TYR_FLT1 (Vascular endothelial growth factor receptor 1)

Total number of chains: 3
Active chains: 2
Family: TYR
Uniprot: VGFR1_HUMAN
Kinase Domain Residues: 827 - 1156
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-P17948-K1A
DFGout BBAminus 1 33.3% 3HNGA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P17948-K1A 819 1164 1338.0 No_ligand No_ligand Active DFGin 6.639 13.76 BLAminus -136.19, -179.71 66.86, 59.25 -80.37, 14.54 291.11, 84.89 -60.01, -28.12 in-in in 7.24 Saltbr-in 2.638 HRD-in -81.32, -43.95 66.24, -14.75 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.36, 109.29 APE9-dihe-in -125.67, 155.45 APE8-dihe-in -79.64, 84.22 APE8-rot-na 35.95 APE67-dihe-in -59.74, -27.17 -45.11, -41.32 APE12-dist-na 14.514 APE11-dist-na 8.264 APE10-dist-na 10.628 APE9-dist-in 6.427 None None None AF2 -1.0 1.0 1.0 A 346 346 0 0 0 0 [[827, 1156]] 1.0 AF-P17948-K1 TYR_FLT1_HUMAN TYR 2.9e-102 347.4 1 260 260 1039 1040 1041 1043 1045 861 878 882 1019 1021 1020 1022 1081 1069 1064 1063 1062 1061 1060 1059 1058 910 Vascular endothelial growth factor receptor 1
AF-P17948-K3A 819 1164 1338.0 No_ligand No_ligand Active DFGin 6.751 13.541 BLAminus -129.08, 179.07 59.25, 64.67 -75.13, 12.9 288.8, 85.82 -60.89, -33.75 in-in in 7.637 Saltbr-in 2.76 HRD-in -84.1, -45.3 66.25, -2.48 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.35, 140.24 APE9-dihe-in -120.74, 145.64 APE8-dihe-in -80.1, 61.84 APE8-rot-na 36.69 APE67-dihe-in -60.78, -25.42 -47.63, -39.79 APE12-dist-na 14.636 APE11-dist-na 8.878 APE10-dist-na 11.994 APE9-dist-in 7.488 None None None AF2 -1.0 1.0 1.0 A 346 346 0 0 0 0 [[827, 1156]] 1.0 AF-P17948-K3 TYR_FLT1_HUMAN TYR 2.9e-102 347.4 1 260 260 1039 1040 1041 1043 1045 861 878 882 1019 1021 1020 1022 1081 1069 1064 1063 1062 1061 1060 1059 1058 910 Vascular endothelial growth factor receptor 1
3HNGA 803 1158 1338.0 8ST:2001 Type2 Inactive DFGout 15.993 9.625 BBAminus -131.85, 179.18 -151.28, 112.52 -67.68, -32.6 274.24, 84.64 67.44, -119.27 in-in in 7.632 Saltbr-in 2.823 HRD-in -79.31, -47.95 79.26, -7.08 in-out-in SNCioi out-in ActLoopNT-out 15.584 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.37, 132.1 APE9-dihe-in -131.51, 147.8 APE8-dihe-in -74.85, 63.25 APE8-rot-na 33.81 APE67-dihe-in -62.4, -16.11 -46.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 13.591 APE10-dist-na 12.449 APE9-dist-in 7.926 None None None XRAY 2.7 0.197 0.26 A 360 288 67 0 0 2 [[827, 1156]] 1.0 3hng TYR_FLT1_HUMAN TYR 3.3e-102 347.2 1 260 260 1039 1040 1041 1043 1045 861 878 882 1019 1021 1020 1022 1081 1069 1064 1063 1062 1061 1060 1059 1058 910 Vascular endothelial growth factor receptor 1

TYR_FLT1 (Vascular endothelial growth factor receptor 1)

Total number of chains: 3
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-P17948-K1A
DFGout BBAminus 1 33.3% 3HNGA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
VGFR1_HUMAN AF-P17948-K1A P17948 819 1164 1338.0 No_ligand No_ligand Active DFGin 6.639 13.76 BLAminus -136.19, -179.71 66.86, 59.25 -80.37, 14.54 291.11, 84.89 -60.01, -28.12 in-in in 7.24 Saltbr-in 2.638 HRD-in -81.32, -43.95 66.24, -14.75 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.36, 109.29 APE9-dihe-in -125.67, 155.45 APE8-dihe-in -79.64, 84.22 APE8-rot-na 35.95 APE67-dihe-in -59.74, -27.17 -45.11, -41.32 APE12-dist-na 14.514 APE11-dist-na 8.264 APE10-dist-na 10.628 APE9-dist-in 6.427 None None None AF2 -1.0 1.0 1.0 A 346 346 0 0 0 0 [[827, 1156]] 1.0 AF-P17948-K1 Homo sapiens TYR_FLT1_HUMAN TYR 2.9e-102 347.4 1 260 260 1039 1040 1041 1043 1045 861 878 882 1019 1021 1020 1022 1081 1069 1064 1063 1062 1061 1060 1059 1058 910 Vascular endothelial growth factor receptor 1
VGFR1_HUMAN AF-P17948-K3A P17948 819 1164 1338.0 No_ligand No_ligand Active DFGin 6.751 13.541 BLAminus -129.08, 179.07 59.25, 64.67 -75.13, 12.9 288.8, 85.82 -60.89, -33.75 in-in in 7.637 Saltbr-in 2.76 HRD-in -84.1, -45.3 66.25, -2.48 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.35, 140.24 APE9-dihe-in -120.74, 145.64 APE8-dihe-in -80.1, 61.84 APE8-rot-na 36.69 APE67-dihe-in -60.78, -25.42 -47.63, -39.79 APE12-dist-na 14.636 APE11-dist-na 8.878 APE10-dist-na 11.994 APE9-dist-in 7.488 None None None AF2 -1.0 1.0 1.0 A 346 346 0 0 0 0 [[827, 1156]] 1.0 AF-P17948-K3 Homo sapiens TYR_FLT1_HUMAN TYR 2.9e-102 347.4 1 260 260 1039 1040 1041 1043 1045 861 878 882 1019 1021 1020 1022 1081 1069 1064 1063 1062 1061 1060 1059 1058 910 Vascular endothelial growth factor receptor 1
VGFR1_HUMAN 3HNGA P17948 803 1158 1338.0 8ST:2001 Type2 Inactive DFGout 15.993 9.625 BBAminus -131.85, 179.18 -151.28, 112.52 -67.68, -32.6 274.24, 84.64 67.44, -119.27 in-in in 7.632 Saltbr-in 2.823 HRD-in -79.31, -47.95 79.26, -7.08 in-out-in SNCioi out-in ActLoopNT-out 15.584 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.37, 132.1 APE9-dihe-in -131.51, 147.8 APE8-dihe-in -74.85, 63.25 APE8-rot-na 33.81 APE67-dihe-in -62.4, -16.11 -46.0, -50.18 APE12-dist-na 999.0 APE11-dist-na 13.591 APE10-dist-na 12.449 APE9-dist-in 7.926 None None None XRAY 2.7 0.197 0.26 A 360 288 67 0 0 2 [[827, 1156]] 1.0 3hng Homo sapiens TYR_FLT1_HUMAN TYR 3.3e-102 347.2 1 260 260 1039 1040 1041 1043 1045 861 878 882 1019 1021 1020 1022 1081 1069 1064 1063 1062 1061 1060 1059 1058 910 Vascular endothelial growth factor receptor 1

TYR_FLT1 (Vascular endothelial growth factor receptor 1)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name