Contact Information
Adrian Canutescu, MD, MBA
Molecular Modeling Facility Manager
Staff Scientist
Room# R461
Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111
Phone: (215)-214-4230
E-mail: Adrian_dot_Canutescu_at_fccc_dot_edu
(replace '_dot_' with '.' and '_at_' with '@')
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Software
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Publications
Xu Q, Canutescu A, Obradovic Z, Dunbrack RL Jr. ProtBuD: a database of biological unit structures of protein families and superfamilies. Bioinformatics, 2006 Dec 1;22(23):2876-82.
Tang Y, Poustovoitov MV, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, Adams PD, Marmorstein R. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol. 2006 Oct;13(10):921-9.
Canutescu AA, Dunbrack RL Jr. MolIDE (Molecular Integrated Development Environment): a homology modeling framework you can click with. Bioinformatics. 2005
Chi Tarn, Erin Merkel, Adrian A. Canutescu, Wei Shen, Yuliya Skorobogatko, Martin J. Heslin, Burton Eisenberg, Ruth Birbe, Arthur Patchefsky, Roland Dunbrack, J. Pablo Arnoletti, Margaret von Mehren and Andrew K. Godwin.
Analysis of KIT Mutations in Sporadic and Familial Gastrointestinal Stromal Tumors: Therapeutic Implications through Protein Modeling. Clin. Cancer Res. Vol. 11, 3668-3677, May 15, 2005
Cheng JD, Valianou M, Canutescu AA, Jaffe EK, Lee HO, Wang H, Lai JH, Bachovchin WW, Weiner LM. Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth. Mol Cancer Ther. 2005 Mar;4(3):351-60.
Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell. 2005 Jan;8(1):19-30.
Canutescu AA, Shelenkov AA, Dunbrack RL Jr. A graph-theory algorithm for rapid protein side-chain prediction. Protein Sci. 2003 Sep;12(9):2001-14.
Canutescu AA, Dunbrack RL Jr. Cyclic coordinate descent: A robotics algorithm for protein loop closure. Protein Sci. 2003 May;12(5):963-72.
Sanders SL, Jennings J, Canutescu A, Link AJ, Weil PA. Proteomics of the eukaryo
tic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol Cell Biol. 2002 Jul;22(13):4723-38.
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