TKL_ARAF (Serine/threonine-protein kinase A-Raf)

Total number of chains: 4
Active chains: 2
Uniprot: ARAF_HUMAN
Kinase Domain Residues: 310 - 569
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 75.0% AF-P10398-K1A
DFGin BLBplus 1 25.0% 9AXMB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ARAF AF-P10398-K1A P10398 302 577 606.0 No_ligand No_ligand Active DFGin 6.5727 14.0112 BLAminus -127.42, -170.25 52.88, 76.79 -87.51, 18.09 287.58, 83.27 -60.45, -27.99 in-in in 9.1878 Saltbr-in 2.9471 HRD-in -74.26, -42.46 67.87, -12.13 in-in-in SNCiii in-in ActLoopNT-in 2.9038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.2, 138.84 APE9-dihe-na 133.4, -178.14 APE8-dihe-in -96.7, 114.64 APE8-rot-in 307.83 APE67-dihe-in -62.21, -28.81 -46.45, -39.17 APE12-dist-in 12.7619 APE11-dist-in 11.7888 APE10-dist-in 6.6945 APE9-dist-in 4.7084 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 30 30 0 [[310, 569]] 1.0 AF-P10398-K1 TKL_ARAF_HUMAN TKL 1e-77 267.2 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
ARAF AF-P10398-K3A P10398 302 577 606.0 No_ligand No_ligand Active DFGin 6.3505 13.7485 BLAminus -131.16, -168.33 53.7, 79.15 -93.74, 16.61 296.34, 93.84 -61.86, -24.02 in-in in 8.8088 Saltbr-in 2.8247 HRD-in -76.2, -39.54 67.03, -16.97 in-in-in SNCiii in-in ActLoopNT-in 2.8974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.19, 138.85 APE9-dihe-na 127.59, -174.22 APE8-dihe-in -97.02, 116.88 APE8-rot-in 291.38 APE67-dihe-in -64.4, -25.31 -48.04, -40.01 APE12-dist-in 11.6684 APE11-dist-in 11.7694 APE10-dist-in 6.1222 APE9-dist-in 4.1949 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 30 30 0 [[310, 569]] 1.0 AF-P10398-K3 TKL_ARAF_HUMAN TKL 1e-77 267.2 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
ARAF 9AXMD P10398 300 574 606.0 No_ligand No_ligand Inactive DFGin 6.537 14.4563 BLAminus -133.64, -166.34 58.44, 74.82 -99.18, 20.43 290.62, 78.99 -62.21, -22.23 in-in in 9.3021 Saltbr-in 2.6289 HRD-in -62.72, -38.43 67.46, -0.31 in-in-out SNCiio in-out ActLoopNT-in 3.1368 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -179.95 APE8-rot-out 175.83 APE67-dihe-in -65.41, -27.15 -90.86, -15.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 Y301D,Y302D None None XRAY 2.42 0.263 0.301 D 280.0 256.0 19 30 16 14 [[310, 569]] 1.0 9axm TKL_ARAF_HUMAN TKL 1.1e-77 267.1 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
ARAF 9AXMB P10398 302 574 606.0 ANP:60602 ATPlike Inactive DFGin 4.5967 13.3268 BLBplus -134.26, 172.61 61.7, 46.72 -103.54, 150.88 54.31, 89.4 54.71, 36.64 out-out out 11.556 Saltbr-out 10.4941 HRD-in -66.55, -46.59 76.65, -12.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.94 APE8-dihe-in -77.25, 142.54 APE8-rot-out 182.59 APE67-dihe-in -67.09, -22.55 -72.82, -26.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.5235 Y301D,Y302D None None XRAY 2.42 0.263 0.301 B 280.0 254.0 19 30 13 17 [[310, 569]] 1.0 9axm TKL_ARAF_HUMAN TKL 1.1e-77 267.1 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf

TKL_ARAF (Serine/threonine-protein kinase A-Raf)

Total number of chains: 4
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 75.0% AF-P10398-K1A
DFGin BLBplus 1 25.0% 9AXMB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ARAF ARAF_HUMAN AF-P10398-K1A P10398 302 577 606.0 No_ligand No_ligand Active DFGin 6.5727 14.0112 BLAminus -127.42, -170.25 52.88, 76.79 -87.51, 18.09 287.58, 83.27 -60.45, -27.99 in-in in 9.1878 Saltbr-in 2.9471 HRD-in -74.26, -42.46 67.87, -12.13 in-in-in SNCiii in-in ActLoopNT-in 2.9038 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.2, 138.84 APE9-dihe-na 133.4, -178.14 APE8-dihe-in -96.7, 114.64 APE8-rot-in 307.83 APE67-dihe-in -62.21, -28.81 -46.45, -39.17 APE12-dist-in 12.7619 APE11-dist-in 11.7888 APE10-dist-in 6.6945 APE9-dist-in 4.7084 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 30 30 0 [[310, 569]] 1.0 AF-P10398-K1 Homo sapiens TKL_ARAF_HUMAN TKL 1e-77 267.2 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
ARAF ARAF_HUMAN AF-P10398-K3A P10398 302 577 606.0 No_ligand No_ligand Active DFGin 6.3505 13.7485 BLAminus -131.16, -168.33 53.7, 79.15 -93.74, 16.61 296.34, 93.84 -61.86, -24.02 in-in in 8.8088 Saltbr-in 2.8247 HRD-in -76.2, -39.54 67.03, -16.97 in-in-in SNCiii in-in ActLoopNT-in 2.8974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.19, 138.85 APE9-dihe-na 127.59, -174.22 APE8-dihe-in -97.02, 116.88 APE8-rot-in 291.38 APE67-dihe-in -64.4, -25.31 -48.04, -40.01 APE12-dist-in 11.6684 APE11-dist-in 11.7694 APE10-dist-in 6.1222 APE9-dist-in 4.1949 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 30 30 0 [[310, 569]] 1.0 AF-P10398-K3 Homo sapiens TKL_ARAF_HUMAN TKL 1e-77 267.2 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
ARAF ARAF_HUMAN 9AXMD P10398 300 574 606.0 No_ligand No_ligand Inactive DFGin 6.537 14.4563 BLAminus -133.64, -166.34 58.44, 74.82 -99.18, 20.43 290.62, 78.99 -62.21, -22.23 in-in in 9.3021 Saltbr-in 2.6289 HRD-in -62.72, -38.43 67.46, -0.31 in-in-out SNCiio in-out ActLoopNT-in 3.1368 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -179.95 APE8-rot-out 175.83 APE67-dihe-in -65.41, -27.15 -90.86, -15.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 Y301D,Y302D None None XRAY 2.42 0.263 0.301 D 280.0 256.0 19 30 16 14 [[310, 569]] 1.0 9axm Homo sapiens TKL_ARAF_HUMAN TKL 1.1e-77 267.1 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
ARAF ARAF_HUMAN 9AXMB P10398 302 574 606.0 ANP:60602 ATPlike Inactive DFGin 4.5967 13.3268 BLBplus -134.26, 172.61 61.7, 46.72 -103.54, 150.88 54.31, 89.4 54.71, 36.64 out-out out 11.556 Saltbr-out 10.4941 HRD-in -66.55, -46.59 76.65, -12.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.94 APE8-dihe-in -77.25, 142.54 APE8-rot-out 182.59 APE67-dihe-in -67.09, -22.55 -72.82, -26.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.5235 Y301D,Y302D None None XRAY 2.42 0.263 0.301 B 280.0 254.0 19 30 13 17 [[310, 569]] 1.0 9axm Homo sapiens TKL_ARAF_HUMAN TKL 1.1e-77 267.1 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf

TKL_ARAF (Serine/threonine-protein kinase A-Raf)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name