| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4A | P49137 | 47 | 351 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9491 | 13.7165 | ABAminus | -128.52, -52.54 | -97.2, 106.03 | -93.21, 12.59 | 278.71, 77.09 | -54.91, -37.99 | in-in | in | 8.6868 | Saltbr-in | 2.8783 | HRD-in | -60.97, -46.53 | 67.55, 11.05 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0474 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, -43.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | A | 318.0 | 288.0 | 17 | 27 | 15 | 12 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4B | P49137 | 47 | 351 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9703 | 13.9303 | ABAminus | -128.62, -52.37 | -96.88, 106.3 | -93.53, 12.94 | 278.79, 76.83 | -53.86, -39.26 | in-in | in | 8.8768 | Saltbr-in | 2.8503 | HRD-in | -61.06, -46.54 | 67.22, 10.97 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0496 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -64.67, -39.29 | 999.0, 159.18 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | B | 318.0 | 289.0 | 16 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4C | P49137 | 48 | 351 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9519 | 13.7695 | ABAminus | -128.61, -52.83 | -97.32, 105.87 | -93.56, 12.92 | 278.25, 77.18 | -54.04, -38.82 | in-in | in | 8.7149 | Saltbr-in | 2.8844 | HRD-in | -60.6, -46.65 | 67.66, 11.02 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0483 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -67.27, -39.02 | 999.0, 154.29 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | C | 318.0 | 283.0 | 21 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4D | P49137 | 47 | 349 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 5.0164 | 13.9779 | ABAminus | -128.47, -52.45 | -96.79, 105.82 | -93.86, 12.98 | 278.72, 76.7 | -54.12, -38.62 | in-in | in | 8.8822 | Saltbr-in | 2.8667 | HRD-in | -61.37, -46.37 | 68.02, 10.61 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0541 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -64.98, -38.84 | 999.0, 155.36 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | D | 318.0 | 284.0 | 19 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4E | P49137 | 47 | 353 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9783 | 13.843 | ABAminus | -128.62, -52.59 | -97.28, 106.12 | -93.2, 12.43 | 279.18, 76.54 | -53.59, -39.54 | in-in | in | 8.7397 | Saltbr-in | 2.8721 | HRD-in | -60.42, -46.83 | 67.49, 11.2 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0452 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -66.61, -38.51 | 999.0, 154.65 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | E | 318.0 | 286.0 | 21 | 27 | 19 | 8 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4F | P49137 | 47 | 353 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9918 | 13.9622 | ABAminus | -128.58, -52.75 | -97.13, 105.72 | -93.36, 12.89 | 278.82, 76.86 | -54.15, -39.31 | in-in | in | 8.8705 | Saltbr-in | 2.8573 | HRD-in | -61.41, -46.48 | 67.82, 10.61 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0492 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -65.63, -38.8 | 999.0, 158.43 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | F | 318.0 | 279.0 | 28 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4G | P49137 | 47 | 348 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9881 | 13.7142 | ABAminus | -128.53, -52.31 | -97.11, 106.65 | -93.35, 12.39 | 279.0, 76.45 | -52.45, -40.58 | in-in | in | 8.7063 | Saltbr-in | 2.8819 | HRD-in | -60.9, -46.46 | 67.81, 10.73 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0488 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -64.07, -38.86 | 999.0, 175.99 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | G | 318.0 | 273.0 | 29 | 27 | 18 | 9 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4H | P49137 | 47 | 358 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 5.0141 | 13.9806 | ABAminus | -128.09, -52.94 | -96.6, 105.83 | -93.09, 12.25 | 278.91, 76.39 | -53.17, -39.42 | in-in | in | 8.8559 | Saltbr-in | 2.8658 | HRD-in | -61.25, -46.49 | 67.38, 11.04 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.0512 | ActLoopCT-out | nonTYR | APEdihe_aanoo | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 68.07 | APE8-rot-out | 50.27 | APE67-dihe-out | -68.41, -38.92 | -61.79, 