RPS6KB1 (Ribosomal protein S6 kinase beta-1)

Group: AGC
Uniprot: KS6B1_HUMAN
Domain boundary: 91 - 352


Total number of chains: 25
Spatial Dihedral Chains Representative
DFGin BLAminus 5 AF-P23443-K1A
DFGin ABAminus 14 4L3JA
DFGin None 4 3WF7A
None None 2 3A60B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
4RLPA 2.79 Inactive DFGin ABAminus none-none in-out 72B Type1 85 - 372 None None 11
4L3JA 2.1 Inactive DFGin ABAminus in-in out-out 5FI Type1 85 - 375 None None 0
4L3LA 2.1 Inactive DFGin ABAminus in-in out-out 5FI Type1 85 - 375 None None 0
7N91A 3.0 Inactive DFGin ABAminus in-in none-out 1RJ Type1 85 - 418 T412E X390,X394 15
7N91B 3.0 Inactive DFGin ABAminus in-in none-none 1RJ Type1 85 - 418 T412E X390,X394 15
7N93A 2.74 Inactive DFGin ABAminus in-in out-out 1SK Type1 87 - 418 T412E X390,X394 11
7N93B 2.74 Inactive DFGin ABAminus in-in none-out 1SK Type1 85 - 418 T412E X390,X394 14
3A62A 2.35 Inactive DFGin ABAminus in-in none-out STU Type1 85 - 372 None X252 10
3WE4A 1.995 Inactive DFGin ABAminus in-in out-out 5FI Type1 85 - 374 None X252 3
3WF5A 2.099 Inactive DFGin ABAminus in-in out-out FZ8 Type1 85 - 374 None X252 0
3WF6A 2.031 Inactive DFGin ABAminus in-in out-out FZ9 Type1 85 - 374 None X252 0
4L45A 2.9 Inactive DFGin ABAminus in-in out-out 5FI Type1 81 - 417 T412E None 11
4L42A 2.8 Inactive DFGin ABAminus in-in out-out 5FI Type1 84 - 417 S403E,A404E,N405Q,Q406E,V407M,L409R,G410D,T412E,V414I,P416D,S417W None 0
4L46A 3.01 Inactive DFGin ABAminus in-in out-out 5FI Type1 80 - 417 None X412 4
AF-P23443-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 83 - 360 None None 0
3WF8A 1.975 Inactive DFGin BLAminus in-in out-out F76 Type1 85 - 372 None X252 0
3WF9A 2.035 Inactive DFGin BLAminus in-in out-out FS7 Type1 85 - 372 None X252 0
4L43A 3.0 Inactive DFGin BLAminus in-in out-out 5FI Type1 81 - 417 T412A None 11
4L44A 2.9 Inactive DFGin BLAminus in-in out-out 5FI Type1 81 - 417 T412A None 5
4RLOA 2.527 Inactive DFGin None in-in in-out 3T3 Type1 85 - 371 None None 12
3A60A 2.8 Inactive DFGin None in-out out-none STU Type1 85 - 371 None None 13
3A61A 3.43 Inactive DFGin None in-in none-out STU Type1 87 - 371 None None 16
3WF7A 1.85 Inactive DFGin None out-out out-out FS9 Type1 83 - 374 None X252 3
4RLOB 2.527 Inactive None None none-none out-none STU Type1 85 - 372 None None 11
3A60B 2.8 Inactive None None none-none in-out STU Type1 85 - 372 None None 10

RPS6KB1 (Ribosomal protein S6 kinase beta-1)

Group: AGC
Total number of chains: 25
Spatial Dihedral Chains Representative
DFGin BLAminus 5 AF-P23443-K1A
DFGin ABAminus 14 4L3JA
DFGin None 4 3WF7A
None None 2 3A60B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens KS6B1_HUMAN 4RLPA 2.79 Inactive DFGin ABAminus none-none in-out 72B Type1 85 - 372 None None 11
Homo sapiens KS6B1_HUMAN 4L3JA 2.1 Inactive DFGin ABAminus in-in out-out 5FI Type1 85 - 375 None None 0
Homo sapiens KS6B1_HUMAN 4L3LA 2.1 Inactive DFGin ABAminus in-in out-out 5FI Type1 85 - 375 None None 0
Homo sapiens KS6B1_HUMAN 7N91A 3.0 Inactive DFGin ABAminus in-in none-out 1RJ Type1 85 - 418 T412E X390,X394 15
Homo sapiens KS6B1_HUMAN 7N91B 3.0 Inactive DFGin ABAminus in-in none-none 1RJ Type1 85 - 418 T412E X390,X394 15
Homo sapiens KS6B1_HUMAN 7N93A 2.74 Inactive DFGin ABAminus in-in out-out 1SK Type1 87 - 418 T412E X390,X394 11
Homo sapiens KS6B1_HUMAN 7N93B 2.74 Inactive DFGin ABAminus in-in none-out 1SK Type1 85 - 418 T412E X390,X394 14
Homo sapiens KS6B1_HUMAN 3A62A 2.35 Inactive DFGin ABAminus in-in none-out STU Type1 85 - 372 None X252 10
Homo sapiens KS6B1_HUMAN 3WE4A 1.995 Inactive DFGin ABAminus in-in out-out 5FI Type1 85 - 374 None X252 3
Homo sapiens KS6B1_HUMAN 3WF5A 2.099 Inactive DFGin ABAminus in-in out-out FZ8 Type1 85 - 374 None X252 0
Homo sapiens KS6B1_HUMAN 3WF6A 2.031 Inactive DFGin ABAminus in-in out-out FZ9 Type1 85 - 374 None X252 0
Homo sapiens KS6B1_HUMAN 4L45A 2.9 Inactive DFGin ABAminus in-in out-out 5FI Type1 81 - 417 T412E None 11
Homo sapiens KS6B1_HUMAN 4L42A 2.8 Inactive DFGin ABAminus in-in out-out 5FI Type1 84 - 417 S403E,A404E,N405Q,Q406E,V407M,L409R,G410D,T412E,V414I,P416D,S417W None 0
Homo sapiens KS6B1_HUMAN 4L46A 3.01 Inactive DFGin ABAminus in-in out-out 5FI Type1 80 - 417 None X412 4
Homo sapiens KS6B1_HUMAN AF-P23443-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 83 - 360 None None 0
Homo sapiens KS6B1_HUMAN 3WF8A 1.975 Inactive DFGin BLAminus in-in out-out F76 Type1 85 - 372 None X252 0
Homo sapiens KS6B1_HUMAN 3WF9A 2.035 Inactive DFGin BLAminus in-in out-out FS7 Type1 85 - 372 None X252 0
Homo sapiens KS6B1_HUMAN 4L43A 3.0 Inactive DFGin BLAminus in-in out-out 5FI Type1 81 - 417 T412A None 11
Homo sapiens KS6B1_HUMAN 4L44A 2.9 Inactive DFGin BLAminus in-in out-out 5FI Type1 81 - 417 T412A None 5
Homo sapiens KS6B1_HUMAN 4RLOA 2.527 Inactive DFGin None in-in in-out 3T3 Type1 85 - 371 None None 12
Homo sapiens KS6B1_HUMAN 3A60A 2.8 Inactive DFGin None in-out out-none STU Type1 85 - 371 None None 13
Homo sapiens KS6B1_HUMAN 3A61A 3.43 Inactive DFGin None in-in none-out STU Type1 87 - 371 None None 16
Homo sapiens KS6B1_HUMAN 3WF7A 1.85 Inactive DFGin None out-out out-out FS9 Type1 83 - 374 None X252 3
Homo sapiens KS6B1_HUMAN 4RLOB 2.527 Inactive None None none-none out-none STU Type1 85 - 372 None None 11
Homo sapiens KS6B1_HUMAN 3A60B 2.8 Inactive None None none-none in-out STU Type1 85 - 372 None None 10

RPS6KB1 (Ribosomal protein S6 kinase beta-1)

No non-human structures known.