CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 13
Active chains: 12
Uniprot: CLK2_HUMAN
Kinase Domain Residues: 163 - 479
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 100.0% AF-P49760-K1A

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CLK2 AF-P49760-K1A P49760 155 487 499.0 No_ligand No_ligand Active DFGin 7.0173 14.4471 BLAminus -126.22, 175.17 64.05, 67.73 -82.36, 10.77 293.87, 94.93 -66.07, -15.18 in-in in 8.6291 Saltbr-in 2.7373 HRD-in -71.37, -38.9 64.95, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.8974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.18, 175.15 APE9-dihe-na 65.62, 146.25 APE8-dihe-in -58.43, 137.37 APE8-rot-in 294.29 APE67-dihe-in -69.47, -18.12 -49.92, -45.23 APE12-dist-in 13.8354 APE11-dist-in 11.8078 APE10-dist-in 7.5036 APE9-dist-in 2.9368 None None None AF2 -1.0 1.0 1.0 A 333.0 333.0 0 25 25 0 [[163, 479]] 1.0 AF-P49760-K1 CMGC_CLK2_HUMAN CMGC 1.3e-92 316.2 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 AF-P49760-K3A P49760 155 487 499.0 No_ligand No_ligand Active DFGin 6.641 14.3581 BLAminus -127.7, 177.09 63.58, 64.12 -79.63, 11.17 297.99, 96.21 -65.88, -8.85 in-in in 8.4703 Saltbr-in 2.6895 HRD-in -74.26, -40.62 70.17, -26.03 in-in-in SNCiii in-in ActLoopNT-in 2.9051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.16, -178.79 APE9-dihe-na 64.17, 140.54 APE8-dihe-in -54.77, 136.12 APE8-rot-in 294.36 APE67-dihe-in -67.89, -21.3 -52.25, -41.65 APE12-dist-in 13.7148 APE11-dist-in 11.7586 APE10-dist-in 7.2986 APE9-dist-in 2.9821 None None None AF2 -1.0 1.0 1.0 A 333.0 333.0 0 25 25 0 [[163, 479]] 1.0 AF-P49760-K3 CMGC_CLK2_HUMAN CMGC 1.3e-92 316.2 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 6FYKA P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.0247 13.933 BLAminus -128.78, 177.13 62.38, 94.51 -113.34, 21.4 294.8, 89.41 -67.4, -12.68 in-in in 8.6929 Saltbr-in 2.6136 HRD-in -66.97, -50.97 77.07, -17.13 in-in-in SNCiii in-in ActLoopNT-in 2.7927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.9, 169.97 APE9-dihe-na 71.5, 144.52 APE8-dihe-in -67.7, 143.43 APE8-rot-in 294.43 APE67-dihe-in -55.56, -28.09 -39.63, -56.25 APE12-dist-in 13.2898 APE11-dist-in 11.7062 APE10-dist-in 7.4097 APE9-dist-in 2.9513 None None None XRAY 2.39 0.196 0.228 A 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 6FYKB P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 6.9791 13.5453 BLAminus -126.36, 176.1 65.04, 89.02 -110.3, 25.2 302.84, 96.68 -72.78, -13.24 in-in in 8.5714 Saltbr-in 2.6918 HRD-in -74.27, -47.13 73.72, -15.28 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.26, 173.72 APE9-dihe-na 72.32, 147.64 APE8-dihe-in -71.42, 138.78 APE8-rot-in 296.31 APE67-dihe-in -62.52, -26.37 -31.99, -52.81 APE12-dist-in 13.304 APE11-dist-in 11.8792 APE10-dist-in 7.3646 APE9-dist-in 2.8961 None None None XRAY 2.39 0.196 0.228 B 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 6FYKC P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.1797 13.8088 BLAminus -122.42, 175.39 66.62, 94.13 -114.05, 24.08 298.67, 87.87 -71.48, -13.77 in-in in 8.5576 Saltbr-in 2.7503 HRD-in -70.0, -49.32 73.58, -20.32 in-in-in SNCiii in-in ActLoopNT-in 2.8236 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.75, 171.99 APE9-dihe-na 73.44, 147.9 APE8-dihe-in -74.12, 135.91 APE8-rot-in 297.57 APE67-dihe-in -59.91, -18.18 -29.96, -58.43 APE12-dist-in 13.4365 APE11-dist-in 12.0418 APE10-dist-in 7.4714 APE9-dist-in 3.0303 None None None XRAY 2.39 0.196 0.228 C 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 6FYLA P49760 144 483 499.0 3NG:501 Type1 Active DFGin 7.1606 14.6375 BLAminus -119.92, -175.89 60.38, 80.92 -97.43, 16.84 290.06, 87.59 -59.22, -23.17 in-in in 9.0542 Saltbr-in 2.4599 HRD-in -71.74, -50.4 78.44, -13.97 in-in-in SNCiii in-in ActLoopNT-in 2.7829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.7, 169.22 APE9-dihe-na 74.63, 150.35 APE8-dihe-in -69.34, 134.45 APE8-rot-in 299.9 APE67-dihe-in -60.04, -23.84 -27.22, -60.14 APE12-dist-in 13.3763 APE11-dist-in 11.8847 APE10-dist-in 7.4666 APE9-dist-in 2.9296 None None None XRAY 1.95 0.19 0.213 A 363.0 340.0 0 25 25 0 [[163, 479]] 1.0 6fyl CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 3NR9A P49760 137 484 499.0 NR9:1 Type1 Active DFGin 6.8458 13.7471 BLAminus -123.69, 174.89 72.04, 86.15 -109.59, 27.26 300.7, 88.68 -62.14, -32.34 in-in in 8.7043 Saltbr-in 2.829 HRD-in -60.57, -48.74 71.45, -13.65 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, -20.74 APE9-dihe-na -109.82, 169.67 APE8-dihe-in -69.01, 132.64 APE8-rot-in 299.22 APE67-dihe-in -61.27, -17.76 -28.49, -59.64 APE12-dist-in 13.0673 APE11-dist-in 11.4893 APE10-dist-in 7.2917 APE9-dist-in 3.3677 None None None XRAY 2.89 0.197 0.252 A 368.0 341.0 7 25 25 0 [[163, 479]] 1.0 3nr9 CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 3NR9B P49760 136 482 499.0 NR9:1 Type1 Active DFGin 6.7722 13.753 BLAminus -123.26, 175.27 70.05, 85.73 -107.85, 26.08 301.04, 90.69 -62.19, -29.36 in-in in 8.7207 Saltbr-in 2.951 HRD-in -60.67, -46.73 70.15, -13.73 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.73, -26.78 APE9-dihe-na -105.37, 169.99 APE8-dihe-in -70.52, 135.28 APE8-rot-in 302.22 APE67-dihe-in -63.02, -18.42 -31.09, -56.66 APE12-dist-in 13.1031 APE11-dist-in 11.4866 APE10-dist-in 7.3696 APE9-dist-in 3.314 None None None XRAY 2.89 0.197 0.252 B 368.0 347.0 0 25 25 0 [[163, 479]] 1.0 3nr9 CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 3NR9C P49760 137 483 499.0 NR9:1 Type1 Active DFGin 6.8349 13.722 BLAminus -125.96, 173.42 73.71, 83.01 -105.61, 25.93 300.12, 91.3 -61.62, -31.53 in-in in 8.5941 Saltbr-in 2.8618 HRD-in -61.41, -47.84 73.07, -14.74 in-in-in SNCiii in-in ActLoopNT-in 2.8275 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.33, -24.97 APE9-dihe-na -107.99, 167.86 APE8-dihe-in -69.22, 136.67 APE8-rot-in 299.26 APE67-dihe-in -60.94, -18.85 -31.44, -60.01 APE12-dist-in 13.1015 APE11-dist-in 11.5105 APE10-dist-in 7.3829 APE9-dist-in 3.2883 None None None XRAY 2.89 0.197 0.252 C 368.0 347.0 0 25 25 0 [[163, 479]] 1.0 3nr9 CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 6FYIA P49760 148 483 499.0 EAE:501 Type1 Active DFGin 7.0594 14.2469 BLAminus -118.89, -176.08 54.9, 90.13 -108.37, 24.54 295.21, 92.22 -68.08, -17.95 in-in in 8.8735 Saltbr-in 2.761 HRD-in -71.46, -43.74 72.78, -37.63 in-in-in SNCiii in-in ActLoopNT-in 2.9169 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 170.24 APE9-dihe-na 75.27, 152.33 APE8-dihe-in -73.5, 140.46 APE8-rot-in 301.64 APE67-dihe-in -60.39, -24.06 -32.87, -56.62 APE12-dist-in 13.495 APE11-dist-in 11.8939 APE10-dist-in 7.3503 APE9-dist-in 3.1742 None None None XRAY 2.6 0.219 0.233 A 368.0 336.0 0 25 25 0 [[163, 479]] 1.0 6fyi CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 5UNPA P49760 137 483 499.0 8FY:2501 Type1 Active DFGin 7.1596 13.8968 BLAminus -119.22, 176.57 67.8, 97.67 -118.69, 14.46 293.66, 90.16 -63.87, -26.47 in-in in 8.1329 Saltbr-in 2.6279 HRD-in -66.12, -54.37 84.64, -17.45 in-in-in SNCiii in-in ActLoopNT-in 2.7912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.92, -43.69 APE9-dihe-na -94.54, 168.49 APE8-dihe-in -67.62, 131.5 APE8-rot-in 301.93 APE67-dihe-in -68.13, -17.33 -27.6, -56.38 APE12-dist-in 13.3584 APE11-dist-in 11.7461 APE10-dist-in 7.7765 APE9-dist-in 3.132 None None None XRAY 2.92 0.202 0.234 A 369.0 347.0 0 25 25 0 [[163, 479]] 1.0 5unp CMGC_CLK2_HUMAN CMGC 1.9e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 5UNPB P49760 137 483 499.0 8FY:2501 Type1 Active DFGin 7.1746 13.8968 BLAminus -119.14, 176.55 68.1, 97.63 -118.63, 14.51 293.87, 90.02 -64.23, -26.2 in-in in 8.1374 Saltbr-in 2.625 HRD-in -66.22, -54.02 84.2, -17.97 in-in-in SNCiii in-in ActLoopNT-in 2.7953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, -43.85 APE9-dihe-na -94.26, 168.59 APE8-dihe-in -67.49, 131.19 APE8-rot-in 302.49 APE67-dihe-in -68.42, -17.37 -27.87, -56.06 APE12-dist-in 13.3549 APE11-dist-in 11.7484 APE10-dist-in 7.78 APE9-dist-in 3.1322 None None None XRAY 2.92 0.202 0.234 B 369.0 347.0 0 25 25 0 [[163, 479]] 1.0 5unp CMGC_CLK2_HUMAN CMGC 1.9e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 6KHEA P49760 144 485 499.0 3NG:1000 Type1 Inactive DFGin 7.0549 14.8367 BLAminus -131.68, -176.57 65.16, 73.84 -91.75, 19.3 289.49, 98.72 -67.18, -14.55 in-in in 9.1864 Saltbr-in 2.6098 HRD-out -72.06, 107.81 -82.72, -0.44 in-in-in SNCiii in-in ActLoopNT-in 3.1139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.6, 166.16 APE9-dihe-na 72.38, -179.55 APE8-dihe-in -103.99, 128.19 APE8-rot-in 299.55 APE67-dihe-in -66.25, -31.78 -33.5, -45.82 APE12-dist-in 13.3233 APE11-dist-in 11.9764 APE10-dist-in 7.4837 APE9-dist-in 3.3178 None None None XRAY 2.8 0.203 0.261 A 499.0 342.0 0 25 25 0 [[163, 479]] 1.0 6khe CMGC_CLK2_HUMAN CMGC 4.9e-92 314.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2

CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 13
Active chains: 12
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 100.0% AF-P49760-K1A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CLK2 CLK2_HUMAN AF-P49760-K1A P49760 155 487 499.0 No_ligand No_ligand Active DFGin 7.0173 14.4471 BLAminus -126.22, 175.17 64.05, 67.73 -82.36, 10.77 293.87, 94.93 -66.07, -15.18 in-in in 8.6291 Saltbr-in 2.7373 HRD-in -71.37, -38.9 64.95, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.8974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.18, 175.15 APE9-dihe-na 65.62, 146.25 APE8-dihe-in -58.43, 137.37 APE8-rot-in 294.29 APE67-dihe-in -69.47, -18.12 -49.92, -45.23 APE12-dist-in 13.8354 APE11-dist-in 11.8078 APE10-dist-in 7.5036 APE9-dist-in 2.9368 None None None AF2 -1.0 1.0 1.0 A 333.0 333.0 0 25 25 0 [[163, 479]] 1.0 AF-P49760-K1 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.3e-92 316.2 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN AF-P49760-K3A P49760 155 487 499.0 No_ligand No_ligand Active DFGin 6.641 14.3581 BLAminus -127.7, 177.09 63.58, 64.12 -79.63, 11.17 297.99, 96.21 -65.88, -8.85 in-in in 8.4703 Saltbr-in 2.6895 HRD-in -74.26, -40.62 70.17, -26.03 in-in-in SNCiii in-in ActLoopNT-in 2.9051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.16, -178.79 APE9-dihe-na 64.17, 140.54 APE8-dihe-in -54.77, 136.12 APE8-rot-in 294.36 APE67-dihe-in -67.89, -21.3 -52.25, -41.65 APE12-dist-in 13.7148 APE11-dist-in 11.7586 APE10-dist-in 7.2986 APE9-dist-in 2.9821 None None None AF2 -1.0 1.0 1.0 A 333.0 333.0 0 25 25 0 [[163, 479]] 1.0 AF-P49760-K3 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.3e-92 316.2 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 6FYKA P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.0247 13.933 BLAminus -128.78, 177.13 62.38, 94.51 -113.34, 21.4 294.8, 89.41 -67.4, -12.68 in-in in 8.6929 Saltbr-in 2.6136 HRD-in -66.97, -50.97 77.07, -17.13 in-in-in SNCiii in-in ActLoopNT-in 2.7927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.9, 169.97 APE9-dihe-na 71.5, 144.52 APE8-dihe-in -67.7, 143.43 APE8-rot-in 294.43 APE67-dihe-in -55.56, -28.09 -39.63, -56.25 APE12-dist-in 13.2898 APE11-dist-in 11.7062 APE10-dist-in 7.4097 APE9-dist-in 2.9513 None None None XRAY 2.39 0.196 0.228 A 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 6FYKB P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 6.9791 13.5453 BLAminus -126.36, 176.1 65.04, 89.02 -110.3, 25.2 302.84, 96.68 -72.78, -13.24 in-in in 8.5714 Saltbr-in 2.6918 HRD-in -74.27, -47.13 73.72, -15.28 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.26, 173.72 APE9-dihe-na 72.32, 147.64 APE8-dihe-in -71.42, 138.78 APE8-rot-in 296.31 APE67-dihe-in -62.52, -26.37 -31.99, -52.81 APE12-dist-in 13.304 APE11-dist-in 11.8792 APE10-dist-in 7.3646 APE9-dist-in 2.8961 None None None XRAY 2.39 0.196 0.228 B 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 6FYKC P49760 137 485 499.0 EAZ:501 Type1 Active DFGin 7.1797 13.8088 BLAminus -122.42, 175.39 66.62, 94.13 -114.05, 24.08 298.67, 87.87 -71.48, -13.77 in-in in 8.5576 Saltbr-in 2.7503 HRD-in -70.0, -49.32 73.58, -20.32 in-in-in SNCiii in-in ActLoopNT-in 2.8236 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.75, 171.99 APE9-dihe-na 73.44, 147.9 APE8-dihe-in -74.12, 135.91 APE8-rot-in 297.57 APE67-dihe-in -59.91, -18.18 -29.96, -58.43 APE12-dist-in 13.4365 APE11-dist-in 12.0418 APE10-dist-in 7.4714 APE9-dist-in 3.0303 None None None XRAY 2.39 0.196 0.228 C 363.0 349.0 0 25 25 0 [[163, 479]] 1.0 6fyk Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 6FYLA P49760 144 483 499.0 3NG:501 Type1 Active DFGin 7.1606 14.6375 BLAminus -119.92, -175.89 60.38, 80.92 -97.43, 16.84 290.06, 87.59 -59.22, -23.17 in-in in 9.0542 Saltbr-in 2.4599 HRD-in -71.74, -50.4 78.44, -13.97 in-in-in SNCiii in-in ActLoopNT-in 2.7829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.7, 169.22 APE9-dihe-na 74.63, 150.35 APE8-dihe-in -69.34, 134.45 APE8-rot-in 299.9 APE67-dihe-in -60.04, -23.84 -27.22, -60.14 APE12-dist-in 13.3763 APE11-dist-in 11.8847 APE10-dist-in 7.4666 APE9-dist-in 2.9296 None None None XRAY 1.95 0.19 0.213 A 363.0 340.0 0 25 25 0 [[163, 479]] 1.0 6fyl Homo sapiens CMGC_CLK2_HUMAN CMGC 1.7e-92 315.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 3NR9A P49760 137 484 499.0 NR9:1 Type1 Active DFGin 6.8458 13.7471 BLAminus -123.69, 174.89 72.04, 86.15 -109.59, 27.26 300.7, 88.68 -62.14, -32.34 in-in in 8.7043 Saltbr-in 2.829 HRD-in -60.57, -48.74 71.45, -13.65 in-in-in SNCiii in-in ActLoopNT-in 2.784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.09, -20.74 APE9-dihe-na -109.82, 169.67 APE8-dihe-in -69.01, 132.64 APE8-rot-in 299.22 APE67-dihe-in -61.27, -17.76 -28.49, -59.64 APE12-dist-in 13.0673 APE11-dist-in 11.4893 APE10-dist-in 7.2917 APE9-dist-in 3.3677 None None None XRAY 2.89 0.197 0.252 A 368.0 341.0 7 25 25 0 [[163, 479]] 1.0 3nr9 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 3NR9B P49760 136 482 499.0 NR9:1 Type1 Active DFGin 6.7722 13.753 BLAminus -123.26, 175.27 70.05, 85.73 -107.85, 26.08 301.04, 90.69 -62.19, -29.36 in-in in 8.7207 Saltbr-in 2.951 HRD-in -60.67, -46.73 70.15, -13.73 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.73, -26.78 APE9-dihe-na -105.37, 169.99 APE8-dihe-in -70.52, 135.28 APE8-rot-in 302.22 APE67-dihe-in -63.02, -18.42 -31.09, -56.66 APE12-dist-in 13.1031 APE11-dist-in 11.4866 APE10-dist-in 7.3696 APE9-dist-in 3.314 None None None XRAY 2.89 0.197 0.252 B 368.0 347.0 0 25 25 0 [[163, 479]] 1.0 3nr9 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 3NR9C P49760 137 483 499.0 NR9:1 Type1 Active DFGin 6.8349 13.722 BLAminus -125.96, 173.42 73.71, 83.01 -105.61, 25.93 300.12, 91.3 -61.62, -31.53 in-in in 8.5941 Saltbr-in 2.8618 HRD-in -61.41, -47.84 73.07, -14.74 in-in-in SNCiii in-in ActLoopNT-in 2.8275 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.33, -24.97 APE9-dihe-na -107.99, 167.86 APE8-dihe-in -69.22, 136.67 APE8-rot-in 299.26 APE67-dihe-in -60.94, -18.85 -31.44, -60.01 APE12-dist-in 13.1015 APE11-dist-in 11.5105 APE10-dist-in 7.3829 APE9-dist-in 3.2883 None None None XRAY 2.89 0.197 0.252 C 368.0 347.0 0 25 25 0 [[163, 479]] 1.0 3nr9 Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 6FYIA P49760 148 483 499.0 EAE:501 Type1 Active DFGin 7.0594 14.2469 BLAminus -118.89, -176.08 54.9, 90.13 -108.37, 24.54 295.21, 92.22 -68.08, -17.95 in-in in 8.8735 Saltbr-in 2.761 HRD-in -71.46, -43.74 72.78, -37.63 in-in-in SNCiii in-in ActLoopNT-in 2.9169 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.68, 170.24 APE9-dihe-na 75.27, 152.33 APE8-dihe-in -73.5, 140.46 APE8-rot-in 301.64 APE67-dihe-in -60.39, -24.06 -32.87, -56.62 APE12-dist-in 13.495 APE11-dist-in 11.8939 APE10-dist-in 7.3503 APE9-dist-in 3.1742 None None None XRAY 2.6 0.219 0.233 A 368.0 336.0 0 25 25 0 [[163, 479]] 1.0 6fyi Homo sapiens CMGC_CLK2_HUMAN CMGC 1.8e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 5UNPA P49760 137 483 499.0 8FY:2501 Type1 Active DFGin 7.1596 13.8968 BLAminus -119.22, 176.57 67.8, 97.67 -118.69, 14.46 293.66, 90.16 -63.87, -26.47 in-in in 8.1329 Saltbr-in 2.6279 HRD-in -66.12, -54.37 84.64, -17.45 in-in-in SNCiii in-in ActLoopNT-in 2.7912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.92, -43.69 APE9-dihe-na -94.54, 168.49 APE8-dihe-in -67.62, 131.5 APE8-rot-in 301.93 APE67-dihe-in -68.13, -17.33 -27.6, -56.38 APE12-dist-in 13.3584 APE11-dist-in 11.7461 APE10-dist-in 7.7765 APE9-dist-in 3.132 None None None XRAY 2.92 0.202 0.234 A 369.0 347.0 0 25 25 0 [[163, 479]] 1.0 5unp Homo sapiens CMGC_CLK2_HUMAN CMGC 1.9e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 5UNPB P49760 137 483 499.0 8FY:2501 Type1 Active DFGin 7.1746 13.8968 BLAminus -119.14, 176.55 68.1, 97.63 -118.63, 14.51 293.87, 90.02 -64.23, -26.2 in-in in 8.1374 Saltbr-in 2.625 HRD-in -66.22, -54.02 84.2, -17.97 in-in-in SNCiii in-in ActLoopNT-in 2.7953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, -43.85 APE9-dihe-na -94.26, 168.59 APE8-dihe-in -67.49, 131.19 APE8-rot-in 302.49 APE67-dihe-in -68.42, -17.37 -27.87, -56.06 APE12-dist-in 13.3549 APE11-dist-in 11.7484 APE10-dist-in 7.78 APE9-dist-in 3.1322 None None None XRAY 2.92 0.202 0.234 B 369.0 347.0 0 25 25 0 [[163, 479]] 1.0 5unp Homo sapiens CMGC_CLK2_HUMAN CMGC 1.9e-92 315.6 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2
CLK2 CLK2_HUMAN 6KHEA P49760 144 485 499.0 3NG:1000 Type1 Inactive DFGin 7.0549 14.8367 BLAminus -131.68, -176.57 65.16, 73.84 -91.75, 19.3 289.49, 98.72 -67.18, -14.55 in-in in 9.1864 Saltbr-in 2.6098 HRD-out -72.06, 107.81 -82.72, -0.44 in-in-in SNCiii in-in ActLoopNT-in 3.1139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.6, 166.16 APE9-dihe-na 72.38, -179.55 APE8-dihe-in -103.99, 128.19 APE8-rot-in 299.55 APE67-dihe-in -66.25, -31.78 -33.5, -45.82 APE12-dist-in 13.3233 APE11-dist-in 11.9764 APE10-dist-in 7.4837 APE9-dist-in 3.3178 None None None XRAY 2.8 0.203 0.261 A 499.0 342.0 0 25 25 0 [[163, 479]] 1.0 6khe Homo sapiens CMGC_CLK2_HUMAN CMGC 4.9e-92 314.7 1.0 301.0 301.0 326 327 328 330 332 193 208 212 287 289 288 290.0 363 351 346 345 344 343 342 341 340 244 Dual specificity protein kinase CLK2

CMGC_CLK2 (Dual specificity protein kinase CLK2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name