5IU2

MAP3K8 (Mitogen-activated protein kinase kinase kinase 8)
Group: STE
Uniprot: M3K8_HUMAN
Organism: Homo sapiens
Domain boundary: 127 - 388
Resolu: 2.7

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-in 6DA Type1 73 - 389 0
B Inactive DFGin BLAminus in-out in-in 6DA Type1 73 - 389 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
        73         83         93        103 
gpsgqevpwL SSVRYGTVED LLAFANHISN takHFYGQRP 
       113        123        133        143 
QESGILLNMV ITPQNGRYQI DSDVLLIPWK LTYRNiGSDF 
       153        163        173        183 
IPRGAFGKVY LAQDIKTKKR MACKLIPVDQ FKPSDVEIQA 
       193        203        213        223 
CFRHENIAEL YGAVLWGETV HLFMEAGEGG SVLEKLESCG 
       233        243        253        263 
PMREFEIIWV TKHVLKGLDF LHSKKVIHHD IKPSNIVFMS 
       273        283        293        303 
TKAVLVDFGL SVQMTEDVYF PKDLRGTEIY MSPEVILCRG 
       313        323        333        343 
HSTKADIYSL GATLIHMQTG TPPWVKRYPR SAYPSYLYII 
       353        363        373        383 
HKQAPPLEDI ADDCSPGMRE LIEASLERNP NHRPRAADLL 
       393 
KHEALNppre dq
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None