156.16 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | H | 318.0 | 281.0 | 31 | 27 | 17 | 10 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4I | P49137 | 47 | 347 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9583 | 13.8272 | ABAminus | -128.35, -52.14 | -97.19, 106.4 | -93.31, 12.69 | 278.76, 76.95 | -54.36, -39.16 | in-in | in | 8.8265 | Saltbr-in | 2.8578 | HRD-in | -61.27, -46.42 | 67.55, 10.91 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0497 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | I | 318.0 | 266.0 | 35 | 27 | 13 | 14 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4J | P49137 | 47 | 350 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9535 | 13.7503 | ABAminus | -128.19, -52.94 | -96.37, 106.17 | -93.76, 12.19 | 278.77, 77.03 | -53.29, -39.12 | in-in | in | 8.654 | Saltbr-in | 2.8859 | HRD-in | -61.27, -46.26 | 67.9, 10.69 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0489 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | J | 318.0 | 273.0 | 31 | 27 | 12 | 15 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4K | P49137 | 47 | 348 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9823 | 13.8551 | ABAminus | -127.78, -52.88 | -96.21, 106.11 | -93.51, 11.66 | 278.96, 76.54 | -52.14, -40.11 | in-in | in | 8.7324 | Saltbr-in | 2.8837 | HRD-in | -61.37, -46.53 | 68.05, 10.32 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0491 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -64.32, -38.96 | 999.0, 154.5 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | K | 318.0 | 269.0 | 33 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4L | P49137 | 47 | 354 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9824 | 13.9272 | ABAminus | -127.97, -52.82 | -96.79, 105.64 | -93.41, 12.6 | 279.02, 76.77 | -54.27, -38.59 | in-in | in | 8.8124 | Saltbr-in | 2.8723 | HRD-in | -61.34, -46.64 | 68.01, 10.51 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0552 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | L | 318.0 | 272.0 | 36 | 27 | 14 | 13 | [[63, 325]] | 1.0 | 8xu4 | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4A | P49137 | 47 | 351 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9491 | 13.7165 | ABAminus | -128.52, -52.54 | -97.2, 106.03 | -93.21, 12.59 | 278.71, 77.09 | -54.91, -37.99 | in-in | in | 8.6868 | Saltbr-in | 2.8783 | HRD-in | -60.97, -46.53 | 67.55, 11.05 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0474 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, -43.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | A | 318.0 | 288.0 | 17 | 27 | 15 | 12 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4B | P49137 | 47 | 351 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9703 | 13.9303 | ABAminus | -128.62, -52.37 | -96.88, 106.3 | -93.53, 12.94 | 278.79, 76.83 | -53.86, -39.26 | in-in | in | 8.8768 | Saltbr-in | 2.8503 | HRD-in | -61.06, -46.54 | 67.22, 10.97 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0496 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -64.67, -39.29 | 999.0, 159.18 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | B | 318.0 | 289.0 | 16 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4C | P49137 | 48 | 351 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9519 | 13.7695 | ABAminus | -128.61, -52.83 | -97.32, 105.87 | -93.56, 12.92 | 278.25, 77.18 | -54.04, -38.82 | in-in | in | 8.7149 | Saltbr-in | 2.8844 | HRD-in | -60.6, -46.65 | 67.66, 11.02 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0483 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -67.27, -39.02 | 999.0, 154.29 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | C | 318.0 | 283.0 | 21 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4D | P49137 | 47 | 349 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 5.0164 | 13.9779 | ABAminus | -128.47, -52.45 | -96.79, 105.82 | -93.86, 12.98 | 278.72, 76.7 | -54.12, -38.62 | in-in | in | 8.8822 | Saltbr-in | 2.8667 | HRD-in | -61.37, -46.37 | 68.02, 10.61 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0541 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -64.98, -38.84 | 999.0, 155.36 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | D | 318.0 | 284.0 | 19 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4E | P49137 | 47 | 353 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9783 | 13.843 | ABAminus | -128.62, -52.59 | -97.28, 106.12 | -93.2, 12.43 | 279.18, 76.54 | -53.59, -39.54 | in-in | in | 8.7397 | Saltbr-in | 2.8721 | HRD-in | -60.42, -46.83 | 67.49, 11.2 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0452 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -66.61, -38.51 | 999.0, 154.65 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | E | 318.0 | 286.0 | 21 | 27 | 19 | 8 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4F | P49137 | 47 | 353 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9918 | 13.9622 | ABAminus | -128.58, -52.75 | -97.13, 105.72 | -93.36, 12.89 | 278.82, 76.86 | -54.15, -39.31 | in-in | in | 8.8705 | Saltbr-in | 2.8573 | HRD-in | -61.41, -46.48 | 67.82, 10.61 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0492 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -65.63, -38.8 | 999.0, 158.43 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | F | 318.0 | 279.0 | 28 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4G | P49137 | 47 | 348 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9881 | 13.7142 | ABAminus | -128.53, -52.31 | -97.11, 106.65 | -93.35, 12.39 | 279.0, 76.45 | -52.45, -40.58 | in-in | in | 8.7063 | Saltbr-in | 2.8819 | HRD-in | -60.9, -46.46 | 67.81, 10.73 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0488 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -64.07, -38.86 | 999.0, 175.99 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | G | 318.0 | 273.0 | 29 | 27 | 18 | 9 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4H | P49137 | 47 | 358 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 5.0141 | 13.9806 | ABAminus | -128.09, -52.94 | -96.6, 105.83 | -93.09, 12.25 | 278.91, 76.39 | -53.17, -39.42 | in-in | in | 8.8559 | Saltbr-in | 2.8658 | HRD-in | -61.25, -46.49 | 67.38, 11.04 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.0512 | ActLoopCT-out | nonTYR | APEdihe_aanoo | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 68.07 | APE8-rot-out | 50.27 | APE67-dihe-out | -68.41, -38.92 | -61.79, 156.16 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | H | 318.0 | 281.0 | 31 | 27 | 17 | 10 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4I | P49137 | 47 | 347 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9583 | 13.8272 | ABAminus | -128.35, -52.14 | -97.19, 106.4 | -93.31, 12.69 | 278.76, 76.95 | -54.36, -39.16 | in-in | in | 8.8265 | Saltbr-in | 2.8578 | HRD-in | -61.27, -46.42 | 67.55, 10.91 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0497 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | I | 318.0 | 266.0 | 35 | 27 | 13 | 14 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4J | P49137 | 47 | 350 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9535 | 13.7503 | ABAminus | -128.19, -52.94 | -96.37, 106.17 | -93.76, 12.19 | 278.77, 77.03 | -53.29, -39.12 | in-in | in | 8.654 | Saltbr-in | 2.8859 | HRD-in | -61.27, -46.26 | 67.9, 10.69 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0489 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | J | 318.0 | 273.0 | 31 | 27 | 12 | 15 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4K | P49137 | 47 | 348 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9823 | 13.8551 | ABAminus | -127.78, -52.88 | -96.21, 106.11 | -93.51, 11.66 | 278.96, 76.54 | -52.14, -40.11 | in-in | in | 8.7324 | Saltbr-in | 2.8837 | HRD-in | -61.37, -46.53 | 68.05, 10.32 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0491 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -64.32, -38.96 | 999.0, 154.5 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | K | 318.0 | 269.0 | 33 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 8XU4L | P49137 | 47 | 354 | 400.0 | No_ligand | No_ligand | Inactive | DFGin | 4.9824 | 13.9272 | ABAminus | -127.97, -52.82 | -96.79, 105.64 | -93.41, 12.6 | 279.02, 76.77 | -54.27, -38.59 | in-in | in | 8.8124 | Saltbr-in | 2.8723 | HRD-in | -61.34, -46.64 | 68.01, 10.51 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0552 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | S216G | None | None | XRAY | 3.4 | 0.216 | 0.263 | L | 318.0 | 272.0 | 36 | 27 | 14 | 13 | [[63, 325]] | 1.0 | 8xu4 | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.5e-80 | 275.0 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|