TKL_LRRK1 (Leucine-rich repeat serine/threonine-protein kinase 1)

Total number of chains: 7
Active chains: 2
Uniprot: LRRK1_HUMAN
Kinase Domain Residues: 1238 - 1522
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 5 71.4% 8E06A
DFGin BLAminus 2 28.6% AF-Q38SD2-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q38SD2-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1230 - 1530 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
AF-Q38SD2-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1230 - 1530 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
8E04A 3.8 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 381 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
8E05A 4.6 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
8E05B 4.6 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
8E06A 4.3 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
8FACA 3.92 Inactive DFGout‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 341 - 2013 0 None None Leucine-rich repeat serine/threonine-protein kinase 1

TKL_LRRK1 (Leucine-rich repeat serine/threonine-protein kinase 1)

Total number of chains: 7
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 5 71.4% 8E06A
DFGin BLAminus 2 28.6% AF-Q38SD2-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
LRRK1_HUMAN AF-Q38SD2-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1230 - 1530 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
LRRK1_HUMAN AF-Q38SD2-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1230 - 1530 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
LRRK1_HUMAN 8E04A 3.8 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 381 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
LRRK1_HUMAN 8E05A 4.6 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
LRRK1_HUMAN 8E05B 4.6 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
LRRK1_HUMAN 8E06A 4.3 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
LRRK1_HUMAN 8FACA 3.92 Inactive DFGout‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 341 - 2013 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens

TKL_LRRK1 (Leucine-rich repeat serine/threonine-protein kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism