KinCore

CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 13

Active chains: 12

Uniprot: CLK2_HUMAN

Kinase Domain Residues: 163 - 479

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	13	100.0%	AF-P49760-K1A

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PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
AF-P49760-K1A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	155 - 487	0	None	None	Dual specificity protein kinase CLK2
AF-P49760-K3A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	155 - 487	0	None	None	Dual specificity protein kinase CLK2
6FYKA	2.39	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	EAZ	Type1	137 - 485	0	None	None	Dual specificity protein kinase CLK2
6FYKB	2.39	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	EAZ	Type1	137 - 485	0	None	None	Dual specificity protein kinase CLK2
6FYKC	2.39	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	EAZ	Type1	137 - 485	0	None	None	Dual specificity protein kinase CLK2
6FYLA	1.95	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	3NG	Type1	144 - 483	0	None	None	Dual specificity protein kinase CLK2
3NR9A	2.89	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	NR9	Type1	137 - 484	0	None	None	Dual specificity protein kinase CLK2
3NR9B	2.89	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	NR9	Type1	136 - 482	0	None	None	Dual specificity protein kinase CLK2
3NR9C	2.89	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	NR9	Type1	137 - 483	0	None	None	Dual specificity protein kinase CLK2
6FYIA	2.6	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	EAE	Type1	148 - 483	0	None	None	Dual specificity protein kinase CLK2
5UNPA	2.92	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	8FY	Type1	137 - 483	0	None	None	Dual specificity protein kinase CLK2
5UNPB	2.92	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	8FY	Type1	137 - 483	0	None	None	Dual specificity protein kinase CLK2
6KHEA	2.8	Inactive	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	3NG	Type1	144 - 485	0	None	None	Dual specificity protein kinase CLK2

CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 13

Active chains: 12

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	13	100.0%	AF-P49760-K1A

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
CLK2_HUMAN	AF-P49760-K1A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	155 - 487	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	AF-P49760-K3A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	155 - 487	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	6FYKA	2.39	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	EAZ	Type1	137 - 485	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	6FYKB	2.39	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	EAZ	Type1	137 - 485	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	6FYKC	2.39	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	EAZ	Type1	137 - 485	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	6FYLA	1.95	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	3NG	Type1	144 - 483	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	3NR9A	2.89	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	NR9	Type1	137 - 484	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	3NR9B	2.89	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	NR9	Type1	136 - 482	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	3NR9C	2.89	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	NR9	Type1	137 - 483	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	6FYIA	2.6	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	EAE	Type1	148 - 483	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	5UNPA	2.92	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	8FY	Type1	137 - 483	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	5UNPB	2.92	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	8FY	Type1	137 - 483	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens
CLK2_HUMAN	6KHEA	2.8	Inactive	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	3NG	Type1	144 - 485	0	None	None	Dual specificity protein kinase CLK2	Homo sapiens

CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 0

Active chains: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism