4JOA

ALK (ALK tyrosine kinase receptor)
Group: TYR
Uniprot: ALK_HUMAN
Organism: Homo sapiens
Domain boundary: 1116 - 1385
Resolu: 2.7

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-out out-out 3DK Type1.5_Front 1107 - 1398 9
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
      1076       1086       1096       1106 
gamgselqsp eyklsklrts timtdynpny cfagktssis 
      1116       1126       1136       1146 
DLKEVPRKNI TLIRGLGhga fgeVYEGQVS gmpndpspLQ 
      1156       1166       1176       1186 
VAVKTLPevc seqdelDFLM EALIISKFNH QNIVRCIGVS 
      1196       1206       1216       1226 
LQSLPRFILL ELMAGGDLKS FLRETRPRps qpssLAMLDL 
      1236       1246       1256       1266 
LHVARDIACG CQYLEENHFI HRDIAARNCL LTCPGPGRVA 
      1276       1286       1296       1306 
KIGDFGMARD IYragyyrkg gCAMLPVKWM PPEAfmeGIF 
      1316       1326       1336       1346 
TSKTDTWSFG VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG 
      1356       1366       1376       1386 
RMDPPKNCPG PVYRIMTQCW QHQPEDRPNF AIILERIEYC 
      1396       1406 
TQDPDVINTA LPieygplve eeek
Lower-case residues are disordered in structure.
Mutations: S1281G
Phosphorylation: None