CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 13
Active chains: 12
Family: CMGC
Uniprot: CLK2_HUMAN
Kinase Domain Residues: 163 - 479
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 100.0% AF-P49760-K1A

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P49760-K1A 155 487 499.0 No_ligand No_ligand Active DFGin 7.017 14.447 BLAminus -126.22, 175.17 64.05, 67.73 -82.36, 10.77 293.87, 94.93 -66.07, -15.18 in-in in 8.629 Saltbr-in 2.737 HRD-in -71.37, -38.9 64.95, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.18, 175.15 APE9-dihe-na 65.62, 146.25 APE8-dihe-in -58.43, 137.37 APE8-rot-in 294.29 APE67-dihe-in -69.47, -18.12 -49.92, -45.23 APE12-dist-in 13.835 APE11-dist-in 11.808 APE10-dist-in 7.504 APE9-dist-in 2.937 None None None AF2 -1.0 1.0 1.0 A 333 333 0 0 0 0 [[163, 479]] 1.0 AF-P49760-K1 CMGC_CLK2_HUMAN CMGC 1.3e-92 316.2 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
AF-P49760-K3A 155 487 499.0 No_ligand No_ligand Active DFGin 6.641 14.358 BLAminus -127.7, 177.09 63.58, 64.12 -79.63, 11.17 297.99, 96.21 -65.88, -8.85 in-in in 8.47 Saltbr-in 2.689 HRD-in -74.26, -40.62 70.17, -26.03 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.16, -178.79 APE9-dihe-na 64.17, 140.54 APE8-dihe-in -54.77, 136.12 APE8-rot-in 294.36 APE67-dihe-in -67.89, -21.3 -52.25, -41.65 APE12-dist-in 13.715 APE11-dist-in 11.759 APE10-dist-in 7.299 APE9-dist-in 2.982 None None None AF2 -1.0 1.0 1.0 A 333 333 0 0 0 0 [[163, 479]] 1.0 AF-P49760-K3 CMGC_CLK2_HUMAN CMGC 1.3e-92 316.2 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
6FYKA 137 485 499.0 EAZ:501 Type1 Active DFGin 7.025 13.933 BLAminus -128.78, 177.13 62.38, 94.51 -113.34, 21.4 294.8, 89.41 -67.4, -12.68 in-in in 8.693 Saltbr-in 2.614 HRD-in -66.97, -50.97 77.07, -17.13 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.9, 169.97 APE9-dihe-na 71.5, 144.52 APE8-dihe-in -67.7, 143.43 APE8-rot-in 294.43 APE67-dihe-in -55.56, -28.09 -39.63, -56.25 APE12-dist-in 13.29 APE11-dist-in 11.706 APE10-dist-in 7.41 APE9-dist-in 2.951 None None None XRAY 2.39 0.196 0.228 A 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
6FYKB 137 485 499.0 EAZ:501 Type1 Active DFGin 6.979 13.545 BLAminus -126.36, 176.1 65.04, 89.02 -110.3, 25.2 302.84, 96.68 -72.78, -13.24 in-in in 8.571 Saltbr-in 2.692 HRD-in -74.27, -47.13 73.72, -15.28 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.26, 173.72 APE9-dihe-na 72.32, 147.64 APE8-dihe-in -71.42, 138.78 APE8-rot-in 296.31 APE67-dihe-in -62.52, -26.37 -31.99, -52.81 APE12-dist-in 13.304 APE11-dist-in 11.879 APE10-dist-in 7.365 APE9-dist-in 2.896 None None None XRAY 2.39 0.196 0.228 B 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
6FYKC 137 485 499.0 EAZ:501 Type1 Active DFGin 7.18 13.809 BLAminus -122.42, 175.39 66.62, 94.13 -114.05, 24.08 298.67, 87.87 -71.48, -13.77 in-in in 8.558 Saltbr-in 2.75 HRD-in -70.0, -49.32 73.58, -20.32 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.75, 171.99 APE9-dihe-na 73.44, 147.9 APE8-dihe-in -74.12, 135.91 APE8-rot-in 297.57 APE67-dihe-in -59.91, -18.18 -29.96, -58.43 APE12-dist-in 13.437 APE11-dist-in 12.042 APE10-dist-in 7.471 APE9-dist-in 3.03 None None None XRAY 2.39 0.196 0.228 C 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
6FYLA 144 483 499.0 3NG:501 Type1 Active DFGin 7.161 14.637 BLAminus -119.92, -175.89 60.38, 80.92 -97.43, 16.84 290.06, 87.59 -59.22, -23.17 in-in in 9.054 Saltbr-in 2.46 HRD-in -71.74, -50.4 78.44, -13.97 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.7, 169.22 APE9-dihe-na 74.63, 150.35 APE8-dihe-in -69.34, 134.45 APE8-rot-in 299.9 APE67-dihe-in -60.04, -23.84 -27.22, -60.14 APE12-dist-in 13.376 APE11-dist-in 11.885 APE10-dist-in 7.467 APE9-dist-in 2.93 None None None XRAY 1.95 0.19 0.213 A 363 340 0 0 0 0 [[163, 479]] 1.0 6fyl CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
3NR9A 137 484 499.0 NR9:1 Type1 Active DFGin 6.846 13.747 BLAminus -123.69, 174.89 72.04, 86.15 -109.59, 27.26 300.7, 88.68 -62.14, -32.34 in-in in 8.704 Saltbr-in 2.829 HRD-in -60.57, -48.74 71.45, -13.65 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, -20.74 APE9-dihe-na -109.82, 169.67 APE8-dihe-in -69.01, 132.64 APE8-rot-in 299.22 APE67-dihe-in -61.27, -17.76 -28.49, -59.64 APE12-dist-in 13.067 APE11-dist-in 11.489 APE10-dist-in 7.292 APE9-dist-in 3.368 None None None XRAY 2.89 0.197 0.252 A 368 341 7 0 0 0 [[163, 479]] 1.0 3nr9 CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
3NR9B 136 482 499.0 NR9:1 Type1 Active DFGin 6.772 13.753 BLAminus -123.26, 175.27 70.05, 85.73 -107.85, 26.08 301.04, 90.69 -62.19, -29.36 in-in in 8.721 Saltbr-in 2.951 HRD-in -60.67, -46.73 70.15, -13.73 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.73, -26.78 APE9-dihe-na -105.37, 169.99 APE8-dihe-in -70.52, 135.28 APE8-rot-in 302.22 APE67-dihe-in -63.02, -18.42 -31.09, -56.66 APE12-dist-in 13.103 APE11-dist-in 11.487 APE10-dist-in 7.37 APE9-dist-in 3.314 None None None XRAY 2.89 0.197 0.252 B 368 347 0 0 0 0 [[163, 479]] 1.0 3nr9 CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
3NR9C 137 483 499.0 NR9:1 Type1 Active DFGin 6.835 13.722 BLAminus -125.96, 173.42 73.71, 83.01 -105.61, 25.93 300.12, 91.3 -61.62, -31.53 in-in in 8.594 Saltbr-in 2.862 HRD-in -61.41, -47.84 73.07, -14.74 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.33, -24.97 APE9-dihe-na -107.99, 167.86 APE8-dihe-in -69.22, 136.67 APE8-rot-in 299.26 APE67-dihe-in -60.94, -18.85 -31.44, -60.01 APE12-dist-in 13.101 APE11-dist-in 11.511 APE10-dist-in 7.383 APE9-dist-in 3.288 None None None XRAY 2.89 0.197 0.252 C 368 347 0 0 0 0 [[163, 479]] 1.0 3nr9 CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
6FYIA 148 483 499.0 EAE:501 Type1 Active DFGin 7.059 14.247 BLAminus -118.89, -176.08 54.9, 90.13 -108.37, 24.54 295.21, 92.22 -68.08, -17.95 in-in in 8.873 Saltbr-in 2.761 HRD-in -71.46, -43.74 72.78, -37.63 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 170.24 APE9-dihe-na 75.27, 152.33 APE8-dihe-in -73.5, 140.46 APE8-rot-in 301.64 APE67-dihe-in -60.39, -24.06 -32.87, -56.62 APE12-dist-in 13.495 APE11-dist-in 11.894 APE10-dist-in 7.35 APE9-dist-in 3.174 None None None XRAY 2.6 0.219 0.233 A 368 336 0 0 0 0 [[163, 479]] 1.0 6fyi CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
5UNPA 137 483 499.0 8FY:2501 Type1 Active DFGin 7.16 13.897 BLAminus -119.22, 176.57 67.8, 97.67 -118.69, 14.46 293.66, 90.16 -63.87, -26.47 in-in in 8.133 Saltbr-in 2.628 HRD-in -66.12, -54.37 84.64, -17.45 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.92, -43.69 APE9-dihe-na -94.54, 168.49 APE8-dihe-in -67.62, 131.5 APE8-rot-in 301.93 APE67-dihe-in -68.13, -17.33 -27.6, -56.38 APE12-dist-in 13.358 APE11-dist-in 11.746 APE10-dist-in 7.777 APE9-dist-in 3.132 None None None XRAY 2.92 0.202 0.234 A 369 347 0 0 0 0 [[163, 479]] 1.0 5unp CMGC_CLK2_HUMAN CMGC 1.9e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
5UNPB 137 483 499.0 8FY:2501 Type1 Active DFGin 7.175 13.897 BLAminus -119.14, 176.55 68.1, 97.63 -118.63, 14.51 293.87, 90.02 -64.23, -26.2 in-in in 8.137 Saltbr-in 2.625 HRD-in -66.22, -54.02 84.2, -17.97 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, -43.85 APE9-dihe-na -94.26, 168.59 APE8-dihe-in -67.49, 131.19 APE8-rot-in 302.49 APE67-dihe-in -68.42, -17.37 -27.87, -56.06 APE12-dist-in 13.355 APE11-dist-in 11.748 APE10-dist-in 7.78 APE9-dist-in 3.132 None None None XRAY 2.92 0.202 0.234 B 369 347 0 0 0 0 [[163, 479]] 1.0 5unp CMGC_CLK2_HUMAN CMGC 1.9e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
6KHEA 144 485 499.0 3NG:1000 Type1 Inactive DFGin 7.055 14.837 BLAminus -131.68, -176.57 65.16, 73.84 -91.75, 19.3 289.49, 98.72 -67.18, -14.55 in-in in 9.186 Saltbr-in 2.61 HRD-out -72.06, 107.81 -82.72, -0.44 in-in-in SNCiii in-in ActLoopNT-in 3.114 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.6, 166.16 APE9-dihe-na 72.38, -179.55 APE8-dihe-in -103.99, 128.19 APE8-rot-in 299.55 APE67-dihe-in -66.25, -31.78 -33.5, -45.82 APE12-dist-in 13.323 APE11-dist-in 11.976 APE10-dist-in 7.484 APE9-dist-in 3.318 None None None XRAY 2.8 0.203 0.261 A 499 342 0 0 0 0 [[163, 479]] 1.0 6khe CMGC_CLK2_HUMAN CMGC 4.9e-92 314.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2

CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 13
Active chains: 12
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 100.0% AF-P49760-K1A

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CLK2_HUMAN AF-P49760-K1A P49760 155 487 499.0 No_ligand No_ligand Active DFGin 7.017 14.447 BLAminus -126.22, 175.17 64.05, 67.73 -82.36, 10.77 293.87, 94.93 -66.07, -15.18 in-in in 8.629 Saltbr-in 2.737 HRD-in -71.37, -38.9 64.95, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.18, 175.15 APE9-dihe-na 65.62, 146.25 APE8-dihe-in -58.43, 137.37 APE8-rot-in 294.29 APE67-dihe-in -69.47, -18.12 -49.92, -45.23 APE12-dist-in 13.835 APE11-dist-in 11.808 APE10-dist-in 7.504 APE9-dist-in 2.937 None None None AF2 -1.0 1.0 1.0 A 333 333 0 0 0 0 [[163, 479]] 1.0 AF-P49760-K1 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.3e-92 316.2 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN AF-P49760-K3A P49760 155 487 499.0 No_ligand No_ligand Active DFGin 6.641 14.358 BLAminus -127.7, 177.09 63.58, 64.12 -79.63, 11.17 297.99, 96.21 -65.88, -8.85 in-in in 8.47 Saltbr-in 2.689 HRD-in -74.26, -40.62 70.17, -26.03 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.16, -178.79 APE9-dihe-na 64.17, 140.54 APE8-dihe-in -54.77, 136.12 APE8-rot-in 294.36 APE67-dihe-in -67.89, -21.3 -52.25, -41.65 APE12-dist-in 13.715 APE11-dist-in 11.759 APE10-dist-in 7.299 APE9-dist-in 2.982 None None None AF2 -1.0 1.0 1.0 A 333 333 0 0 0 0 [[163, 479]] 1.0 AF-P49760-K3 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.3e-92 316.2 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 6FYKA P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.025 13.933 BLAminus -128.78, 177.13 62.38, 94.51 -113.34, 21.4 294.8, 89.41 -67.4, -12.68 in-in in 8.693 Saltbr-in 2.614 HRD-in -66.97, -50.97 77.07, -17.13 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.9, 169.97 APE9-dihe-na 71.5, 144.52 APE8-dihe-in -67.7, 143.43 APE8-rot-in 294.43 APE67-dihe-in -55.56, -28.09 -39.63, -56.25 APE12-dist-in 13.29 APE11-dist-in 11.706 APE10-dist-in 7.41 APE9-dist-in 2.951 None None None XRAY 2.39 0.196 0.228 A 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 6FYKB P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 6.979 13.545 BLAminus -126.36, 176.1 65.04, 89.02 -110.3, 25.2 302.84, 96.68 -72.78, -13.24 in-in in 8.571 Saltbr-in 2.692 HRD-in -74.27, -47.13 73.72, -15.28 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.26, 173.72 APE9-dihe-na 72.32, 147.64 APE8-dihe-in -71.42, 138.78 APE8-rot-in 296.31 APE67-dihe-in -62.52, -26.37 -31.99, -52.81 APE12-dist-in 13.304 APE11-dist-in 11.879 APE10-dist-in 7.365 APE9-dist-in 2.896 None None None XRAY 2.39 0.196 0.228 B 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 6FYKC P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.18 13.809 BLAminus -122.42, 175.39 66.62, 94.13 -114.05, 24.08 298.67, 87.87 -71.48, -13.77 in-in in 8.558 Saltbr-in 2.75 HRD-in -70.0, -49.32 73.58, -20.32 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.75, 171.99 APE9-dihe-na 73.44, 147.9 APE8-dihe-in -74.12, 135.91 APE8-rot-in 297.57 APE67-dihe-in -59.91, -18.18 -29.96, -58.43 APE12-dist-in 13.437 APE11-dist-in 12.042 APE10-dist-in 7.471 APE9-dist-in 3.03 None None None XRAY 2.39 0.196 0.228 C 363 349 0 0 0 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 6FYLA P49760 144 483 499.0 3NG:501 Type1 Active DFGin 7.161 14.637 BLAminus -119.92, -175.89 60.38, 80.92 -97.43, 16.84 290.06, 87.59 -59.22, -23.17 in-in in 9.054 Saltbr-in 2.46 HRD-in -71.74, -50.4 78.44, -13.97 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.7, 169.22 APE9-dihe-na 74.63, 150.35 APE8-dihe-in -69.34, 134.45 APE8-rot-in 299.9 APE67-dihe-in -60.04, -23.84 -27.22, -60.14 APE12-dist-in 13.376 APE11-dist-in 11.885 APE10-dist-in 7.467 APE9-dist-in 2.93 None None None XRAY 1.95 0.19 0.213 A 363 340 0 0 0 0 [[163, 479]] 1.0 6fyl Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 3NR9A P49760 137 484 499.0 NR9:1 Type1 Active DFGin 6.846 13.747 BLAminus -123.69, 174.89 72.04, 86.15 -109.59, 27.26 300.7, 88.68 -62.14, -32.34 in-in in 8.704 Saltbr-in 2.829 HRD-in -60.57, -48.74 71.45, -13.65 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, -20.74 APE9-dihe-na -109.82, 169.67 APE8-dihe-in -69.01, 132.64 APE8-rot-in 299.22 APE67-dihe-in -61.27, -17.76 -28.49, -59.64 APE12-dist-in 13.067 APE11-dist-in 11.489 APE10-dist-in 7.292 APE9-dist-in 3.368 None None None XRAY 2.89 0.197 0.252 A 368 341 7 0 0 0 [[163, 479]] 1.0 3nr9 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 3NR9B P49760 136 482 499.0 NR9:1 Type1 Active DFGin 6.772 13.753 BLAminus -123.26, 175.27 70.05, 85.73 -107.85, 26.08 301.04, 90.69 -62.19, -29.36 in-in in 8.721 Saltbr-in 2.951 HRD-in -60.67, -46.73 70.15, -13.73 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.73, -26.78 APE9-dihe-na -105.37, 169.99 APE8-dihe-in -70.52, 135.28 APE8-rot-in 302.22 APE67-dihe-in -63.02, -18.42 -31.09, -56.66 APE12-dist-in 13.103 APE11-dist-in 11.487 APE10-dist-in 7.37 APE9-dist-in 3.314 None None None XRAY 2.89 0.197 0.252 B 368 347 0 0 0 0 [[163, 479]] 1.0 3nr9 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 3NR9C P49760 137 483 499.0 NR9:1 Type1 Active DFGin 6.835 13.722 BLAminus -125.96, 173.42 73.71, 83.01 -105.61, 25.93 300.12, 91.3 -61.62, -31.53 in-in in 8.594 Saltbr-in 2.862 HRD-in -61.41, -47.84 73.07, -14.74 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.33, -24.97 APE9-dihe-na -107.99, 167.86 APE8-dihe-in -69.22, 136.67 APE8-rot-in 299.26 APE67-dihe-in -60.94, -18.85 -31.44, -60.01 APE12-dist-in 13.101 APE11-dist-in 11.511 APE10-dist-in 7.383 APE9-dist-in 3.288 None None None XRAY 2.89 0.197 0.252 C 368 347 0 0 0 0 [[163, 479]] 1.0 3nr9 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 6FYIA P49760 148 483 499.0 EAE:501 Type1 Active DFGin 7.059 14.247 BLAminus -118.89, -176.08 54.9, 90.13 -108.37, 24.54 295.21, 92.22 -68.08, -17.95 in-in in 8.873 Saltbr-in 2.761 HRD-in -71.46, -43.74 72.78, -37.63 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 170.24 APE9-dihe-na 75.27, 152.33 APE8-dihe-in -73.5, 140.46 APE8-rot-in 301.64 APE67-dihe-in -60.39, -24.06 -32.87, -56.62 APE12-dist-in 13.495 APE11-dist-in 11.894 APE10-dist-in 7.35 APE9-dist-in 3.174 None None None XRAY 2.6 0.219 0.233 A 368 336 0 0 0 0 [[163, 479]] 1.0 6fyi Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 5UNPA P49760 137 483 499.0 8FY:2501 Type1 Active DFGin 7.16 13.897 BLAminus -119.22, 176.57 67.8, 97.67 -118.69, 14.46 293.66, 90.16 -63.87, -26.47 in-in in 8.133 Saltbr-in 2.628 HRD-in -66.12, -54.37 84.64, -17.45 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.92, -43.69 APE9-dihe-na -94.54, 168.49 APE8-dihe-in -67.62, 131.5 APE8-rot-in 301.93 APE67-dihe-in -68.13, -17.33 -27.6, -56.38 APE12-dist-in 13.358 APE11-dist-in 11.746 APE10-dist-in 7.777 APE9-dist-in 3.132 None None None XRAY 2.92 0.202 0.234 A 369 347 0 0 0 0 [[163, 479]] 1.0 5unp Homo sapiens CMGC_CLK2_HUMAN CMGC 1.9e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 5UNPB P49760 137 483 499.0 8FY:2501 Type1 Active DFGin 7.175 13.897 BLAminus -119.14, 176.55 68.1, 97.63 -118.63, 14.51 293.87, 90.02 -64.23, -26.2 in-in in 8.137 Saltbr-in 2.625 HRD-in -66.22, -54.02 84.2, -17.97 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, -43.85 APE9-dihe-na -94.26, 168.59 APE8-dihe-in -67.49, 131.19 APE8-rot-in 302.49 APE67-dihe-in -68.42, -17.37 -27.87, -56.06 APE12-dist-in 13.355 APE11-dist-in 11.748 APE10-dist-in 7.78 APE9-dist-in 3.132 None None None XRAY 2.92 0.202 0.234 B 369 347 0 0 0 0 [[163, 479]] 1.0 5unp Homo sapiens CMGC_CLK2_HUMAN CMGC 1.9e-92 315.6 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2_HUMAN 6KHEA P49760 144 485 499.0 3NG:1000 Type1 Inactive DFGin 7.055 14.837 BLAminus -131.68, -176.57 65.16, 73.84 -91.75, 19.3 289.49, 98.72 -67.18, -14.55 in-in in 9.186 Saltbr-in 2.61 HRD-out -72.06, 107.81 -82.72, -0.44 in-in-in SNCiii in-in ActLoopNT-in 3.114 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.6, 166.16 APE9-dihe-na 72.38, -179.55 APE8-dihe-in -103.99, 128.19 APE8-rot-in 299.55 APE67-dihe-in -66.25, -31.78 -33.5, -45.82 APE12-dist-in 13.323 APE11-dist-in 11.976 APE10-dist-in 7.484 APE9-dist-in 3.318 None None None XRAY 2.8 0.203 0.261 A 499 342 0 0 0 0 [[163, 479]] 1.0 6khe Homo sapiens CMGC_CLK2_HUMAN CMGC 4.9e-92 314.7 1 301 301 326 327 328 330 332 193 208 212 287 289 288 290 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2

CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name