TKL_MAP3K9 (Mitogen-activated protein kinase kinase kinase 9)

Total number of chains: 5
Active chains: 2
Family: TKL
Uniprot: M3K9_HUMAN
Kinase Domain Residues: 144 - 405
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 60.0% 4UY9A
DFGin BLAminus 2 40.0% AF-P80192-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P80192-K1A 136 413 1104.0 No_ligand No_ligand Active DFGin 6.824 13.849 BLAminus -136.57, 176.39 63.77, 67.83 -79.73, 12.36 294.5, 94.44 -60.81, -31.69 in-in in 9.092 Saltbr-in 2.843 HRD-in -72.89, -44.14 69.32, -5.01 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.57, 148.49 APE9-dihe-na 130.75, 179.78 APE8-dihe-in -89.08, 119.11 APE8-rot-in 309.67 APE67-dihe-in -66.92, -17.15 -47.96, -39.05 APE12-dist-in 9.555 APE11-dist-in 11.484 APE10-dist-in 5.853 APE9-dist-in 3.531 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[144, 405]] 1.0 AF-P80192-K1 TKL_MAP3K9_HUMAN TKL 7.1e-88 300.5 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9
AF-P80192-K3A 136 413 1104.0 No_ligand No_ligand Active DFGin 6.436 13.527 BLAminus -138.9, -178.76 64.57, 66.99 -83.2, 8.82 296.68, 96.12 -59.76, -30.13 in-in in 8.653 Saltbr-in 2.708 HRD-in -74.75, -41.91 68.52, -9.28 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.99, 153.87 APE9-dihe-na 121.29, -170.43 APE8-dihe-in -102.7, 118.96 APE8-rot-in 311.44 APE67-dihe-in -69.25, -18.0 -50.5, -36.12 APE12-dist-in 9.272 APE11-dist-in 11.433 APE10-dist-in 5.839 APE9-dist-in 3.612 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[144, 405]] 1.0 AF-P80192-K3 TKL_MAP3K9_HUMAN TKL 7.1e-88 300.5 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9
4UY9A 135 447 1104.0 No_ligand No_ligand Inactive DFGin 7.285 13.655 BLBplus -129.0, -179.35 57.23, 49.28 -123.04, 149.59 52.87, 88.24 -98.71, 139.38 in-out in 9.711 Saltbr-out 7.094 HRD-in -67.55, -46.36 79.11, -14.6 out-out-out SNCooo out-out ActLoopNT-out 9.837 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -170.64, -82.19 APE9-dihe-na -128.75, 20.04 APE8-dihe-out -75.95, -7.44 APE8-rot-out 97.35 APE67-dihe-in -57.91, -30.08 -63.33, -24.99 APE12-dist-out 20.056 APE11-dist-out 19.986 APE10-dist-out 23.048 APE9-dist-out 13.107 None None None XRAY 2.81 0.189 0.228 A 323 313 0 0 0 0 [[144, 405]] 1.0 4uy9 TKL_MAP3K9_HUMAN TKL 1.2e-87 299.8 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9
4UY9B 135 449 1104.0 No_ligand No_ligand Inactive DFGin 6.939 13.255 BLBplus -130.03, -179.75 55.71, 44.36 -113.61, 132.45 54.14, 95.1 -90.07, 138.45 in-none in 9.169 Saltbr-none 999.0 HRD-in -67.07, -45.19 78.5, -15.33 none-out-out SNCnoo out-out ActLoopNT-out 9.781 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -168.42, -78.16 APE9-dihe-na -119.08, 20.32 APE8-dihe-out -76.61, -12.91 APE8-rot-none 999.0 APE67-dihe-in -57.1, -25.42 -65.12, -30.76 APE12-dist-out 19.856 APE11-dist-out 19.786 APE10-dist-out 23.19 APE9-dist-out 12.957 None None None XRAY 2.81 0.189 0.228 B 323 315 0 0 0 0 [[144, 405]] 1.0 4uy9 TKL_MAP3K9_HUMAN TKL 1.2e-87 299.8 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9
3DTCA 136 405 1104.0 VIN:6331 Type1 Inactive DFGin 5.947 12.963 BLBplus -138.84, -179.46 54.61, 25.57 -77.27, 153.49 35.75, 70.87 -76.97, 139.8 out-out out 11.401 Saltbr-out 8.998 HRD-in -60.59, -53.78 81.11, -16.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -13.68 APE8-dihe-in -133.41, 60.47 APE8-rot-none 999.0 APE67-dihe-in -58.29, -17.6 -63.56, -33.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.647 T312A None None XRAY 2.6 0.221 0.282 A 271 245 25 0 0 13 [[144, 405]] 1.0 3dtc TKL_MAP3K9_HUMAN TKL 3.5e-87 298.2 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9

TKL_MAP3K9 (Mitogen-activated protein kinase kinase kinase 9)

Total number of chains: 5
Active chains: 2
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 60.0% 4UY9A
DFGin BLAminus 2 40.0% AF-P80192-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
M3K9_HUMAN AF-P80192-K1A P80192 136 413 1104.0 No_ligand No_ligand Active DFGin 6.824 13.849 BLAminus -136.57, 176.39 63.77, 67.83 -79.73, 12.36 294.5, 94.44 -60.81, -31.69 in-in in 9.092 Saltbr-in 2.843 HRD-in -72.89, -44.14 69.32, -5.01 in-in-in SNCiii in-in ActLoopNT-in 2.991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.57, 148.49 APE9-dihe-na 130.75, 179.78 APE8-dihe-in -89.08, 119.11 APE8-rot-in 309.67 APE67-dihe-in -66.92, -17.15 -47.96, -39.05 APE12-dist-in 9.555 APE11-dist-in 11.484 APE10-dist-in 5.853 APE9-dist-in 3.531 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[144, 405]] 1.0 AF-P80192-K1 Homo sapiens TKL_MAP3K9_HUMAN TKL 7.1e-88 300.5 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9
M3K9_HUMAN AF-P80192-K3A P80192 136 413 1104.0 No_ligand No_ligand Active DFGin 6.436 13.527 BLAminus -138.9, -178.76 64.57, 66.99 -83.2, 8.82 296.68, 96.12 -59.76, -30.13 in-in in 8.653 Saltbr-in 2.708 HRD-in -74.75, -41.91 68.52, -9.28 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.99, 153.87 APE9-dihe-na 121.29, -170.43 APE8-dihe-in -102.7, 118.96 APE8-rot-in 311.44 APE67-dihe-in -69.25, -18.0 -50.5, -36.12 APE12-dist-in 9.272 APE11-dist-in 11.433 APE10-dist-in 5.839 APE9-dist-in 3.612 None None None AF2 -1.0 1.0 1.0 A 278 278 0 0 0 0 [[144, 405]] 1.0 AF-P80192-K3 Homo sapiens TKL_MAP3K9_HUMAN TKL 7.1e-88 300.5 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9
M3K9_HUMAN 4UY9A P80192 135 447 1104.0 No_ligand No_ligand Inactive DFGin 7.285 13.655 BLBplus -129.0, -179.35 57.23, 49.28 -123.04, 149.59 52.87, 88.24 -98.71, 139.38 in-out in 9.711 Saltbr-out 7.094 HRD-in -67.55, -46.36 79.11, -14.6 out-out-out SNCooo out-out ActLoopNT-out 9.837 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -170.64, -82.19 APE9-dihe-na -128.75, 20.04 APE8-dihe-out -75.95, -7.44 APE8-rot-out 97.35 APE67-dihe-in -57.91, -30.08 -63.33, -24.99 APE12-dist-out 20.056 APE11-dist-out 19.986 APE10-dist-out 23.048 APE9-dist-out 13.107 None None None XRAY 2.81 0.189 0.228 A 323 313 0 0 0 0 [[144, 405]] 1.0 4uy9 Homo sapiens TKL_MAP3K9_HUMAN TKL 1.2e-87 299.8 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9
M3K9_HUMAN 4UY9B P80192 135 449 1104.0 No_ligand No_ligand Inactive DFGin 6.939 13.255 BLBplus -130.03, -179.75 55.71, 44.36 -113.61, 132.45 54.14, 95.1 -90.07, 138.45 in-none in 9.169 Saltbr-none 999.0 HRD-in -67.07, -45.19 78.5, -15.33 none-out-out SNCnoo out-out ActLoopNT-out 9.781 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -168.42, -78.16 APE9-dihe-na -119.08, 20.32 APE8-dihe-out -76.61, -12.91 APE8-rot-none 999.0 APE67-dihe-in -57.1, -25.42 -65.12, -30.76 APE12-dist-out 19.856 APE11-dist-out 19.786 APE10-dist-out 23.19 APE9-dist-out 12.957 None None None XRAY 2.81 0.189 0.228 B 323 315 0 0 0 0 [[144, 405]] 1.0 4uy9 Homo sapiens TKL_MAP3K9_HUMAN TKL 1.2e-87 299.8 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9
M3K9_HUMAN 3DTCA P80192 136 405 1104.0 VIN:6331 Type1 Inactive DFGin 5.947 12.963 BLBplus -138.84, -179.46 54.61, 25.57 -77.27, 153.49 35.75, 70.87 -76.97, 139.8 out-out out 11.401 Saltbr-out 8.998 HRD-in -60.59, -53.78 81.11, -16.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -13.68 APE8-dihe-in -133.41, 60.47 APE8-rot-none 999.0 APE67-dihe-in -58.29, -17.6 -63.56, -33.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.647 T312A None None XRAY 2.6 0.221 0.282 A 271 245 25 0 0 13 [[144, 405]] 1.0 3dtc Homo sapiens TKL_MAP3K9_HUMAN TKL 3.5e-87 298.2 2 266 265 293 294 295 297 299 171 191 195 265 267 266 268 331 319 314 313 312 311 310 309 308 221 Mitogen-activated protein kinase kinase kinase 9

TKL_MAP3K9 (Mitogen-activated protein kinase kinase kinase 9)

Total number of chains: 0
Active chains: 0
Family: TKL
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name