5N23

PRKACA (cAMP-dependent protein kinase catalytic subunit alpha)
Group: AGC
Uniprot: KAPCA_HUMAN
Organism: Homo sapiens
Domain boundary: 44 - 298
Resolu: 2.088

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in 35R Type1 9 - 351 0
Representative sequence - Chain A
10 20 30 40
mgnaaaakKG SEQESVKEFL AKAKEDFLKK WESPAQNTAH
50 60 70 80
LDQFERIRTL GTGSFGRVML VKHKETGNHY AMKILDKQKV
90 100 110 120
VKLKQIEHTL NEKRIQQAVN FPFLVKLEFS FKDNSNLYMV
130 140 150 160
LEYAPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS
170 180 190 199
LDLIYRDLKP ENLLIDQQGY IKVADFGFAK RVKGRTpWTL
209 219 229 239
CGTPEYLAPE IILSKGYNKA VDWWALGVLI YEMAAGYPPF
249 259 269 279
FADQPIQIYE KIVSGKVRFP SHFSSDLKDL LRNLLQVDLT
289 299 309 319
KRFGNLKNGV NDIKNHKWFA TTDWIAIYQR KVEAPFIPKF
329 339 349
kgpgdtSNFD DYEEEEIRVS INEKCGKEFS EF
Lower-case residues are disordered in structure.
Mutations: K48R,L96Q,M121L,V124A,Q182K,T184A
Phosphorylation: X11,X140,X198,X339