 324 273 24 0 0 13 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
3A2CL 48 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.92 14.32 BLAminus -139.15, 172.7 64.17, 88.89 -98.58, 16.8 276.6, 62.53 -69.99, 7.3 in-in in 9.404 Saltbr-in 3.576 HRD-in -76.45, -46.65 74.85, -9.83 in-in-none SNCiin in-none ActLoopNT-in 2.966 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 L 324 276 21 0 0 12 [[63, 325]] 1.0 3a2c CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6T8XB 45 329 400.0 B97:401,MW8:403 Type1,Allosteric None DFGin 4.499 13.631 BLAminus -129.76, 174.11 63.68, 95.47 -98.99, 32.39 289.86, 73.64 -62.73, -29.4 in-in in 8.644 Saltbr-in 2.799 HRD-in -70.3, -40.77 63.38, 5.93 in-in-none SNCiin in-none ActLoopNT-in 2.983 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.94 APE8-rot-in 320.74 APE67-dihe-in -57.79, -34.07 -54.58, -48.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E,T334E None None XRAY 2.81 0.229 0.247 B 319 276 9 0 0 9 [[63, 325]] 1.0 6t8x CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
6T8XC 44 329 400.0 B97:401,MW8:403 Type1,Allosteric None DFGin 4.542 13.623 BLAminus -130.94, 173.46 63.89, 94.6 -98.12, 31.68 290.58, 73.54 -62.98, -29.52 in-in in 8.608 Saltbr-in 2.836 HRD-in -74.07, -44.94 68.64, 5.14 in-in-none SNCiin in-none ActLoopNT-in 2.985 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.58 APE8-rot-in 319.09 APE67-dihe-in -57.21, -34.86 -54.2, -47.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E,T334E None None XRAY 2.81 0.229 0.247 C 319 276 10 0 0 10 [[63, 325]] 1.0 6t8x CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2

CAMK_MAPKAPK2 (MAP kinase-activated protein kinase 2)

Total number of chains: 119
Active chains: 2
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 107 89.9% AF-P49137-K1A
DFGin ABAminus 12 10.1% 8XU4B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAPK2_HUMAN AF-P49137-K1A P49137 55 333 400.0 No_ligand No_ligand Active DFGin 4.546 13.824 BLAminus -134.44, -178.32 60.99, 73.02 -77.16, 14.94 284.91, 72.06 -61.19, -19.08 in-in in 9.222 Saltbr-in 2.655 HRD-in -73.97, -44.93 66.36, 6.92 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.85, 117.34 APE9-dihe-na -163.87, 158.43 APE8-dihe-in -103.05, 128.91 APE8-rot-in 302.59 APE67-dihe-in -76.17, -21.81 -42.87, -45.53 APE12-dist-in 8.406 APE11-dist-in 10.793 APE10-dist-in 5.107 APE9-dist-in 4.569 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[63, 325]] 1.0 AF-P49137-K1 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 2e-80 275.7 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN AF-P49137-K3A P49137 55 333 400.0 No_ligand No_ligand Active DFGin 4.263 13.854 BLAminus -139.32, -176.01 59.17, 72.48 -74.28, 14.66 284.7, 72.91 -60.93, -20.2 in-in in 9.302 Saltbr-in 2.682 HRD-in -78.07, -45.55 66.87, 7.53 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 122.38 APE9-dihe-na -167.75, 155.99 APE8-dihe-in -92.86, 129.83 APE8-rot-in 298.63 APE67-dihe-in -72.76, -25.18 -45.14, -45.86 APE12-dist-in 8.677 APE11-dist-in 11.15 APE10-dist-in 5.293 APE9-dist-in 4.364 None None None AF2 -1.0 1.0 1.0 A 279 279 0 0 0 0 [[63, 325]] 1.0 AF-P49137-K3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 2e-80 275.7 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4A P49137 47 351 400.0 No_ligand No_ligand Inactive DFGin 4.949 13.716 ABAminus -128.52, -52.54 -97.2, 106.03 -93.21, 12.59 278.71, 77.09 -54.91, -37.99 in-in in 8.687 Saltbr-in 2.878 HRD-in -60.97, -46.53 67.55, 11.05 in-in-none SNCiin in-none ActLoopNT-in 3.047 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -43.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 A 318 288 17 0 0 12 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4B P49137 47 351 400.0 No_ligand No_ligand Inactive DFGin 4.97 13.93 ABAminus -128.62, -52.37 -96.88, 106.3 -93.53, 12.94 278.79, 76.83 -53.86, -39.26 in-in in 8.877 Saltbr-in 2.85 HRD-in -61.06, -46.54 67.22, 10.97 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.67, -39.29 999.0, 159.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 B 318 289 16 0 0 11 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4C P49137 48 351 400.0 No_ligand No_ligand Inactive DFGin 4.952 13.77 ABAminus -128.61, -52.83 -97.32, 105.87 -93.56, 12.92 278.25, 77.18 -54.04, -38.82 in-in in 8.715 Saltbr-in 2.884 HRD-in -60.6, -46.65 67.66, 11.02 in-in-none SNCiin in-none ActLoopNT-in 3.048 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -67.27, -39.02 999.0, 154.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 C 318 283 21 0 0 11 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4D P49137 47 349 400.0 No_ligand No_ligand Inactive DFGin 5.016 13.978 ABAminus -128.47, -52.45 -96.79, 105.82 -93.86, 12.98 278.72, 76.7 -54.12, -38.62 in-in in 8.882 Saltbr-in 2.867 HRD-in -61.37, -46.37 68.02, 10.61 in-in-none SNCiin in-none ActLoopNT-in 3.054 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.98, -38.84 999.0, 155.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 D 318 284 19 0 0 11 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4E P49137 47 353 400.0 No_ligand No_ligand Inactive DFGin 4.978 13.843 ABAminus -128.62, -52.59 -97.28, 106.12 -93.2, 12.43 279.18, 76.54 -53.59, -39.54 in-in in 8.74 Saltbr-in 2.872 HRD-in -60.42, -46.83 67.49, 11.2 in-in-none SNCiin in-none ActLoopNT-in 3.045 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.61, -38.51 999.0, 154.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 E 318 286 21 0 0 8 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4F P49137 47 353 400.0 No_ligand No_ligand Inactive DFGin 4.992 13.962 ABAminus -128.58, -52.75 -97.13, 105.72 -93.36, 12.89 278.82, 76.86 -54.15, -39.31 in-in in 8.87 Saltbr-in 2.857 HRD-in -61.41, -46.48 67.82, 10.61 in-in-none SNCiin in-none ActLoopNT-in 3.049 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.63, -38.8 999.0, 158.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 F 318 279 28 0 0 11 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4G P49137 47 348 400.0 No_ligand No_ligand Inactive DFGin 4.988 13.714 ABAminus -128.53, -52.31 -97.11, 106.65 -93.35, 12.39 279.0, 76.45 -52.45, -40.58 in-in in 8.706 Saltbr-in 2.882 HRD-in -60.9, -46.46 67.81, 10.73 in-in-none SNCiin in-none ActLoopNT-in 3.049 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.07, -38.86 999.0, 175.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 G 318 273 29 0 0 9 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4H P49137 47 358 400.0 No_ligand No_ligand Inactive DFGin 5.014 13.981 ABAminus -128.09, -52.94 -96.6, 105.83 -93.09, 12.25 278.91, 76.39 -53.17, -39.42 in-in in 8.856 Saltbr-in 2.866 HRD-in -61.25, -46.49 67.38, 11.04 in-in-out SNCiio in-out ActLoopNT-in 3.051 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 68.07 APE8-rot-out 50.27 APE67-dihe-out -68.41, -38.92 -61.79, 156.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 H 318 281 31 0 0 10 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4I P49137 47 347 400.0 No_ligand No_ligand Inactive DFGin 4.958 13.827 ABAminus -128.35, -52.14 -97.19, 106.4 -93.31, 12.69 278.76, 76.95 -54.36, -39.16 in-in in 8.826 Saltbr-in 2.858 HRD-in -61.27, -46.42 67.55, 10.91 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 I 318 266 35 0 0 14 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4J P49137 47 350 400.0 No_ligand No_ligand Inactive DFGin 4.954 13.75 ABAminus -128.19, -52.94 -96.37, 106.17 -93.76, 12.19 278.77, 77.03 -53.29, -39.12 in-in in 8.654 Saltbr-in 2.886 HRD-in -61.27, -46.26 67.9, 10.69 in-in-none SNCiin in-none ActLoopNT-in 3.049 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 J 318 273 31 0 0 15 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4K P49137 47 348 400.0 No_ligand No_ligand Inactive DFGin 4.982 13.855 ABAminus -127.78, -52.88 -96.21, 106.11 -93.51, 11.66 278.96, 76.54 -52.14, -40.11 in-in in 8.732 Saltbr-in 2.884 HRD-in -61.37, -46.53 68.05, 10.32 in-in-none SNCiin in-none ActLoopNT-in 3.049 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.32, -38.96 999.0, 154.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 K 318 269 33 0 0 11 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XU4L P49137 47 354 400.0 No_ligand No_ligand Inactive DFGin 4.982 13.927 ABAminus -127.97, -52.82 -96.79, 105.64 -93.41, 12.6 279.02, 76.77 -54.27, -38.59 in-in in 8.812 Saltbr-in 2.872 HRD-in -61.34, -46.64 68.01, 10.51 in-in-none SNCiin in-none ActLoopNT-in 3.055 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S216G None None XRAY 3.4 0.216 0.263 L 318 272 36 0 0 13 [[63, 325]] 1.0 8xu4 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 1NY3A P49137 46 345 400.0 ADP:401 ATPlike Inactive DFGin 4.213 13.918 BLAminus -139.11, 173.49 82.65, 112.5 -121.18, 20.23 280.18, 65.28 -53.92, -18.87 out-out out 10.039 Saltbr-out 6.106 HRD-in -63.84, -48.41 55.55, 34.09 out-in-none SNCoin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -47.32, -19.47 999.0, 98.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.27 0.292 A 400 277 23 0 0 9 [[63, 325]] 1.0 1ny3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2PZYD P49137 43 342 400.0 No_ligand No_ligand Inactive DFGin 4.062 13.922 BLAminus -152.15, 165.55 73.92, 95.4 -98.52, 24.64 286.52, 78.72 -40.74, -59.3 in-in in 8.771 Saltbr-in 2.73 HRD-in -82.11, -45.31 68.56, -1.03 in-in-out SNCiio in-out ActLoopNT-in 3.031 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 58.75 APE9-dihe-na -176.76, -129.46 APE8-dihe-out 94.27, 109.95 APE8-rot-in 285.39 APE67-dihe-out -47.44, -18.99 -80.83, 132.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 31.238 APE9-dist-out 32.707 None None None XRAY 2.9 0.251 0.313 D 324 288 12 0 0 8 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 4TYHA P49137 51 400 400.0 No_ligand No_ligand Inactive DFGin 4.441 14.325 BLAminus -142.08, 171.7 55.29, 109.24 -104.89, 23.52 273.51, 53.57 -64.22, -15.92 out-out out 11.187 Saltbr-out 3.993 HRD-out -83.42, 132.47 -122.22, 37.78 out-in-out SNCoio in-out ActLoopNT-in 2.936 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -76.48, -33.25 APE9-dihe-na -107.91, 124.37 APE8-dihe-in -138.48, 156.89 APE8-rot-out 74.08 APE67-dihe-out -72.03, -25.61 -71.89, 168.09 APE12-dist-out 28.197 APE11-dist-out 33.461 APE10-dist-out 36.005 APE9-dist-out 33.065 None None None XRAY 3.0 0.232 0.313 A 350 339 11 0 0 0 [[63, 325]] 1.0 4tyh Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 4.4e-80 274.8 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2OZAA P49137 51 390 400.0 No_ligand No_ligand Inactive DFGin 4.518 14.471 BLAminus -123.6, 174.75 70.29, 93.68 -101.87, 20.63 281.37, 55.77 -53.13, -26.57 out-in out 10.386 Saltbr-in 3.436 HRD-in -72.68, -56.57 75.31, 21.22 in-in-out SNCiio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -78.43, -27.23 APE9-dihe-na -116.51, 130.73 APE8-dihe-in -149.24, 149.83 APE8-rot-out 53.32 APE67-dihe-out -67.3, -35.95 -56.79, 159.27 APE12-dist-out 27.346 APE11-dist-out 32.873 APE10-dist-out 35.564 APE9-dist-out 32.631 None None None XRAY 2.7 0.239 0.296 A 356 332 8 0 0 0 [[63, 325]] 1.0 2oza Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 4.7e-80 274.8 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6TCAA P49137 51 399 400.0 No_ligand No_ligand Inactive DFGin 4.808 14.709 BLAminus -135.67, -169.38 58.66, 66.44 -82.91, 21.97 272.01, 70.02 -62.4, -32.28 out-out out 10.543 Saltbr-out 4.578 HRD-out -51.48, 137.64 -139.83, 40.36 out-in-out SNCoio in-out ActLoopNT-in 2.542 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -76.04, -19.94 APE9-dihe-na -101.4, 109.34 APE8-dihe-in -124.3, 144.8 APE8-rot-out 81.9 APE67-dihe-out -65.78, -45.04 -67.31, 169.54 APE12-dist-out 27.566 APE11-dist-out 32.877 APE10-dist-out 34.713 APE9-dist-out 32.586 None None None XRAY 3.7 0.254 0.297 A 371 345 4 0 0 0 [[63, 325]] 1.0 6tca Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 5.3e-80 274.6 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6TCAC P49137 51 397 400.0 No_ligand No_ligand Inactive DFGin 4.398 14.006 BLAminus -137.3, -177.32 55.62, 70.05 -77.27, 20.32 283.21, 48.26 -39.45, -41.82 out-out out 10.681 Saltbr-out 5.209 HRD-out -67.04, 142.78 -136.57, 25.0 out-in-out SNCoio in-out ActLoopNT-in 3.096 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -62.01, -43.21 APE9-dihe-na -111.68, 156.05 APE8-dihe-in -156.69, 147.09 APE8-rot-out 176.79 APE67-dihe-out -79.69, -42.53 -75.02, -178.41 APE12-dist-out 29.503 APE11-dist-out 33.956 APE10-dist-out 37.358 APE9-dist-out 34.003 None None None XRAY 3.7 0.254 0.297 C 371 326 21 0 0 0 [[63, 325]] 1.0 6tca Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 5.3e-80 274.6 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6TCAE P49137 51 394 400.0 No_ligand No_ligand Inactive DFGin 4.64 15.205 BLAminus -127.42, -167.98 61.16, 68.59 -80.76, 21.11 276.97, 51.93 -62.95, -41.61 out-none out 10.928 Saltbr-none 999.0 HRD-out -75.87, 144.22 -136.93, 24.68 none-in-out SNCnio in-out ActLoopNT-in 2.748 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -91.5, -33.23 APE9-dihe-na -97.26, 70.28 APE8-dihe-in -92.3, 143.46 APE8-rot-out 73.64 APE67-dihe-out -74.99, -22.66 -65.33, 170.76 APE12-dist-out 27.729 APE11-dist-out 33.33 APE10-dist-out 35.098 APE9-dist-out 33.635 None None None XRAY 3.7 0.254 0.297 E 371 327 17 0 0 0 [[63, 325]] 1.0 6tca Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 5.3e-80 274.6 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6TCAG P49137 51 397 400.0 No_ligand No_ligand Inactive DFGin 5.283 14.452 BLAminus -126.97, -178.87 58.45, 67.91 -84.51, 24.35 287.29, 64.0 -66.48, -20.58 out-none out 10.942 Saltbr-none 999.0 HRD-out -70.0, 138.95 -123.96, 22.22 none-in-out SNCnio in-out ActLoopNT-in 3.329 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -79.36, -46.18 APE9-dihe-na -86.11, 115.37 APE8-dihe-in -128.35, 144.51 APE8-rot-out 165.31 APE67-dihe-out -65.52, -41.43 -66.57, 167.52 APE12-dist-out 28.221 APE11-dist-out 33.733 APE10-dist-out 35.943 APE9-dist-out 32.937 None None None XRAY 3.7 0.254 0.297 G 371 337 10 0 0 0 [[63, 325]] 1.0 6tca Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 5.3e-80 274.6 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 1KWPA P49137 46 385 400.0 No_ligand No_ligand Inactive DFGin 4.429 13.889 BLAminus -126.95, -164.58 53.05, 82.7 -89.43, 29.12 276.39, 66.04 -76.65, 13.1 out-out out 10.974 Saltbr-out 5.651 HRD-in -68.44, -51.49 60.45, 15.74 out-in-none SNCoin in-none ActLoopNT-in 2.707 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.233 0.245 A 400 319 21 0 0 17 [[63, 325]] 1.0 1kwp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 1KWPB P49137 44 378 400.0 No_ligand No_ligand Inactive DFGin 4.377 14.119 BLAminus -117.6, -155.6 68.63, 73.62 -94.92, 21.17 280.86, 68.81 -59.61, -28.18 out-out out 10.182 Saltbr-out 4.977 HRD-in -60.1, -56.36 69.04, 7.85 out-in-none SNCoin in-none ActLoopNT-in 2.762 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.233 0.245 B 400 313 22 0 0 17 [[63, 325]] 1.0 1kwp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2ONLC P49137 46 393 400.0 No_ligand No_ligand Inactive DFGin 5.372 13.877 BLAminus -144.71, 177.23 57.74, 79.95 -93.42, 20.24 283.94, 44.28 -42.17, -30.27 out-out out 10.482 Saltbr-out 5.159 HRD-in -63.93, -50.35 64.99, 1.87 out-in-out SNCoio in-out ActLoopNT-in 2.678 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.05, 148.13 APE9-dihe-na -79.09, -172.22 APE8-dihe-out -151.58, -163.46 APE8-rot-in 293.27 APE67-dihe-out -61.73, 102.69 -87.71, -35.23 APE12-dist-out 31.664 APE11-dist-out 35.028 APE10-dist-out 35.94 APE9-dist-out 30.146 None None None XRAY 4.0 0.315 0.331 C 406 317 31 0 0 0 [[63, 325]] 1.0 2onl Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2ONLD P49137 46 393 400.0 No_ligand No_ligand Inactive DFGin 4.225 13.848 BLAminus -137.37, 177.77 67.14, 69.15 -84.34, 79.92 286.72, 38.57 -108.36, -19.15 out-out out 11.005 Saltbr-out 7.408 HRD-out -59.16, 114.42 -89.49, -17.7 out-in-out SNCoio in-out ActLoopNT-in 2.595 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -152.0, 123.99 APE9-dihe-na -67.05, 173.86 APE8-dihe-out -109.94, -76.7 APE8-rot-out 147.79 APE67-dihe-out -164.84, -165.18 -122.96, 14.75 APE12-dist-out 31.018 APE11-dist-out 34.196 APE10-dist-out 36.371 APE9-dist-out 29.902 None None None XRAY 4.0 0.315 0.331 D 406 313 35 0 0 0 [[63, 325]] 1.0 2onl Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3WI6A P49137 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.536 13.832 BLAminus -135.2, -179.28 63.48, 87.85 -99.08, 27.55 280.11, 67.56 -72.5, -23.63 out-out out 10.624 Saltbr-out 6.333 HRD-in -70.73, -49.93 64.06, 23.09 out-in-none SNCoin in-none ActLoopNT-in 2.805 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -94.82, -2.38 999.0, 84.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 A 324 282 20 0 0 10 [[63, 325]] 1.0 3wi6 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3WI6B P49137 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.515 13.714 BLAminus -134.59, 176.34 65.99, 87.98 -98.51, 25.22 282.93, 64.99 -67.04, -26.83 out-out out 10.562 Saltbr-out 6.423 HRD-in -66.95, -50.26 60.54, 21.62 out-in-none SNCoin in-none ActLoopNT-in 2.866 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.97, 0.01 999.0, 94.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 B 324 283 19 0 0 10 [[63, 325]] 1.0 3wi6 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3WI6C P49137 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.504 13.721 BLAminus -134.82, 178.56 63.86, 88.03 -96.41, 23.84 282.48, 61.55 -65.28, -26.77 out-out out 10.611 Saltbr-out 6.149 HRD-in -68.02, -48.56 59.13, 24.29 out-in-none SNCoin in-none ActLoopNT-in 2.819 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -95.37, 0.55 999.0, 92.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 C 324 283 19 0 0 10 [[63, 325]] 1.0 3wi6 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3WI6D P49137 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.584 13.811 BLAminus -134.2, 179.76 62.42, 89.36 -98.33, 27.39 283.59, 63.54 -69.5, -24.8 out-out out 10.711 Saltbr-out 6.248 HRD-in -69.08, -49.01 61.71, 22.88 out-in-none SNCoin in-none ActLoopNT-in 2.864 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -93.52, -6.37 999.0, 92.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 D 324 282 20 0 0 10 [[63, 325]] 1.0 3wi6 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3WI6E P49137 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.572 13.765 BLAminus -140.29, 177.62 64.15, 87.56 -97.84, 28.21 283.48, 62.99 -68.98, -27.5 out-out out 10.68 Saltbr-out 6.68 HRD-in -69.93, -48.5 64.52, 21.01 out-in-none SNCoin in-none ActLoopNT-in 2.898 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -99.02, -1.95 999.0, 92.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 E 324 283 19 0 0 10 [[63, 325]] 1.0 3wi6 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3WI6F P49137 46 347 400.0 YRZ:901 Type1 Inactive DFGin 4.55 13.75 BLAminus -134.82, 178.96 64.08, 87.79 -97.95, 26.96 281.15, 62.98 -67.35, -27.07 out-out out 10.599 Saltbr-out 6.064 HRD-in -71.75, -47.02 59.62, 20.27 out-in-none SNCoin in-none ActLoopNT-in 2.854 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -95.39, -0.45 999.0, 88.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.99 0.242 0.283 F 324 283 19 0 0 10 [[63, 325]] 1.0 3wi6 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3FPMA P49137 44 345 400.0 793:1 Type1 Inactive DFGin 4.526 13.6 BLAminus -111.73, -179.28 68.06, 93.12 -104.74, 29.09 277.15, 66.6 -75.69, -5.19 out-out out 10.299 Saltbr-out 6.423 HRD-in -77.57, -45.45 63.38, 17.34 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.98 APE8-rot-in 312.19 APE67-dihe-out -94.66, 6.84 -102.2, 101.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.3 0.284 0.337 A 325 283 19 0 0 9 [[63, 325]] 1.0 3fpm Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2P3GX P49137 45 364 400.0 F10:401 Type1 Inactive DFGin 4.636 13.497 BLAminus -126.99, -179.06 63.74, 79.6 -89.5, 29.28 285.47, 37.86 -65.44, -2.41 out-out out 10.049 Saltbr-out 5.912 HRD-in -79.61, -38.01 59.63, 23.28 out-in-none SNCoin in-none ActLoopNT-in 2.77 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.8 0.303 0.374 X 327 282 38 0 0 17 [[63, 325]] 1.0 2p3g Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3FYJX P49137 45 364 400.0 B97:372 Type1 Inactive DFGin 4.808 12.764 BLAminus -143.93, -168.45 50.75, 86.11 -92.87, 22.38 289.04, 32.96 -62.16, -2.8 out-out out 10.249 Saltbr-out 6.285 HRD-in -79.69, -43.1 68.94, 27.85 out-in-none SNCoin in-none ActLoopNT-in 2.466 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.8 0.331 0.388 X 327 282 38 0 0 17 [[63, 325]] 1.0 3fyj Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3FYKX P49137 45 364 400.0 B98:372 Type1 Inactive DFGin 4.312 13.507 BLAminus -134.88, -177.51 58.62, 91.5 -96.03, 29.83 280.37, 46.93 -66.4, -8.98 out-out out 10.374 Saltbr-out 6.291 HRD-in -78.77, -40.47 62.21, 24.85 out-in-none SNCoin in-none ActLoopNT-in 2.877 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.5 0.267 0.296 X 327 282 38 0 0 17 [[63, 325]] 1.0 3fyk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 7NRYX P49137 45 366 400.0 B97:401 Type1 Inactive DFGin 4.627 14.222 BLAminus -139.32, 169.04 60.45, 76.63 -78.82, 16.72 283.41, 68.06 -65.88, -11.72 out-out out 10.683 Saltbr-out 7.218 HRD-in -78.99, -50.58 73.3, 6.74 out-in-none SNCoin in-none ActLoopNT-in 3.137 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.8 0.235 0.275 X 327 283 39 0 0 17 [[63, 325]] 1.0 7nry Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBOA P49137 44 347 400.0 P4O:1348 Type1 Inactive DFGin 4.522 13.443 BLAminus -128.45, 174.66 76.7, 105.07 -117.13, 15.66 280.46, 72.55 -57.97, -19.55 in-in in 9.062 Saltbr-in 2.814 HRD-in -85.59, -45.77 68.85, 12.78 in-in-out SNCiio in-out ActLoopNT-in 2.892 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 115.47 APE9-dihe-na -176.67, 6.0 APE8-dihe-in -119.96, 55.28 APE8-rot-out 175.51 APE67-dihe-in -48.92, -37.26 -101.11, -10.