CMGC_MAPK10 (Mitogen-activated protein kinase 10)

Total number of chains: 77
Active chains: 2
Family: CMGC
Uniprot: MK10_HUMAN
Kinase Domain Residues: 64 - 359
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 67 87.0% 7ORFA
DFGin None 4 5.2% 8VS0A
DFGin BLAminus 3 3.9% AF-P53779-K1A
DFGin BLBplus 3 3.9% 4H36A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P53779-K1A 56 367 464.0 No_ligand No_ligand Active DFGin 6.461 13.71 BLAminus -144.66, 178.16 68.02, 68.74 -85.51, 7.91 305.04, 111.79 -58.24, -29.28 in-in in 8.829 Saltbr-in 2.715 HRD-in -69.27, -45.02 65.07, 2.71 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.65, -32.06 APE9-dihe-na -74.92, 149.28 APE8-dihe-in -65.14, 122.16 APE8-rot-in 305.61 APE67-dihe-in -66.3, -21.56 -45.78, -48.77 APE12-dist-in 12.875 APE11-dist-in 12.513 APE10-dist-in 6.811 APE9-dist-in 4.313 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[64, 359]] 1.0 AF-P53779-K1 CMGC_MAPK10_HUMAN CMGC 7.9e-86 293.8 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
AF-P53779-K3A 56 367 464.0 No_ligand No_ligand Active DFGin 6.136 14.386 BLAminus -130.69, 176.63 64.98, 65.42 -74.02, 10.59 295.0, 92.08 -61.15, -20.17 in-in in 9.657 Saltbr-in 2.764 HRD-in -73.92, -48.01 61.49, 18.19 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -72.08, 164.58 APE9-dihe-na 64.54, 133.53 APE8-dihe-in -55.1, 131.39 APE8-rot-in 297.6 APE67-dihe-in -67.58, -22.08 -46.44, -46.0 APE12-dist-in 12.729 APE11-dist-in 10.98 APE10-dist-in 6.404 APE9-dist-in 3.154 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[64, 359]] 1.0 AF-P53779-K3 CMGC_MAPK10_HUMAN CMGC 7.9e-86 293.8 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
8WGFA 44 400 464.0 ANP:60401 ATPlike Inactive DFGin 3.669 14.04 ABAminus -79.02, -31.55 -136.84, 175.04 -119.07, 8.28 296.56, 96.93 82.35, -157.09 in-out in 9.384 Saltbr-out 5.018 HRD-in -58.91, -63.96 74.85, 1.04 out-out-out SNCooo out-out ActLoopNT-out 7.325 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -90.96, 137.03 APE9-dihe-na -73.55, 128.96 APE8-dihe-in -72.45, 116.03 APE8-rot-in 306.62 APE67-dihe-in -62.34, -20.8 -105.53, -9.26 APE12-dist-out 20.953 APE11-dist-out 15.692 APE10-dist-out 16.374 APE9-dist-out 11.022 None None None XRAY 1.85 0.212 0.266 A 364 345 4 0 0 4 [[64, 359]] 1.0 8wgf CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4KKEA 45 400 464.0 AMP:501 ATPlike Inactive DFGin 3.889 14.134 ABAminus -83.98, -33.4 -131.72, 175.68 -114.08, 11.08 302.89, 82.85 75.62, -152.87 in-out in 9.705 Saltbr-out 5.629 HRD-in -71.56, -61.65 73.66, -1.84 out-out-out SNCooo out-out ActLoopNT-out 5.896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -98.43, 129.33 APE9-dihe-na -82.63, 139.65 APE8-dihe-in -89.17, 118.02 APE8-rot-in 308.05 APE67-dihe-in -54.19, -24.02 -104.28, -7.92 APE12-dist-out 21.356 APE11-dist-out 16.314 APE10-dist-out 17.192 APE9-dist-out 11.507 None None None XRAY 2.2 0.233 0.291 A 365 354 2 0 0 2 [[64, 359]] 1.0 4kke CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
6EQ9B 47 400 464.0 ACP:502 ATPlike Inactive DFGin 3.849 14.536 ABAminus -85.08, -18.98 -157.51, 177.19 -105.91, 17.98 303.5, 84.3 71.4, -149.1 in-in in 9.644 Saltbr-in 2.882 HRD-in -75.97, -57.51 71.23, 0.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.58 APE8-dihe-in -64.66, 120.8 APE8-rot-in 307.67 APE67-dihe-in -65.89, -19.34 -114.84, 1.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.043 None None None XRAY 1.83 0.207 0.252 B 367 332 14 0 0 14 [[64, 359]] 1.0 6eq9 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
1JNKA 45 400 464.0 ANP:1001 ATPlike Inactive DFGin 3.929 14.397 ABAminus -78.22, -57.34 -98.44, 177.55 -110.1, 6.65 294.57, 85.06 91.46, -137.75 in-out in 9.683 Saltbr-out 4.075 HRD-in -45.57, -68.64 69.61, 1.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.55, 160.68 APE9-dihe-na -118.58, 134.57 APE8-dihe-in -89.41, 118.53 APE8-rot-in 305.71 APE67-dihe-in -40.1, -24.2 -103.88, -20.46 APE12-dist-out 21.317 APE11-dist-out 17.873 APE10-dist-out 16.746 APE9-dist-out 11.497 None None None XRAY 2.3 0.222 0.274 A 423 346 5 0 0 5 [[64, 359]] 1.0 1jnk CMGC_MAPK10_HUMAN CMGC 2.3e-85 292.5 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
6EQ9A 46 400 464.0 ACP:505,C15:506 ATPlike,Allosteric Inactive DFGin 3.763 14.179 ABAminus -90.84, -25.71 -146.46, -174.02 -119.81, 8.04 305.39, 99.67 64.39, -162.69 in-out in 9.653 Saltbr-out 3.917 HRD-in -74.99, -56.85 72.96, -15.02 out-out-out SNCooo out-out ActLoopNT-out 6.285 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.37 APE8-dihe-in -112.64, 106.03 APE8-rot-in 290.72 APE67-dihe-in -70.8, -9.5 -110.9, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.517 None None None XRAY 1.83 0.207 0.252 A 367 350 5 0 0 5 [[64, 359]] 1.0 6eq9 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4Z9LA 45 400 464.0 ANP:501,880:502 Allosteric,Type1 Inactive DFGin 4.174 14.445 ABAminus -84.27, -25.72 -124.69, 176.34 -117.02, 11.08 300.14, 92.59 64.94, -148.04 out-out out 10.091 Saltbr-out 4.206 HRD-in -57.93, -67.24 75.49, -7.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.12 APE8-dihe-in -74.24, 114.86 APE8-rot-in 306.24 APE67-dihe-in -45.55, -30.35 -108.57, -9.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.617 None None None XRAY 2.1 0.201 0.226 A 364 333 12 0 0 10 [[64, 359]] 1.0 4z9l CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4KKGA 45 400 464.0 No_ligand No_ligand Inactive DFGin 3.937 13.676 ABAminus -75.83, -45.13 -131.33, 176.64 -113.17, 12.41 309.43, 86.41 80.11, -157.33 in-in in 9.443 Saltbr-in 2.728 HRD-in -64.48, -65.76 69.66, 7.0 in-out-out SNCioo out-out ActLoopNT-out 7.028 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -73.39, 145.44 APE9-dihe-na -88.72, 145.7 APE8-dihe-in -84.83, 121.79 APE8-rot-in 312.15 APE67-dihe-in -55.99, -20.76 -107.55, -3.77 APE12-dist-out 20.754 APE11-dist-out 15.948 APE10-dist-out 16.774 APE9-dist-out 11.081 None None None XRAY 2.4 0.242 0.3 A 365 353 3 0 0 3 [[64, 359]] 1.0 4kkg CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3FI2A 45 400 464.0 JK1:60600 Type1 Inactive DFGin 4.013 14.36 ABAminus -97.98, -16.74 -139.04, 175.81 -116.69, 9.05 296.36, 85.23 76.44, -166.15 out-out out 10.054 Saltbr-out 6.393 HRD-in -82.97, -57.99 73.2, -7.49 out-out-out SNCooo out-out ActLoopNT-out 7.443 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.11 APE8-dihe-in -80.77, 109.8 APE8-rot-out 57.74 APE67-dihe-in -61.36, -20.96 -115.45, 26.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.343 None None OCY117,OCY201,UNK364,UNK376,UNK377,UNK378,UNK379,UNK380 XRAY 2.28 0.189 0.267 A 353 328 17 0 0 12 [[64, 359]] 1.0 3fi2 CMGC_MAPK10_HUMAN CMGC 1.2e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3FV8A 46 400 464.0 JK3:60500 Type1 Inactive DFGin 3.606 13.821 ABAminus -83.18, -27.03 -139.59, 175.59 -113.26, 11.78 301.15, 84.13 68.03, -169.16 in-in in 9.042 Saltbr-in 2.757 HRD-in -79.73, -69.99 84.21, -14.23 in-out-out SNCioo out-out ActLoopNT-out 6.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -24.4 APE8-dihe-in -97.4, 91.46 APE8-rot-out 58.89 APE67-dihe-in -57.36, -31.78 -99.48, 38.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.051 None None OCY117,OCY154,OCY201,UNK367,UNK368,UNK369,UNK370,UNK380 XRAY 2.28 0.204 0.284 A 355 334 12 0 0 12 [[64, 359]] 1.0 3fv8 CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2B1PA 46 400 464.0 AIZ:501 Type1 Inactive DFGin 4.119 14.333 ABAminus -99.39, -15.41 -130.06, 173.11 -117.75, 9.76 295.76, 89.93 77.33, -157.17 out-out out 10.345 Saltbr-out 6.134 HRD-in -69.84, -62.91 74.58, -6.74 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 112.23 APE8-rot-out 139.52 APE67-dihe-in -64.66, -21.56 -121.59, 10.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.222 0.267 A 355 331 17 0 0 15 [[64, 359]] 1.0 2b1p CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2R9SA 46 401 464.0 255:502 Type1 Inactive DFGin 3.941 13.425 ABAminus -77.42, -30.98 -148.5, -179.18 -116.23, 5.52 300.46, 90.99 75.53, -150.76 in-in in 8.713 Saltbr-in 2.84 HRD-in -76.22, -69.01 82.11, -12.83 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.42, -24.81 999.0, 139.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None OCY154,OCY175,OCY201 XRAY 2.4 0.209 0.29 A 356 328 15 0 0 15 [[64, 359]] 1.0 2r9s CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2R9SB 46 401 464.0 255:501 Type1 Inactive DFGin 3.986 13.55 ABAminus -79.38, -32.11 -143.61, -178.83 -118.88, 2.05 295.67, 88.66 84.96, -147.54 in-in in 8.807 Saltbr-in 2.972 HRD-in -81.84, -63.74 74.18, -13.93 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.16, -23.99 999.0, -56.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None OCY154,OCY175,OCY201 XRAY 2.4 0.209 0.29 B 356 328 15 0 0 15 [[64, 359]] 1.0 2r9s CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2EXCX 45 400 464.0 JNK:600 Type1 Inactive DFGin 3.902 14.113 ABAminus -86.73, -35.58 -120.45, 171.6 -113.23, 9.08 304.24, 90.44 88.87, -156.45 out-out out 10.072 Saltbr-out 5.779 HRD-in -61.35, -62.65 72.11, 16.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.39 APE8-dihe-in -44.08, 104.86 APE8-rot-in 320.1 APE67-dihe-in -63.27, -29.62 -104.88, 2.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.548 None None None XRAY 2.75 0.213 0.314 X 356 335 16 0 0 13 [[64, 359]] 1.0 2exc CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3OY1A 46 400 464.0 589:1 Type1 Inactive DFGin 4.017 13.867 ABAminus -89.64, -26.62 -122.11, 179.0 -120.2, 5.88 299.82, 88.25 81.88, -146.56 out-out out 10.377 Saltbr-out 4.958 HRD-in -69.49, -59.44 73.29, -14.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.85 APE8-dihe-in -79.68, 121.61 APE8-rot-out 142.24 APE67-dihe-in -65.74, -23.23 -110.95, 4.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8 None None None XRAY 1.7 0.259 0.299 A 362 329 17 0 0 14 [[64, 359]] 1.0 3oy1 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3RTPA 46 400 464.0 34I:1 Type1 Inactive DFGin 4.038 14.309 ABAminus -84.14, -44.73 -108.39, 176.15 -118.78, 3.85 293.43, 91.4 79.03, -140.19 in-out in 8.954 Saltbr-out 6.176 HRD-in -62.02, -56.63 68.99, -58.63 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.39 APE8-rot-out 105.29 APE67-dihe-in -64.26, -10.2 -111.75, 8.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.24 0.309 A 363 331 18 0 0 15 [[64, 359]] 1.0 3rtp CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2O2UA 46 400 464.0 738:403 Type1 Inactive DFGin 3.624 14.6 ABAminus -96.37, -18.31 -146.17, 177.04 -117.75, 12.14 292.86, 88.35 89.63, -161.36 out-out out 10.451 Saltbr-out 5.348 HRD-in -63.89, -59.65 62.49, 9.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 122.67 APE8-dihe-in -70.45, 112.53 APE8-rot-in 300.44 APE67-dihe-in -64.48, -20.81 -106.3, 0.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.623 None None None XRAY 2.45 0.234 0.281 A 364 319 15 0 0 13 [[64, 359]] 1.0 2o2u CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2WAJA 46 400 464.0 SNB:1401 Type1 Inactive DFGin 4.389 14.39 ABAminus -101.81, -14.62 -130.98, 175.54 -120.43, 11.32 300.47, 83.01 89.07, -150.28 out-out out 10.807 Saltbr-out 6.144 HRD-in -65.72, -59.02 76.83, -9.7 out-out-out SNCooo out-out ActLoopNT-out 8.23 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -103.28, 143.75 APE9-dihe-na -81.16, 129.27 APE8-dihe-in -82.13, 120.86 APE8-rot-in 298.58 APE67-dihe-in -63.59, -18.92 -106.32, -8.79 APE12-dist-out 21.47 APE11-dist-out 16.714 APE10-dist-out 16.61 APE9-dist-out 11.33 None None None XRAY 2.4 0.187 0.264 A 364 348 5 0 0 3 [[64, 359]] 1.0 2waj CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2ZDTA 45 400 464.0 46C:901 Type1 Inactive DFGin 4.389 13.951 ABAminus -92.15, -23.37 -141.03, 174.08 -115.92, 11.2 298.79, 102.57 73.19, -155.12 in-in in 8.937 Saltbr-in 2.639 HRD-in -71.5, -55.65 75.23, -10.