TYR_DDR2 (Discoidin domain-containing receptor 2)

Total number of chains: 15
Active chains: 2
Family: TYR
Uniprot: DDR2_HUMAN
Kinase Domain Residues: 563 - 851
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 13 86.7% 6FERD
DFGin BLAminus 2 13.3% AF-Q16832-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q16832-K1A 555 855 855.0 No_ligand No_ligand Active DFGin 6.522 14.001 BLAminus -134.09, -175.83 55.0, 76.56 -90.24, 12.69 290.2, 94.33 -61.78, -36.5 in-in in 8.533 Saltbr-in 2.758 HRD-in -71.97, -43.11 67.4, -19.14 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.74, 125.51 APE9-dihe-in -128.98, 145.76 APE8-dihe-in -79.57, 67.41 APE8-rot-na 35.74 APE67-dihe-in -69.91, -17.76 -44.28, -44.12 APE12-dist-na 14.412 APE11-dist-na 8.724 APE10-dist-na 10.215 APE9-dist-in 6.94 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[563, 851]] 1.0 AF-Q16832-K1 TYR_DDR2_HUMAN TYR 4.6e-94 320.6 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
AF-Q16832-K3A 555 855 855.0 No_ligand No_ligand Active DFGin 6.402 13.981 BLAminus -135.91, -175.45 55.57, 71.17 -84.63, 7.42 289.68, 100.1 -59.07, -35.6 in-in in 8.519 Saltbr-in 2.837 HRD-in -73.02, -44.28 66.23, -11.12 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.58, 126.99 APE9-dihe-in -133.19, 141.17 APE8-dihe-in -81.9, 65.78 APE8-rot-na 37.31 APE67-dihe-in -68.96, -21.91 -52.54, -32.44 APE12-dist-na 14.016 APE11-dist-na 8.548 APE10-dist-na 10.153 APE9-dist-in 6.758 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[563, 851]] 1.0 AF-Q16832-K3 TYR_DDR2_HUMAN TYR 4.6e-94 320.6 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERD 553 851 855.0 D6Q:61001 Type1 Inactive DFGout 15.048 11.18 BBAminus -141.71, -167.98 -156.8, 79.55 -67.75, -26.19 300.45, 79.17 78.28, 46.44 in-in in 8.412 Saltbr-in 3.141 HRD-in -83.01, -45.68 80.7, -20.98 in-out-in SNCioi out-in ActLoopNT-out 18.024 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.58, 133.44 APE9-dihe-in -141.66, 149.0 APE8-dihe-in -81.01, 77.02 APE8-rot-na 29.49 APE67-dihe-in -69.71, -27.41 -64.87, -24.92 APE12-dist-na 14.792 APE11-dist-na 10.535 APE10-dist-na 7.523 APE9-dist-in 7.286 None None None XRAY 2.87 0.204 0.287 D 309 280 19 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERI 555 851 855.0 D6Q:61001 Type1 Inactive DFGout 15.402 10.31 BBAminus -132.27, -171.91 -161.26, 94.67 -74.56, -5.27 299.81, 74.63 77.59, -166.5 in-out in 8.885 Saltbr-out 5.15 HRD-in -81.65, -48.42 90.96, -35.1 out-out-in SNCooi out-in ActLoopNT-out 18.493 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.26, 135.88 APE9-dihe-in -140.61, 149.06 APE8-dihe-in -82.39, 74.94 APE8-rot-na 29.06 APE67-dihe-in -77.04, -15.38 -63.23, -27.33 APE12-dist-na 15.088 APE11-dist-na 10.557 APE10-dist-na 7.631 APE9-dist-in 7.582 None None None XRAY 2.87 0.204 0.287 I 309 267 30 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERA 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.245 10.898 BBAminus -131.01, -161.19 -165.57, 85.81 -71.62, -22.19 292.79, 77.61 87.02, 171.1 in-in in 8.229 Saltbr-in 3.123 HRD-in -78.48, -40.44 78.21, 0.96 in-out-in SNCioi out-in ActLoopNT-out 17.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.42, 135.3 APE9-dihe-in -143.91, 144.35 APE8-dihe-in -78.22, 83.26 APE8-rot-na 30.7 APE67-dihe-in -66.88, -28.77 -66.87, -28.14 APE12-dist-na 14.194 APE11-dist-na 10.183 APE10-dist-na 6.783 APE9-dist-in 6.88 None None None XRAY 2.87 0.204 0.287 A 309 271 28 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERB 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.224 10.909 BBAminus -127.81, -169.47 -146.77, 88.56 -62.8, -31.18 282.96, 83.31 88.64, -173.95 in-out in 8.363 Saltbr-out 3.722 HRD-in -74.34, -52.61 80.32, -19.63 out-out-in SNCooi out-in ActLoopNT-out 18.052 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.74, 132.64 APE9-dihe-in -134.86, 151.26 APE8-dihe-in -86.7, 73.28 APE8-rot-na 31.63 APE67-dihe-in -65.3, -29.12 -61.29, -33.89 APE12-dist-na 14.548 APE11-dist-na 10.3 APE10-dist-na 7.247 APE9-dist-in 7.099 None None None XRAY 2.87 0.204 0.287 B 309 279 20 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERC 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.21 11.05 BBAminus -127.75, -173.41 -150.11, 72.9 -58.51, -29.04 285.6, 72.31 79.25, -175.65 in-in in 8.67 Saltbr-in 2.916 HRD-in -85.59, -35.44 61.71, -1.22 in-out-in SNCioi out-in ActLoopNT-out 18.27 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.35, 137.18 APE9-dihe-in -143.43, 152.72 APE8-dihe-in -83.17, 77.08 APE8-rot-na 28.26 APE67-dihe-in -75.22, -12.07 -67.05, -27.85 APE12-dist-na 14.858 APE11-dist-na 10.558 APE10-dist-na 7.199 APE9-dist-in 6.685 None None None XRAY 2.87 0.204 0.287 C 309 272 27 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERE 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.264 10.99 BBAminus -126.1, -167.99 -152.67, 85.15 -64.71, -27.86 287.81, 77.85 87.09, -179.31 in-in in 8.338 Saltbr-in 3.107 HRD-in -75.41, -44.62 82.1, -24.87 in-out-in SNCioi out-in ActLoopNT-out 17.977 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.51, 127.71 APE9-dihe-in -135.01, 143.16 APE8-dihe-in -79.71, 73.04 APE8-rot-na 24.02 APE67-dihe-in -61.32, -31.19 -66.82, -27.62 APE12-dist-na 14.758 APE11-dist-na 10.559 APE10-dist-na 7.349 APE9-dist-in 7.107 None None None XRAY 2.87 0.204 0.287 E 309 273 26 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERF 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.113 10.764 BBAminus -140.71, -179.08 -143.29, 102.47 -82.91, -34.74 277.3, 90.24 100.56, -173.7 in-in in 8.836 Saltbr-in 3.009 HRD-in -66.08, -54.22 76.99, 20.12 in-out-in SNCioi out-in ActLoopNT-out 18.309 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.5, 132.69 APE9-dihe-in -143.49, 146.9 APE8-dihe-in -72.24, 88.45 APE8-rot-na 29.06 APE67-dihe-in -70.54, -20.46 -67.15, -34.42 APE12-dist-na 14.622 APE11-dist-na 10.223 APE10-dist-na 7.228 APE9-dist-in 7.075 None None None XRAY 2.87 0.204 0.287 F 309 275 24 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERG 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.257 11.079 BBAminus -134.11, -165.18 -155.03, 92.91 -67.29, -29.37 290.61, 78.0 95.55, 168.12 in-in in 8.678 Saltbr-in 2.884 HRD-in -105.49, -41.99 71.99, 7.69 in-out-in SNCioi out-in ActLoopNT-out 18.411 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.11, 134.52 APE9-dihe-in -137.65, 151.67 APE8-dihe-in -84.28, 72.06 APE8-rot-na 19.95 APE67-dihe-in -75.08, -7.07 -61.09, -28.41 APE12-dist-na 14.378 APE11-dist-na 10.396 APE10-dist-na 6.97 APE9-dist-in 7.001 None None None XRAY 2.87 0.204 0.287 G 309 273 26 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERH 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.095 10.933 BBAminus -142.83, 168.63 -122.36, 100.12 -70.19, -36.19 283.69, 91.64 87.97, 177.22 in-in in 8.553 Saltbr-in 3.231 HRD-in -73.54, -42.33 73.13, -22.81 in-out-in SNCioi out-in ActLoopNT-out 17.75 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.99, 137.12 APE9-dihe-in -142.97, 145.81 APE8-dihe-in -80.78, 71.67 APE8-rot-na 25.87 APE67-dihe-in -72.01, -17.72 -64.34, -28.14 APE12-dist-na 14.634 APE11-dist-na 10.407 APE10-dist-na 7.031 APE9-dist-in 7.362 None None None XRAY 2.87 0.204 0.287 H 309 272 27 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERJ 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.477 10.784 BBAminus -90.14, 173.37 -132.39, 94.12 -71.06, -21.48 270.06, 101.58 83.17, 174.89 in-in in 8.661 Saltbr-in 3.579 HRD-in -71.36, -38.66 70.83, -2.79 in-out-in SNCioi out-in ActLoopNT-out 17.647 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.84, 139.18 APE9-dihe-in -140.75, 146.9 APE8-dihe-in -86.36, 72.01 APE8-rot-na 34.26 APE67-dihe-in -70.93, -23.5 -62.26, -27.59 APE12-dist-na 14.683 APE11-dist-na 10.348 APE10-dist-na 7.008 APE9-dist-in 7.255 None None None XRAY 2.87 0.204 0.287 J 309 272 27 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERK 555 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.346 10.853 BBAminus -120.5, 176.02 -138.03, 87.64 -63.47, -36.8 289.67, 91.46 99.89, -174.41 in-out in 8.946 Saltbr-out 4.67 HRD-in -75.59, -38.82 74.02, -15.98 out-out-in SNCooi out-in ActLoopNT-out 17.611 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.04, 132.02 APE9-dihe-in -135.98, 149.11 APE8-dihe-in -82.11, 72.97 APE8-rot-na 32.97 APE67-dihe-in -77.05, -11.08 -63.58, -29.85 APE12-dist-na 14.555 APE11-dist-na 10.224 APE10-dist-na 7.239 APE9-dist-in 7.16 None None None XRAY 2.87 0.204 0.287 K 309 268 29 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
6FERL 554 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.256 10.648 BBAminus -143.28, -178.18 -140.44, 112.67 -85.11, -10.01 280.47, 77.67 77.9, -177.12 in-out in 8.711 Saltbr-out 3.846 HRD-in -63.81, -51.6 79.8, -24.05 out-out-in SNCooi out-in ActLoopNT-out 17.919 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.25, 128.22 APE9-dihe-in -136.74, 150.94 APE8-dihe-in -89.6, 76.1 APE8-rot-na 34.55 APE67-dihe-in -66.81, -23.48 -62.67, -26.4 APE12-dist-na 14.849 APE11-dist-na 10.48 APE10-dist-na 7.24 APE9-dist-in 7.243 None None None XRAY 2.87 0.204 0.287 L 309 273 25 0 0 0 [[563, 851]] 1.0 6fer TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
7AYMA 558 849 855.0 4VD:60901 Type2 Inactive DFGout 12.934 10.737 BBAminus -126.27, -175.26 -146.23, 109.91 -97.21, -14.54 291.29, 92.82 81.23, -151.81 in-out in 8.294 Saltbr-out 3.646 HRD-in -55.87, -45.87 73.73, -21.91 out-out-in SNCooi out-in ActLoopNT-out 17.738 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.77, 160.69 APE9-dihe-in -137.56, 132.17 APE8-dihe-in -85.39, 64.69 APE8-rot-na 30.49 APE67-dihe-in -73.72, -20.63 -51.74, -30.28 APE12-dist-na 10.125 APE11-dist-na 10.501 APE10-dist-na 5.978 APE9-dist-in 7.491 K826E,L847R None None XRAY 2.12 0.239 0.289 A 337 270 22 0 0 0 [[563, 851]] 1.0 7aym TYR_DDR2_HUMAN TYR 5.9e-94 320.2 1 260 260 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2

TYR_DDR2 (Discoidin domain-containing receptor 2)

Total number of chains: 15
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 13 86.7% 6FERD
DFGin BLAminus 2 13.3% AF-Q16832-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
DDR2_HUMAN AF-Q16832-K1A Q16832 555 855 855.0 No_ligand No_ligand Active DFGin 6.522 14.001 BLAminus -134.09, -175.83 55.0, 76.56 -90.24, 12.69 290.2, 94.33 -61.78, -36.5 in-in in 8.533 Saltbr-in 2.758 HRD-in -71.97, -43.11 67.4, -19.14 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.74, 125.51 APE9-dihe-in -128.98, 145.76 APE8-dihe-in -79.57, 67.41 APE8-rot-na 35.74 APE67-dihe-in -69.91, -17.76 -44.28, -44.12 APE12-dist-na 14.412 APE11-dist-na 8.724 APE10-dist-na 10.215 APE9-dist-in 6.94 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[563, 851]] 1.0 AF-Q16832-K1 Homo sapiens TYR_DDR2_HUMAN TYR 4.6e-94 320.6 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN AF-Q16832-K3A Q16832 555 855 855.0 No_ligand No_ligand Active DFGin 6.402 13.981 BLAminus -135.91, -175.45 55.57, 71.17 -84.63, 7.42 289.68, 100.1 -59.07, -35.6 in-in in 8.519 Saltbr-in 2.837 HRD-in -73.02, -44.28 66.23, -11.12 in-in-in SNCiii in-in ActLoopNT-in 2.872 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.58, 126.99 APE9-dihe-in -133.19, 141.17 APE8-dihe-in -81.9, 65.78 APE8-rot-na 37.31 APE67-dihe-in -68.96, -21.91 -52.54, -32.44 APE12-dist-na 14.016 APE11-dist-na 8.548 APE10-dist-na 10.153 APE9-dist-in 6.758 None None None AF2 -1.0 1.0 1.0 A 301 301 0 0 0 0 [[563, 851]] 1.0 AF-Q16832-K3 Homo sapiens TYR_DDR2_HUMAN TYR 4.6e-94 320.6 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERD Q16832 553 851 855.0 D6Q:61001 Type1 Inactive DFGout 15.048 11.18 BBAminus -141.71, -167.98 -156.8, 79.55 -67.75, -26.19 300.45, 79.17 78.28, 46.44 in-in in 8.412 Saltbr-in 3.141 HRD-in -83.01, -45.68 80.7, -20.98 in-out-in SNCioi out-in ActLoopNT-out 18.024 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.58, 133.44 APE9-dihe-in -141.66, 149.0 APE8-dihe-in -81.01, 77.02 APE8-rot-na 29.49 APE67-dihe-in -69.71, -27.41 -64.87, -24.92 APE12-dist-na 14.792 APE11-dist-na 10.535 APE10-dist-na 7.523 APE9-dist-in 7.286 None None None XRAY 2.87 0.204 0.287 D 309 280 19 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERI Q16832 555 851 855.0 D6Q:61001 Type1 Inactive DFGout 15.402 10.31 BBAminus -132.27, -171.91 -161.26, 94.67 -74.56, -5.27 299.81, 74.63 77.59, -166.5 in-out in 8.885 Saltbr-out 5.15 HRD-in -81.65, -48.42 90.96, -35.1 out-out-in SNCooi out-in ActLoopNT-out 18.493 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.26, 135.88 APE9-dihe-in -140.61, 149.06 APE8-dihe-in -82.39, 74.94 APE8-rot-na 29.06 APE67-dihe-in -77.04, -15.38 -63.23, -27.33 APE12-dist-na 15.088 APE11-dist-na 10.557 APE10-dist-na 7.631 APE9-dist-in 7.582 None None None XRAY 2.87 0.204 0.287 I 309 267 30 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERA Q16832 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.245 10.898 BBAminus -131.01, -161.19 -165.57, 85.81 -71.62, -22.19 292.79, 77.61 87.02, 171.1 in-in in 8.229 Saltbr-in 3.123 HRD-in -78.48, -40.44 78.21, 0.96 in-out-in SNCioi out-in ActLoopNT-out 17.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.42, 135.3 APE9-dihe-in -143.91, 144.35 APE8-dihe-in -78.22, 83.26 APE8-rot-na 30.7 APE67-dihe-in -66.88, -28.77 -66.87, -28.14 APE12-dist-na 14.194 APE11-dist-na 10.183 APE10-dist-na 6.783 APE9-dist-in 6.88 None None None XRAY 2.87 0.204 0.287 A 309 271 28 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERB Q16832 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.224 10.909 BBAminus -127.81, -169.47 -146.77, 88.56 -62.8, -31.18 282.96, 83.31 88.64, -173.95 in-out in 8.363 Saltbr-out 3.722 HRD-in -74.34, -52.61 80.32, -19.63 out-out-in SNCooi out-in ActLoopNT-out 18.052 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.74, 132.64 APE9-dihe-in -134.86, 151.26 APE8-dihe-in -86.7, 73.28 APE8-rot-na 31.63 APE67-dihe-in -65.3, -29.12 -61.29, -33.89 APE12-dist-na 14.548 APE11-dist-na 10.3 APE10-dist-na 7.247 APE9-dist-in 7.099 None None None XRAY 2.87 0.204 0.287 B 309 279 20 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERC Q16832 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.21 11.05 BBAminus -127.75, -173.41 -150.11, 72.9 -58.51, -29.04 285.6, 72.31 79.25, -175.65 in-in in 8.67 Saltbr-in 2.916 HRD-in -85.59, -35.44 61.71, -1.22 in-out-in SNCioi out-in ActLoopNT-out 18.27 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.35, 137.18 APE9-dihe-in -143.43, 152.72 APE8-dihe-in -83.17, 77.08 APE8-rot-na 28.26 APE67-dihe-in -75.22, -12.07 -67.05, -27.85 APE12-dist-na 14.858 APE11-dist-na 10.558 APE10-dist-na 7.199 APE9-dist-in 6.685 None None None XRAY 2.87 0.204 0.287 C 309 272 27 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERE Q16832 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.264 10.99 BBAminus -126.1, -167.99 -152.67, 85.15 -64.71, -27.86 287.81, 77.85 87.09, -179.31 in-in in 8.338 Saltbr-in 3.107 HRD-in -75.41, -44.62 82.1, -24.87 in-out-in SNCioi out-in ActLoopNT-out 17.977 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.51, 127.71 APE9-dihe-in -135.01, 143.16 APE8-dihe-in -79.71, 73.04 APE8-rot-na 24.02 APE67-dihe-in -61.32, -31.19 -66.82, -27.62 APE12-dist-na 14.758 APE11-dist-na 10.559 APE10-dist-na 7.349 APE9-dist-in 7.107 None None None XRAY 2.87 0.204 0.287 E 309 273 26 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERF Q16832 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.113 10.764 BBAminus -140.71, -179.08 -143.29, 102.47 -82.91, -34.74 277.3, 90.24 100.56, -173.7 in-in in 8.836 Saltbr-in 3.009 HRD-in -66.08, -54.22 76.99, 20.12 in-out-in SNCioi out-in ActLoopNT-out 18.309 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.5, 132.69 APE9-dihe-in -143.49, 146.9 APE8-dihe-in -72.24, 88.45 APE8-rot-na 29.06 APE67-dihe-in -70.54, -20.46 -67.15, -34.42 APE12-dist-na 14.622 APE11-dist-na 10.223 APE10-dist-na 7.228 APE9-dist-in 7.075 None None None XRAY 2.87 0.204 0.287 F 309 275 24 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERG Q16832 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.257 11.079 BBAminus -134.11, -165.18 -155.03, 92.91 -67.29, -29.37 290.61, 78.0 95.55, 168.12 in-in in 8.678 Saltbr-in 2.884 HRD-in -105.49, -41.99 71.99, 7.69 in-out-in SNCioi out-in ActLoopNT-out 18.411 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.11, 134.52 APE9-dihe-in -137.65, 151.67 APE8-dihe-in -84.28, 72.06 APE8-rot-na 19.95 APE67-dihe-in -75.08, -7.07 -61.09, -28.41 APE12-dist-na 14.378 APE11-dist-na 10.396 APE10-dist-na 6.97 APE9-dist-in 7.001 None None None XRAY 2.87 0.204 0.287 G 309 273 26 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERH Q16832 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.095 10.933 BBAminus -142.83, 168.63 -122.36, 100.12 -70.19, -36.19 283.69, 91.64 87.97, 177.22 in-in in 8.553 Saltbr-in 3.231 HRD-in -73.54, -42.33 73.13, -22.81 in-out-in SNCioi out-in ActLoopNT-out 17.75 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.99, 137.12 APE9-dihe-in -142.97, 145.81 APE8-dihe-in -80.78, 71.67 APE8-rot-na 25.87 APE67-dihe-in -72.01, -17.72 -64.34, -28.14 APE12-dist-na 14.634 APE11-dist-na 10.407 APE10-dist-na 7.031 APE9-dist-in 7.362 None None None XRAY 2.87 0.204 0.287 H 309 272 27 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERJ Q16832 553 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.477 10.784 BBAminus -90.14, 173.37 -132.39, 94.12 -71.06, -21.48 270.06, 101.58 83.17, 174.89 in-in in 8.661 Saltbr-in 3.579 HRD-in -71.36, -38.66 70.83, -2.79 in-out-in SNCioi out-in ActLoopNT-out 17.647 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.84, 139.18 APE9-dihe-in -140.75, 146.9 APE8-dihe-in -86.36, 72.01 APE8-rot-na 34.26 APE67-dihe-in -70.93, -23.5 -62.26, -27.59 APE12-dist-na 14.683 APE11-dist-na 10.348 APE10-dist-na 7.008 APE9-dist-in 7.255 None None None XRAY 2.87 0.204 0.287 J 309 272 27 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERK Q16832 555 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.346 10.853 BBAminus -120.5, 176.02 -138.03, 87.64 -63.47, -36.8 289.67, 91.46 99.89, -174.41 in-out in 8.946 Saltbr-out 4.67 HRD-in -75.59, -38.82 74.02, -15.98 out-out-in SNCooi out-in ActLoopNT-out 17.611 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.04, 132.02 APE9-dihe-in -135.98, 149.11 APE8-dihe-in -82.11, 72.97 APE8-rot-na 32.97 APE67-dihe-in -77.05, -11.08 -63.58, -29.85 APE12-dist-na 14.555 APE11-dist-na 10.224 APE10-dist-na 7.239 APE9-dist-in 7.16 None None None XRAY 2.87 0.204 0.287 K 309 268 29 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 6FERL Q16832 554 851 855.0 D6Q:61001 Type2 Inactive DFGout 15.256 10.648 BBAminus -143.28, -178.18 -140.44, 112.67 -85.11, -10.01 280.47, 77.67 77.9, -177.12 in-out in 8.711 Saltbr-out 3.846 HRD-in -63.81, -51.6 79.8, -24.05 out-out-in SNCooi out-in ActLoopNT-out 17.919 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.25, 128.22 APE9-dihe-in -136.74, 150.94 APE8-dihe-in -89.6, 76.1 APE8-rot-na 34.55 APE67-dihe-in -66.81, -23.48 -62.67, -26.4 APE12-dist-na 14.849 APE11-dist-na 10.48 APE10-dist-na 7.24 APE9-dist-in 7.243 None None None XRAY 2.87 0.204 0.287 L 309 273 25 0 0 0 [[563, 851]] 1.0 6fer Homo sapiens TYR_DDR2_HUMAN TYR 5.1e-94 320.4 1 259 259 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2
DDR2_HUMAN 7AYMA Q16832 558 849 855.0 4VD:60901 Type2 Inactive DFGout 12.934 10.737 BBAminus -126.27, -175.26 -146.23, 109.91 -97.21, -14.54 291.29, 92.82 81.23, -151.81 in-out in 8.294 Saltbr-out 3.646 HRD-in -55.87, -45.87 73.73, -21.91 out-out-in SNCooi out-in ActLoopNT-out 17.738 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.77, 160.69 APE9-dihe-in -137.56, 132.17 APE8-dihe-in -85.39, 64.69 APE8-rot-na 30.49 APE67-dihe-in -73.72, -20.63 -51.74, -30.28 APE12-dist-na 10.125 APE11-dist-na 10.501 APE10-dist-na 5.978 APE9-dist-in 7.491 K826E,L847R None None XRAY 2.12 0.239 0.289 A 337 270 22 0 0 0 [[563, 851]] 1.0 7aym Homo sapiens TYR_DDR2_HUMAN TYR 5.9e-94 320.2 1 260 260 727 728 729 731 733 608 625 629 707 709 708 710 769 757 752 751 750 749 748 747 746 655 Discoidin domain-containing receptor 2

TYR_DDR2 (Discoidin domain-containing receptor 2)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name