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 31.255 APE9-dist-out 36.058 None None None XRAY 3.1 0.232 0.274 A 326 296 8 0 0 8 [[63, 325]] 1.0 2jbo Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPL P49137 44 345 400.0 P4O:1345 Type1 Inactive DFGin 4.327 13.69 BLAminus -115.16, -156.79 35.96, 109.78 -107.71, 6.88 277.06, 60.03 -55.27, -5.39 in-out in 8.636 Saltbr-out 3.699 HRD-in -78.67, -41.91 74.03, 10.39 out-in-none SNCoin in-none ActLoopNT-in 2.794 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 L 326 268 34 0 0 18 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 9R59A P49137 48 364 400.0 A1JH4:60401 Type1 Inactive DFGin 4.506 13.971 BLAminus -133.79, -179.1 58.15, 93.82 -95.19, 25.62 274.7, 64.62 -81.37, 7.19 out-none out 10.304 Saltbr-none 999.0 HRD-in -85.22, -50.74 73.31, 11.03 none-in-none SNCnin in-none ActLoopNT-in 2.927 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.202 0.229 A 320 280 37 0 0 18 [[63, 325]] 1.0 9r59 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 1NXKD P49137 43 342 400.0 STU:401 Type1 Inactive DFGin 4.831 13.91 BLAminus -136.01, 172.45 58.97, 96.18 -97.02, 30.62 280.59, 64.96 -55.97, -37.81 in-in in 8.803 Saltbr-in 2.649 HRD-in -61.55, -54.52 76.31, -8.43 in-in-out SNCiio in-out ActLoopNT-in 3.004 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 21.79 APE9-dihe-na -95.93, -89.71 APE8-dihe-out 87.4, 89.72 APE8-rot-in 304.66 APE67-dihe-out -57.06, -12.13 -63.98, 136.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 30.487 APE9-dist-out 33.331 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 D 400 288 12 0 0 8 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CB P49137 47 345 400.0 PDY:1,PDY:2 Type1,Allosteric Inactive DFGin 4.737 13.553 BLAminus -125.31, 179.32 62.03, 93.3 -105.16, 21.09 287.49, 59.11 -59.5, -21.99 in-out in 9.297 Saltbr-out 4.157 HRD-in -77.44, -36.26 59.31, 7.54 out-in-none SNCoin in-none ActLoopNT-in 3.019 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 B 324 277 22 0 0 13 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CI P49137 48 343 400.0 PDY:1,PDY:2 Type1,Allosteric Inactive DFGin 4.809 13.72 BLAminus -125.53, 174.35 66.59, 96.73 -108.15, 23.97 284.55, 62.17 -70.07, 2.45 in-out in 9.281 Saltbr-out 4.752 HRD-in -79.24, -45.58 66.95, 0.2 out-in-none SNCoin in-none ActLoopNT-in 2.94 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 I 324 275 21 0 0 12 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6T8XA P49137 44 330 400.0 B97:401,MW8:403 Type1,Allosteric Inactive DFGin 4.57 13.434 BLAminus -131.03, 170.9 67.7, 100.81 -106.86, 34.47 292.12, 79.14 -67.76, -27.73 in-in in 8.612 Saltbr-in 2.792 HRD-in -69.35, -49.87 72.11, 11.43 in-in-out SNCiio in-out ActLoopNT-in 2.99 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 162.12 APE8-dihe-in -95.72, 126.31 APE8-rot-in 315.68 APE67-dihe-in -58.39, -33.83 -52.68, -49.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.841 T222E,T334E None None XRAY 2.81 0.229 0.247 A 319 279 8 0 0 8 [[63, 325]] 1.0 6t8x Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6T8XD P49137 44 331 400.0 B97:401,MW8:403 Type1,Allosteric Inactive DFGin 4.483 13.55 BLAminus -130.63, 174.14 63.49, 94.3 -98.34, 31.83 289.68, 73.36 -61.87, -29.24 in-in in 8.601 Saltbr-in 2.791 HRD-in -63.87, -41.66 67.57, -0.14 in-in-out SNCiio in-out ActLoopNT-in 2.996 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 38.4 APE9-dihe-na -174.63, 165.43 APE8-dihe-in -95.48, 125.63 APE8-rot-in 314.21 APE67-dihe-in -57.53, -34.17 -53.38, -48.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 32.963 APE9-dist-out 33.763 T222E,T334E None None XRAY 2.81 0.229 0.247 D 319 280 8 0 0 8 [[63, 325]] 1.0 6t8x Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6T8XE P49137 45 329 400.0 B97:401,MW8:403 Type1,Allosteric Inactive DFGin 4.527 13.597 BLAminus -130.92, 174.05 63.5, 95.58 -99.57, 31.94 289.7, 73.63 -62.69, -28.68 in-in in 8.618 Saltbr-in 2.792 HRD-in -71.65, -41.81 62.96, 8.53 in-in-out SNCiio in-out ActLoopNT-in 2.995 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 30.44 APE9-dihe-na -173.7, 165.91 APE8-dihe-in -95.92, 126.31 APE8-rot-in 315.63 APE67-dihe-in -58.29, -33.74 -53.7, -48.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 32.403 APE9-dist-out 33.801 T222E,T334E None None XRAY 2.81 0.229 0.247 E 319 277 8 0 0 8 [[63, 325]] 1.0 6t8x Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6T8XF P49137 45 329 400.0 B97:401,MW8:403 Type1,Allosteric Inactive DFGin 4.489 13.68 BLAminus -127.96, 174.83 62.76, 90.11 -94.3, 29.64 283.77, 77.92 -65.54, -27.43 in-in in 8.611 Saltbr-in 2.786 HRD-in -71.8, -44.12 66.14, 4.48 in-in-out SNCiio in-out ActLoopNT-in 2.979 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.56 APE8-dihe-in -95.39, 126.47 APE8-rot-in 315.37 APE67-dihe-in -57.73, -34.19 -54.15, -48.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.826 T222E,T334E None None XRAY 2.81 0.229 0.247 F 319 276 9 0 0 9 [[63, 325]] 1.0 6t8x Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BC P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.699 13.755 BLAminus -145.08, 171.25 61.11, 107.16 -112.51, 31.96 284.23, 68.66 -61.45, -37.77 in-in in 8.935 Saltbr-in 2.757 HRD-in -69.97, -44.39 78.89, -25.31 in-in-none SNCiin in-none ActLoopNT-in 3.064 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.67, -20.62 999.0, 173.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 C 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BD P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.711 13.906 BLAminus -145.79, 167.53 68.59, 102.7 -108.4, 30.91 282.62, 68.72 -66.3, -36.77 in-in in 8.983 Saltbr-in 3.408 HRD-in -69.48, -46.19 68.3, 18.38 in-in-none SNCiin in-none ActLoopNT-in 3.29 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -107.53, -10.82 999.0, -167.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 D 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BE P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.837 13.766 BLAminus -139.59, 169.54 69.21, 97.38 -104.17, 34.32 282.85, 67.94 -62.67, -38.94 in-in in 8.985 Saltbr-in 2.679 HRD-in -71.5, -45.64 70.77, 10.18 in-in-none SNCiin in-none ActLoopNT-in 3.092 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -99.43, -1.37 999.0, -172.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 E 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BF P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.621 13.688 BLAminus -142.07, 170.01 64.83, 98.1 -101.81, 30.72 282.18, 71.32 -65.73, -35.15 in-in in 8.992 Saltbr-in 2.702 HRD-in -80.67, -40.94 69.92, -1.27 in-in-none SNCiin in-none ActLoopNT-in 3.032 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -101.55, -20.21 999.0, -176.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 F 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BG P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.714 14.011 BLAminus -137.77, 173.07 72.09, 96.81 -108.03, 29.22 281.02, 70.25 -63.92, -39.04 in-in in 9.1 Saltbr-in 2.657 HRD-in -83.07, -38.78 69.53, -15.76 in-in-none SNCiin in-none ActLoopNT-in 2.998 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -92.27, -2.06 999.0, -177.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 G 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BH P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.783 13.684 BLAminus -141.56, 171.1 67.42, 98.81 -106.45, 32.94 281.72, 69.09 -63.41, -39.6 in-in in 8.81 Saltbr-in 2.638 HRD-in -69.99, -38.96 66.77, 4.24 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -98.5, -19.42 999.0, -171.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 H 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BI P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.832 13.615 BLAminus -144.83, 172.47 66.99, 98.69 -105.77, 31.32 281.48, 70.34 -64.97, -40.42 in-none in 8.902 Saltbr-none 999.0 HRD-in -71.72, -44.4 66.46, 8.73 none-in-none SNCnin in-none ActLoopNT-in 2.992 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -89.48, -16.84 999.0, -178.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 I 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BJ P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.585 13.726 BLAminus -139.73, 172.93 64.33, 98.73 -104.15, 24.81 279.87, 69.77 -58.59, -39.13 in-in in 8.829 Saltbr-in 2.742 HRD-in -76.49, -44.95 70.08, 8.99 in-in-none SNCiin in-none ActLoopNT-in 3.006 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -95.9, -9.71 999.0, -177.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 J 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BK P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.649 13.886 BLAminus -142.88, 173.31 64.15, 96.21 -100.21, 30.51 279.28, 69.33 -63.22, -35.24 in-in in 8.951 Saltbr-in 2.645 HRD-in -75.63, -40.1 74.89, -28.49 in-in-none SNCiin in-none ActLoopNT-in 3.055 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -102.3, -6.38 999.0, -170.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 K 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BL P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.754 13.811 BLAminus -149.62, 172.88 62.04, 95.8 -100.2, 29.15 282.37, 69.48 -62.27, -33.8 in-in in 8.809 Saltbr-in 2.54 HRD-in -71.4, -42.73 71.32, 3.36 in-in-none SNCiin in-none ActLoopNT-in 3.086 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -93.48, -10.45 999.0, 179.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 L 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3G P49137 43 342 400.0 No_ligand No_ligand None DFGin 4.403 12.831 BLAminus -153.55, -179.38 55.29, 116.19 -117.23, 10.89 291.13, 75.69 -43.5, -24.71 in-in in 8.551 Saltbr-in 3.076 HRD-in -68.58, -34.89 71.69, -26.95 in-in-none SNCiin in-none ActLoopNT-in 3.413 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 G 324 276 24 0 0 14 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPJ P49137 48 328 400.0 No_ligand No_ligand None DFGin 4.458 13.647 BLAminus -143.07, -174.18 50.09, 100.81 -101.05, 31.78 269.94, 23.78 -83.21, -13.12 in-in in 8.094 Saltbr-in 3.175 HRD-in -63.4, -41.75 72.41, 26.69 in-in-none SNCiin in-none ActLoopNT-in 3.026 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 J 326 225 56 0 0 18 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 8XX1A P49137 47 364 400.0 No_ligand No_ligand None DFGin 4.495 14.22 BLAminus -125.96, 176.04 66.8, 91.73 -96.65, 23.36 281.49, 65.79 -64.79, -14.16 in-in in 9.722 Saltbr-in 2.918 HRD-in -77.76, -52.02 68.77, 17.81 in-in-none SNCiin in-none ActLoopNT-in 2.956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.55 0.17 0.245 A 318 293 25 0 0 17 [[63, 325]] 1.0 8xx1 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BA P49137 47 345 400.0 05B:1000 Type1 None DFGin 4.793 14.039 BLAminus -133.6, 172.77 62.95, 100.31 -104.2, 34.41 278.04, 66.12 -71.39, -34.54 in-in in 9.008 Saltbr-in 2.409 HRD-in -83.09, -47.43 74.93, -6.02 in-in-none SNCiin in-none ActLoopNT-in 3.112 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.52, -24.55 999.0, -179.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 A 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2BB P49137 47 345 400.0 05B:1000 Type1 None DFGin 4.54 13.845 BLAminus -142.13, 174.13 65.41, 93.56 -99.51, 29.64 280.69, 67.08 -63.86, -41.52 in-in in 9.102 Saltbr-in 2.593 HRD-in -69.44, -43.13 63.83, 12.28 in-in-none SNCiin in-none ActLoopNT-in 3.017 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.51, -10.75 999.0, -173.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 B 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R2YA P49137 46 345 400.0 P4O:3 Type1 None DFGin 4.51 13.529 BLAminus -139.75, 177.52 74.44, 98.73 -113.49, 19.9 276.17, 64.33 -51.78, -25.44 in-in in 8.652 Saltbr-in 2.551 HRD-in -79.45, -34.37 67.58, -79.89 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.294 0.334 A 319 259 41 0 0 18 [[63, 325]] 1.0 3r2y Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3R30A P49137 46 345 400.0 CD2:1 Type1 None DFGin 4.276 13.617 BLAminus -134.32, 174.77 70.14, 102.44 -110.03, 21.6 275.81, 65.59 -62.22, -28.91 in-in in 8.733 Saltbr-in 2.951 HRD-in -89.69, -43.87 75.38, -83.52 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.284 0.332 A 319 264 36 0 0 16 [[63, 325]] 1.0 3r30 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.2e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2PZYA P49137 42 346 400.0 B18:1 Type1 None DFGin 4.58 13.976 BLAminus -104.95, 167.84 71.31, 102.38 -102.76, 24.4 284.1, 63.71 -59.24, -43.49 in-in in 8.6 Saltbr-in 2.624 HRD-in -76.66, -46.66 68.5, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.747 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -117.11, -34.75 999.0, -126.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 A 324 291 14 0 0 11 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2PZYB P49137 44 345 400.0 B18:2 Type1 None DFGin 4.541 13.833 BLAminus -135.83, 172.16 61.22, 108.34 -113.0, 27.32 291.58, 57.74 -68.8, -9.66 in-in in 8.917 Saltbr-in 2.953 HRD-in -74.89, -51.86 41.3, 40.89 in-in-none SNCiin in-none ActLoopNT-in 2.826 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.0, -7.36 999.0, 151.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 B 324 283 19 0 0 11 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2PZYC P49137 42 359 400.0 STU:3 Type1 None DFGin 4.742 13.584 BLAminus -137.32, 155.33 89.76, 83.85 -93.67, 22.39 287.9, 52.26 -71.67, 3.21 in-in in 8.899 Saltbr-in 2.479 HRD-in -82.26, -44.82 71.63, -15.61 in-in-none SNCiin in-none ActLoopNT-in 2.823 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.01, -7.47 999.0, -140.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 C 324 307 11 0 0 11 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3A P49137 43 347 400.0 MK2:500 Type1 None DFGin 4.557 13.885 BLAminus -135.8, -176.83 67.41, 90.4 -94.59, 16.73 291.73, 73.07 -43.87, -36.09 in-in in 9.109 Saltbr-in 2.597 HRD-in -79.47, -55.59 75.47, 16.47 in-in-none SNCiin in-none ActLoopNT-in 3.09 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.87, 1.13 999.0, 124.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 A 324 288 17 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3B P49137 44 349 400.0 MK2:500 Type1 None DFGin 4.882 13.792 BLAminus -132.93, 176.5 69.16, 89.86 -95.19, 24.7 286.31, 75.82 -62.52, -14.87 in-in in 8.556 Saltbr-in 2.527 HRD-in -84.62, -39.61 65.84, 1.69 in-in-none SNCiin in-none ActLoopNT-in 3.033 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -67.96, -17.69 999.0, 172.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 B 324 290 16 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3C P49137 41 345 400.0 MK2:500 Type1 None DFGin 4.718 13.596 BLAminus -138.58, -178.81 60.4, 102.94 -104.46, 17.28 285.49, 73.29 -64.82, -5.96 in-in in 8.931 Saltbr-in 2.774 HRD-in -72.28, -46.2 69.4, 2.58 in-in-none SNCiin in-none ActLoopNT-in 2.986 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.35, -6.27 999.0, 125.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 C 324 281 24 0 0 12 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3D P49137 46 342 400.0 MK2:500 Type1 None DFGin 4.505 13.916 BLAminus -137.86, 175.26 61.96, 98.93 -99.81, 17.41 286.59, 67.21 -44.85, -25.56 in-in in 8.851 Saltbr-in 2.546 HRD-in -66.46, -43.69 66.23, -1.99 in-in-none SNCiin in-none ActLoopNT-in 2.83 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 D 324 269 28 0 0 15 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3E P49137 44 345 400.0 MK2:500 Type1 None DFGin 4.773 13.965 BLAminus -128.92, -178.83 60.96, 110.53 -118.06, 18.13 288.23, 69.3 -53.96, -31.23 in-in in 9.094 Saltbr-in 2.496 HRD-in -67.96, -46.81 65.87, -10.72 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -176.66, -15.58 999.0, -104.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 E 324 287 15 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3F P49137 44 350 400.0 MK2:500 Type1 None DFGin 4.917 13.869 BLAminus -134.88, 179.04 76.75, 94.93 -104.84, 22.2 282.85, 74.6 -64.74, -17.47 in-in in 8.995 Saltbr-in 2.731 HRD-in -79.49, -56.77 86.68, 2.72 in-in-none SNCiin in-none ActLoopNT-in 2.94 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.34, 144.53 999.0, 179.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 F 324 293 14 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3H P49137 44 350 400.0 MK2:500 Type1 None DFGin 4.607 13.429 BLAminus -138.19, -172.17 57.05, 102.0 -106.68, 27.15 292.81, 72.2 -57.13, -29.31 in-in in 8.726 Saltbr-in 2.696 HRD-in -74.06, -45.37 69.29, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.761 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.73, -8.44 999.0, 98.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 H 324 290 17 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3I P49137 45 356 400.0 MK2:500 Type1 None DFGin 4.689 13.646 BLAminus -127.79, 171.26 71.85, 103.11 -106.85, 28.41 284.17, 74.69 -57.35, -27.49 in-in in 8.555 Saltbr-in 2.402 HRD-in -93.72, -30.87 60.32, -1.04 in-in-none SNCiin in-none ActLoopNT-in 2.894 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 I 324 295 17 0 0 13 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3J P49137 43 348 400.0 MK2:500 Type1 None DFGin 4.718 13.802 BLAminus -125.72, -175.9 62.46, 84.05 -88.35, 25.1 281.01, 81.77 -82.54, 2.25 in-in in 9.128 Saltbr-in 3.314 HRD-in -78.38, -40.95 69.7, 4.74 in-in-none SNCiin in-none ActLoopNT-in 3.075 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.62, -14.39 999.0, 120.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 J 324 288 18 0 0 9 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3K P49137 44 345 400.0 MK2:500 Type1 None DFGin 4.468 13.615 BLAminus -140.04, -177.82 52.3, 117.47 -116.32, 11.78 277.13, 82.36 -69.91, 0.72 in-in in 8.958 Saltbr-in 2.78 HRD-in -74.88, -50.37 73.49, 9.77 in-in-none SNCiin in-none ActLoopNT-in 3.333 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 K 324 280 22 0 0 14 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KC3L P49137 42 348 400.0 MK2:500 Type1 None DFGin 4.821 13.855 BLAminus -130.63, 174.42 78.71, 90.78 -100.08, 26.64 282.13, 65.04 -59.13, -39.73 in-in in 9.255 Saltbr-in 2.663 HRD-in -90.63, -50.0 65.8, 13.75 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.39, -28.9 999.0, 127.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 L 324 291 16 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPA P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.478 13.85 BLAminus -133.98, 174.95 70.89, 89.1 -93.56, 24.83 287.0, 65.27 -55.43, -29.01 in-in in 8.726 Saltbr-in 2.604 HRD-in -85.33, -35.83 65.16, 16.45 in-in-none SNCiin in-none ActLoopNT-in 3.057 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 A 326 283 22 0 0 15 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPB P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.579 13.852 BLAminus -138.34, 174.48 73.85, 84.83 -88.84, 30.16 284.72, 60.62 -64.51, -26.86 in-in in 8.707 Saltbr-in 2.535 HRD-in -85.86, -36.04 69.02, 7.05 in-in-none SNCiin in-none ActLoopNT-in 3.061 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -40.26, -29.78 999.0, 121.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 B 326 290 15 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPC P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.503 13.831 BLAminus -133.29, -179.58 64.71, 93.56 -95.15, 25.62 283.97, 64.1 -59.22, -26.85 in-in in 8.767 Saltbr-in 2.926 HRD-in -80.25, -42.98 69.55, 17.83 in-in-none SNCiin in-none ActLoopNT-in 3.088 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.2, -7.86 999.0, 175.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 C 326 284 21 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPD P49137 47 350 400.0 P4O:1351 Type1 None DFGin 4.523 13.952 BLAminus -137.03, -179.33 64.04, 94.44 -97.23, 21.04 282.65, 66.88 -48.31, -30.44 in-in in 8.832 Saltbr-in 2.714 HRD-in -81.64, -32.5 57.25, 21.38 in-in-none SNCiin in-none ActLoopNT-in 2.967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -148.58, -26.73 999.0, -145.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 D 326 286 18 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPE P49137 44 345 400.0 P4O:1345 Type1 None DFGin 4.724 13.859 BLAminus -136.12, 175.35 73.31, 80.12 -82.5, 33.85 283.92, 48.58 -62.96, -45.19 in-in in 8.59 Saltbr-in 2.959 HRD-in -104.14, -29.02 60.75, 18.27 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -151.62, -21.91 999.0, -152.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 E 326 283 19 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPF P49137 45 350 400.0 P4O:1350 Type1 None DFGin 4.595 13.837 BLAminus -132.13, 175.04 70.48, 88.46 -92.2, 24.44 284.08, 67.86 -58.09, -29.79 in-in in 8.685 Saltbr-in 2.569 HRD-in -92.78, -39.0 72.25, 8.97 in-in-none SNCiin in-none ActLoopNT-in 3.082 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -131.16, 4.71 999.0, 165.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 F 326 288 18 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPG P49137 45 350 400.0 P4O:1350 Type1 None DFGin 4.58 13.726 BLAminus -138.34, 174.28 71.04, 87.0 -92.84, 24.64 284.29, 71.24 -62.44, -18.91 in-in in 8.739 Saltbr-in 2.523 HRD-in -84.59, -34.64 66.84, 14.57 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.82, -9.25 999.0, -129.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 G 326 288 18 0 0 10 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPH P49137 46 347 400.0 P4O:1347 Type1 None DFGin 4.207 13.746 BLAminus -134.88, 173.26 70.14, 89.63 -96.59, 27.77 281.47, 58.87 -55.42, -35.35 in-in in 8.808 Saltbr-in 2.548 HRD-in -90.46, -32.76 68.86, 13.14 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 H 326 283 19 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPI P49137 45 350 400.0 P4O:1351 Type1 None DFGin 4.558 13.813 BLAminus -140.96, 171.77 69.8, 89.64 -96.08, 24.27 287.29, 67.6 -46.64, -33.04 in-in in 8.736 Saltbr-in 2.735 HRD-in -89.03, -36.29 66.61, 16.32 in-in-none SNCiin in-none ActLoopNT-in 3.06 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -162.11, 79.7 999.0, -145.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 I 326 289 17 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 2JBPK P49137 47 345 400.0 P4O:1345 Type1 None DFGin 4.452 13.779 BLAminus -134.43, 174.45 70.58, 87.87 -93.92, 23.8 282.34, 69.99 -55.95, -30.42 in-in in 8.751 Saltbr-in 2.364 HRD-in -80.27, -34.62 66.03, 15.08 in-in-none SNCiin in-none ActLoopNT-in 3.168 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 K 326 265 34 0 0 19 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKA P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.589 13.771 BLAminus -126.65, 173.47 71.0, 100.22 -103.09, 25.12 288.21, 68.89 -63.74, -22.07 in-in in 8.808 Saltbr-in 2.833 HRD-in -83.14, -45.68 70.24, 10.29 in-in-none SNCiin in-none ActLoopNT-in 2.999 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 A 334 285 20 0 0 13 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKB P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.574 13.71 BLAminus -126.17, 171.53 76.59, 101.21 -106.82, 28.17 283.51, 70.31 -69.3, -20.78 in-in in 8.8 Saltbr-in 2.767 HRD-in -83.32, -42.01 66.8, 9.77 in-in-none SNCiin in-none ActLoopNT-in 2.956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -76.35, -4.83 999.0, -139.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 B 334 290 15 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKC P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.542 13.708 BLAminus -127.95, 171.63 72.32, 100.54 -105.36, 27.99 284.77, 68.66 -70.12, -18.04 in-in in 8.818 Saltbr-in 2.76 HRD-in -83.09, -44.86 72.76, 6.72 in-in-none SNCiin in-none ActLoopNT-in 3.021 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -151.92, 3.8 999.0, -64.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 C 334 285 20 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKD P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.552 13.762 BLAminus -126.6, 170.16 75.93, 99.4 -106.12, 27.5 286.71, 67.62 -64.49, -22.4 in-in in 8.826 Saltbr-in 2.7 HRD-in -78.53, -45.63 70.0, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 D 334 283 22 0 0 15 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKE P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.694 BLAminus -126.73, 170.86 73.31, 97.65 -100.72, 25.15 284.53, 70.5 -65.36, -19.29 in-in in 8.823 Saltbr-in 2.816 HRD-in -80.98, -44.08 70.38, 5.75 in-in-none SNCiin in-none ActLoopNT-in 3.006 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -110.91, 12.45 999.0, 143.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 E 334 290 15 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKF P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.474 13.706 BLAminus -127.85, 174.17 70.83, 96.56 -99.93, 26.89 286.07, 67.62 -67.09, -18.68 in-in in 8.833 Saltbr-in 2.795 HRD-in -80.56, -45.1 72.92, 6.47 in-in-none SNCiin in-none ActLoopNT-in 3.015 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -140.44, 23.91 999.0, -39.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 F 334 284 21 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKG P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.723 BLAminus -127.83, 169.9 76.58, 97.3 -103.07, 31.55 285.98, 70.31 -69.86, -24.12 in-in in 8.832 Saltbr-in 2.773 HRD-in -83.6, -42.88 70.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.958 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.46 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 G 334 286 19 0 0 12 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKH P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.701 BLAminus -127.46, 173.5 71.38, 99.68 -106.67, 28.02 284.54, 69.36 -65.15, -20.54 in-in in 8.87 Saltbr-in 2.758 HRD-in -82.45, -44.8 70.18, 5.58 in-in-none SNCiin in-none ActLoopNT-in 2.987 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.35, 40.25 999.0, -116.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 H 334 290 15 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKI P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.446 13.686 BLAminus -127.75, 172.18 73.28, 98.61 -103.78, 25.37 284.35, 71.35 -64.93, -20.35 in-in in 8.771 Saltbr-in 2.738 HRD-in -82.7, -44.15 67.61, 9.58 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -120.54, 0.33 999.0, -77.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 I 334 284 21 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKJ P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.516 13.696 BLAminus -125.94, 171.03 73.59, 99.21 -101.22, 24.36 288.17, 72.78 -63.96, -20.62 in-in in 8.837 Saltbr-in 2.841 HRD-in -84.33, -42.62 69.41, 8.71 in-in-none SNCiin in-none ActLoopNT-in 3.076 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 J 334 283 22 0 0 15 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKK P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.495 13.74 BLAminus -127.59, 167.14 77.13, 99.42 -103.98, 27.43 284.8, 74.73 -67.14, -17.07 in-in in 8.865 Saltbr-in 2.825 HRD-in -83.96, -44.73 69.47, 7.73 in-in-none SNCiin in-none ActLoopNT-in 3.043 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.78, -37.53 999.0, -135.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 K 334 290 15 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3GOKL P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.548 13.687 BLAminus -128.35, 173.4 71.1, 97.91 -103.12, 25.34 286.16, 67.54 -60.79, -25.02 in-in in 8.821 Saltbr-in 2.744 HRD-in -84.04, -41.11 66.0, 8.07 in-in-none SNCiin in-none ActLoopNT-in 3.03 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -106.57, 23.19 999.0, 177.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 L 334 284 21 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.8e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KA0A P49137 47 364 400.0 MK3:500 Type1 None DFGin 4.835 13.747 BLAminus -134.09, 176.23 64.42, 97.77 -108.27, 26.09 291.3, 65.21 -54.85, -29.31 in-in in 9.224 Saltbr-in 2.84 HRD-in -80.5, -45.65 65.5, 4.98 in-in-none SNCiin in-none ActLoopNT-in 2.817 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E None None XRAY 2.9 0.232 0.265 A 320 279 39 0 0 19 [[63, 325]] 1.0 3ka0 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.7e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 1NXKA P49137 42 345 400.0 STU:401 Type1 None DFGin 4.829 13.428 BLAminus -122.05, -170.73 42.15, 101.84 -103.58, 19.28 282.18, 65.24 -58.03, -23.15 in-in in 8.716 Saltbr-in 2.473 HRD-in -79.4, -39.47 62.13, 0.83 in-in-none SNCiin in-none ActLoopNT-in 2.683 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.16, 3.04 999.0, 148.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 A 400 290 14 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 1NXKB P49137 44 345 400.0 STU:403 Type1 None DFGin 4.577 13.822 BLAminus -128.27, 177.79 53.09, 103.0 -104.87, 20.3 276.49, 67.38 -57.0, -14.43 in-in in 8.647 Saltbr-in 2.563 HRD-in -64.22, -46.2 66.47, 1.25 in-in-none SNCiin in-none ActLoopNT-in 2.82 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.0, -19.87 999.0, 111.