PDB: 8SCV — TKL IRAK4_HUMAN

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 8SCVA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL IRAK4 IRAK4_HUMAN 8SCVA 2.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVG Type1 163 - 458 0 SEP284,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 8SCVB 2.69 Inactive DFGin‑BLAminus in-none none-out nonTYR APEdihe_aannn APEdist_ooon ZVG Type1 165 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4

PDB: 8SCV — TKL IRAK4_HUMAN

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 8SCVA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL IRAK4 IRAK4_HUMAN 8SCVA 2.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZVG Type1 163 - 458 0 SEP284,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 8SCVB 2.69 Inactive DFGin‑BLAminus in-none none-out nonTYR APEdihe_aannn APEdist_ooon ZVG Type1 165 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens

PDB: 8SCV — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism