PDB: 8TO3 — TYR EGFR_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 50.0% 8TO3A
DFGin BLBtrans 2 50.0% 8TO3D
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 8TO3B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.657 14.934 BLBplus -134.55, 162.66 68.08, 49.36 -93.73, 164.43 101.15, 105.54 56.1, 2.84 out-out out 13.767 Saltbr-out 13.971 HRD-in -68.15, -46.1 73.95, -11.19 out-out-out SNCooo out-out ActLoopNT-out 6.842 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.24 APE8-dihe-in -74.12, 71.61 APE8-rot-na 27.49 APE67-dihe-in -65.2, -1.6 -53.66, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.13 T790M,V948R None None XRAY 2.49 0.231 0.269 B 328 291 18 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3A P00533 702 1007 1210.0 IXC:1101 Type1.5_Front Inactive DFGin 4.371 13.996 BLBplus -135.94, 169.11 67.48, 22.01 -70.94, 138.5 62.13, 97.63 90.56, 75.28 out-out out 13.482 Saltbr-out 16.432 HRD-in -64.1, -62.98 87.72, -19.67 out-out-out SNCooo out-out ActLoopNT-out 8.667 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.18 APE8-dihe-in -84.44, 67.85 APE8-rot-na 34.08 APE67-dihe-in -75.79, -1.46 -59.58, -38.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.492 T790M,V948R None None XRAY 2.49 0.231 0.269 A 328 291 15 0 0 15 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3C P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 5.753 16.533 BLBtrans -133.38, -174.65 59.98, 24.74 -65.74, 136.64 157.32, 80.88 79.44, -13.7 out-out out 13.655 Saltbr-out 13.531 HRD-in -66.43, -56.05 80.37, -11.56 out-out-out SNCooo out-out ActLoopNT-out 6.373 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.97 APE8-dihe-in -84.11, 59.51 APE8-rot-na 29.31 APE67-dihe-in -74.18, -0.3 -51.78, -42.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.174 T790M,V948R None None XRAY 2.49 0.231 0.269 C 328 295 16 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3D P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 6.266 16.712 BLBtrans -127.69, 172.31 68.6, 30.15 -69.25, 140.14 165.75, 69.84 67.25, -4.22 out-out out 14.386 Saltbr-out 13.199 HRD-in -68.61, -53.44 82.24, -15.94 out-out-out SNCooo out-out ActLoopNT-out 6.552 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.24 APE8-dihe-in -79.84, 75.73 APE8-rot-na 31.27 APE67-dihe-in -78.58, -0.75 -60.94, -39.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 T790M,V948R None None XRAY 2.49 0.231 0.269 D 328 293 14 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

PDB: 8TO3 — TYR EGFR_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 50.0% 8TO3A
DFGin BLBtrans 2 50.0% 8TO3D
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 8TO3B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.657 14.934 BLBplus -134.55, 162.66 68.08, 49.36 -93.73, 164.43 101.15, 105.54 56.1, 2.84 out-out out 13.767 Saltbr-out 13.971 HRD-in -68.15, -46.1 73.95, -11.19 out-out-out SNCooo out-out ActLoopNT-out 6.842 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.24 APE8-dihe-in -74.12, 71.61 APE8-rot-na 27.49 APE67-dihe-in -65.2, -1.6 -53.66, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.13 T790M,V948R None None XRAY 2.49 0.231 0.269 B 328 291 18 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3A P00533 702 1007 1210.0 IXC:1101 Type1.5_Front Inactive DFGin 4.371 13.996 BLBplus -135.94, 169.11 67.48, 22.01 -70.94, 138.5 62.13, 97.63 90.56, 75.28 out-out out 13.482 Saltbr-out 16.432 HRD-in -64.1, -62.98 87.72, -19.67 out-out-out SNCooo out-out ActLoopNT-out 8.667 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.18 APE8-dihe-in -84.44, 67.85 APE8-rot-na 34.08 APE67-dihe-in -75.79, -1.46 -59.58, -38.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.492 T790M,V948R None None XRAY 2.49 0.231 0.269 A 328 291 15 0 0 15 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3C P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 5.753 16.533 BLBtrans -133.38, -174.65 59.98, 24.74 -65.74, 136.64 157.32, 80.88 79.44, -13.7 out-out out 13.655 Saltbr-out 13.531 HRD-in -66.43, -56.05 80.37, -11.56 out-out-out SNCooo out-out ActLoopNT-out 6.373 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.97 APE8-dihe-in -84.11, 59.51 APE8-rot-na 29.31 APE67-dihe-in -74.18, -0.3 -51.78, -42.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.174 T790M,V948R None None XRAY 2.49 0.231 0.269 C 328 295 16 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3D P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 6.266 16.712 BLBtrans -127.69, 172.31 68.6, 30.15 -69.25, 140.14 165.75, 69.84 67.25, -4.22 out-out out 14.386 Saltbr-out 13.199 HRD-in -68.61, -53.44 82.24, -15.94 out-out-out SNCooo out-out ActLoopNT-out 6.552 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.24 APE8-dihe-in -79.84, 75.73 APE8-rot-na 31.27 APE67-dihe-in -78.58, -0.75 -60.94, -39.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 T790M,V948R None None XRAY 2.49 0.231 0.269 D 328 293 14 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

PDB: 8TO3 — TYR EGFR_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name