CMGC_CDKL2 (Cyclin-dependent kinase-like 2)

Total number of chains: 6
Active chains: 2
Uniprot: CDKL2_HUMAN
Kinase Domain Residues: 4 - 287
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q92772-K1A
DFGin BLBminus 2 33.3% 8S6IA
DFGin BLAplus 1 16.7% 4BBMB
DFGin None 1 16.7% 4BBMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q92772-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 295 0 None None Cyclin-dependent kinase-like 2
AF-Q92772-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 295 0 None None Cyclin-dependent kinase-like 2
4BBMB 2.0 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaooi APEdist_iooo TC0 Type1 1 - 308 0 None T159D,Y161E Cyclin-dependent kinase-like 2
4AAAA 1.53 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaiii APEdist_nooo DKI Type1 1 - 302 0 None T159D,Y161E Cyclin-dependent kinase-like 2
8S6IA 1.72 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo A1H5G Type1 1 - 305 0 None None Cyclin-dependent kinase-like 2
4BBMA 2.0 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaooi APEdist_iooo TC0 Type1 1 - 308 0 None T159D,Y161E Cyclin-dependent kinase-like 2

CMGC_CDKL2 (Cyclin-dependent kinase-like 2)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q92772-K1A
DFGin BLBminus 2 33.3% 8S6IA
DFGin BLAplus 1 16.7% 4BBMB
DFGin None 1 16.7% 4BBMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CDKL2_HUMAN AF-Q92772-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 295 0 None None Cyclin-dependent kinase-like 2 Homo sapiens
CDKL2_HUMAN AF-Q92772-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 1 - 295 0 None None Cyclin-dependent kinase-like 2 Homo sapiens
CDKL2_HUMAN 4BBMB 2.0 Inactive DFGin‑BLAplus out-none out-out nonTYR APEdihe_aaooi APEdist_iooo TC0 Type1 1 - 308 0 None T159D,Y161E Cyclin-dependent kinase-like 2 Homo sapiens
CDKL2_HUMAN 4AAAA 1.53 Inactive DFGin‑BLBminus out-none none-out nonTYR APEdihe_aaiii APEdist_nooo DKI Type1 1 - 302 0 None T159D,Y161E Cyclin-dependent kinase-like 2 Homo sapiens
CDKL2_HUMAN 8S6IA 1.72 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo A1H5G Type1 1 - 305 0 None None Cyclin-dependent kinase-like 2 Homo sapiens
CDKL2_HUMAN 4BBMA 2.0 Inactive DFGin‑None out-none out-out nonTYR APEdihe_aaooi APEdist_iooo TC0 Type1 1 - 308 0 None T159D,Y161E Cyclin-dependent kinase-like 2 Homo sapiens

CMGC_CDKL2 (Cyclin-dependent kinase-like 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism