TYR_FLT1 (Vascular endothelial growth factor receptor 1)

Total number of chains: 3
Active chains: 2
Uniprot: VGFR1_HUMAN
Kinase Domain Residues: 827 - 1156
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-P17948-K1A
DFGout BBAminus 1 33.3% 3HNGA

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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P17948-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 819 - 1164 0 None None Vascular endothelial growth factor receptor 1
AF-P17948-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 819 - 1164 0 None None Vascular endothelial growth factor receptor 1
3HNGA 2.7 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 8ST Type2 803 - 1158 0 None None Vascular endothelial growth factor receptor 1

TYR_FLT1 (Vascular endothelial growth factor receptor 1)

Total number of chains: 3
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% AF-P17948-K1A
DFGout BBAminus 1 33.3% 3HNGA

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
VGFR1_HUMAN AF-P17948-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 819 - 1164 0 None None Vascular endothelial growth factor receptor 1 Homo sapiens
VGFR1_HUMAN AF-P17948-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 819 - 1164 0 None None Vascular endothelial growth factor receptor 1 Homo sapiens
VGFR1_HUMAN 3HNGA 2.7 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 8ST Type2 803 - 1158 0 None None Vascular endothelial growth factor receptor 1 Homo sapiens

TYR_FLT1 (Vascular endothelial growth factor receptor 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism