4RA4

PRKCA (Protein kinase C alpha type)
Group: AGC
Uniprot: KPCA_HUMAN
Organism: Homo sapiens
Domain boundary: 339 - 597
Resolu: 2.63

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in 3KZ Type1 332 - 666 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       327        337        347        357 
ispsedrkqp snnlDRVKLT DFNFLMVLGK GSFGKVMLAD 
       367        377        387        397 
RKGTEELYAI KILKKDVVIQ DDDVECTMVE KRVLALLDKP 
       407        417        427        437 
PFLTQLHSCF QTVDRLYFVM EYVNGGDLMY HIQQVGKFKE 
       447        457        467        477 
PQAVFYAAEI SIGLFFLHKR GIIYRDLKLD NVMLDSEGHI 
       487        497        507        517 
KIADFGMCKE HMMDGVTTRT FCGTPDYIAP EIIAYQPYGK 
       527        537        547        557 
SVDWWAYGVL LYEMLAGQPP FDGEDEDELF QSIMEHNVSY 
       567        577        587        597 
PKSLSKEAVS ICKGLMTKHP AKRLGCGPEG ERDVREHAFF 
       607        617        627        637 
RRIDWEKLEN REIQPPFKPK vsgkgaenfd kfftrGQPVL 
       647        657        667 
TPPDQLVIAN IDQSDFEGFS YVNPQFVHPi lqsav
Lower-case residues are disordered in structure.
Mutations: C619S
Phosphorylation: X497,X638,X657