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 B 400 283 19 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 1NXKC P49137 41 357 400.0 STU:401 Type1 None DFGin 4.963 13.774 BLAminus -132.89, 178.15 57.47, 93.76 -100.34, 25.49 283.43, 65.32 -70.88, 11.4 in-in in 8.684 Saltbr-in 2.34 HRD-in -75.36, -47.72 65.17, 8.17 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.28, 2.34 999.0, 115.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 C 400 306 11 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3KGAA P49137 47 364 400.0 LX9:365 Type1 None DFGin 4.446 13.678 BLAminus -124.87, 174.18 69.13, 92.77 -95.92, 21.23 282.6, 67.95 -62.32, -18.3 in-in in 8.84 Saltbr-in 2.692 HRD-in -73.16, -55.01 73.82, 13.46 in-in-none SNCiin in-none ActLoopNT-in 3.001 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.55 0.183 0.235 A 299 290 7 0 0 0 [[63, 325]] 1.0 3kga Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3M2WA P49137 47 364 400.0 L8I:1 Type1 None DFGin 4.422 13.673 BLAminus -122.16, 170.83 75.18, 88.88 -90.88, 16.66 279.1, 67.47 -57.47, -17.13 in-in in 8.951 Saltbr-in 2.544 HRD-in -74.98, -51.41 69.8, 12.51 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.41 0.187 0.227 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m2w Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3M42A P49137 47 364 400.0 HGF:365 Type1 None DFGin 4.265 13.765 BLAminus -127.28, 170.7 71.87, 101.44 -103.87, 20.75 277.01, 69.5 -61.92, -8.22 in-in in 9.26 Saltbr-in 3.091 HRD-in -73.72, -58.45 76.25, 11.76 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.68 0.186 0.232 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m42 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CA P49137 47 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 5.014 14.198 BLAminus -114.29, 177.7 65.08, 82.59 -97.76, 30.04 283.71, 62.65 -83.2, 2.17 in-in in 9.603 Saltbr-in 2.896 HRD-in -71.23, -50.47 72.84, 4.07 in-in-none SNCiin in-none ActLoopNT-in 2.824 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 A 324 274 24 0 0 13 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CC P49137 48 342 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.716 14.256 BLAminus -128.21, 173.02 63.81, 82.24 -94.68, 28.25 283.43, 68.99 -82.34, 1.06 in-in in 9.591 Saltbr-in 3.278 HRD-in -77.67, -40.68 59.71, 0.01 in-in-none SNCiin in-none ActLoopNT-in 2.721 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 C 324 273 22 0 0 12 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CD P49137 48 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.807 14.05 BLAminus -134.61, 177.48 60.17, 88.04 -99.2, 27.01 287.17, 57.58 -68.85, -16.25 in-in in 9.516 Saltbr-in 3.391 HRD-in -71.25, -48.29 67.38, -0.24 in-in-none SNCiin in-none ActLoopNT-in 2.893 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 D 324 277 20 0 0 13 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CE P49137 48 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.811 14.494 BLAminus -118.71, 175.79 66.97, 85.41 -100.83, 39.75 283.04, 64.41 -78.69, -21.27 in-in in 9.883 Saltbr-in 3.247 HRD-in -75.69, -51.67 70.77, 11.52 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 E 324 276 21 0 0 12 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CF P49137 47 345 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.629 13.803 BLAminus -127.88, 179.32 59.24, 93.48 -106.61, 16.66 278.85, 67.85 -68.32, 3.18 in-in in 9.127 Saltbr-in 2.699 HRD-in -69.45, -47.69 65.57, 9.98 in-in-none SNCiin in-none ActLoopNT-in 2.945 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 F 324 287 12 0 0 12 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CG P49137 48 342 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.876 13.836 BLAminus -119.34, 176.47 66.35, 96.55 -109.04, 20.64 281.55, 64.63 -61.28, -15.4 in-in in 9.181 Saltbr-in 2.837 HRD-in -65.24, -45.15 65.73, 3.99 in-in-none SNCiin in-none ActLoopNT-in 3.16 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 G 324 273 22 0 0 12 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CH P49137 47 343 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.744 14.093 BLAminus -121.63, 176.48 63.37, 90.03 -101.58, 35.19 280.13, 69.73 -76.98, -23.87 in-in in 9.443 Saltbr-in 2.813 HRD-in -82.97, -49.71 72.47, 4.66 in-in-none SNCiin in-none ActLoopNT-in 2.875 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 H 324 275 22 0 0 12 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CJ P49137 48 343 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 5.134 14.239 BLAminus -131.68, 169.07 71.74, 90.49 -103.64, 47.99 277.77, 64.09 -101.18, 2.5 in-in in 9.268 Saltbr-in 2.955 HRD-in -70.85, -53.4 79.34, -2.41 in-in-none SNCiin in-none ActLoopNT-in 3.233 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 J 324 275 21 0 0 12 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CK P49137 48 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.784 13.688 BLAminus -132.3, 173.04 63.29, 100.11 -111.51, 35.65 282.7, 65.16 -83.49, -1.19 in-in in 9.392 Saltbr-in 2.78 HRD-in -81.49, -46.78 68.74, 4.82 in-in-none SNCiin in-none ActLoopNT-in 2.939 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 K 324 273 24 0 0 13 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 3A2CL P49137 48 344 400.0 PDY:1,PDY:2 Type1,Allosteric None DFGin 4.92 14.32 BLAminus -139.15, 172.7 64.17, 88.89 -98.58, 16.8 276.6, 62.53 -69.99, 7.3 in-in in 9.404 Saltbr-in 3.576 HRD-in -76.45, -46.65 74.85, -9.83 in-in-none SNCiin in-none ActLoopNT-in 2.966 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.288 0.335 L 324 276 21 0 0 12 [[63, 325]] 1.0 3a2c Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.4e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6T8XB P49137 45 329 400.0 B97:401,MW8:403 Type1,Allosteric None DFGin 4.499 13.631 BLAminus -129.76, 174.11 63.68, 95.47 -98.99, 32.39 289.86, 73.64 -62.73, -29.4 in-in in 8.644 Saltbr-in 2.799 HRD-in -70.3, -40.77 63.38, 5.93 in-in-none SNCiin in-none ActLoopNT-in 2.983 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.94 APE8-rot-in 320.74 APE67-dihe-in -57.79, -34.07 -54.58, -48.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E,T334E None None XRAY 2.81 0.229 0.247 B 319 276 9 0 0 9 [[63, 325]] 1.0 6t8x Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
MAPK2_HUMAN 6T8XC P49137 44 329 400.0 B97:401,MW8:403 Type1,Allosteric None DFGin 4.542 13.623 BLAminus -130.94, 173.46 63.89, 94.6 -98.12, 31.68 290.58, 73.54 -62.98, -29.52 in-in in 8.608 Saltbr-in 2.836 HRD-in -74.07, -44.94 68.64, 5.14 in-in-none SNCiin in-none ActLoopNT-in 2.985 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.58 APE8-rot-in 319.09 APE67-dihe-in -57.21, -34.86 -54.2, -47.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E,T334E None None XRAY 2.81 0.229 0.247 C 319 276 10 0 0 10 [[63, 325]] 1.0 6t8x Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.6e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2

CAMK_MAPKAPK2 (MAP kinase-activated protein kinase 2)

Total number of chains: 0
Active chains: 0
Family: CAMK
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name