3I6W

CHEK2 (Serine/threonine-protein kinase Chk2)
Group: CAMK
Uniprot: CHK2_HUMAN
Organism: Homo sapiens
Domain boundary: 220 - 486
Resolu: 3.25

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 18
B None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 5
C Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 18
D None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 5
E Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 18
F None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 5
G Inactive DFGin None out-none none-none No_ligand No_ligand 92 - 501 18
H None DFGin BLAminus out-none in-none No_ligand No_ligand 92 - 501 5
Representative sequence - Chain H
79 89 99 109
elysipedqe pedqepeept paPWARLWAL QDGFANLECV
119 129 139 149
NDNYWFGRDK SCEYCFDEPL LKRTDKYRTY SKKHFRIFRE
159 169 179 189
VGPKNSYIAY IEDHSGNGTF VNTELVGKGK RRPLNNNSEI
199 209 219 229
ALSLSRNKVF VFFDLTVDDQ SVYPKALRDE YIMSKTLGsg
239 249 259 269
acgEVKLAFE RKTCKKVAIR IISKrkfaig sareadpaLN
279 289 299 309
VETEIEILKK LNHPCIIKIK NFFDAEDYYI VLELMEGGEL
319 329 339 349
FDKVVGNKRL KEATCKLYFY QMLLAVQYLH ENGIIHRDLK
359 369 379 389
PENVLLSSQE EDCLIKITDF GHSKILGETS LMRtlcgtPT
399 409 419 429
YLAPEVLVsv gtAGYNRAVD CWSLGVILFI CLSGYPPFSE
439 449 459 469
HRTQVSLKDQ ITSGKYNFIP EVWAEVSEKA LDLVKKLLVV
479 489 499 509
DPKARFTTEE ALRHPWLQDE DMKRKFQDLL SEenestalp

qvl
Lower-case residues are disordered in structure.
Mutations: K249R
Phosphorylation: None