OTHER_CDC7 (Cell division cycle 7-related protein kinase)

Total number of chains: 11
Active chains: 2
Uniprot: CDC7_HUMAN
Kinase Domain Residues: 58 - 569
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 100.0% AF-O00311-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDC7 AF-O00311-K1A O00311 50 574 574.0 No_ligand No_ligand Active DFGin 5.9498 14.1766 BLAminus -129.58, 170.96 66.26, 66.12 -80.51, 16.59 285.96, 75.59 -64.0, -18.9 in-in in 9.0429 Saltbr-in 2.6465 HRD-in -70.08, -43.27 61.9, 11.94 in-in-in SNCiii in-in ActLoopNT-in 2.8451 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -57.06, 169.65 APE9-dihe-na -22.62, -165.28 APE8-dihe-in -75.42, 125.22 APE8-rot-in 295.02 APE67-dihe-inflip 114.52, -42.17 -51.79, 128.13 APE12-dist-in 7.2805 APE11-dist-in 10.794 APE10-dist-in 6.853 APE9-dist-in 4.1254 None None None AF2 -1.0 1.0 1.0 A 525.0 525.0 0 188 188 0 [[58, 569]] 1.0 AF-O00311-K1 OTHER_CDC7_HUMAN CAMK 1.8e-16 136.0 1.0 154.0 259.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 374 373 372 135 Cell division cycle 7-related protein kinase
CDC7 AF-O00311-K3A O00311 50 574 574.0 No_ligand No_ligand Active DFGin 5.6723 14.126 BLAminus -130.86, 172.4 65.31, 69.78 -80.97, 15.05 291.64, 76.67 -63.99, -19.66 in-in in 9.1063 Saltbr-in 2.6484 HRD-in -70.9, -38.36 68.14, -18.59 in-in-in SNCiii in-in ActLoopNT-in 2.7832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -62.79, 152.01 APE9-dihe-na 121.05, 152.26 APE8-dihe-in -66.89, 133.21 APE8-rot-in 295.57 APE67-dihe-inflip 90.18, -22.02 -52.1, 138.77 APE12-dist-in 9.0782 APE11-dist-in 11.2325 APE10-dist-in 5.3361 APE9-dist-in 3.296 None None None AF2 -1.0 1.0 1.0 A 525.0 525.0 0 188 188 0 [[58, 569]] 1.0 AF-O00311-K3 OTHER_CDC7_HUMAN CAMK 1.8e-16 136.0 1.0 154.0 259.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 374 373 372 135 Cell division cycle 7-related protein kinase
CDC7 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.8696 13.865 BLAminus -125.0, 176.56 71.88, 86.33 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.7935 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.7316 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361.0 312.0 42 188 168 20 [[58, 569]] 1.0 4f99 OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.7594 13.9364 BLAminus -128.61, 175.54 70.41, 87.99 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.7565 Saltbr-in 3.4076 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.9281 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361.0 315.0 41 188 168 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.9131 14.2074 BLAminus -118.89, -178.58 68.69, 81.33 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.8461 Saltbr-in 2.6338 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.6428 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361.0 317.0 41 188 168 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.8885 14.044 BLAminus -126.02, 169.07 75.11, 84.03 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.9367 Saltbr-in 2.7749 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.8118 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7143 None None None XRAY 1.67 0.158 0.185 A 358.0 345.0 5 188 183 5 [[58, 569]] 1.0 6ya7 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.1681 14.0868 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.7089 Saltbr-in 2.7382 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8876 None None None XRAY 1.79 0.167 0.197 A 359.0 338.0 13 188 175 13 [[58, 569]] 1.0 6ya8 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 4F9BA O00311 39 572 574.0 0SY:601 Type1 None DFGin 5.7635 14.014 BLAminus -127.87, 167.58 73.15, 98.39 -107.19, 18.49 295.91, 97.29 -66.44, -7.97 in-in in 9.0882 Saltbr-in 2.9635 HRD-in -56.22, -51.45 80.31, -5.48 in-in-none SNCiin in-none ActLoopNT-in 2.8273 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -71.45, 117.57 APE8-rot-in 316.95 APE67-dihe-in -71.7, -9.89 -46.76, -40.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 A 361.0 318.0 38 188 171 17 [[58, 569]] 1.0 4f9b OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 4F9BC O00311 37 572 574.0 0SY:601 Type1 None DFGin 5.5958 14.1367 BLAminus -121.21, 173.13 67.81, 82.77 -85.78, 14.03 293.34, 97.94 -53.73, -27.05 in-in in 8.8859 Saltbr-in 2.7493 HRD-in -63.82, -49.28 75.73, -3.37 in-in-none SNCiin in-none ActLoopNT-in 2.7859 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -74.89, 119.22 APE8-rot-in 309.91 APE67-dihe-in -59.77, -15.79 -42.06, -45.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 C 361.0 316.0 42 188 167 21 [[58, 569]] 1.0 4f9b OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 4F9CA O00311 41 572 574.0 0SX:601 Type1 None DFGin 5.8676 14.2002 BLAminus -130.13, 163.69 79.42, 87.08 -94.29, 18.63 289.91, 100.22 -72.97, -7.76 in-in in 8.945 Saltbr-in 2.6969 HRD-in -63.65, -50.25 73.79, -1.33 in-in-none SNCiin in-none ActLoopNT-in 2.7802 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -72.81, 123.96 APE8-rot-in 305.35 APE67-dihe-in -59.52, -17.81 -47.91, -44.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.08 0.206 0.249 A 361.0 306.0 48 188 162 26 [[58, 569]] 1.0 4f9c OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 6YA6A O00311 38 573 574.0 0SX:60601,BO3:60604 Type1,Type1 None DFGin 5.6833 14.123 BLAminus -124.62, 164.87 81.15, 86.75 -92.84, 17.97 293.82, 101.75 -74.2, -7.34 in-in in 8.984 Saltbr-in 2.6534 HRD-in -67.91, -46.07 79.98, -17.89 in-in-none SNCiin in-none ActLoopNT-in 2.8041 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 166.27, -149.55 APE8-dihe-in -136.79, 136.61 APE8-rot-in 295.13 APE67-dihe-inflip 96.71, -11.03 -52.89, 131.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5861 None None None XRAY 1.44 0.168 0.193 A 359.0 340.0 12 188 176 12 [[58, 569]] 1.0 6ya6 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase

OTHER_CDC7 (Cell division cycle 7-related protein kinase)

Total number of chains: 16
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 75.0% AF-O00311-K1A
DFGin ABAminus 3 18.8% 7PT68
DFGin BLAplus 1 6.2% 7P5Z1
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDC7 CDC7_HUMAN AF-O00311-K1A O00311 50 574 574.0 No_ligand No_ligand Active DFGin 5.9498 14.1766 BLAminus -129.58, 170.96 66.26, 66.12 -80.51, 16.59 285.96, 75.59 -64.0, -18.9 in-in in 9.0429 Saltbr-in 2.6465 HRD-in -70.08, -43.27 61.9, 11.94 in-in-in SNCiii in-in ActLoopNT-in 2.8451 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -57.06, 169.65 APE9-dihe-na -22.62, -165.28 APE8-dihe-in -75.42, 125.22 APE8-rot-in 295.02 APE67-dihe-inflip 114.52, -42.17 -51.79, 128.13 APE12-dist-in 7.2805 APE11-dist-in 10.794 APE10-dist-in 6.853 APE9-dist-in 4.1254 None None None AF2 -1.0 1.0 1.0 A 525.0 525.0 0 188 188 0 [[58, 569]] 1.0 AF-O00311-K1 Homo sapiens OTHER_CDC7_HUMAN CAMK 1.8e-16 136.0 1.0 154.0 259.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 374 373 372 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN AF-O00311-K3A O00311 50 574 574.0 No_ligand No_ligand Active DFGin 5.6723 14.126 BLAminus -130.86, 172.4 65.31, 69.78 -80.97, 15.05 291.64, 76.67 -63.99, -19.66 in-in in 9.1063 Saltbr-in 2.6484 HRD-in -70.9, -38.36 68.14, -18.59 in-in-in SNCiii in-in ActLoopNT-in 2.7832 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -62.79, 152.01 APE9-dihe-na 121.05, 152.26 APE8-dihe-in -66.89, 133.21 APE8-rot-in 295.57 APE67-dihe-inflip 90.18, -22.02 -52.1, 138.77 APE12-dist-in 9.0782 APE11-dist-in 11.2325 APE10-dist-in 5.3361 APE9-dist-in 3.296 None None None AF2 -1.0 1.0 1.0 A 525.0 525.0 0 188 188 0 [[58, 569]] 1.0 AF-O00311-K3 Homo sapiens OTHER_CDC7_HUMAN CAMK 1.8e-16 136.0 1.0 154.0 259.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 374 373 372 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.8696 13.865 BLAminus -125.0, 176.56 71.88, 86.33 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.7935 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.7316 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361.0 312.0 42 188 168 20 [[58, 569]] 1.0 4f99 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.7594 13.9364 BLAminus -128.61, 175.54 70.41, 87.99 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.7565 Saltbr-in 3.4076 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.9281 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361.0 315.0 41 188 168 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.9131 14.2074 BLAminus -118.89, -178.58 68.69, 81.33 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.8461 Saltbr-in 2.6338 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.6428 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361.0 317.0 41 188 168 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.8885 14.044 BLAminus -126.02, 169.07 75.11, 84.03 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.9367 Saltbr-in 2.7749 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.8118 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7143 None None None XRAY 1.67 0.158 0.185 A 358.0 345.0 5 188 183 5 [[58, 569]] 1.0 6ya7 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.1681 14.0868 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.7089 Saltbr-in 2.7382 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8876 None None None XRAY 1.79 0.167 0.197 A 359.0 338.0 13 188 175 13 [[58, 569]] 1.0 6ya8 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 4F9BA O00311 39 572 574.0 0SY:601 Type1 None DFGin 5.7635 14.014 BLAminus -127.87, 167.58 73.15, 98.39 -107.19, 18.49 295.91, 97.29 -66.44, -7.97 in-in in 9.0882 Saltbr-in 2.9635 HRD-in -56.22, -51.45 80.31, -5.48 in-in-none SNCiin in-none ActLoopNT-in 2.8273 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -71.45, 117.57 APE8-rot-in 316.95 APE67-dihe-in -71.7, -9.89 -46.76, -40.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 A 361.0 318.0 38 188 171 17 [[58, 569]] 1.0 4f9b Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 4F9BC O00311 37 572 574.0 0SY:601 Type1 None DFGin 5.5958 14.1367 BLAminus -121.21, 173.13 67.81, 82.77 -85.78, 14.03 293.34, 97.94 -53.73, -27.05 in-in in 8.8859 Saltbr-in 2.7493 HRD-in -63.82, -49.28 75.73, -3.37 in-in-none SNCiin in-none ActLoopNT-in 2.7859 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -74.89, 119.22 APE8-rot-in 309.91 APE67-dihe-in -59.77, -15.79 -42.06, -45.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 C 361.0 316.0 42 188 167 21 [[58, 569]] 1.0 4f9b Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 4F9CA O00311 41 572 574.0 0SX:601 Type1 None DFGin 5.8676 14.2002 BLAminus -130.13, 163.69 79.42, 87.08 -94.29, 18.63 289.91, 100.22 -72.97, -7.76 in-in in 8.945 Saltbr-in 2.6969 HRD-in -63.65, -50.25 73.79, -1.33 in-in-none SNCiin in-none ActLoopNT-in 2.7802 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -72.81, 123.96 APE8-rot-in 305.35 APE67-dihe-in -59.52, -17.81 -47.91, -44.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.08 0.206 0.249 A 361.0 306.0 48 188 162 26 [[58, 569]] 1.0 4f9c Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_HUMAN 6YA6A O00311 38 573 574.0 0SX:60601,BO3:60604 Type1,Type1 None DFGin 5.6833 14.123 BLAminus -124.62, 164.87 81.15, 86.75 -92.84, 17.97 293.82, 101.75 -74.2, -7.34 in-in in 8.984 Saltbr-in 2.6534 HRD-in -67.91, -46.07 79.98, -17.89 in-in-none SNCiin in-none ActLoopNT-in 2.8041 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 166.27, -149.55 APE8-dihe-in -136.79, 136.61 APE8-rot-in 295.13 APE67-dihe-inflip 96.71, -11.03 -52.89, 131.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5861 None None None XRAY 1.44 0.168 0.193 A 359.0 340.0 12 188 176 12 [[58, 569]] 1.0 6ya6 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
CDC7 CDC7_YEAST 7PT68 P06243 10 475 507.0 AGS:1001 ATPlike Inactive DFGin 6.5704 14.3798 ABAminus -105.18, -52.81 -73.02, 144.04 -146.73, 7.18 274.51, 95.44 -55.63, -34.23 in-in in 8.6106 Saltbr-in 2.8556 HRD-out -82.55, 76.99 -43.85, -49.64 in-in-in SNCiii in-in ActLoopNT-in 2.7548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.89, 138.79 APE9-dihe-na 154.11, -158.58 APE8-dihe-in -131.43, 137.43 APE8-rot-in 301.28 APE67-dihe-inflip 83.88, -1.28 -44.87, 132.79 APE12-dist-in 9.0231 APE11-dist-in 10.8046 APE10-dist-in 4.8485 APE9-dist-in 4.6606 None None None EM 3.2 999.0 999.0 8 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt6 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CDC7 CDC7_YEAST 7PT6H P06243 10 475 507.0 AGS:1001 ATPlike Inactive DFGin 6.5701 14.3794 ABAminus -105.26, -52.78 -73.04, 144.07 -146.75, 7.22 274.49, 95.39 -55.64, -34.26 in-in in 8.61 Saltbr-in 2.856 HRD-out -82.58, 77.02 -43.85, -49.65 in-in-in SNCiii in-in ActLoopNT-in 2.7551 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.95, 138.81 APE9-dihe-na 154.08, -158.6 APE8-dihe-in -131.38, 137.47 APE8-rot-in 301.27 APE67-dihe-inflip 83.81, -1.31 -44.91, 132.85 APE12-dist-in 9.0241 APE11-dist-in 10.8052 APE10-dist-in 4.8487 APE9-dist-in 4.6608 None None None EM 3.2 999.0 999.0 H 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt6 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.8279 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.9564 Saltbr-out 6.8378 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.4184 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.8541 APE11-dist-in 11.0152 APE10-dist-in 5.0432 APE9-dist-in 4.6257 None None None EM 3.8 999.0 999.0 8 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CDC7 CDC7_YEAST 7V3VH P06243 12 473 507.0 AGS:2001 ATPlike Inactive DFGin 7.406 15.0611 BLAminus -128.9, -172.48 62.33, 64.7 -96.34, 20.92 294.13, 91.42 -71.72, -23.69 in-in in 9.7148 Saltbr-in 2.9774 HRD-in -91.43, -47.78 57.88, 18.12 in-in-out SNCiio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.2, 5.85 APE9-dihe-na -75.12, -172.29 APE8-dihe-in -97.45, 157.79 APE8-rot-out 187.23 APE67-dihe-inflip 88.73, -6.04 -67.06, 131.23 APE12-dist-in 9.828 APE11-dist-in 11.6406 APE10-dist-in 5.8595 APE9-dist-in 3.5117 None None None EM 2.9 999.0 999.0 H 507.0 381.0 81 107 45 62 [[33, 469]] 1.0 7v3v Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CDC7 CDC7_YEAST 7P5Z1 P06243 16 471 507.0 No_ligand No_ligand Inactive DFGin 5.5084 11.007 BLAplus -152.8, 169.35 54.71, 51.95 -117.52, 37.04 48.89, 101.7 -61.88, -24.93 in-out in 9.6838 Saltbr-out 6.1693 HRD-in -63.65, -49.09 69.59, -8.19 out-in-out SNCoio in-out ActLoopNT-in 2.4888 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.83, 148.66 APE9-dihe-na 133.44, -157.43 APE8-dihe-in -106.62, 142.31 APE8-rot-out 181.85 APE67-dihe-inflip 87.47, -1.72 -66.15, 144.58 APE12-dist-in 9.7512 APE11-dist-in 11.6758 APE10-dist-in 6.0883 APE9-dist-in 4.2938 None None None EM 3.3 999.0 999.0 1 507.0 336.0 120 107 61 46 [[33, 469]] 1.0 7p5z Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7

OTHER_CDC7 (Cell division cycle 7-related protein kinase)

Total number of chains: 5
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 3 60.0% 7PT68
DFGin BLAminus 1 20.0% 7V3VH
DFGin BLAplus 1 20.0% 7P5Z1
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDC7 CDC7_YEAST 7PT68 P06243 10 475 507.0 AGS:1001 ATPlike Inactive DFGin 6.5704 14.3798 ABAminus -105.18, -52.81 -73.02, 144.04 -146.73, 7.18 274.51, 95.44 -55.63, -34.23 in-in in 8.6106 Saltbr-in 2.8556 HRD-out -82.55, 76.99 -43.85, -49.64 in-in-in SNCiii in-in ActLoopNT-in 2.7548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.89, 138.79 APE9-dihe-na 154.11, -158.58 APE8-dihe-in -131.43, 137.43 APE8-rot-in 301.28 APE67-dihe-inflip 83.88, -1.28 -44.87, 132.79 APE12-dist-in 9.0231 APE11-dist-in 10.8046 APE10-dist-in 4.8485 APE9-dist-in 4.6606 None None None EM 3.2 999.0 999.0 8 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt6 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CDC7 CDC7_YEAST 7PT6H P06243 10 475 507.0 AGS:1001 ATPlike Inactive DFGin 6.5701 14.3794 ABAminus -105.26, -52.78 -73.04, 144.07 -146.75, 7.22 274.49, 95.39 -55.64, -34.26 in-in in 8.61 Saltbr-in 2.856 HRD-out -82.58, 77.02 -43.85, -49.65 in-in-in SNCiii in-in ActLoopNT-in 2.7551 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.95, 138.81 APE9-dihe-na 154.08, -158.6 APE8-dihe-in -131.38, 137.47 APE8-rot-in 301.27 APE67-dihe-inflip 83.81, -1.31 -44.91, 132.85 APE12-dist-in 9.0241 APE11-dist-in 10.8052 APE10-dist-in 4.8487 APE9-dist-in 4.6608 None None None EM 3.2 999.0 999.0 H 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt6 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.8279 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.9564 Saltbr-out 6.8378 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.4184 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.8541 APE11-dist-in 11.0152 APE10-dist-in 5.0432 APE9-dist-in 4.6257 None None None EM 3.8 999.0 999.0 8 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CDC7 CDC7_YEAST 7V3VH P06243 12 473 507.0 AGS:2001 ATPlike Inactive DFGin 7.406 15.0611 BLAminus -128.9, -172.48 62.33, 64.7 -96.34, 20.92 294.13, 91.42 -71.72, -23.69 in-in in 9.7148 Saltbr-in 2.9774 HRD-in -91.43, -47.78 57.88, 18.12 in-in-out SNCiio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.2, 5.85 APE9-dihe-na -75.12, -172.29 APE8-dihe-in -97.45, 157.79 APE8-rot-out 187.23 APE67-dihe-inflip 88.73, -6.04 -67.06, 131.23 APE12-dist-in 9.828 APE11-dist-in 11.6406 APE10-dist-in 5.8595 APE9-dist-in 3.5117 None None None EM 2.9 999.0 999.0 H 507.0 381.0 81 107 45 62 [[33, 469]] 1.0 7v3v Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CDC7 CDC7_YEAST 7P5Z1 P06243 16 471 507.0 No_ligand No_ligand Inactive DFGin 5.5084 11.007 BLAplus -152.8, 169.35 54.71, 51.95 -117.52, 37.04 48.89, 101.7 -61.88, -24.93 in-out in 9.6838 Saltbr-out 6.1693 HRD-in -63.65, -49.09 69.59, -8.19 out-in-out SNCoio in-out ActLoopNT-in 2.4888 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -139.83, 148.66 APE9-dihe-na 133.44, -157.43 APE8-dihe-in -106.62, 142.31 APE8-rot-out 181.85 APE67-dihe-inflip 87.47, -1.72 -66.15, 144.58 APE12-dist-in 9.7512 APE11-dist-in 11.6758 APE10-dist-in 6.0883 APE9-dist-in 4.2938 None None None EM 3.3 999.0 999.0 1 507.0 336.0 120 107 61 46 [[33, 469]] 1.0 7p5z Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7