HCK (Tyrosine-protein kinase HCK)

Group: TYR
Uniprot: HCK_HUMAN
Domain boundary: 262 - 513


Total number of chains: 44
Spatial Dihedral Chains Representative
DFGin BLAminus 6 AF-P08631-K1A
DFGin BLBplus 24 5H0BA
DFGin BLBtrans 8 3VRZB
DFGin None 6 3VS1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P08631-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 254 - 521 None None 0
1AD5A 2.6 Inactive DFGin BLAminus out-out out-out ANP Type1 79 - 526 None X522 0
1AD5B 2.6 Inactive DFGin BLAminus out-out out-out ANP Type1 79 - 526 None X522 0
2HCKA 3.0 Inactive DFGin BLAminus out-out out-out QUE Type1 79 - 526 None X522 0
2HCKB 3.0 Inactive DFGin BLAminus out-out out-out QUE Type1 79 - 526 None X522 0
2HK5A 2.0 Active DFGin BLAminus in-in in-in 1BM Type1.5_Back 247 - 514 None None 0
5ZJ6A 1.696 Inactive DFGin BLBplus out-out out-in VSE Type1 248 - 518 None None 0
1QCFA 2.0 Inactive DFGin BLBplus out-out out-out PP1 Type1 81 - 526 Q523E,Q524E,Q525I X522 0
3VS2A 2.609 Inactive DFGin BLBplus out-out out-none VSB Type1 81 - 526 Q523E,Q524E,Q525I X522 13
3VS5A 2.851 Inactive DFGin BLBplus out-out out-none VSG Type1 81 - 526 Q523E,Q524E,Q525I X522 13
3VS5B 2.851 Inactive DFGin BLBplus out-out out-none VSG Type1 81 - 526 Q523E,Q524E,Q525I X522 13
3VS7B 3.001 Inactive DFGin BLBplus out-out out-none KS1 Type1 81 - 526 Q523E,Q524E,Q525I X522 15
4LUDA 2.85 Inactive DFGin BLBplus out-out out-none SK8 Type1 81 - 526 Q523E,Q524E,Q525I X522 13
4LUDB 2.85 Inactive DFGin BLBplus out-out out-none SK8 Type1 81 - 524 Q523E,Q524E,Q525I X522 13
5H0GA 1.8 Inactive DFGin BLBplus out-out out-in OOU Type1 81 - 526 Q523E,Q524E,Q525I X522 0
5ZJ6B 1.696 Inactive DFGin BLBplus out-out out-in VSE Type1.5_Back 249 - 518 None None 0
3VRYA 2.481 Inactive DFGin BLBplus out-out out-out B43 Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
3VRYB 2.481 Inactive DFGin BLBplus out-out out-out B43 Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
3VS3A 2.17 Inactive DFGin BLBplus out-out out-out VSE Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
3VS3B 2.17 Inactive DFGin BLBplus out-out out-out VSE Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 10
3VS4A 2.747 Inactive DFGin BLBplus out-out out-out VSF Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 11
3VS4B 2.747 Inactive DFGin BLBplus out-out out-out VSF Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
3VS6A 2.373 Inactive DFGin BLBplus out-out out-out VSH Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
3VS6B 2.373 Inactive DFGin BLBplus out-out out-out VSH Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
4LUEA 3.04 Inactive DFGin BLBplus out-out out-none VSE Type1.5_Back 81 - 525 Q523E,Q524E,Q525I X522 13
4LUEB 3.04 Inactive DFGin BLBplus out-out out-none VSE Type1.5_Back 81 - 525 Q523E,Q524E,Q525I X522 13
5H09A 1.945 Inactive DFGin BLBplus out-out out-in OOO Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 0
5H0BA 1.651 Inactive DFGin BLBplus out-out out-in OOQ Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 0
5H0EA 2.1 Inactive DFGin BLBplus out-out out-in OOS Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 0
5H0HA 1.72 Inactive DFGin BLBplus out-out out-in OOV Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 0
2C0IB 2.3 Inactive DFGin BLBtrans out-out out-none L1G Type1 81 - 526 Q523E,Q524E,Q525I X522 13
2C0OB 2.85 Inactive DFGin BLBtrans out-out out-none L2G Type1 81 - 526 Q523E,Q524E,Q525I X522 13
2C0IA 2.3 Inactive DFGin BLBtrans out-out out-none L1G Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
2C0OA 2.85 Inactive DFGin BLBtrans out-out out-none L2G Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
2C0TA 2.15 Inactive DFGin BLBtrans out-out out-none L3G Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
2C0TB 2.15 Inactive DFGin BLBtrans out-out out-none L3G Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
3VRZA 2.218 Inactive DFGin BLBtrans out-out out-none VRZ Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
3VRZB 2.218 Inactive DFGin BLBtrans out-out out-out VRZ Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 12
3VS0A 2.934 Inactive DFGin None out-out out-none VS0 Type1 81 - 526 Q523E,Q524E,Q525I X522 13
3VS0B 2.934 Inactive DFGin None out-out out-none VS0 Type1 81 - 526 Q523E,Q524E,Q525I X522 13
3VS1B 2.464 Inactive DFGin None out-out out-none VSA Type1 81 - 526 Q523E,Q524E,Q525I X522 13
3VS2B 2.609 Inactive DFGin None out-out out-none VSB Type1 81 - 526 Q523E,Q524E,Q525I X522 13
3VS7A 3.001 Inactive DFGin None out-out out-none KS1 Type1 81 - 526 Q523E,Q524E,Q525I X522 14
3VS1A 2.464 Inactive DFGin None out-out out-none VSA Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 13

HCK (Tyrosine-protein kinase HCK)

Group: TYR
Total number of chains: 44
Spatial Dihedral Chains Representative
DFGin BLAminus 6 AF-P08631-K1A
DFGin BLBplus 24 5H0BA
DFGin BLBtrans 8 3VRZB
DFGin None 6 3VS1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens HCK_HUMAN AF-P08631-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 254 - 521 None None 0
Homo sapiens HCK_HUMAN 1AD5A 2.6 Inactive DFGin BLAminus out-out out-out ANP Type1 79 - 526 None X522 0
Homo sapiens HCK_HUMAN 1AD5B 2.6 Inactive DFGin BLAminus out-out out-out ANP Type1 79 - 526 None X522 0
Homo sapiens HCK_HUMAN 2HCKA 3.0 Inactive DFGin BLAminus out-out out-out QUE Type1 79 - 526 None X522 0
Homo sapiens HCK_HUMAN 2HCKB 3.0 Inactive DFGin BLAminus out-out out-out QUE Type1 79 - 526 None X522 0
Homo sapiens HCK_HUMAN 2HK5A 2.0 Active DFGin BLAminus in-in in-in 1BM Type1.5_Back 247 - 514 None None 0
Homo sapiens HCK_HUMAN 5ZJ6A 1.696 Inactive DFGin BLBplus out-out out-in VSE Type1 248 - 518 None None 0
Homo sapiens HCK_HUMAN 1QCFA 2.0 Inactive DFGin BLBplus out-out out-out PP1 Type1 81 - 526 Q523E,Q524E,Q525I X522 0
Homo sapiens HCK_HUMAN 3VS2A 2.609 Inactive DFGin BLBplus out-out out-none VSB Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VS5A 2.851 Inactive DFGin BLBplus out-out out-none VSG Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VS5B 2.851 Inactive DFGin BLBplus out-out out-none VSG Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VS7B 3.001 Inactive DFGin BLBplus out-out out-none KS1 Type1 81 - 526 Q523E,Q524E,Q525I X522 15
Homo sapiens HCK_HUMAN 4LUDA 2.85 Inactive DFGin BLBplus out-out out-none SK8 Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 4LUDB 2.85 Inactive DFGin BLBplus out-out out-none SK8 Type1 81 - 524 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 5H0GA 1.8 Inactive DFGin BLBplus out-out out-in OOU Type1 81 - 526 Q523E,Q524E,Q525I X522 0
Homo sapiens HCK_HUMAN 5ZJ6B 1.696 Inactive DFGin BLBplus out-out out-in VSE Type1.5_Back 249 - 518 None None 0
Homo sapiens HCK_HUMAN 3VRYA 2.481 Inactive DFGin BLBplus out-out out-out B43 Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
Homo sapiens HCK_HUMAN 3VRYB 2.481 Inactive DFGin BLBplus out-out out-out B43 Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
Homo sapiens HCK_HUMAN 3VS3A 2.17 Inactive DFGin BLBplus out-out out-out VSE Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
Homo sapiens HCK_HUMAN 3VS3B 2.17 Inactive DFGin BLBplus out-out out-out VSE Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 10
Homo sapiens HCK_HUMAN 3VS4A 2.747 Inactive DFGin BLBplus out-out out-out VSF Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 11
Homo sapiens HCK_HUMAN 3VS4B 2.747 Inactive DFGin BLBplus out-out out-out VSF Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
Homo sapiens HCK_HUMAN 3VS6A 2.373 Inactive DFGin BLBplus out-out out-out VSH Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
Homo sapiens HCK_HUMAN 3VS6B 2.373 Inactive DFGin BLBplus out-out out-out VSH Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 12
Homo sapiens HCK_HUMAN 4LUEA 3.04 Inactive DFGin BLBplus out-out out-none VSE Type1.5_Back 81 - 525 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 4LUEB 3.04 Inactive DFGin BLBplus out-out out-none VSE Type1.5_Back 81 - 525 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 5H09A 1.945 Inactive DFGin BLBplus out-out out-in OOO Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 0
Homo sapiens HCK_HUMAN 5H0BA 1.651 Inactive DFGin BLBplus out-out out-in OOQ Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 0
Homo sapiens HCK_HUMAN 5H0EA 2.1 Inactive DFGin BLBplus out-out out-in OOS Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 0
Homo sapiens HCK_HUMAN 5H0HA 1.72 Inactive DFGin BLBplus out-out out-in OOV Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 0
Homo sapiens HCK_HUMAN 2C0IB 2.3 Inactive DFGin BLBtrans out-out out-none L1G Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 2C0OB 2.85 Inactive DFGin BLBtrans out-out out-none L2G Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 2C0IA 2.3 Inactive DFGin BLBtrans out-out out-none L1G Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 2C0OA 2.85 Inactive DFGin BLBtrans out-out out-none L2G Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 2C0TA 2.15 Inactive DFGin BLBtrans out-out out-none L3G Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 2C0TB 2.15 Inactive DFGin BLBtrans out-out out-none L3G Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VRZA 2.218 Inactive DFGin BLBtrans out-out out-none VRZ Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VRZB 2.218 Inactive DFGin BLBtrans out-out out-out VRZ Type1.5_Front 81 - 526 Q523E,Q524E,Q525I X522 12
Homo sapiens HCK_HUMAN 3VS0A 2.934 Inactive DFGin None out-out out-none VS0 Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VS0B 2.934 Inactive DFGin None out-out out-none VS0 Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VS1B 2.464 Inactive DFGin None out-out out-none VSA Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VS2B 2.609 Inactive DFGin None out-out out-none VSB Type1 81 - 526 Q523E,Q524E,Q525I X522 13
Homo sapiens HCK_HUMAN 3VS7A 3.001 Inactive DFGin None out-out out-none KS1 Type1 81 - 526 Q523E,Q524E,Q525I X522 14
Homo sapiens HCK_HUMAN 3VS1A 2.464 Inactive DFGin None out-out out-none VSA Type1.5_Back 81 - 526 Q523E,Q524E,Q525I X522 13

HCK (Tyrosine-protein kinase HCK)

No non-human structures known.