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.3, 124.16 APE9-dihe-na -78.97, 134.1 APE8-dihe-in -81.99, 117.03 APE8-rot-in 291.63 APE67-dihe-in -57.51, -21.79 -111.59, 1.66 APE12-dist-out 21.411 APE11-dist-out 16.19 APE10-dist-out 17.22 APE9-dist-out 11.605 None None None XRAY 2.0 0.216 0.262 A 364 342 5 0 0 5 [[64, 359]] 1.0 2zdt CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2ZDUA 46 400 464.0 446:901 Type1 Inactive DFGin 4.509 13.921 ABAminus -92.67, -29.12 -139.81, -177.57 -119.55, 20.22 301.57, 81.84 53.33, -144.86 in-out in 9.916 Saltbr-out 4.541 HRD-in -76.89, -46.06 62.49, -5.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -77.21 APE8-dihe-in -52.28, 112.5 APE8-rot-out 58.09 APE67-dihe-in -61.33, -9.13 -107.74, 8.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.664 None None None XRAY 2.5 0.241 0.319 A 364 330 13 0 0 13 [[64, 359]] 1.0 2zdu CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3FI3A 45 401 464.0 JK2:600 Type1 Inactive DFGin 4.098 14.502 ABAminus -95.27, -22.44 -138.06, 179.21 -118.55, 12.32 297.53, 97.24 81.07, -161.83 out-out out 10.179 Saltbr-out 6.056 HRD-in -83.59, -60.07 74.75, -14.48 out-out-out SNCooo out-out ActLoopNT-out 7.127 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -52.29 APE8-dihe-in -82.93, 104.28 APE8-rot-none 999.0 APE67-dihe-in -62.47, -21.2 -131.09, 35.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.039 None None OCY117,OCY154,OCY175,OCY201 XRAY 2.2 0.187 0.249 A 364 332 17 0 0 12 [[64, 359]] 1.0 3fi3 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3KVXA 46 401 464.0 FMY:403 Type1 Inactive DFGin 4.178 14.845 ABAminus -68.74, -40.9 -149.05, -179.98 -95.84, -1.21 296.53, 141.11 74.59, -148.38 in-out in 9.582 Saltbr-out 4.367 HRD-in -69.12, -64.97 79.94, -8.98 out-out-out SNCooo out-out ActLoopNT-out 6.693 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.74 APE8-dihe-in -77.86, 88.06 APE8-rot-none 999.0 APE67-dihe-in -59.39, -29.94 -116.04, 36.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.548 None None OCY154,OCY175,OCY201 XRAY 2.4 0.222 0.269 A 364 330 12 0 0 12 [[64, 359]] 1.0 3kvx CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3V6RA 45 401 464.0 CQQ:403 Type1 Inactive DFGin 4.028 13.951 ABAminus -80.87, -43.54 -97.1, 172.04 -129.85, -2.71 300.43, 106.35 62.52, -138.57 in-in in 9.406 Saltbr-in 2.929 HRD-in -59.9, -58.47 73.09, -7.56 in-out-out SNCioo out-out ActLoopNT-out 5.256 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -18.11 APE8-dihe-in -114.43, 112.51 APE8-rot-in 287.62 APE67-dihe-in -58.79, -14.57 -115.01, 0.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.871 None None None XRAY 2.6 0.21 0.264 A 364 350 4 0 0 4 [[64, 359]] 1.0 3v6r CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3V6RB 45 401 464.0 CQQ:403 Type1 Inactive DFGin 3.715 13.399 ABAminus -79.96, -42.28 -118.99, -179.28 -116.59, 11.94 308.1, 94.69 75.23, -171.92 in-in in 9.344 Saltbr-in 2.929 HRD-in -58.63, -58.81 71.84, -7.45 in-out-out SNCioo out-out ActLoopNT-out 7.409 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -22.15 APE8-dihe-in -64.39, 126.53 APE8-rot-in 309.1 APE67-dihe-in -73.89, -13.82 -132.78, 15.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.961 None None None XRAY 2.6 0.21 0.264 B 364 347 6 0 0 6 [[64, 359]] 1.0 3v6r CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3V6SA 45 401 464.0 0F0:501 Type1 Inactive DFGin 3.996 13.909 ABAminus -80.53, -45.47 -95.36, 173.26 -130.02, -1.36 300.07, 105.59 61.35, -137.32 in-in in 9.356 Saltbr-in 2.958 HRD-in -60.22, -58.13 73.08, -7.99 in-out-out SNCioo out-out ActLoopNT-out 5.287 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -15.49 APE8-dihe-in -114.54, 111.28 APE8-rot-in 287.86 APE67-dihe-in -57.69, -13.81 -115.62, -0.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.086 None None None XRAY 2.97 0.219 0.263 A 364 349 5 0 0 5 [[64, 359]] 1.0 3v6s CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3V6SB 45 401 464.0 0F0:501 Type1 Inactive DFGin 3.701 13.356 ABAminus -78.85, -43.81 -118.4, -177.55 -117.02, 14.3 308.53, 91.83 72.18, -167.22 in-in in 9.236 Saltbr-in 2.944 HRD-in -59.07, -58.09 71.95, -8.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 46.06 APE8-dihe-out -57.33, -57.64 APE8-rot-in 282.12 APE67-dihe-out -71.89, -14.32 71.18, -3.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.216 None None None XRAY 2.97 0.219 0.263 B 364 341 13 0 0 13 [[64, 359]] 1.0 3v6s CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
1PMNA 45 400 464.0 984:501 Type1 Inactive DFGin 4.012 14.592 ABAminus -94.08, -17.82 -131.05, 174.1 -109.15, 11.87 301.92, 88.96 81.29, -155.79 out-out out 10.636 Saltbr-out 4.955 HRD-in -67.0, -62.79 73.62, -6.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -78.04, -176.93 APE9-dihe-na -102.36, 150.06 APE8-dihe-in -90.71, 115.44 APE8-rot-in 310.97 APE67-dihe-in -48.47, -21.41 -110.06, -2.04 APE12-dist-out 21.376 APE11-dist-out 17.946 APE10-dist-out 15.789 APE9-dist-out 11.489 None None None XRAY 2.2 0.231 0.266 A 364 344 5 0 0 5 [[64, 359]] 1.0 1pmn CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
1PMUA 45 400 464.0 9HP:501 Type1 Inactive DFGin 3.309 13.735 ABAminus -71.28, -47.98 -119.25, 164.66 -96.58, 38.26 303.66, 97.89 37.13, -161.06 in-out in 9.258 Saltbr-out 5.162 HRD-in -50.61, -53.95 59.36, -7.26 out-out-out SNCooo out-out ActLoopNT-out 5.988 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na 40.69, 45.81 APE9-dihe-na -127.15, 91.11 APE8-dihe-in -55.58, 96.38 APE8-rot-in 312.16 APE67-dihe-in -54.92, -19.91 -93.9, -2.59 APE12-dist-in 13.23 APE11-dist-out 15.983 APE10-dist-out 14.5 APE9-dist-out 9.947 None None None XRAY 2.7 0.221 0.285 A 364 342 8 0 0 8 [[64, 359]] 1.0 1pmu CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
7ORFA 45 401 464.0 0G3:501 Type1 Inactive DFGin 4.115 14.737 ABAminus -97.99, -12.98 -132.84, 171.89 -116.88, 8.67 294.57, 101.3 76.53, -147.07 out-out out 10.875 Saltbr-out 6.414 HRD-in -70.63, -58.24 75.59, 2.07 out-out-out SNCooo out-out ActLoopNT-out 6.542 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.76, 123.47 APE9-dihe-na -117.31, 139.61 APE8-dihe-in -83.98, 143.05 APE8-rot-out 52.4 APE67-dihe-in -63.07, -25.74 -136.0, 35.01 APE12-dist-out 17.61 APE11-dist-out 17.145 APE10-dist-out 17.177 APE9-dist-out 11.844 None None None XRAY 1.7 0.169 0.205 A 365 351 0 0 0 0 [[64, 359]] 1.0 7orf CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2OK1A 46 400 464.0 33A:1 Type1 Inactive DFGin 3.567 14.673 ABAminus -92.46, -22.86 -139.75, 178.47 -118.63, 10.81 302.45, 82.92 65.72, -145.61 out-out out 10.035 Saltbr-out 5.535 HRD-in -66.04, -65.13 76.53, -1.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.98 APE8-dihe-in -86.1, 116.64 APE8-rot-in 298.81 APE67-dihe-in -61.55, -38.95 -106.56, 7.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.934 None None None XRAY 2.4 0.246 0.294 A 365 333 15 0 0 13 [[64, 359]] 1.0 2ok1 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2P33A 45 400 464.0 J07:507 Type1 Inactive DFGin 3.87 14.212 ABAminus -87.66, -46.82 -121.28, -179.5 -108.24, 17.91 304.2, 78.7 72.88, -164.04 in-in in 9.336 Saltbr-in 3.254 HRD-in -40.72, -67.88 73.94, -1.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.09, 177.46 APE9-dihe-na -113.04, 137.19 APE8-dihe-in -75.66, 139.62 APE8-rot-out 55.82 APE67-dihe-in -62.62, -20.71 -131.46, 19.13 APE12-dist-out 20.927 APE11-dist-out 17.626 APE10-dist-out 15.96 APE9-dist-out 11.525 None None None XRAY 2.4 0.253 0.304 A 365 332 5 0 0 5 [[64, 359]] 1.0 2p33 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3CGFA 45 400 464.0 JNF:523 Type1 Inactive DFGin 3.719 14.039 ABAminus -89.59, -53.32 -106.99, -179.49 -117.03, 20.53 309.75, 79.33 76.52, -162.79 in-out in 9.602 Saltbr-out 3.611 HRD-in -43.19, -70.09 72.17, 4.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.93, 178.32 APE9-dihe-na -126.54, 145.54 APE8-dihe-in -86.07, 133.09 APE8-rot-in 307.62 APE67-dihe-in -51.07, -34.7 -123.34, -6.64 APE12-dist-out 21.335 APE11-dist-out 17.893 APE10-dist-out 16.615 APE9-dist-out 11.474 None None None XRAY 3.0 0.225 0.317 A 365 346 5 0 0 5 [[64, 359]] 1.0 3cgf CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3CGOA 45 400 464.0 JNO:510 Type1 Inactive DFGin 3.378 14.153 ABAminus -83.67, -72.6 -89.36, -177.08 -119.2, 23.06 300.34, 81.24 73.78, -174.64 in-in in 9.436 Saltbr-in 3.186 HRD-in -42.19, -65.15 69.86, 5.89 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -77.72, 162.09 APE9-dihe-na -104.67, 146.16 APE8-dihe-in -67.82, 138.78 APE8-rot-in 299.63 APE67-dihe-in -60.19, -32.75 -128.74, -0.9 APE12-dist-out 20.815 APE11-dist-out 17.228 APE10-dist-out 16.125 APE9-dist-out 11.219 None None None XRAY 3.0 0.243 0.318 A 365 332 5 0 0 5 [[64, 359]] 1.0 3cgo CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3G90X 46 400 464.0 J72:1 Type1 Inactive DFGin 3.709 14.207 ABAminus -86.93, -36.26 -125.57, 172.99 -112.97, 14.99 300.31, 89.91 83.13, -154.03 in-in in 8.928 Saltbr-in 2.754 HRD-in -76.16, -59.0 73.09, 0.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -102.89, 143.68 APE9-dihe-na -84.81, 124.61 APE8-dihe-in -64.62, 135.18 APE8-rot-in 301.16 APE67-dihe-in -55.87, -16.77 -115.41, -9.85 APE12-dist-out 20.726 APE11-dist-out 16.374 APE10-dist-out 16.246 APE9-dist-out 11.143 None None None XRAY 2.4 0.218 0.266 X 365 345 7 0 0 5 [[64, 359]] 1.0 3g90 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3G9LX 46 400 464.0 J67:1 Type1 Inactive DFGin 3.895 14.059 ABAminus -87.8, -17.93 -139.88, 174.81 -117.11, 15.44 302.15, 78.23 80.81, -161.08 in-out in 9.646 Saltbr-out 5.79 HRD-in -66.73, -58.39 75.56, -1.78 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 133.51 APE8-dihe-in -55.6, 118.56 APE8-rot-in 311.34 APE67-dihe-in -52.31, -24.07 -117.1, 12.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.562 None None None XRAY 2.2 0.222 0.285 X 365 336 14 0 0 9 [[64, 359]] 1.0 3g9l CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3G9NA 45 400 464.0 J88:60359 Type1 Inactive DFGin 4.041 14.445 ABAminus -80.81, -31.42 -126.47, 165.06 -103.96, 16.15 306.12, 88.19 66.52, -150.08 in-in in 9.103 Saltbr-in 3.014 HRD-in -76.23, -65.0 76.61, 4.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.83, 123.04 APE9-dihe-na -61.39, 135.67 APE8-dihe-in -80.18, 140.44 APE8-rot-in 338.37 APE67-dihe-in -58.4, -8.71 -121.58, -23.12 APE12-dist-out 21.225 APE11-dist-out 15.86 APE10-dist-out 16.537 APE9-dist-out 11.137 None None None XRAY 2.8 0.23 0.326 A 365 346 6 0 0 5 [[64, 359]] 1.0 3g9n CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4KKHA 45 400 464.0 1RQ:501 Type1 Inactive DFGin 4.126 13.825 ABAminus -95.75, -15.69 -135.52, 174.06 -119.9, 12.53 301.49, 87.75 78.76, -148.77 out-out out 10.144 Saltbr-out 4.826 HRD-in -71.66, -60.14 72.25, -5.72 out-out-out SNCooo out-out ActLoopNT-out 6.471 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -78.96, 159.17 APE9-dihe-na -89.66, 137.03 APE8-dihe-in -81.4, 116.29 APE8-rot-in 295.68 APE67-dihe-in -65.99, -18.77 -112.85, 0.32 APE12-dist-out 20.881 APE11-dist-out 17.066 APE10-dist-out 16.26 APE9-dist-out 11.463 None None None XRAY 2.0 0.232 0.277 A 365 351 2 0 0 2 [[64, 359]] 1.0 4kkh CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4W4VA 45 400 464.0 3H8:501 Type1 Inactive DFGin 4.351 14.497 ABAminus -93.0, -11.83 -133.7, 176.77 -119.58, 8.26 299.23, 92.01 75.51, -157.41 out-out out 10.46 Saltbr-out 5.599 HRD-in -58.13, -67.37 74.81, -8.22 out-out-out SNCooo out-out ActLoopNT-out 7.304 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -103.83, 146.28 APE9-dihe-na -90.18, 132.68 APE8-dihe-in -79.34, 115.74 APE8-rot-in 300.63 APE67-dihe-in -54.95, -21.12 -110.05, -7.87 APE12-dist-out 21.637 APE11-dist-out 16.383 APE10-dist-out 16.245 APE9-dist-out 11.441 None None None XRAY 2.01 0.196 0.234 A 366 342 0 0 0 0 [[64, 359]] 1.0 4w4v CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4W4WA 45 400 464.0 3HJ:501 Type1 Inactive DFGin 4.14 14.484 ABAminus -95.32, -15.24 -129.93, 177.53 -119.99, 14.86 299.83, 88.78 73.77, -145.48 out-out out 10.368 Saltbr-out 5.41 HRD-in -60.41, -62.47 73.69, -7.9 out-out-out SNCooo out-out ActLoopNT-out 7.225 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -113.29, 138.66 APE9-dihe-na -79.36, 130.56 APE8-dihe-in -77.38, 118.21 APE8-rot-in 296.85 APE67-dihe-in -57.29, -19.39 -111.76, -6.09 APE12-dist-out 21.541 APE11-dist-out 16.372 APE10-dist-out 16.365 APE9-dist-out 11.393 None None None XRAY 1.9 0.193 0.219 A 366 349 2 0 0 2 [[64, 359]] 1.0 4w4w CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4W4XA 45 400 464.0 3HN:501 Type1 Inactive DFGin 4.171 14.413 ABAminus -89.63, -15.13 -132.25, 173.84 -116.31, 13.6 303.46, 86.27 62.05, -143.63 out-out out 10.457 Saltbr-out 5.4 HRD-in -53.75, -64.52 70.95, -14.06 out-out-out SNCooo out-out ActLoopNT-out 6.011 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -78.52, 132.74 APE9-dihe-na -99.6, 111.7 APE8-dihe-in -76.02, 110.64 APE8-rot-in 292.76 APE67-dihe-in -53.4, -28.67 -106.72, -8.85 APE12-dist-out 21.227 APE11-dist-out 16.168 APE10-dist-out 16.608 APE9-dist-out 11.495 None None None XRAY 2.65 0.197 0.284 A 366 342 0 0 0 0 [[64, 359]] 1.0 4w4x CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4W4YA 45 400 464.0 3HQ:501 Type1 Inactive DFGin 4.194 14.361 ABAminus -87.33, -26.69 -126.91, -179.25 -120.49, 13.13 299.0, 90.7 71.56, -157.39 out-out out 10.203 Saltbr-out 5.196 HRD-in -55.41, -66.43 74.14, -8.64 out-out-out SNCooo out-out ActLoopNT-out 6.654 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.95, 136.26 APE9-dihe-na -89.73, 127.08 APE8-dihe-in -82.99, 118.47 APE8-rot-in 303.19 APE67-dihe-in -63.8, -18.45 -114.76, -4.29 APE12-dist-out 21.509 APE11-dist-out 16.292 APE10-dist-out 16.738 APE9-dist-out 11.498 None None None XRAY 2.3 0.199 0.26 A 366 350 0 0 0 0 [[64, 359]] 1.0 4w4y CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4Y46A 45 400 464.0 4F2:501 Type1 Inactive DFGin 3.823 14.289 ABAminus -87.7, -26.58 -138.88, 174.85 -115.07, 15.83 303.63, 92.35 77.0, -156.68 in-in in 9.463 Saltbr-in 3.267 HRD-in -68.07, -60.06 75.02, -5.57 in-out-out SNCioo out-out ActLoopNT-out 7.326 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -91.12, 132.18 APE9-dihe-na -83.98, 139.29 APE8-dihe-in -88.94, 112.56 APE8-rot-in 298.23 APE67-dihe-in -59.51, -23.67 -103.52, -5.53 APE12-dist-out 21.02 APE11-dist-out 16.194 APE10-dist-out 16.81 APE9-dist-out 11.397 None None None XRAY 2.04 0.214 0.265 A 366 340 2 0 0 2 [[64, 359]] 1.0 4y46 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4Y5HA 45 400 464.0 519:501 Type1 Inactive DFGin 3.648 14.149 ABAminus -89.57, -28.69 -137.82, 174.11 -115.38, 14.05 301.98, 88.19 82.26, -166.72 in-in in 9.213 Saltbr-in 2.732 HRD-in -66.8, -64.56 74.72, -12.11 in-out-out SNCioo out-out ActLoopNT-out 7.24 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -86.33, 133.03 APE9-dihe-na -87.94, 130.0 APE8-dihe-in -83.3, 114.48 APE8-rot-in 295.13 APE67-dihe-in -58.73, -24.66 -109.58, -9.58 APE12-dist-out 20.822 APE11-dist-out 16.224 APE10-dist-out 16.682 APE9-dist-out 11.423 None None None XRAY 2.055 0.238 0.285 A 366 349 2 0 0 2 [[64, 359]] 1.0 4y5h CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4X21A 46 400 464.0 3WH:501 Type1 Inactive DFGin 3.877 14.084 ABAminus -86.15, -29.47 -144.69, -176.02 -119.22, 12.33 302.12, 89.55 63.86, -139.07 in-in in 9.362 Saltbr-in 2.891 HRD-in -67.92, -54.72 67.34, -6.59 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.48 APE8-dihe-in -96.56, 122.08 APE8-rot-out 53.42 APE67-dihe-in -63.39, -15.55 -110.05, 4.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.486 None None None XRAY 1.95 0.201 0.224 A 367 336 14 0 0 14 [[64, 359]] 1.0 4x21 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4X21B 47 400 464.0 3WH:501 Type1 Inactive DFGin 3.917 14.216 ABAminus -86.96, -29.76 -145.94, -175.14 -114.66, 15.37 298.36, 95.81 78.31, -160.57 in-in in 9.042 Saltbr-in 2.817 HRD-in -68.55, -57.06 69.42, -2.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.49 APE8-dihe-in -93.23, 121.56 APE8-rot-out 53.27 APE67-dihe-in -59.62, -14.73 -109.14, 8.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.101 None None None XRAY 1.95 0.201 0.224 B 367 336 13 0 0 13 [[64, 359]] 1.0 4x21 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
6EKDA 46 400 464.0 B9K:503 Type1 Inactive DFGin 4.029 14.011 ABAminus -84.51, -24.1 -150.4, 174.76 -107.15, 10.05 302.03, 94.73 70.49, -149.5 in-in in 8.965 Saltbr-in 2.817 HRD-in -81.16, -60.98 79.57, -9.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 166.28 APE8-dihe-in -121.05, 109.73 APE8-rot-out 66.83 APE67-dihe-in -53.76, -29.69 -102.65, 28.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.682 None None None XRAY 2.1 0.208 0.259 A 367 325 14 0 0 14 [[64, 359]] 1.0 6ekd CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
6EMHC 46 400 464.0 BGE:503 Type1 Inactive DFGin 4.011 14.039 ABAminus -78.44, -28.09 -141.81, 177.01 -104.97, 12.36 301.49, 97.27 78.59, -161.37 in-in in 8.947 Saltbr-in 3.04 HRD-in -74.95, -52.97 66.65, 0.5 in-out-out SNCioo out-out ActLoopNT-out 6.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 130.1 APE8-dihe-in -107.4, 124.09 APE8-rot-in 288.83 APE67-dihe-in -65.02, -21.01 -106.3, -7.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.291 None None None XRAY 1.76 999.0 999.0 C 367 334 15 0 0 10 [[64, 359]] 1.0 6emh CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
6EMHD 46 400 464.0 BGE:503 Type1 Inactive DFGin 3.956 14.409 ABAminus -86.47, -17.97 -146.7, 169.61 -110.56, 12.64 296.15, 94.28 76.93, -162.97 in-in in 9.265 Saltbr-in 3.345 HRD-in -69.69, -55.56 66.61, 3.24 in-out-none SNCion out-none ActLoopNT-out 6.333 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 113.89 APE8-rot-in 293.93 APE67-dihe-in -67.17, -21.93 -103.77, -5.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.76 999.0 999.0 D 367 331 16 0 0 11 [[64, 359]] 1.0 6emh CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4WHZA 45 400 464.0 3NL:501 Type1 Inactive DFGin 4.257 14.358 ABAminus -94.47, -12.46 -131.05, 177.47 -120.57, 15.02 300.43, 89.73 70.56, -144.0 out-out out 10.438 Saltbr-out 5.467 HRD-in -57.31, -62.68 71.7, -10.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -95.65, 152.59 APE9-dihe-na -86.61, 142.35 APE8-dihe-in -94.98, 113.25 APE8-rot-in 300.05 APE67-dihe-in -57.44, -22.55 -104.46, -7.63 APE12-dist-out 21.348 APE11-dist-out 16.55 APE10-dist-out 16.44 APE9-dist-out 11.591 None None None XRAY 1.79 0.195 0.227 A 385 342 5 0 0 5 [[64, 359]] 1.0 4whz CMGC_MAPK10_HUMAN CMGC 1.7e-85 292.9 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3TTIA 46 400 464.0 KBI:465 Type1 Inactive DFGin 3.745 14.309 ABAminus -84.84, -25.79 -129.54, 177.43 -125.37, 9.45 291.53, 89.72 87.55, -161.72 out-out out 10.51 Saltbr-out 5.376 HRD-in -71.84, -58.13 69.57, -6.93 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.57, 148.08 APE9-dihe-na -76.54, 151.7 APE8-dihe-in -106.76, 121.82 APE8-rot-in 307.84 APE67-dihe-in -50.46, -22.4 -103.35, -21.09 APE12-dist-out 21.096 APE11-dist-out 16.517 APE10-dist-out 16.279 APE9-dist-out 11.447 None None None XRAY 2.2 0.246 0.335 A 464 341 5 0 0 5 [[64, 359]] 1.0 3tti CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3TTJA 46 400 464.0 JBI:465 Type1 Inactive DFGin 4.413 14.258 ABAminus -95.22, -16.81 -130.98, 179.24 -123.69, 12.32 296.9, 84.63 77.36, -154.84 out-out out 10.607 Saltbr-out 5.614 HRD-in -85.5, -56.18 74.17, -9.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 115.72 APE8-dihe-in -84.17, 122.25 APE8-rot-out 96.39 APE67-dihe-in -58.1, -21.32 -106.9, -2.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.663 None None None XRAY 2.1 0.206 0.272 A 464 333 9 0 0 9 [[64, 359]] 1.0 3ttj CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
7KSIA 45 400 464.0 X3S:1101 Type1 Inactive DFGin 4.201 14.723 ABAminus -89.26, -22.16 -129.97, 175.12 -114.1, 11.57 295.43, 98.8 80.12, -158.01 out-out out 10.326 Saltbr-out 5.364 HRD-in -66.95, -62.95 75.06, -11.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -94.72, 144.07 APE9-dihe-na -76.27, 148.22 APE8-dihe-in -86.08, 117.1 APE8-rot-in 301.17 APE67-dihe-in -61.75, -19.69 -108.58, -0.06 APE12-dist-out 21.104 APE11-dist-out 16.31 APE10-dist-out 15.905 APE9-dist-out 11.39 None None None XRAY 1.726 0.221 0.255 A 464 346 5 0 0 5 [[64, 359]] 1.0 7ksi CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
7KSJA 45 400 464.0 X3Y:1101 Type1 Inactive DFGin 4.34 14.524 ABAminus -88.89, -37.93 -103.42, -177.58 -125.41, 12.05 293.67, 93.67 92.58, -163.49 out-out out 10.111 Saltbr-out 4.718 HRD-in -65.96, -66.8 78.31, -5.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -107.27, 143.11 APE9-dihe-na -69.18, 147.23 APE8-dihe-in -85.77, 117.85 APE8-rot-in 295.24 APE67-dihe-in -61.01, -25.79 -109.67, 2.88 APE12-dist-out 21.288 APE11-dist-out 16.954 APE10-dist-out 15.727 APE9-dist-out 11.43 None None None XRAY 2.06 0.233 0.292 A 464 346 5 0 0 5 [[64, 359]] 1.0 7ksj CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
7KSKA 45 400 464.0 X3V:1101 Type1 Inactive DFGin 4.523 14.372 ABAminus -100.92, -6.8 -137.01, 172.81 -122.6, 12.61 298.52, 92.45 90.97, -155.88 out-out out 10.502 Saltbr-out 5.59 HRD-in -66.05, -63.01 75.99, -4.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onoo APE10-dihe-na 999.0, 158.61 APE9-dihe-na -97.07, 142.09 APE8-dihe-in -92.84, 118.88 APE8-rot-in 301.68 APE67-dihe-in -69.41, -17.0 -110.23, -1.72 APE12-dist-out 21.218 APE11-dist-none 999.0 APE10-dist-out 16.13 APE9-dist-out 11.416 None None None XRAY 1.84 0.249 0.29 A 464 334 10 0 0 6 [[64, 359]] 1.0 7ksk CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
7S1NA 45 400 464.0 86C:1101 Type1 Inactive DFGin 4.257 14.409 ABAminus -100.47, -4.53 -140.08, 175.62 -121.04, 13.67 301.16, 91.25 86.93, -157.26 out-out out 10.538 Saltbr-out 5.18 HRD-in -70.92, -66.24 79.41, -3.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -98.13, 148.47 APE9-dihe-na -82.7, 146.33 APE8-dihe-in -98.05, 119.87 APE8-rot-in 289.15 APE67-dihe-in -64.0, -15.64 -116.66, 0.57 APE12-dist-out 21.11 APE11-dist-out 16.976 APE10-dist-out 16.179 APE9-dist-out 11.552 None None None XRAY 2.11 0.228 0.267 A 464 346 5 0 0 5 [[64, 359]] 1.0 7s1n CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
7YL1A 45 400 464.0 J6F:501 Type1 Inactive DFGin 3.995 14.06 ABAminus -80.16, -27.18 -141.36, 174.64 -114.52, 17.98 302.24, 85.17 76.51, -161.32 in-in in 9.23 Saltbr-in 2.755 HRD-in -85.09, -59.15 76.16, -2.31 in-out-out SNCioo out-out ActLoopNT-out 6.441 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -89.31, 134.84 APE9-dihe-na -84.54, 138.55 APE8-dihe-in -77.28, 127.44 APE8-rot-in 291.87 APE67-dihe-in -54.76, -19.99 -106.7, -13.11 APE12-dist-out 20.721 APE11-dist-out 15.877 APE10-dist-out 16.196 APE9-dist-out 11.273 None None None XRAY 2.48 0.208 0.294 A 464 352 2 0 0 2 [[64, 359]] 1.0 7yl1 CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
8ENJA 45 400 464.0 WNK:1101 Type1 Inactive DFGin 3.842 14.248 ABAminus -88.05, -38.73 -121.5, 168.67 -103.33, 1.25 297.63, 93.54 89.89, -178.3 in-in in 9.37 Saltbr-in 2.707 HRD-in -55.46, -50.11 59.77, 12.88 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -122.42, 132.55 APE9-dihe-na -66.9, 153.4 APE8-dihe-in -105.79, 106.38 APE8-rot-in 301.96 APE67-dihe-in -58.49, -29.65 -105.57, 5.07 APE12-dist-out 20.558 APE11-dist-out 15.563 APE10-dist-out 16.03 APE9-dist-out 11.203 None None None XRAY 2.81 0.239 0.295 A 464 333 5 0 0 5 [[64, 359]] 1.0 8enj CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
