TKL_MAP3K9 (Mitogen-activated protein kinase kinase kinase 9)

Total number of chains: 5
Active chains: 2
Family: TKL
Uniprot: M3K9_HUMAN
Kinase Domain Residues: 144 - 405
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 60.0% 4UY9A
DFGin BLAminus 2 40.0% AF-P80192-K1A

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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P80192-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 136 - 413 0 None None Mitogen-activated protein kinase kinase kinase 9
AF-P80192-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 136 - 413 0 None None Mitogen-activated protein kinase kinase kinase 9
4UY9A 2.81 Inactive DFGin‑BLBplus in-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 135 - 447 0 None None Mitogen-activated protein kinase kinase kinase 9
4UY9B 2.81 Inactive DFGin‑BLBplus in-none out-out nonTYR APEdihe_aaoni APEdist_oooo No_ligand No_ligand 135 - 449 0 None None Mitogen-activated protein kinase kinase kinase 9
3DTCA 2.6 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaini APEdist_nnno VIN Type1 136 - 405 0 None T312A Mitogen-activated protein kinase kinase kinase 9

TKL_MAP3K9 (Mitogen-activated protein kinase kinase kinase 9)

Total number of chains: 5
Active chains: 2
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 60.0% 4UY9A
DFGin BLAminus 2 40.0% AF-P80192-K1A

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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
M3K9_HUMAN AF-P80192-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 136 - 413 0 None None Mitogen-activated protein kinase kinase kinase 9 Homo sapiens
M3K9_HUMAN AF-P80192-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 136 - 413 0 None None Mitogen-activated protein kinase kinase kinase 9 Homo sapiens
M3K9_HUMAN 4UY9A 2.81 Inactive DFGin‑BLBplus in-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 135 - 447 0 None None Mitogen-activated protein kinase kinase kinase 9 Homo sapiens
M3K9_HUMAN 4UY9B 2.81 Inactive DFGin‑BLBplus in-none out-out nonTYR APEdihe_aaoni APEdist_oooo No_ligand No_ligand 135 - 449 0 None None Mitogen-activated protein kinase kinase kinase 9 Homo sapiens
M3K9_HUMAN 3DTCA 2.6 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaini APEdist_nnno VIN Type1 136 - 405 0 None T312A Mitogen-activated protein kinase kinase kinase 9 Homo sapiens

TKL_MAP3K9 (Mitogen-activated protein kinase kinase kinase 9)

Total number of chains: 0
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative

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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism