CMGC_CDKL2 (Cyclin-dependent kinase-like 2)

Total number of chains: 6
Active chains: 2
Uniprot: CDKL2_HUMAN
Kinase Domain Residues: 4 - 287
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q92772-K1A
DFGin BLBminus 2 33.3% 8S6IA
DFGin BLAplus 1 16.7% 4BBMB
DFGin None 1 16.7% 4BBMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDKL2 AF-Q92772-K1A Q92772 1 295 493.0 No_ligand No_ligand Active DFGin 6.993 14.998 BLAminus -134.59, -179.35 57.52, 62.74 -76.04, 17.57 278.67, 72.2 -58.79, -42.35 in-in in 8.7566 Saltbr-in 3.0899 HRD-in -78.13, -48.9 63.51, 19.47 in-in-in SNCiii in-in ActLoopNT-in 2.8642 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.5, 169.46 APE9-dihe-na 64.46, 150.31 APE8-dihe-in -68.94, 137.38 APE8-rot-in 303.1 APE67-dihe-in -63.99, -25.05 -50.91, -45.55 APE12-dist-in 7.9052 APE11-dist-in 10.8681 APE10-dist-in 5.9263 APE9-dist-in 3.3123 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 28 28 0 [[4, 287]] 1.0 AF-Q92772-K1 CMGC_CDKL2_HUMAN CMGC 2.1e-80 276.1 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 AF-Q92772-K3A Q92772 1 295 493.0 No_ligand No_ligand Active DFGin 6.5798 14.4153 BLAminus -134.61, -177.21 52.78, 70.14 -78.41, 16.28 283.58, 76.95 -60.4, -38.39 in-in in 8.5027 Saltbr-in 2.893 HRD-in -79.58, -49.97 64.41, 19.51 in-in-in SNCiii in-in ActLoopNT-in 2.8676 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.71, 165.75 APE9-dihe-na 58.95, 147.38 APE8-dihe-in -61.89, 136.02 APE8-rot-in 299.98 APE67-dihe-in -61.09, -20.97 -53.39, -45.2 APE12-dist-in 12.5753 APE11-dist-in 10.4231 APE10-dist-in 6.0668 APE9-dist-in 3.187 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 28 28 0 [[4, 287]] 1.0 AF-Q92772-K3 CMGC_CDKL2_HUMAN CMGC 2.1e-80 276.1 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 4BBMB Q92772 1 308 493.0 TC0:60500 Type1 Inactive DFGin 7.0095 13.643 BLAplus -116.95, 172.46 71.25, 70.14 -140.96, 65.73 46.41, 86.58 130.11, -39.29 out-none out 11.912 Saltbr-none 999.0 HRD-in -66.2, -48.12 65.5, 13.04 none-out-out SNCnoo out-out ActLoopNT-out 10.2702 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -64.23, -50.52 APE9-dihe-na -57.38, -32.72 APE8-dihe-out -101.31, 4.49 APE8-rot-out 58.21 APE67-dihe-in -66.8, -18.02 -40.05, -47.42 APE12-dist-in 12.2798 APE11-dist-out 16.7739 APE10-dist-out 19.4327 APE9-dist-out 9.3923 T159D,Y161E None None XRAY 2.0 0.244 0.269 B 331.0 288.0 20 28 28 0 [[4, 287]] 1.0 4bbm CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 4AAAA Q92772 1 302 493.0 DKI:60500 Type1 Inactive DFGin 9.8175 16.5623 BLBminus -155.51, 174.54 62.34, 44.23 -57.57, 144.91 282.77, 68.32 -67.57, 25.01 out-none out 12.6425 Saltbr-none 999.0 HRD-in -76.44, -55.33 82.36, -14.07 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -93.2, 21.78 APE9-dihe-na -63.46, 142.18 APE8-dihe-in -70.26, 133.25 APE8-rot-in 305.07 APE67-dihe-in -60.17, -26.15 -101.44, 1.52 APE12-dist-none 999.0 APE11-dist-out 16.0519 APE10-dist-out 20.0315 APE9-dist-out 10.5947 T159D,Y161E None None XRAY 1.53 0.182 0.208 A 331.0 290.0 12 28 16 12 [[4, 287]] 1.0 4aaa CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 8S6IA Q92772 1 305 493.0 A1H5G:60401 Type1 Inactive DFGin 10.8992 16.6113 BLBminus -145.81, 159.25 64.03, 52.3 -70.3, 154.63 284.81, 72.82 -94.57, 119.59 out-out out 11.7806 Saltbr-out 8.7718 HRD-in -68.88, -57.54 78.23, -5.1 out-out-out SNCooo out-out ActLoopNT-out 10.119 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -79.88 APE9-dihe-na -86.16, 151.19 APE8-dihe-in -63.12, 136.66 APE8-rot-out 198.87 APE67-dihe-in -62.07, -26.67 -105.51, 4.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.6805 APE9-dist-out 9.9971 None None None XRAY 1.72 0.205 0.222 A 331.0 295.0 10 28 18 10 [[4, 287]] 1.0 8s6i CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 4BBMA Q92772 1 308 493.0 TC0:60500 Type1 Inactive DFGin 7.1518 13.3139 None -116.66, 173.28 70.79, 69.66 -144.2, 73.96 44.17, 99.05 132.17, -46.5 out-none out 11.8482 Saltbr-none 999.0 HRD-in -64.8, -48.49 65.16, 11.9 none-out-out SNCnoo out-out ActLoopNT-out 10.2517 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -63.85, -51.88 APE9-dihe-na -56.62, -32.94 APE8-dihe-out -101.86, 5.45 APE8-rot-out 58.5 APE67-dihe-in -66.8, -17.87 -40.06, -47.54 APE12-dist-in 12.3155 APE11-dist-out 16.808 APE10-dist-out 19.4627 APE9-dist-out 9.3714 T159D,Y161E None None XRAY 2.0 0.244 0.269 A 331.0 306.0 2 28 28 0 [[4, 287]] 1.0 4bbm CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2

CMGC_CDKL2 (Cyclin-dependent kinase-like 2)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q92772-K1A
DFGin BLBminus 2 33.3% 8S6IA
DFGin BLAplus 1 16.7% 4BBMB
DFGin None 1 16.7% 4BBMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDKL2 CDKL2_HUMAN AF-Q92772-K1A Q92772 1 295 493.0 No_ligand No_ligand Active DFGin 6.993 14.998 BLAminus -134.59, -179.35 57.52, 62.74 -76.04, 17.57 278.67, 72.2 -58.79, -42.35 in-in in 8.7566 Saltbr-in 3.0899 HRD-in -78.13, -48.9 63.51, 19.47 in-in-in SNCiii in-in ActLoopNT-in 2.8642 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.5, 169.46 APE9-dihe-na 64.46, 150.31 APE8-dihe-in -68.94, 137.38 APE8-rot-in 303.1 APE67-dihe-in -63.99, -25.05 -50.91, -45.55 APE12-dist-in 7.9052 APE11-dist-in 10.8681 APE10-dist-in 5.9263 APE9-dist-in 3.3123 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 28 28 0 [[4, 287]] 1.0 AF-Q92772-K1 Homo sapiens CMGC_CDKL2_HUMAN CMGC 2.1e-80 276.1 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 CDKL2_HUMAN AF-Q92772-K3A Q92772 1 295 493.0 No_ligand No_ligand Active DFGin 6.5798 14.4153 BLAminus -134.61, -177.21 52.78, 70.14 -78.41, 16.28 283.58, 76.95 -60.4, -38.39 in-in in 8.5027 Saltbr-in 2.893 HRD-in -79.58, -49.97 64.41, 19.51 in-in-in SNCiii in-in ActLoopNT-in 2.8676 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.71, 165.75 APE9-dihe-na 58.95, 147.38 APE8-dihe-in -61.89, 136.02 APE8-rot-in 299.98 APE67-dihe-in -61.09, -20.97 -53.39, -45.2 APE12-dist-in 12.5753 APE11-dist-in 10.4231 APE10-dist-in 6.0668 APE9-dist-in 3.187 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 28 28 0 [[4, 287]] 1.0 AF-Q92772-K3 Homo sapiens CMGC_CDKL2_HUMAN CMGC 2.1e-80 276.1 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 CDKL2_HUMAN 4BBMB Q92772 1 308 493.0 TC0:60500 Type1 Inactive DFGin 7.0095 13.643 BLAplus -116.95, 172.46 71.25, 70.14 -140.96, 65.73 46.41, 86.58 130.11, -39.29 out-none out 11.912 Saltbr-none 999.0 HRD-in -66.2, -48.12 65.5, 13.04 none-out-out SNCnoo out-out ActLoopNT-out 10.2702 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -64.23, -50.52 APE9-dihe-na -57.38, -32.72 APE8-dihe-out -101.31, 4.49 APE8-rot-out 58.21 APE67-dihe-in -66.8, -18.02 -40.05, -47.42 APE12-dist-in 12.2798 APE11-dist-out 16.7739 APE10-dist-out 19.4327 APE9-dist-out 9.3923 T159D,Y161E None None XRAY 2.0 0.244 0.269 B 331.0 288.0 20 28 28 0 [[4, 287]] 1.0 4bbm Homo sapiens CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 CDKL2_HUMAN 4AAAA Q92772 1 302 493.0 DKI:60500 Type1 Inactive DFGin 9.8175 16.5623 BLBminus -155.51, 174.54 62.34, 44.23 -57.57, 144.91 282.77, 68.32 -67.57, 25.01 out-none out 12.6425 Saltbr-none 999.0 HRD-in -76.44, -55.33 82.36, -14.07 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -93.2, 21.78 APE9-dihe-na -63.46, 142.18 APE8-dihe-in -70.26, 133.25 APE8-rot-in 305.07 APE67-dihe-in -60.17, -26.15 -101.44, 1.52 APE12-dist-none 999.0 APE11-dist-out 16.0519 APE10-dist-out 20.0315 APE9-dist-out 10.5947 T159D,Y161E None None XRAY 1.53 0.182 0.208 A 331.0 290.0 12 28 16 12 [[4, 287]] 1.0 4aaa Homo sapiens CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 CDKL2_HUMAN 8S6IA Q92772 1 305 493.0 A1H5G:60401 Type1 Inactive DFGin 10.8992 16.6113 BLBminus -145.81, 159.25 64.03, 52.3 -70.3, 154.63 284.81, 72.82 -94.57, 119.59 out-out out 11.7806 Saltbr-out 8.7718 HRD-in -68.88, -57.54 78.23, -5.1 out-out-out SNCooo out-out ActLoopNT-out 10.119 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -79.88 APE9-dihe-na -86.16, 151.19 APE8-dihe-in -63.12, 136.66 APE8-rot-out 198.87 APE67-dihe-in -62.07, -26.67 -105.51, 4.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.6805 APE9-dist-out 9.9971 None None None XRAY 1.72 0.205 0.222 A 331.0 295.0 10 28 18 10 [[4, 287]] 1.0 8s6i Homo sapiens CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2
CDKL2 CDKL2_HUMAN 4BBMA Q92772 1 308 493.0 TC0:60500 Type1 Inactive DFGin 7.1518 13.3139 None -116.66, 173.28 70.79, 69.66 -144.2, 73.96 44.17, 99.05 132.17, -46.5 out-none out 11.8482 Saltbr-none 999.0 HRD-in -64.8, -48.49 65.16, 11.9 none-out-out SNCnoo out-out ActLoopNT-out 10.2517 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -63.85, -51.88 APE9-dihe-na -56.62, -32.94 APE8-dihe-out -101.86, 5.45 APE8-rot-out 58.5 APE67-dihe-in -66.8, -17.87 -40.06, -47.54 APE12-dist-in 12.3155 APE11-dist-out 16.808 APE10-dist-out 19.4627 APE9-dist-out 9.3714 T159D,Y161E None None XRAY 2.0 0.244 0.269 A 331.0 306.0 2 28 28 0 [[4, 287]] 1.0 4bbm Homo sapiens CMGC_CDKL2_HUMAN CMGC 2.2e-79 272.8 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 2

CMGC_CDKL2 (Cyclin-dependent kinase-like 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name