8VNXA 45 400 464.0 WHQ:501 Type1 Inactive DFGin 3.941 14.507 ABAminus -102.24, -9.11 -136.18, 172.0 -118.53, 8.8 298.29, 96.77 92.72, -156.21 out-out out 10.471 Saltbr-out 5.082 HRD-in -72.08, -64.12 78.01, -7.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -140.26, 141.98 APE9-dihe-na -90.13, 137.7 APE8-dihe-in -85.91, 121.26 APE8-rot-in 296.57 APE67-dihe-in -68.08, -16.86 -115.62, -1.33 APE12-dist-out 20.965 APE11-dist-out 15.365 APE10-dist-out 16.042 APE9-dist-out 11.362 None None None XRAY 2.0 0.214 0.256 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vnx CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
8VO4A 45 400 464.0 WHE:501 Type1 Inactive DFGin 4.176 14.552 ABAminus -102.24, -9.15 -135.02, 177.44 -121.18, 14.43 298.17, 99.84 82.54, -155.94 out-out out 10.38 Saltbr-out 5.005 HRD-in -73.08, -59.91 72.72, -2.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -134.27, 137.72 APE9-dihe-na -91.19, 127.94 APE8-dihe-in -84.25, 116.24 APE8-rot-in 287.58 APE67-dihe-in -62.21, -17.3 -111.13, -1.32 APE12-dist-out 21.049 APE11-dist-out 15.697 APE10-dist-out 16.23 APE9-dist-out 11.418 None None None XRAY 2.07 0.222 0.251 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vo4 CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
8VTFA 45 400 464.0 A1ACP:1101 Type1 Inactive DFGin 4.123 14.437 ABAminus -80.88, -55.79 -105.49, 178.52 -116.12, 4.6 292.24, 108.11 97.34, -165.3 out-out out 10.177 Saltbr-out 6.059 HRD-in -81.08, -68.87 73.64, -1.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.73, 154.5 APE9-dihe-na -85.68, 161.75 APE8-dihe-in -104.45, 122.83 APE8-rot-in 288.76 APE67-dihe-in -66.26, -13.42 -118.39, 6.09 APE12-dist-out 21.204 APE11-dist-out 17.128 APE10-dist-out 16.367 APE9-dist-out 11.624 None None None XRAY 2.4 0.258 0.297 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vtf CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
8BZPA 46 400 464.0 SWM:501,C15:512 Type1,Allosteric Inactive DFGin 3.949 13.914 ABAminus -89.43, -27.22 -142.11, 175.41 -118.21, 7.54 305.21, 97.74 61.64, -136.69 in-none in 9.325 Saltbr-none 999.0 HRD-in -70.92, -54.64 68.45, -3.99 none-out-out SNCnoo out-out ActLoopNT-out 5.613 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 153.19 APE8-dihe-in -106.65, 112.81 APE8-rot-in 284.72 APE67-dihe-in -67.36, -13.74 -110.92, 6.88 APE12-dist-out 16.009 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.846 None None None XRAY 1.86 0.19 0.216 A 364 350 5 0 0 5 [[64, 359]] 1.0 8bzp CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
6EMHA 46 400 464.0 BGE:504,C15:506 Type1,Allosteric Inactive DFGin 3.93 14.084 ABAminus -88.94, -22.23 -144.23, 173.35 -118.59, 4.36 304.38, 93.6 70.22, -170.04 in-in in 9.224 Saltbr-in 2.946 HRD-in -75.21, -57.6 72.31, -9.22 in-out-out SNCioo out-out ActLoopNT-out 6.35 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -72.6 APE8-dihe-in -99.06, 111.23 APE8-rot-in 304.28 APE67-dihe-in -64.51, -16.6 -105.92, -9.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.843 None None None XRAY 1.76 999.0 999.0 A 367 344 11 0 0 5 [[64, 359]] 1.0 6emh CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
6EMHB 46 400 464.0 BGE:502,C15:504 Type1,Allosteric Inactive DFGin 3.984 13.975 ABAminus -90.53, -23.08 -143.55, 174.7 -119.54, -1.04 302.02, 90.55 71.56, -172.09 in-in in 9.088 Saltbr-in 3.139 HRD-in -71.43, -57.72 66.61, -12.51 in-out-out SNCioo out-out ActLoopNT-out 6.469 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 150.41 APE8-dihe-in -92.15, 115.96 APE8-rot-in 304.13 APE67-dihe-in -65.86, -16.66 -109.13, -2.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.98 None None None XRAY 1.76 999.0 999.0 B 367 344 11 0 0 5 [[64, 359]] 1.0 6emh CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
7OREA 44 402 464.0 0EI:501,0EI:502 Type1,Type1 Inactive DFGin 4.023 14.301 ABAminus -98.97, -20.09 -132.83, 164.99 -116.84, 14.6 302.9, 89.22 80.62, -146.78 out-out out 10.038 Saltbr-out 3.961 HRD-in -72.28, -69.38 82.06, -0.79 out-out-out SNCooo out-out ActLoopNT-out 6.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -101.98, 127.32 APE9-dihe-na -80.64, 136.59 APE8-dihe-in -94.78, 120.74 APE8-rot-out 76.6 APE67-dihe-in -55.36, -20.69 -121.31, 6.07 APE12-dist-out 21.48 APE11-dist-out 16.203 APE10-dist-out 16.802 APE9-dist-out 11.541 None None None XRAY 2.18 0.219 0.276 A 365 352 0 0 0 0 [[64, 359]] 1.0 7ore CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
8BZPB 47 400 464.0 SWM:502,C15:509,C15:510 Type1,Type1,Allosteric Inactive DFGin 3.894 14.372 ABAminus -88.61, -25.41 -141.39, 172.54 -107.56, 12.73 298.48, 92.43 76.94, -166.0 in-out in 9.47 Saltbr-out 3.71 HRD-in -75.07, -55.95 68.9, 0.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.71 APE8-rot-out 62.47 APE67-dihe-in -67.38, -8.49 -119.38, 11.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.86 0.19 0.216 B 364 326 19 0 0 15 [[64, 359]] 1.0 8bzp CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
2O0UA 46 400 464.0 C0M:2000 Type1.5_Back Inactive DFGin 4.014 14.575 ABAminus -96.14, 3.75 -155.59, 163.16 -108.19, 4.6 294.5, 99.42 86.16, -149.68 out-out out 10.0 Saltbr-out 6.885 HRD-in -74.91, -60.71 75.15, -8.51 out-out-out SNCooo out-out ActLoopNT-out 7.739 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -110.11, 136.55 APE9-dihe-na -78.15, 152.6 APE8-dihe-in -96.18, 117.85 APE8-rot-in 305.46 APE67-dihe-in -57.93, -20.71 -109.84, -4.34 APE12-dist-out 21.534 APE11-dist-out 16.964 APE10-dist-out 17.003 APE9-dist-out 11.333 None None None XRAY 2.1 0.225 0.283 A 364 331 5 0 0 5 [[64, 359]] 1.0 2o0u CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3DA6A 46 401 464.0 BZ9:1 Type1.5_Front Inactive DFGin 3.929 14.747 ABAminus -106.52, -2.79 -134.69, 178.18 -120.78, 7.15 305.58, 102.19 77.8, -154.0 out-out out 11.165 Saltbr-out 7.563 HRD-in -66.32, -64.11 78.04, -4.14 out-out-out SNCooo out-out ActLoopNT-out 7.545 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 119.26 APE9-dihe-na -81.12, 139.86 APE8-dihe-in -90.77, 119.11 APE8-rot-out 151.47 APE67-dihe-in -57.67, -20.17 -106.88, -4.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.019 APE9-dist-out 11.829 None None None XRAY 2.0 0.259 0.32 A 364 328 12 0 0 10 [[64, 359]] 1.0 3da6 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4U79A 44 400 464.0 3EL:501 Type1.5_Front Inactive DFGin 4.272 14.867 ABAminus -89.42, -22.99 -142.11, 177.19 -106.92, 6.69 291.05, 92.1 89.72, -154.87 out-out out 10.185 Saltbr-out 7.925 HRD-in -77.27, -59.41 68.42, 2.43 out-out-out SNCooo out-out ActLoopNT-out 6.442 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.02 APE8-dihe-in -101.3, 127.09 APE8-rot-out 123.68 APE67-dihe-in -52.45, -19.16 -120.61, -1.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.63 None None None XRAY 2.23 0.218 0.249 A 364 337 13 0 0 11 [[64, 359]] 1.0 4u79 CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4H39A 45 400 464.0 No_ligand No_ligand Inactive DFGin 5.25 14.574 BLAminus -135.74, 177.64 67.79, 58.03 -48.04, 39.4 308.27, 161.33 82.76, 999.0 in-in in 9.412 Saltbr-in 3.021 HRD-in -65.57, -62.31 77.5, -15.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na -125.25, 126.08 APE9-dihe-na -59.68, 142.31 APE8-dihe-out -61.66, -167.74 APE8-rot-in 336.06 APE67-dihe-out -51.11, -30.59 94.07, -66.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.077 None None None XRAY 1.992 0.211 0.239 A 356 340 16 0 0 11 [[64, 359]] 1.0 4h39 CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4H36A 45 400 464.0 No_ligand No_ligand Inactive DFGin 4.352 13.961 BLBplus -105.58, 164.65 61.07, 38.9 -74.16, 126.14 41.86, 88.84 66.48, 30.02 in-in in 9.412 Saltbr-in 3.132 HRD-in -63.45, -56.99 70.69, -34.38 in-out-out SNCioo out-out ActLoopNT-out 11.592 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -137.41, 144.25 APE9-dihe-na -77.09, 149.63 APE8-dihe-out -77.78, -16.34 APE8-rot-in 333.94 APE67-dihe-in -62.0, -31.26 -52.55, -42.99 APE12-dist-out 19.427 APE11-dist-out 15.301 APE10-dist-out 16.017 APE9-dist-out 10.921 None None None XRAY 3.0 0.219 0.269 A 356 353 3 0 0 0 [[64, 359]] 1.0 4h36 CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4H3BA 45 400 464.0 No_ligand No_ligand Inactive DFGin 4.716 14.029 BLBplus -123.41, 176.65 67.2, 22.96 -66.31, 128.63 45.16, 92.75 81.86, 0.06 in-in in 9.211 Saltbr-in 2.82 HRD-in -72.51, -55.43 76.6, -32.39 in-out-out SNCioo out-out ActLoopNT-out 10.984 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -127.64, 145.01 APE9-dihe-na -67.81, 151.17 APE8-dihe-out -78.78, -22.86 APE8-rot-in 318.88 APE67-dihe-in -63.25, -19.39 -46.58, -43.53 APE12-dist-out 19.354 APE11-dist-out 15.058 APE10-dist-out 16.389 APE9-dist-out 10.981 None None None XRAY 2.08 0.187 0.235 A 356 351 5 0 0 0 [[64, 359]] 1.0 4h3b CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
4H3BC 45 400 464.0 No_ligand No_ligand Inactive DFGin 4.631 13.991 BLBplus -121.69, 179.82 65.29, 21.46 -67.38, 128.27 47.58, 92.38 80.35, 1.93 in-in in 9.236 Saltbr-in 2.937 HRD-in -73.51, -54.45 77.5, -31.66 in-out-out SNCioo out-out ActLoopNT-out 11.102 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -132.97, 144.71 APE9-dihe-na -66.82, 150.47 APE8-dihe-out -80.28, -21.43 APE8-rot-in 321.01 APE67-dihe-in -63.29, -18.12 -48.05, -42.67 APE12-dist-out 19.434 APE11-dist-out 15.119 APE10-dist-out 16.352 APE9-dist-out 10.965 None None None XRAY 2.08 0.187 0.235 C 356 351 5 0 0 0 [[64, 359]] 1.0 4h3b CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3OXIA 46 400 464.0 SYY:60001 Type1 Inactive DFGin 4.785 13.316 None -65.65, -67.29 -149.24, -142.55 -154.51, 112.55 32.12, 89.18 -52.06, 999.0 in-in in 9.813 Saltbr-in 2.847 HRD-in -69.6, -55.6 74.47, -18.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.07 APE8-dihe-in -67.1, 115.71 APE8-rot-in 310.72 APE67-dihe-in -75.18, -9.96 -113.13, 12.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.482 None None None XRAY 2.2 0.232 0.275 A 362 322 19 0 0 15 [[64, 359]] 1.0 3oxi CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
3PTGA 46 401 464.0 932:60001 Type1 Inactive DFGin 3.713 13.158 None -76.5, -95.65 -85.65, -153.0 -174.62, 83.6 38.12, 37.79 -80.26, -75.99 in-in in 8.949 Saltbr-in 2.713 HRD-in -82.38, -47.37 67.19, -16.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -33.68 APE8-dihe-out 167.39, -0.43 APE8-rot-out 180.66 APE67-dihe-in -48.92, -26.13 -62.89, -39.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.804 None None None XRAY 2.43 0.247 0.316 A 363 340 16 0 0 13 [[64, 359]] 1.0 3ptg CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
1PMVA 45 400 464.0 537:501 Type1 Inactive DFGin 4.225 14.739 None -81.65, -103.82 -56.07, 179.4 -108.34, 6.78 292.4, 71.45 88.17, -161.99 out-out out 10.043 Saltbr-out 5.502 HRD-in -44.57, -73.88 76.33, -1.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -55.4, 164.21 APE9-dihe-na -103.96, 46.79 APE8-dihe-in -57.98, 139.58 APE8-rot-in 313.89 APE67-dihe-in -60.79, -25.59 -166.19, 12.11 APE12-dist-out 19.386 APE11-dist-in 13.73 APE10-dist-out 15.58 APE9-dist-out 12.255 None None None XRAY 2.5 0.222 0.282 A 364 347 5 0 0 5 [[64, 359]] 1.0 1pmv CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
8VS0A 45 400 464.0 A1ACT:501 Type1 Inactive DFGin 4.012 14.611 None -113.83, -24.3 -131.4, -10.59 66.04, -11.26 300.28, 122.45 85.3, -162.24 out-out out 10.031 Saltbr-out 5.964 HRD-in -58.98, -68.6 78.5, 4.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.17, 144.09 APE9-dihe-na -84.41, 142.6 APE8-dihe-in -87.18, 136.96 APE8-rot-in 297.81 APE67-dihe-in -68.04, -18.46 -128.93, 1.97 APE12-dist-out 21.494 APE11-dist-out 16.364 APE10-dist-out 16.312 APE9-dist-out 11.376 None None None XRAY 2.46 0.198 0.25 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vs0 CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10

CMGC_MAPK10 (Mitogen-activated protein kinase 10)

Total number of chains: 77
Active chains: 2
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 67 87.0% 7ORFA
DFGin None 4 5.2% 8VS0A
DFGin BLAminus 3 3.9% AF-P53779-K1A
DFGin BLBplus 3 3.9% 4H36A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MK10_HUMAN AF-P53779-K1A P53779 56 367 464.0 No_ligand No_ligand Active DFGin 6.461 13.71 BLAminus -144.66, 178.16 68.02, 68.74 -85.51, 7.91 305.04, 111.79 -58.24, -29.28 in-in in 8.829 Saltbr-in 2.715 HRD-in -69.27, -45.02 65.07, 2.71 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.65, -32.06 APE9-dihe-na -74.92, 149.28 APE8-dihe-in -65.14, 122.16 APE8-rot-in 305.61 APE67-dihe-in -66.3, -21.56 -45.78, -48.77 APE12-dist-in 12.875 APE11-dist-in 12.513 APE10-dist-in 6.811 APE9-dist-in 4.313 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[64, 359]] 1.0 AF-P53779-K1 Homo sapiens CMGC_MAPK10_HUMAN CMGC 7.9e-86 293.8 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN AF-P53779-K3A P53779 56 367 464.0 No_ligand No_ligand Active DFGin 6.136 14.386 BLAminus -130.69, 176.63 64.98, 65.42 -74.02, 10.59 295.0, 92.08 -61.15, -20.17 in-in in 9.657 Saltbr-in 2.764 HRD-in -73.92, -48.01 61.49, 18.19 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -72.08, 164.58 APE9-dihe-na 64.54, 133.53 APE8-dihe-in -55.1, 131.39 APE8-rot-in 297.6 APE67-dihe-in -67.58, -22.08 -46.44, -46.0 APE12-dist-in 12.729 APE11-dist-in 10.98 APE10-dist-in 6.404 APE9-dist-in 3.154 None None None AF2 -1.0 1.0 1.0 A 312 312 0 0 0 0 [[64, 359]] 1.0 AF-P53779-K3 Homo sapiens CMGC_MAPK10_HUMAN CMGC 7.9e-86 293.8 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 8WGFA P53779 44 400 464.0 ANP:60401 ATPlike Inactive DFGin 3.669 14.04 ABAminus -79.02, -31.55 -136.84, 175.04 -119.07, 8.28 296.56, 96.93 82.35, -157.09 in-out in 9.384 Saltbr-out 5.018 HRD-in -58.91, -63.96 74.85, 1.04 out-out-out SNCooo out-out ActLoopNT-out 7.325 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -90.96, 137.03 APE9-dihe-na -73.55, 128.96 APE8-dihe-in -72.45, 116.03 APE8-rot-in 306.62 APE67-dihe-in -62.34, -20.8 -105.53, -9.26 APE12-dist-out 20.953 APE11-dist-out 15.692 APE10-dist-out 16.374 APE9-dist-out 11.022 None None None XRAY 1.85 0.212 0.266 A 364 345 4 0 0 4 [[64, 359]] 1.0 8wgf Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4KKEA P53779 45 400 464.0 AMP:501 ATPlike Inactive DFGin 3.889 14.134 ABAminus -83.98, -33.4 -131.72, 175.68 -114.08, 11.08 302.89, 82.85 75.62, -152.87 in-out in 9.705 Saltbr-out 5.629 HRD-in -71.56, -61.65 73.66, -1.84 out-out-out SNCooo out-out ActLoopNT-out 5.896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -98.43, 129.33 APE9-dihe-na -82.63, 139.65 APE8-dihe-in -89.17, 118.02 APE8-rot-in 308.05 APE67-dihe-in -54.19, -24.02 -104.28, -7.92 APE12-dist-out 21.356 APE11-dist-out 16.314 APE10-dist-out 17.192 APE9-dist-out 11.507 None None None XRAY 2.2 0.233 0.291 A 365 354 2 0 0 2 [[64, 359]] 1.0 4kke Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 6EQ9B P53779 47 400 464.0 ACP:502 ATPlike Inactive DFGin 3.849 14.536 ABAminus -85.08, -18.98 -157.51, 177.19 -105.91, 17.98 303.5, 84.3 71.4, -149.1 in-in in 9.644 Saltbr-in 2.882 HRD-in -75.97, -57.51 71.23, 0.13 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 107.58 APE8-dihe-in -64.66, 120.8 APE8-rot-in 307.67 APE67-dihe-in -65.89, -19.34 -114.84, 1.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.043 None None None XRAY 1.83 0.207 0.252 B 367 332 14 0 0 14 [[64, 359]] 1.0 6eq9 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 1JNKA P53779 45 400 464.0 ANP:1001 ATPlike Inactive DFGin 3.929 14.397 ABAminus -78.22, -57.34 -98.44, 177.55 -110.1, 6.65 294.57, 85.06 91.46, -137.75 in-out in 9.683 Saltbr-out 4.075 HRD-in -45.57, -68.64 69.61, 1.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.55, 160.68 APE9-dihe-na -118.58, 134.57 APE8-dihe-in -89.41, 118.53 APE8-rot-in 305.71 APE67-dihe-in -40.1, -24.2 -103.88, -20.46 APE12-dist-out 21.317 APE11-dist-out 17.873 APE10-dist-out 16.746 APE9-dist-out 11.497 None None None XRAY 2.3 0.222 0.274 A 423 346 5 0 0 5 [[64, 359]] 1.0 1jnk Homo sapiens CMGC_MAPK10_HUMAN CMGC 2.3e-85 292.5 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 6EQ9A P53779 46 400 464.0 ACP:505,C15:506 ATPlike,Allosteric Inactive DFGin 3.763 14.179 ABAminus -90.84, -25.71 -146.46, -174.02 -119.81, 8.04 305.39, 99.67 64.39, -162.69 in-out in 9.653 Saltbr-out 3.917 HRD-in -74.99, -56.85 72.96, -15.02 out-out-out SNCooo out-out ActLoopNT-out 6.285 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -45.37 APE8-dihe-in -112.64, 106.03 APE8-rot-in 290.72 APE67-dihe-in -70.8, -9.5 -110.9, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.517 None None None XRAY 1.83 0.207 0.252 A 367 350 5 0 0 5 [[64, 359]] 1.0 6eq9 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4Z9LA P53779 45 400 464.0 ANP:501,880:502 Allosteric,Type1 Inactive DFGin 4.174 14.445 ABAminus -84.27, -25.72 -124.69, 176.34 -117.02, 11.08 300.14, 92.59 64.94, -148.04 out-out out 10.091 Saltbr-out 4.206 HRD-in -57.93, -67.24 75.49, -7.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.12 APE8-dihe-in -74.24, 114.86 APE8-rot-in 306.24 APE67-dihe-in -45.55, -30.35 -108.57, -9.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.617 None None None XRAY 2.1 0.201 0.226 A 364 333 12 0 0 10 [[64, 359]] 1.0 4z9l Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4KKGA P53779 45 400 464.0 No_ligand No_ligand Inactive DFGin 3.937 13.676 ABAminus -75.83, -45.13 -131.33, 176.64 -113.17, 12.41 309.43, 86.41 80.11, -157.33 in-in in 9.443 Saltbr-in 2.728 HRD-in -64.48, -65.76 69.66, 7.0 in-out-out SNCioo out-out ActLoopNT-out 7.028 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -73.39, 145.44 APE9-dihe-na -88.72, 145.7 APE8-dihe-in -84.83, 121.79 APE8-rot-in 312.15 APE67-dihe-in -55.99, -20.76 -107.55, -3.77 APE12-dist-out 20.754 APE11-dist-out 15.948 APE10-dist-out 16.774 APE9-dist-out 11.081 None None None XRAY 2.4 0.242 0.3 A 365 353 3 0 0 3 [[64, 359]] 1.0 4kkg Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3FI2A P53779 45 400 464.0 JK1:60600 Type1 Inactive DFGin 4.013 14.36 ABAminus -97.98, -16.74 -139.04, 175.81 -116.69, 9.05 296.36, 85.23 76.44, -166.15 out-out out 10.054 Saltbr-out 6.393 HRD-in -82.97, -57.99 73.2, -7.49 out-out-out SNCooo out-out ActLoopNT-out 7.443 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 106.11 APE8-dihe-in -80.77, 109.8 APE8-rot-out 57.74 APE67-dihe-in -61.36, -20.96 -115.45, 26.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.343 None None OCY117,OCY201,UNK364,UNK376,UNK377,UNK378,UNK379,UNK380 XRAY 2.28 0.189 0.267 A 353 328 17 0 0 12 [[64, 359]] 1.0 3fi2 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.2e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3FV8A P53779 46 400 464.0 JK3:60500 Type1 Inactive DFGin 3.606 13.821 ABAminus -83.18, -27.03 -139.59, 175.59 -113.26, 11.78 301.15, 84.13 68.03, -169.16 in-in in 9.042 Saltbr-in 2.757 HRD-in -79.73, -69.99 84.21, -14.23 in-out-out SNCioo out-out ActLoopNT-out 6.808 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -24.4 APE8-dihe-in -97.4, 91.46 APE8-rot-out 58.89 APE67-dihe-in -57.36, -31.78 -99.48, 38.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.051 None None OCY117,OCY154,OCY201,UNK367,UNK368,UNK369,UNK370,UNK380 XRAY 2.28 0.204 0.284 A 355 334 12 0 0 12 [[64, 359]] 1.0 3fv8 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2B1PA P53779 46 400 464.0 AIZ:501 Type1 Inactive DFGin 4.119 14.333 ABAminus -99.39, -15.41 -130.06, 173.11 -117.75, 9.76 295.76, 89.93 77.33, -157.17 out-out out 10.345 Saltbr-out 6.134 HRD-in -69.84, -62.91 74.58, -6.74 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 112.23 APE8-rot-out 139.52 APE67-dihe-in -64.66, -21.56 -121.59, 10.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.222 0.267 A 355 331 17 0 0 15 [[64, 359]] 1.0 2b1p Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2R9SA P53779 46 401 464.0 255:502 Type1 Inactive DFGin 3.941 13.425 ABAminus -77.42, -30.98 -148.5, -179.18 -116.23, 5.52 300.46, 90.99 75.53, -150.76 in-in in 8.713 Saltbr-in 2.84 HRD-in -76.22, -69.01 82.11, -12.83 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.42, -24.81 999.0, 139.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None OCY154,OCY175,OCY201 XRAY 2.4 0.209 0.29 A 356 328 15 0 0 15 [[64, 359]] 1.0 2r9s Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2R9SB P53779 46 401 464.0 255:501 Type1 Inactive DFGin 3.986 13.55 ABAminus -79.38, -32.11 -143.61, -178.83 -118.88, 2.05 295.67, 88.66 84.96, -147.54 in-in in 8.807 Saltbr-in 2.972 HRD-in -81.84, -63.74 74.18, -13.93 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.16, -23.99 999.0, -56.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None OCY154,OCY175,OCY201 XRAY 2.4 0.209 0.29 B 356 328 15 0 0 15 [[64, 359]] 1.0 2r9s Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2EXCX P53779 45 400 464.0 JNK:600 Type1 Inactive DFGin 3.902 14.113 ABAminus -86.73, -35.58 -120.45, 171.6 -113.23, 9.08 304.24, 90.44 88.87, -156.45 out-out out 10.072 Saltbr-out 5.779 HRD-in -61.35, -62.65 72.11, 16.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 103.39 APE8-dihe-in -44.08, 104.86 APE8-rot-in 320.1 APE67-dihe-in -63.27, -29.62 -104.88, 2.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.548 None None None XRAY 2.75 0.213 0.314 X 356 335 16 0 0 13 [[64, 359]] 1.0 2exc Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3OY1A P53779 46 400 464.0 589:1 Type1 Inactive DFGin 4.017 13.867 ABAminus -89.64, -26.62 -122.11, 179.0 -120.2, 5.88 299.82, 88.25 81.88, -146.56 out-out out 10.377 Saltbr-out 4.958 HRD-in -69.49, -59.44 73.29, -14.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.85 APE8-dihe-in -79.68, 121.61 APE8-rot-out 142.24 APE67-dihe-in -65.74, -23.23 -110.95, 4.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.8 None None None XRAY 1.7 0.259 0.299 A 362 329 17 0 0 14 [[64, 359]] 1.0 3oy1 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3RTPA P53779 46 400 464.0 34I:1 Type1 Inactive DFGin 4.038 14.309 ABAminus -84.14, -44.73 -108.39, 176.15 -118.78, 3.85 293.43, 91.4 79.03, -140.19 in-out in 8.954 Saltbr-out 6.176 HRD-in -62.02, -56.63 68.99, -58.63 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.39 APE8-rot-out 105.29 APE67-dihe-in -64.26, -10.2 -111.75, 8.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.24 0.309 A 363 331 18 0 0 15 [[64, 359]] 1.0 3rtp Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2O2UA P53779 46 400 464.0 738:403 Type1 Inactive DFGin 3.624 14.6 ABAminus -96.37, -18.31 -146.17, 177.04 -117.75, 12.14 292.86, 88.35 89.63, -161.36 out-out out 10.451 Saltbr-out 5.348 HRD-in -63.89, -59.65 62.49, 9.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 122.67 APE8-dihe-in -70.45, 112.53 APE8-rot-in 300.44 APE67-dihe-in -64.48, -20.81 -106.3, 0.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.623 None None None XRAY 2.45 0.234 0.281 A 364 319 15 0 0 13 [[64, 359]] 1.0 2o2u Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2WAJA P53779 46 400 464.0 SNB:1401 Type1 Inactive DFGin 4.389 14.39 ABAminus -101.81, -14.62 -130.98, 175.54 -120.43, 11.32 300.47, 83.01 89.07, -150.28 out-out out 10.807 Saltbr-out 6.144 HRD-in -65.72, -59.02 76.83, -9.7 out-out-out SNCooo out-out ActLoopNT-out 8.23 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -103.28, 143.75 APE9-dihe-na -81.16, 129.27 APE8-dihe-in -82.13, 120.86 APE8-rot-in 298.58 APE67-dihe-in -63.59, -18.92 -106.32, -8.79 APE12-dist-out 21.47 APE11-dist-out 16.714 APE10-dist-out 16.61 APE9-dist-out 11.33 None None None XRAY 2.4 0.187 0.264 A 364 348 5 0 0 3 [[64, 359]] 1.0 2waj Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2ZDTA P53779 45 400 464.0 46C:901 Type1 Inactive DFGin 4.389 13.951 ABAminus -92.15, -23.37 -141.03, 174.08 -115.92, 11.2 298.79, 102.57 73.19, -155.12 in-in in 8.937 Saltbr-in 2.639 HRD-in -71.5, -55.65 75.23, -10.99 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.3, 124.16 APE9-dihe-na -78.97, 134.1 APE8-dihe-in -81.99, 117.03 APE8-rot-in 291.63 APE67-dihe-in -57.51, -21.79 -111.59, 1.66 APE12-dist-out 21.411 APE11-dist-out 16.19 APE10-dist-out 17.22 APE9-dist-out 11.605 None None None XRAY 2.0 0.216 0.262 A 364 342 5 0 0 5 [[64, 359]] 1.0 2zdt Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2ZDUA P53779 46 400 464.0 446:901 Type1 Inactive DFGin 4.509 13.921 ABAminus -92.67, -29.12 -139.81, -177.57 -119.55, 20.22 301.57, 81.84 53.33, -144.86 in-out in 9.916 Saltbr-out 4.541 HRD-in -76.89, -46.06 62.49, -5.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -77.21 APE8-dihe-in -52.28, 112.5 APE8-rot-out 58.09 APE67-dihe-in -61.33, -9.13 -107.74, 8.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.664 None None None XRAY 2.5 0.241 0.319 A 364 330 13 0 0 13 [[64, 359]] 1.0 2zdu Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3FI3A P53779 45 401 464.0 JK2:600 Type1 Inactive DFGin 4.098 14.502 ABAminus -95.27, -22.44 -138.06, 179.21 -118.55, 12.32 297.53, 97.24 81.07, -161.83 out-out out 10.179 Saltbr-out 6.056 HRD-in -83.59, -60.07 74.75, -14.48 out-out-out SNCooo out-out ActLoopNT-out 7.127 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -52.29 APE8-dihe-in -82.93, 104.28 APE8-rot-none 999.0 APE67-dihe-in -62.47, -21.2 -131.09, 35.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.039 None None OCY117,OCY154,OCY175,OCY201 XRAY 2.2 0.187 0.249 A 364 332 17 0 0 12 [[64, 359]] 1.0 3fi3 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3KVXA P53779 46 401 464.0 FMY:403 Type1 Inactive DFGin 4.178 14.845 ABAminus -68.74, -40.9 -149.05, -179.98 -95.84, -1.21 296.53, 141.11 74.59, -148.38 in-out in 9.582 Saltbr-out 4.367 HRD-in -69.12, -64.97 79.94, -8.98 out-out-out SNCooo out-out ActLoopNT-out 6.693 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.74 APE8-dihe-in -77.86, 88.06 APE8-rot-none 999.0 APE67-dihe-in -59.39, -29.94 -116.04, 36.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.548 None None OCY154,OCY175,OCY201 XRAY 2.4 0.222 0.269 A 364 330 12 0 0 12 [[64, 359]] 1.0 3kvx Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3V6RA P53779 45 401 464.0 CQQ:403 Type1 Inactive DFGin 4.028 13.951 ABAminus -80.87, -43.54 -97.1, 172.04 -129.85, -2.71 300.43, 106.35 62.52, -138.57 in-in in 9.406 Saltbr-in 2.929 HRD-in -59.9, -58.47 73.09, -7.56 in-out-out SNCioo out-out ActLoopNT-out 5.256 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -18.11 APE8-dihe-in -114.43, 112.51 APE8-rot-in 287.62 APE67-dihe-in -58.79, -14.57 -115.01, 0.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.871 None None None XRAY 2.6 0.21 0.264 A 364 350 4 0 0 4 [[64, 359]] 1.0 3v6r Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3V6RB P53779 45 401 464.0 CQQ:403 Type1 Inactive DFGin 3.715 13.399 ABAminus -79.96, -42.28 -118.99, -179.28 -116.59, 11.94 308.1, 94.69 75.23, -171.92 in-in in 9.344 Saltbr-in 2.929 HRD-in -58.63, -58.81 71.84, -7.45 in-out-out SNCioo out-out ActLoopNT-out 7.409 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -22.15 APE8-dihe-in -64.39, 126.53 APE8-rot-in 309.1 APE67-dihe-in -73.89, -13.82 -132.78, 15.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.961 None None None XRAY 2.6 0.21 0.264 B 364 347 6 0 0 6 [[64, 359]] 1.0 3v6r Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3V6SA P53779 45 401 464.0 0F0:501 Type1 Inactive DFGin 3.996 13.909 ABAminus -80.53, -45.47 -95.36, 173.26 -130.02, -1.36 300.07, 105.59 61.35, -137.32 in-in in 9.356 Saltbr-in 2.958 HRD-in -60.22, -58.13 73.08, -7.99 in-out-out SNCioo out-out ActLoopNT-out 5.287 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -15.49 APE8-dihe-in -114.54, 111.28 APE8-rot-in 287.86 APE67-dihe-in -57.69, -13.81 -115.62, -0.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.086 None None None XRAY 2.97 0.219 0.263 A 364 349 5 0 0 5 [[64, 359]] 1.0 3v6s Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3V6SB P53779 45 401 464.0 0F0:501 Type1 Inactive DFGin 3.701 13.356 ABAminus -78.85, -43.81 -118.4, -177.55 -117.02, 14.3 308.53, 91.83 72.18, -167.22 in-in in 9.236 Saltbr-in 2.944 HRD-in -59.07, -58.09 71.95, -8.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 46.06 APE8-dihe-out -57.33, -57.64 APE8-rot-in 282.12 APE67-dihe-out -71.89, -14.32 71.18, -3.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.216 None None None XRAY 2.97 0.219 0.263 B 364 341 13 0 0 13 [[64, 359]] 1.0 3v6s Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 1PMNA P53779 45 400 464.0 984:501 Type1 Inactive DFGin 4.012 14.592 ABAminus -94.08, -17.82 -131.05, 174.1 -109.15, 11.87 301.92, 88.96 81.29, -155.79 out-out out 10.636 Saltbr-out 4.955 HRD-in -67.0, -62.79 73.62, -6.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -78.04, -176.93 APE9-dihe-na -102.36, 150.06 APE8-dihe-in -90.71, 115.44 APE8-rot-in 310.97 APE67-dihe-in -48.47, -21.41 -110.06, -2.04 APE12-dist-out 21.376 APE11-dist-out 17.946 APE10-dist-out 15.789 APE9-dist-out 11.489 None None None XRAY 2.2 0.231 0.266 A 364 344 5 0 0 5 [[64, 359]] 1.0 1pmn Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 1PMUA P53779 45 400 464.0 9HP:501 Type1 Inactive DFGin 3.309 13.735 ABAminus -71.28, -47.98 -119.25, 164.66 -96.58, 38.26 303.66, 97.89 37.13, -161.06 in-out in 9.258 Saltbr-out 5.162 HRD-in -50.61, -53.95 59.36, -7.26 out-out-out SNCooo out-out ActLoopNT-out 5.988 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na 40.69, 45.81 APE9-dihe-na -127.15, 91.11 APE8-dihe-in -55.58, 96.38 APE8-rot-in 312.16 APE67-dihe-in -54.92, -19.91 -93.9, -2.59 APE12-dist-in 13.23 APE11-dist-out 15.983 APE10-dist-out 14.5 APE9-dist-out 9.947 None None None XRAY 2.7 0.221 0.285 A 364 342 8 0 0 8 [[64, 359]] 1.0 1pmu Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 7ORFA P53779 45 401 464.0 0G3:501 Type1 Inactive DFGin 4.115 14.737 ABAminus -97.99, -12.98 -132.84, 171.89 -116.88, 8.67 294.57, 101.3 76.53, -147.07 out-out out 10.875 Saltbr-out 6.414 HRD-in -70.63, -58.24 75.59, 2.07 out-out-out SNCooo out-out ActLoopNT-out 6.542 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -64.76, 123.47 APE9-dihe-na -117.31, 139.61 APE8-dihe-in -83.98, 143.05 APE8-rot-out 52.4 APE67-dihe-in -63.07, -25.74 -136.0, 35.01 APE12-dist-out 17.61 APE11-dist-out 17.145 APE10-dist-out 17.177 APE9-dist-out 11.844 None None None XRAY 1.7 0.169 0.205 A 365 351 0 0 0 0 [[64, 359]] 1.0 7orf Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2OK1A P53779 46 400 464.0 33A:1 Type1 Inactive DFGin 3.567 14.673 ABAminus -92.46, -22.86 -139.75, 178.47 -118.63, 10.81 302.45, 82.92 65.72, -145.61 out-out out 10.035 Saltbr-out 5.535 HRD-in -66.04, -65.13 76.53, -1.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.98 APE8-dihe-in -86.1, 116.64 APE8-rot-in 298.81 APE67-dihe-in -61.55, -38.95 -106.56, 7.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.934 None None None XRAY 2.4 0.246 0.294 A 365 333 15 0 0 13 [[64, 359]] 1.0 2ok1 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2P33A P53779 45 400 464.0 J07:507 Type1 Inactive DFGin 3.87 14.212 ABAminus -87.66, -46.82 -121.28, -179.5 -108.24, 17.91 304.2, 78.7 72.88, -164.04 in-in in 9.336 Saltbr-in 3.254 HRD-in -40.72, -67.88 73.94, -1.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -89.09, 177.46 APE9-dihe-na -113.04, 137.19 APE8-dihe-in -75.66, 139.62 APE8-rot-out 55.82 APE67-dihe-in -62.62, -20.71 -131.46, 19.13 APE12-dist-out 20.927 APE11-dist-out 17.626 APE10-dist-out 15.96 APE9-dist-out 11.525 None None None XRAY 2.4 0.253 0.304 A 365 332 5 0 0 5 [[64, 359]] 1.0 2p33 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3CGFA P53779 45 400 464.0 JNF:523 Type1 Inactive DFGin 3.719 14.039 ABAminus -89.59, -53.32 -106.99, -179.49 -117.03, 20.53 309.75, 79.33 76.52, -162.79 in-out in 9.602 Saltbr-out 3.611 HRD-in -43.19, -70.09 72.17, 4.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.93, 178.32 APE9-dihe-na -126.54, 145.54 APE8-dihe-in -86.07, 133.09 APE8-rot-in 307.62 APE67-dihe-in -51.07, -34.7 -123.34, -6.64 APE12-dist-out 21.335 APE11-dist-out 17.893 APE10-dist-out 16.615 APE9-dist-out 11.474 None None None XRAY 3.0 0.225 0.317 A 365 346 5 0 0 5 [[64, 359]] 1.0 3cgf Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3CGOA P53779 45 400 464.0 JNO:510 Type1 Inactive DFGin 3.378 14.153 ABAminus -83.67, -72.6 -89.36, -177.08 -119.2, 23.06 300.34, 81.24 73.78, -174.64 in-in in 9.436 Saltbr-in 3.186 HRD-in -42.19, -65.15 69.86, 5.89 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -77.72, 162.09 APE9-dihe-na -104.67, 146.16 APE8-dihe-in -67.82, 138.78 APE8-rot-in 299.63 APE67-dihe-in -60.19, -32.75 -128.74, -0.9 APE12-dist-out 20.815 APE11-dist-out 17.228 APE10-dist-out 16.125 APE9-dist-out 11.219 None None None XRAY 3.0 0.243 0.318 A 365 332 5 0 0 5 [[64, 359]] 1.0 3cgo Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3G90X P53779 46 400 464.0 J72:1 Type1 Inactive DFGin 3.709 14.207 ABAminus -86.93, -36.26 -125.57, 172.99 -112.97, 14.99 300.31, 89.91 83.13, -154.03 in-in in 8.928 Saltbr-in 2.754 HRD-in -76.16, -59.0 73.09, 0.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -102.89, 143.68 APE9-dihe-na -84.81, 124.61 APE8-dihe-in -64.62, 135.18 APE8-rot-in 301.16 APE67-dihe-in -55.87, -16.77 -115.41, -9.85 APE12-dist-out 20.726 APE11-dist-out 16.374 APE10-dist-out 16.246 APE9-dist-out 11.143 None None None XRAY 2.4 0.218 0.266 X 365 345 7 0 0 5 [[64, 359]] 1.0 3g90 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3G9LX P53779 46 400 464.0 J67:1 Type1 Inactive DFGin 3.895 14.059 ABAminus -87.8, -17.93 -139.88, 174.81 -117.11, 15.44 302.15, 78.23 80.81, -161.08 in-out in 9.646 Saltbr-out 5.79 HRD-in -66.73, -58.39 75.56, -1.78 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 133.51 APE8-dihe-in -55.6, 118.56 APE8-rot-in 311.34 APE67-dihe-in -52.31, -24.07 -117.1, 12.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.562 None None None XRAY 2.2 0.222 0.285 X 365 336 14 0 0 9 [[64, 359]] 1.0 3g9l Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3G9NA P53779 45 400 464.0 J88:60359 Type1 Inactive DFGin 4.041 14.445 ABAminus -80.81, -31.42 -126.47, 165.06 -103.96, 16.15 306.12, 88.19 66.52, -150.08 in-in in 9.103 Saltbr-in 3.014 HRD-in -76.23, -65.0 76.61, 4.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.83, 123.04 APE9-dihe-na -61.39, 135.67 APE8-dihe-in -80.18, 140.44 APE8-rot-in 338.37 APE67-dihe-in -58.4, -8.71 -121.58, -23.12 APE12-dist-out 21.225 APE11-dist-out 15.86 APE10-dist-out 16.537 APE9-dist-out 11.137 None None None XRAY 2.8 0.23 0.326 A 365 346 6 0 0 5 [[64, 359]] 1.0 3g9n Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4KKHA P53779 45 400 464.0 1RQ:501 Type1 Inactive DFGin 4.126 13.825 ABAminus -95.75, -15.69 -135.52, 174.06 -119.9, 12.53 301.49, 87.75 78.76, -148.77 out-out out 10.144 Saltbr-out 4.826 HRD-in -71.66, -60.14 72.25, -5.72 out-out-out SNCooo out-out ActLoopNT-out 6.471 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -78.96, 159.17 APE9-dihe-na -89.66, 137.03 APE8-dihe-in -81.4, 116.29 APE8-rot-in 295.68 APE67-dihe-in -65.99, -18.77 -112.85, 0.32 APE12-dist-out 20.881 APE11-dist-out 17.066 APE10-dist-out 16.26 APE9-dist-out 11.463 None None None XRAY 2.0 0.232 0.277 A 365 351 2 0 0 2 [[64, 359]] 1.0 4kkh Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4W4VA P53779 45 400 464.0 3H8:501 Type1 Inactive DFGin 4.351 14.497 ABAminus -93.0, -11.83 -133.7, 176.77 -119.58, 8.26 299.23, 92.01 75.51, -157.41 out-out out 10.46 Saltbr-out 5.599 HRD-in -58.13, -67.37 74.81, -8.22 out-out-out SNCooo out-out ActLoopNT-out 7.304 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -103.83, 146.28 APE9-dihe-na -90.18, 132.68 APE8-dihe-in -79.34, 115.74 APE8-rot-in 300.63 APE67-dihe-in -54.95, -21.12 -110.05, -7.87 APE12-dist-out 21.637 APE11-dist-out 16.383 APE10-dist-out 16.245 APE9-dist-out 11.441 None None None XRAY 2.01 0.196 0.234 A 366 342 0 0 0 0 [[64, 359]] 1.0 4w4v Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4W4WA P53779 45 400 464.0 3HJ:501 Type1 Inactive DFGin 4.14 14.484 ABAminus -95.32, -15.24 -129.93, 177.53 -119.99, 14.86 299.83, 88.78 73.77, -145.48 out-out out 10.368 Saltbr-out 5.41 HRD-in -60.41, -62.47 73.69, -7.9 out-out-out SNCooo out-out ActLoopNT-out 7.225 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -113.29, 138.66 APE9-dihe-na -79.36, 130.56 APE8-dihe-in -77.38, 118.21 APE8-rot-in 296.85 APE67-dihe-in -57.29, -19.39 -111.76, -6.09 APE12-dist-out 21.541 APE11-dist-out 16.372 APE10-dist-out 16.365 APE9-dist-out 11.393 None None None XRAY 1.9 0.193 0.219 A 366 349 2 0 0 2 [[64, 359]] 1.0 4w4w Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4W4XA P53779 45 400 464.0 3HN:501 Type1 Inactive DFGin 4.171 14.413 ABAminus -89.63, -15.13 -132.25, 173.84 -116.31, 13.6 303.46, 86.27 62.05, -143.63 out-out out 10.457 Saltbr-out 5.4 HRD-in -53.75, -64.52 70.95, -14.06 out-out-out SNCooo out-out ActLoopNT-out 6.011 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -78.52, 132.74 APE9-dihe-na -99.6, 111.7 APE8-dihe-in -76.02, 110.64 APE8-rot-in 292.76 APE67-dihe-in -53.4, -28.67 -106.72, -8.85 APE12-dist-out 21.227 APE11-dist-out 16.168 APE10-dist-out 16.608 APE9-dist-out 11.495 None None None XRAY 2.65 0.197 0.284 A 366 342 0 0 0 0 [[64, 359]] 1.0 4w4x Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4W4YA P53779 45 400 464.0 3HQ:501 Type1 Inactive DFGin 4.194 14.361 ABAminus -87.33, -26.69 -126.91, -179.25 -120.49, 13.13 299.0, 90.7 71.56, -157.39 out-out out 10.203 Saltbr-out 5.196 HRD-in -55.41, -66.43 74.14, -8.64 out-out-out SNCooo out-out ActLoopNT-out 6.654 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.95, 136.26 APE9-dihe-na -89.73, 127.08 APE8-dihe-in -82.99, 118.47 APE8-rot-in 303.19 APE67-dihe-in -63.8, -18.45 -114.76, -4.29 APE12-dist-out 21.509 APE11-dist-out 16.292 APE10-dist-out 16.738 APE9-dist-out 11.498 None None None XRAY 2.3 0.199 0.26 A 366 350 0 0 0 0 [[64, 359]] 1.0 4w4y Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4Y46A P53779 45 400 464.0 4F2:501 Type1 Inactive DFGin 3.823 14.289 ABAminus -87.7, -26.58 -138.88, 174.85 -115.07, 15.83 303.63, 92.35 77.0, -156.68 in-in in 9.463 Saltbr-in 3.267 HRD-in -68.07, -60.06 75.02, -5.57 in-out-out SNCioo out-out ActLoopNT-out 7.326 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -91.12, 132.18 APE9-dihe-na -83.98, 139.29 APE8-dihe-in -88.94, 112.56 APE8-rot-in 298.23 APE67-dihe-in -59.51, -23.67 -103.52, -5.53 APE12-dist-out 21.02 APE11-dist-out 16.194 APE10-dist-out 16.81 APE9-dist-out 11.397 None None None XRAY 2.04 0.214 0.265 A 366 340 2 0 0 2 [[64, 359]] 1.0 4y46 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4Y5HA P53779 45 400 464.0 519:501 Type1 Inactive DFGin 3.648 14.149 ABAminus -89.57, -28.69 -137.82, 174.11 -115.38, 14.05 301.98, 88.19 82.26, -166.72 in-in in 9.213 Saltbr-in 2.732 HRD-in -66.8, -64.56 74.72, -12.11 in-out-out SNCioo out-out ActLoopNT-out 7.24 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -86.33, 133.03 APE9-dihe-na -87.94, 130.0 APE8-dihe-in -83.3, 114.48 APE8-rot-in 295.13 APE67-dihe-in -58.73, -24.66 -109.58, -9.58 APE12-dist-out 20.822 APE11-dist-out 16.224 APE10-dist-out 16.682 APE9-dist-out 11.423 None None None XRAY 2.055 0.238 0.285 A 366 349 2 0 0 2 [[64, 359]] 1.0 4y5h Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4X21A P53779 46 400 464.0 3WH:501 Type1 Inactive DFGin 3.877 14.084 ABAminus -86.15, -29.47 -144.69, -176.02 -119.22, 12.33 302.12, 89.55 63.86, -139.07 in-in in 9.362 Saltbr-in 2.891 HRD-in -67.92, -54.72 67.34, -6.59 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.48 APE8-dihe-in -96.56, 122.08 APE8-rot-out 53.42 APE67-dihe-in -63.39, -15.55 -110.05, 4.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.486 None None None XRAY 1.95 0.201 0.224 A 367 336 14 0 0 14 [[64, 359]] 1.0 4x21 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4X21B P53779 47 400 464.0 3WH:501 Type1 Inactive DFGin 3.917 14.216 ABAminus -86.96, -29.76 -145.94, -175.14 -114.66, 15.37 298.36, 95.81 78.31, -160.57 in-in in 9.042 Saltbr-in 2.817 HRD-in -68.55, -57.06 69.42, -2.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.49 APE8-dihe-in -93.23, 121.56 APE8-rot-out 53.27 APE67-dihe-in -59.62, -14.73 -109.14, 8.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.101 None None None XRAY 1.95 0.201 0.224 B 367 336 13 0 0 13 [[64, 359]] 1.0 4x21 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 6EKDA P53779 46 400 464.0 B9K:503 Type1 Inactive DFGin 4.029 14.011 ABAminus -84.51, -24.1 -150.4, 174.76 -107.15, 10.05 302.03, 94.73 70.49, -149.5 in-in in 8.965 Saltbr-in 2.817 HRD-in -81.16, -60.98 79.57, -9.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 166.28 APE8-dihe-in -121.05, 109.73 APE8-rot-out 66.83 APE67-dihe-in -53.76, -29.69 -102.65, 28.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.682 None None None XRAY 2.1 0.208 0.259 A 367 325 14 0 0 14 [[64, 359]] 1.0 6ekd Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 6EMHC P53779 46 400 464.0 BGE:503 Type1 Inactive DFGin 4.011 14.039 ABAminus -78.44, -28.09 -141.81, 177.01 -104.97, 12.36 301.49, 97.27 78.59, -161.37 in-in in 8.947 Saltbr-in 3.04 HRD-in -74.95, -52.97 66.65, 0.5 in-out-out SNCioo out-out ActLoopNT-out 6.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 130.1 APE8-dihe-in -107.4, 124.09 APE8-rot-in 288.83 APE67-dihe-in -65.02, -21.01 -106.3, -7.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.291 None None None XRAY 1.76 999.0 999.0 C 367 334 15 0 0 10 [[64, 359]] 1.0 6emh Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 6EMHD P53779 46 400 464.0 BGE:503 Type1 Inactive DFGin 3.956 14.409 ABAminus -86.47, -17.97 -146.7, 169.61 -110.56, 12.64 296.15, 94.28 76.93, -162.97 in-in in 9.265 Saltbr-in 3.345 HRD-in -69.69, -55.56 66.61, 3.24 in-out-none SNCion out-none ActLoopNT-out 6.333 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 113.89 APE8-rot-in 293.93 APE67-dihe-in -67.17, -21.93 -103.77, -5.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.76 999.0 999.0 D 367 331 16 0 0 11 [[64, 359]] 1.0 6emh Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4WHZA P53779 45 400 464.0 3NL:501 Type1 Inactive DFGin 4.257 14.358 ABAminus -94.47, -12.46 -131.05, 177.47 -120.57, 15.02 300.43, 89.73 70.56, -144.0 out-out out 10.438 Saltbr-out 5.467 HRD-in -57.31, -62.68 71.7, -10.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -95.65, 152.59 APE9-dihe-na -86.61, 142.35 APE8-dihe-in -94.98, 113.25 APE8-rot-in 300.05 APE67-dihe-in -57.44, -22.55 -104.46, -7.63 APE12-dist-out 21.348 APE11-dist-out 16.55 APE10-dist-out 16.44 APE9-dist-out 11.591 None None None XRAY 1.79 0.195 0.227 A 385 342 5 0 0 5 [[64, 359]] 1.0 4whz Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.7e-85 292.9 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3TTIA P53779 46 400 464.0 KBI:465 Type1 Inactive DFGin 3.745 14.309 ABAminus -84.84, -25.79 -129.54, 177.43 -125.37, 9.45 291.53, 89.72 87.55, -161.72 out-out out 10.51 Saltbr-out 5.376 HRD-in -71.84, -58.13 69.57, -6.93 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.57, 148.08 APE9-dihe-na -76.54, 151.7 APE8-dihe-in -106.76, 121.82 APE8-rot-in 307.84 APE67-dihe-in -50.46, -22.4 -103.35, -21.09 APE12-dist-out 21.096 APE11-dist-out 16.517 APE10-dist-out 16.279 APE9-dist-out 11.447 None None None XRAY 2.2 0.246 0.335 A 464 341 5 0 0 5 [[64, 359]] 1.0 3tti Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3TTJA P53779 46 400 464.0 JBI:465 Type1 Inactive DFGin 4.413 14.258 ABAminus -95.22, -16.81 -130.98, 179.24 -123.69, 12.32 296.9, 84.63 77.36, -154.84 out-out out 10.607 Saltbr-out 5.614 HRD-in -85.5, -56.18 74.17, -9.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 115.72 APE8-dihe-in -84.17, 122.25 APE8-rot-out 96.39 APE67-dihe-in -58.1, -21.32 -106.9, -2.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.663 None None None XRAY 2.1 0.206 0.272 A 464 333 9 0 0 9 [[64, 359]] 1.0 3ttj Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 7KSIA P53779 45 400 464.0 X3S:1101 Type1 Inactive DFGin 4.201 14.723 ABAminus -89.26, -22.16 -129.97, 175.12 -114.1, 11.57 295.43, 98.8 80.12, -158.01 out-out out 10.326 Saltbr-out 5.364 HRD-in -66.95, -62.95 75.06, -11.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -94.72, 144.07 APE9-dihe-na -76.27, 148.22 APE8-dihe-in -86.08, 117.1 APE8-rot-in 301.17 APE67-dihe-in -61.75, -19.69 -108.58, -0.06 APE12-dist-out 21.104 APE11-dist-out 16.31 APE10-dist-out 15.905 APE9-dist-out 11.39 None None None XRAY 1.726 0.221 0.255 A 464 346 5 0 0 5 [[64, 359]] 1.0 7ksi Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 7KSJA P53779 45 400 464.0 X3Y:1101 Type1 Inactive DFGin 4.34 14.524 ABAminus -88.89, -37.93 -103.42, -177.58 -125.41, 12.05 293.67, 93.67 92.58, -163.49 out-out out 10.111 Saltbr-out 4.718 HRD-in -65.96, -66.8 78.31, -5.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -107.27, 143.11 APE9-dihe-na -69.18, 147.23 APE8-dihe-in -85.77, 117.85 APE8-rot-in 295.24 APE67-dihe-in -61.01, -25.79 -109.67, 2.88 APE12-dist-out 21.288 APE11-dist-out 16.954 APE10-dist-out 15.727 APE9-dist-out 11.43 None None None XRAY 2.06 0.233 0.292 A 464 346 5 0 0 5 [[64, 359]] 1.0 7ksj Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 7KSKA P53779 45 400 464.0 X3V:1101 Type1 Inactive DFGin 4.523 14.372 ABAminus -100.92, -6.8 -137.01, 172.81 -122.6, 12.61 298.52, 92.45 90.97, -155.88 out-out out 10.502 Saltbr-out 5.59 HRD-in -66.05, -63.01 75.99, -4.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onoo APE10-dihe-na 999.0, 158.61 APE9-dihe-na -97.07, 142.09 APE8-dihe-in -92.84, 118.88 APE8-rot-in 301.68 APE67-dihe-in -69.41, -17.0 -110.23, -1.72 APE12-dist-out 21.218 APE11-dist-none 999.0 APE10-dist-out 16.13 APE9-dist-out 11.416 None None None XRAY 1.84 0.249 0.29 A 464 334 10 0 0 6 [[64, 359]] 1.0 7ksk Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 7S1NA P53779 45 400 464.0 86C:1101 Type1 Inactive DFGin 4.257 14.409 ABAminus -100.47, -4.53 -140.08, 175.62 -121.04, 13.67 301.16, 91.25 86.93, -157.26 out-out out 10.538 Saltbr-out 5.18 HRD-in -70.92, -66.24 79.41, -3.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -98.13, 148.47 APE9-dihe-na -82.7, 146.33 APE8-dihe-in -98.05, 119.87 APE8-rot-in 289.15 APE67-dihe-in -64.0, -15.64 -116.66, 0.57 APE12-dist-out 21.11 APE11-dist-out 16.976 APE10-dist-out 16.179 APE9-dist-out 11.552 None None None XRAY 2.11 0.228 0.267 A 464 346 5 0 0 5 [[64, 359]] 1.0 7s1n Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 7YL1A P53779 45 400 464.0 J6F:501 Type1 Inactive DFGin 3.995 14.06 ABAminus -80.16, -27.18 -141.36, 174.64 -114.52, 17.98 302.24, 85.17 76.51, -161.32 in-in in 9.23 Saltbr-in 2.755 HRD-in -85.09, -59.15 76.16, -2.31 in-out-out SNCioo out-out ActLoopNT-out 6.441 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -89.31, 134.84 APE9-dihe-na -84.54, 138.55 APE8-dihe-in -77.28, 127.44 APE8-rot-in 291.87 APE67-dihe-in -54.76, -19.99 -106.7, -13.11 APE12-dist-out 20.721 APE11-dist-out 15.877 APE10-dist-out 16.196 APE9-dist-out 11.273 None None None XRAY 2.48 0.208 0.294 A 464 352 2 0 0 2 [[64, 359]] 1.0 7yl1 Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 8ENJA P53779 45 400 464.0 WNK:1101 Type1 Inactive DFGin 3.842 14.248 ABAminus -88.05, -38.73 -121.5, 168.67 -103.33, 1.25 297.63, 93.54 89.89, -178.3 in-in in 9.37 Saltbr-in 2.707 HRD-in -55.46, -50.11 59.77, 12.88 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -122.42, 132.55 APE9-dihe-na -66.9, 153.4 APE8-dihe-in -105.79, 106.38 APE8-rot-in 301.96 APE67-dihe-in -58.49, -29.65 -105.57, 5.07 APE12-dist-out 20.558 APE11-dist-out 15.563 APE10-dist-out 16.03 APE9-dist-out 11.203 None None None XRAY 2.81 0.239 0.295 A 464 333 5 0 0 5 [[64, 359]] 1.0 8enj Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 8VNXA P53779 45 400 464.0 WHQ:501 Type1 Inactive DFGin 3.941 14.507 ABAminus -102.24, -9.11 -136.18, 172.0 -118.53, 8.8 298.29, 96.77 92.72, -156.21 out-out out 10.471 Saltbr-out 5.082 HRD-in -72.08, -64.12 78.01, -7.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -140.26, 141.98 APE9-dihe-na -90.13, 137.7 APE8-dihe-in -85.91, 121.26 APE8-rot-in 296.57 APE67-dihe-in -68.08, -16.86 -115.62, -1.33 APE12-dist-out 20.965 APE11-dist-out 15.365 APE10-dist-out 16.042 APE9-dist-out 11.362 None None None XRAY 2.0 0.214 0.256 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vnx Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 8VO4A P53779 45 400 464.0 WHE:501 Type1 Inactive DFGin 4.176 14.552 ABAminus -102.24, -9.15 -135.02, 177.44 -121.18, 14.43 298.17, 99.84 82.54, -155.94 out-out out 10.38 Saltbr-out 5.005 HRD-in -73.08, -59.91 72.72, -2.94 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -134.27, 137.72 APE9-dihe-na -91.19, 127.94 APE8-dihe-in -84.25, 116.24 APE8-rot-in 287.58 APE67-dihe-in -62.21, -17.3 -111.13, -1.32 APE12-dist-out 21.049 APE11-dist-out 15.697 APE10-dist-out 16.23 APE9-dist-out 11.418 None None None XRAY 2.07 0.222 0.251 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vo4 Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 8VTFA P53779 45 400 464.0 A1ACP:1101 Type1 Inactive DFGin 4.123 14.437 ABAminus -80.88, -55.79 -105.49, 178.52 -116.12, 4.6 292.24, 108.11 97.34, -165.3 out-out out 10.177 Saltbr-out 6.059 HRD-in -81.08, -68.87 73.64, -1.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.73, 154.5 APE9-dihe-na -85.68, 161.75 APE8-dihe-in -104.45, 122.83 APE8-rot-in 288.76 APE67-dihe-in -66.26, -13.42 -118.39, 6.09 APE12-dist-out 21.204 APE11-dist-out 17.128 APE10-dist-out 16.367 APE9-dist-out 11.624 None None None XRAY 2.4 0.258 0.297 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vtf Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 8BZPA P53779 46 400 464.0 SWM:501,C15:512 Type1,Allosteric Inactive DFGin 3.949 13.914 ABAminus -89.43, -27.22 -142.11, 175.41 -118.21, 7.54 305.21, 97.74 61.64, -136.69 in-none in 9.325 Saltbr-none 999.0 HRD-in -70.92, -54.64 68.45, -3.99 none-out-out SNCnoo out-out ActLoopNT-out 5.613 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 153.19 APE8-dihe-in -106.65, 112.81 APE8-rot-in 284.72 APE67-dihe-in -67.36, -13.74 -110.92, 6.88 APE12-dist-out 16.009 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.846 None None None XRAY 1.86 0.19 0.216 A 364 350 5 0 0 5 [[64, 359]] 1.0 8bzp Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 6EMHA P53779 46 400 464.0 BGE:504,C15:506 Type1,Allosteric Inactive DFGin 3.93 14.084 ABAminus -88.94, -22.23 -144.23, 173.35 -118.59, 4.36 304.38, 93.6 70.22, -170.04 in-in in 9.224 Saltbr-in 2.946 HRD-in -75.21, -57.6 72.31, -9.22 in-out-out SNCioo out-out ActLoopNT-out 6.35 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -72.6 APE8-dihe-in -99.06, 111.23 APE8-rot-in 304.28 APE67-dihe-in -64.51, -16.6 -105.92, -9.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.843 None None None XRAY 1.76 999.0 999.0 A 367 344 11 0 0 5 [[64, 359]] 1.0 6emh Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 6EMHB P53779 46 400 464.0 BGE:502,C15:504 Type1,Allosteric Inactive DFGin 3.984 13.975 ABAminus -90.53, -23.08 -143.55, 174.7 -119.54, -1.04 302.02, 90.55 71.56, -172.09 in-in in 9.088 Saltbr-in 3.139 HRD-in -71.43, -57.72 66.61, -12.51 in-out-out SNCioo out-out ActLoopNT-out 6.469 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 150.41 APE8-dihe-in -92.15, 115.96 APE8-rot-in 304.13 APE67-dihe-in -65.86, -16.66 -109.13, -2.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.98 None None None XRAY 1.76 999.0 999.0 B 367 344 11 0 0 5 [[64, 359]] 1.0 6emh Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.0 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 7OREA P53779 44 402 464.0 0EI:501,0EI:502 Type1,Type1 Inactive DFGin 4.023 14.301 ABAminus -98.97, -20.09 -132.83, 164.99 -116.84, 14.6 302.9, 89.22 80.62, -146.78 out-out out 10.038 Saltbr-out 3.961 HRD-in -72.28, -69.38 82.06, -0.79 out-out-out SNCooo out-out ActLoopNT-out 6.715 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -101.98, 127.32 APE9-dihe-na -80.64, 136.59 APE8-dihe-in -94.78, 120.74 APE8-rot-out 76.6 APE67-dihe-in -55.36, -20.69 -121.31, 6.07 APE12-dist-out 21.48 APE11-dist-out 16.203 APE10-dist-out 16.802 APE9-dist-out 11.541 None None None XRAY 2.18 0.219 0.276 A 365 352 0 0 0 0 [[64, 359]] 1.0 7ore Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 8BZPB P53779 47 400 464.0 SWM:502,C15:509,C15:510 Type1,Type1,Allosteric Inactive DFGin 3.894 14.372 ABAminus -88.61, -25.41 -141.39, 172.54 -107.56, 12.73 298.48, 92.43 76.94, -166.0 in-out in 9.47 Saltbr-out 3.71 HRD-in -75.07, -55.95 68.9, 0.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.71 APE8-rot-out 62.47 APE67-dihe-in -67.38, -8.49 -119.38, 11.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.86 0.19 0.216 B 364 326 19 0 0 15 [[64, 359]] 1.0 8bzp Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 2O0UA P53779 46 400 464.0 C0M:2000 Type1.5_Back Inactive DFGin 4.014 14.575 ABAminus -96.14, 3.75 -155.59, 163.16 -108.19, 4.6 294.5, 99.42 86.16, -149.68 out-out out 10.0 Saltbr-out 6.885 HRD-in -74.91, -60.71 75.15, -8.51 out-out-out SNCooo out-out ActLoopNT-out 7.739 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -110.11, 136.55 APE9-dihe-na -78.15, 152.6 APE8-dihe-in -96.18, 117.85 APE8-rot-in 305.46 APE67-dihe-in -57.93, -20.71 -109.84, -4.34 APE12-dist-out 21.534 APE11-dist-out 16.964 APE10-dist-out 17.003 APE9-dist-out 11.333 None None None XRAY 2.1 0.225 0.283 A 364 331 5 0 0 5 [[64, 359]] 1.0 2o0u Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3DA6A P53779 46 401 464.0 BZ9:1 Type1.5_Front Inactive DFGin 3.929 14.747 ABAminus -106.52, -2.79 -134.69, 178.18 -120.78, 7.15 305.58, 102.19 77.8, -154.0 out-out out 11.165 Saltbr-out 7.563 HRD-in -66.32, -64.11 78.04, -4.14 out-out-out SNCooo out-out ActLoopNT-out 7.545 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 119.26 APE9-dihe-na -81.12, 139.86 APE8-dihe-in -90.77, 119.11 APE8-rot-out 151.47 APE67-dihe-in -57.67, -20.17 -106.88, -4.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.019 APE9-dist-out 11.829 None None None XRAY 2.0 0.259 0.32 A 364 328 12 0 0 10 [[64, 359]] 1.0 3da6 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4U79A P53779 44 400 464.0 3EL:501 Type1.5_Front Inactive DFGin 4.272 14.867 ABAminus -89.42, -22.99 -142.11, 177.19 -106.92, 6.69 291.05, 92.1 89.72, -154.87 out-out out 10.185 Saltbr-out 7.925 HRD-in -77.27, -59.41 68.42, 2.43 out-out-out SNCooo out-out ActLoopNT-out 6.442 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.02 APE8-dihe-in -101.3, 127.09 APE8-rot-out 123.68 APE67-dihe-in -52.45, -19.16 -120.61, -1.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.63 None None None XRAY 2.23 0.218 0.249 A 364 337 13 0 0 11 [[64, 359]] 1.0 4u79 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4H39A P53779 45 400 464.0 No_ligand No_ligand Inactive DFGin 5.25 14.574 BLAminus -135.74, 177.64 67.79, 58.03 -48.04, 39.4 308.27, 161.33 82.76, 999.0 in-in in 9.412 Saltbr-in 3.021 HRD-in -65.57, -62.31 77.5, -15.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na -125.25, 126.08 APE9-dihe-na -59.68, 142.31 APE8-dihe-out -61.66, -167.74 APE8-rot-in 336.06 APE67-dihe-out -51.11, -30.59 94.07, -66.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.077 None None None XRAY 1.992 0.211 0.239 A 356 340 16 0 0 11 [[64, 359]] 1.0 4h39 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4H36A P53779 45 400 464.0 No_ligand No_ligand Inactive DFGin 4.352 13.961 BLBplus -105.58, 164.65 61.07, 38.9 -74.16, 126.14 41.86, 88.84 66.48, 30.02 in-in in 9.412 Saltbr-in 3.132 HRD-in -63.45, -56.99 70.69, -34.38 in-out-out SNCioo out-out ActLoopNT-out 11.592 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -137.41, 144.25 APE9-dihe-na -77.09, 149.63 APE8-dihe-out -77.78, -16.34 APE8-rot-in 333.94 APE67-dihe-in -62.0, -31.26 -52.55, -42.99 APE12-dist-out 19.427 APE11-dist-out 15.301 APE10-dist-out 16.017 APE9-dist-out 10.921 None None None XRAY 3.0 0.219 0.269 A 356 353 3 0 0 0 [[64, 359]] 1.0 4h36 Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4H3BA P53779 45 400 464.0 No_ligand No_ligand Inactive DFGin 4.716 14.029 BLBplus -123.41, 176.65 67.2, 22.96 -66.31, 128.63 45.16, 92.75 81.86, 0.06 in-in in 9.211 Saltbr-in 2.82 HRD-in -72.51, -55.43 76.6, -32.39 in-out-out SNCioo out-out ActLoopNT-out 10.984 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -127.64, 145.01 APE9-dihe-na -67.81, 151.17 APE8-dihe-out -78.78, -22.86 APE8-rot-in 318.88 APE67-dihe-in -63.25, -19.39 -46.58, -43.53 APE12-dist-out 19.354 APE11-dist-out 15.058 APE10-dist-out 16.389 APE9-dist-out 10.981 None None None XRAY 2.08 0.187 0.235 A 356 351 5 0 0 0 [[64, 359]] 1.0 4h3b Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 4H3BC P53779 45 400 464.0 No_ligand No_ligand Inactive DFGin 4.631 13.991 BLBplus -121.69, 179.82 65.29, 21.46 -67.38, 128.27 47.58, 92.38 80.35, 1.93 in-in in 9.236 Saltbr-in 2.937 HRD-in -73.51, -54.45 77.5, -31.66 in-out-out SNCioo out-out ActLoopNT-out 11.102 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -132.97, 144.71 APE9-dihe-na -66.82, 150.47 APE8-dihe-out -80.28, -21.43 APE8-rot-in 321.01 APE67-dihe-in -63.29, -18.12 -48.05, -42.67 APE12-dist-out 19.434 APE11-dist-out 15.119 APE10-dist-out 16.352 APE9-dist-out 10.965 None None None XRAY 2.08 0.187 0.235 C 356 351 5 0 0 0 [[64, 359]] 1.0 4h3b Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.3e-85 293.2 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3OXIA P53779 46 400 464.0 SYY:60001 Type1 Inactive DFGin 4.785 13.316 None -65.65, -67.29 -149.24, -142.55 -154.51, 112.55 32.12, 89.18 -52.06, 999.0 in-in in 9.813 Saltbr-in 2.847 HRD-in -69.6, -55.6 74.47, -18.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.07 APE8-dihe-in -67.1, 115.71 APE8-rot-in 310.72 APE67-dihe-in -75.18, -9.96 -113.13, 12.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.482 None None None XRAY 2.2 0.232 0.275 A 362 322 19 0 0 15 [[64, 359]] 1.0 3oxi Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 3PTGA P53779 46 401 464.0 932:60001 Type1 Inactive DFGin 3.713 13.158 None -76.5, -95.65 -85.65, -153.0 -174.62, 83.6 38.12, 37.79 -80.26, -75.99 in-in in 8.949 Saltbr-in 2.713 HRD-in -82.38, -47.37 67.19, -16.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -33.68 APE8-dihe-out 167.39, -0.43 APE8-rot-out 180.66 APE67-dihe-in -48.92, -26.13 -62.89, -39.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.804 None None None XRAY 2.43 0.247 0.316 A 363 340 16 0 0 13 [[64, 359]] 1.0 3ptg Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 1PMVA P53779 45 400 464.0 537:501 Type1 Inactive DFGin 4.225 14.739 None -81.65, -103.82 -56.07, 179.4 -108.34, 6.78 292.4, 71.45 88.17, -161.99 out-out out 10.043 Saltbr-out 5.502 HRD-in -44.57, -73.88 76.33, -1.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -55.4, 164.21 APE9-dihe-na -103.96, 46.79 APE8-dihe-in -57.98, 139.58 APE8-rot-in 313.89 APE67-dihe-in -60.79, -25.59 -166.19, 12.11 APE12-dist-out 19.386 APE11-dist-in 13.73 APE10-dist-out 15.58 APE9-dist-out 12.255 None None None XRAY 2.5 0.222 0.282 A 364 347 5 0 0 5 [[64, 359]] 1.0 1pmv Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
MK10_HUMAN 8VS0A P53779 45 400 464.0 A1ACT:501 Type1 Inactive DFGin 4.012 14.611 None -113.83, -24.3 -131.4, -10.59 66.04, -11.26 300.28, 122.45 85.3, -162.24 out-out out 10.031 Saltbr-out 5.964 HRD-in -58.98, -68.6 78.5, 4.43 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -105.17, 144.09 APE9-dihe-na -84.41, 142.6 APE8-dihe-in -87.18, 136.96 APE8-rot-in 297.81 APE67-dihe-in -68.04, -18.46 -128.93, 1.97 APE12-dist-out 21.494 APE11-dist-out 16.364 APE10-dist-out 16.312 APE9-dist-out 11.376 None None None XRAY 2.46 0.198 0.25 A 464 346 5 0 0 5 [[64, 359]] 1.0 8vs0 Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10

CMGC_MAPK10 (Mitogen-activated protein kinase 10)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name