8UAK

PRKCA (Protein kinase C alpha type)
Group: AGC
Uniprot: KPCA_HUMAN
Organism: Homo sapiens
Domain boundary: 339 - 597
Resolu: 2.82

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in W39 Type1 332 - 666 0
Representative sequence - Chain A
328 338 348 358
gpsedrkqps nnlDRVKLTD FNFLMVLGKG SFGKVMLADR
368 378 388 398
KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP
408 418 428 438
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP
448 458 468 478
QAVFYAAEIS IGLFFLHKRG IIYRNLKLDN VMLDSEGHIK
488 498 508 518
IADFGMCKEH MMDGVTTRTF CGTPDYIAPE IIAYQPYGKS
528 538 548 558
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP
568 578 588 598
KSLSKEAVSI CKGLMTKHPA KRLGCGPEGE RDVREHAFFR
608 618 628 638
RIDWEKLENR EIQPPFKPKV cgkgaenfdk fftrgqPVLT
648 658 668
PPDQLVIANI DQSDFEGFEY VNPQFVHPil qsav
Lower-case residues are disordered in structure.
Mutations: D463N,V568I,S657E
Phosphorylation: X497,X638