4FOB

ALK (ALK tyrosine kinase receptor)
Group: TYR
Uniprot: ALK_HUMAN
Organism: Homo sapiens
Domain boundary: 1116 - 1385
Resolu: 1.9

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in out-in 0US Type1 1093 - 1402 6
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
      1067       1077       1087       1097 
vyrrkhqelq amqmelqspe yklsklrtst imtdyNPNYS 
      1107       1117       1127       1137 
FAGKTSSISD LKEVPRKNIT LIRGLGHGAF GEVYEGQVSg 
      1147       1157       1167       1177 
mpndpSPLQV AVKTLPEVCS EQDELDFLME ALIISKFNHQ 
      1187       1197       1207       1217 
NIVRCIGVSL QSLPRFILLE LMAGGDLKSF LRETRPRPsq 
      1227       1237       1247       1257 
pSSLAMLDLL HVARDIACGC QYLEENHFIH RDIAARNCLL 
      1267       1277       1287       1297 
TCPGPGRVAK IGDFGMARDI YRAsyyrkgG CAMLPVKWMP 
      1307       1317       1327       1337 
PEAFMEGIFT SKTDTWSFGV LLWEIFSLGY MPYPSKSNQE 
      1347       1357       1367       1377 
VLEFVTSGGR MDPPKNCPGP VYRIMTQCWQ HQPEDRPNFA 
      1387       1397       1407 
IILERIEYCT QDPDVINTAL PIEYGplvee eek
Lower-case residues are disordered in structure.
Mutations: C1097S
Phosphorylation: None