3I6U

CHEK2 (Serine/threonine-protein kinase Chk2)
Group: CAMK
Uniprot: CHK2_HUMAN
Organism: Homo sapiens
Domain boundary: 220 - 486
Resolu: 3.0

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAplus out-none out-none No_ligand No_ligand 89 - 501 11
B Inactive DFGin None out-none none-none No_ligand No_ligand 89 - 501 18
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
        93        103        113        123 
epeepTPAPW ARLWALQDGF ANLECVNDNY WFGRDKSCEY 
       133        143        153        163 
CFDEPLLKRT DKYRTYSKKH FRIFREVGPK NSYIAYIEDH 
       173        183        193        203 
SGNGTFVNTE LVGKGKRRPL NNNSEIALSL SRNKVFVFFD 
       213        223        233        243 
LTVDDQSVYP KALRDEYIMS KTLGSGACGE VKLAFERKTC 
       253        263        273        283 
KKVAIRIISK RKFAIGsare adpaLNVETE IEILKKLNHP 
       293        303        313        323 
CIIKIKNFFD AEDYYIVLEL MEGGELFDKV VGNKRLKEAT 
       333        343        353        363 
CKLYFYQMLL AVQYLHENGI IHRDLKPENV LLSSQEEDCL 
       373        383        393        403 
IKITDFghsk ilgetslmrt lcgtPTYLAP EVLVsvgtag 
       413        423        433        443 
yNRAVDCWSL GVILFICLSG YPPFSEhrtq VSLKDQITSG 
       453        463        473        483 
KYNFIPEVWA EVSEKALDLV KKLLVVDPKA RFTTEEALRH 
       493 
PWLQDEDMKR KFQDLLSEe
Lower-case residues are disordered in structure.
Mutations: K249R
Phosphorylation: None