6C9D

MARK1 (Serine/threonine-protein kinase MARK1)
Group: CAMK
Uniprot: MARK1_HUMAN
Organism: Homo sapiens
Domain boundary: 60 - 311
Resolu: 2.499

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in No_ligand No_ligand 53 - 795 0
B Active DFGin BLAminus in-in in-in No_ligand No_ligand 53 - 795 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
        47         57         67         77 
mhhhhhhnsi tsatdEQPHI GNYRLQKTIG KGNFAKVKLA 
        87         97        107        117 
RHVLTGREVA VKIIDKTQLN PTSLQKLFRE VRIMKILNHP 
       127        137        147        157 
NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK 
       167        177        187        197 
EARAKFRQIV SAVQYCHQKY IVHRDLKAEN LLLDGDMNIK 
       207        217        227        237 
IADFGFSNEF TVGNKLDEFC GSPPYAAPEL FQGKKYDGPE 
       247        257        267        277 
VDVWSLGVIL YTLVSGSLPF DGQNLKELRE RVLRGKYRIP 
       287        297        307        317 
FYMSTDCENL LKKLLVLNPI KRGSLEQIMK DRWMNVGHEE 
       327        337        347        357 
EELKPYTEPD PDFNDTKRID IMVTMGFARD EINDALINQK 
       367        377        686        696 
YDEVMATYIL LGRKPPefeg geslsgepke rdkeegkdSK 
       706        716        726        736 
PRSLRFTWSM KTTSSMDPND MMREIRKVLD ANNCDYEQKE 
       746        756        766        776 
RFLLFCVHGD ARQDSLVQWE MEVCSLPSLS LNGVRFKRIS 
       786 
GTSIAFKNIA SKIANELKL
Lower-case residues are disordered in structure.
Mutations: T215E,K761S,R764S
Phosphorylation: None