PDB: 8BUG — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 2 66.7% 8BUGH
DFGin BLAminus 1 33.3% 8BUGE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUGE Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.5082 15.7435 BLAminus -142.95, -165.93 46.31, 64.06 -92.32, 17.1 280.22, 84.99 -61.9, -35.84 in-in in 8.2122 Saltbr-in 3.1127 HRD-in -63.09, -51.61 71.91, 6.47 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -74.97, -44.52 APE9-dihe-na -69.42, 151.3 APE8-dihe-in -61.28, 146.55 APE8-rot-out 168.8 APE67-dihe-in -63.35, -29.72 -54.01, -46.01 APE12-dist-in 13.2222 APE11-dist-in 12.7218 APE10-dist-in 6.9462 APE9-dist-in 3.4313 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUGH Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 6.8959 15.5984 None -126.85, -81.65 -69.29, 99.31 -95.06, 17.81 283.55, 80.77 -62.15, -37.73 in-out in 8.4976 Saltbr-out 4.2388 HRD-in -64.31, -53.09 70.58, 6.39 out-in-out SNCoio in-out ActLoopNT-in 3.0823 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.05, -49.38 APE9-dihe-na -69.37, 152.54 APE8-dihe-in -59.34, 145.1 APE8-rot-out 62.3 APE67-dihe-in -62.01, -33.03 -53.97, -44.11 APE12-dist-in 12.9733 APE11-dist-in 12.4826 APE10-dist-in 6.5883 APE9-dist-in 3.6522 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUGB Q9NYV4 715 1041 1490.0 RPW:61101 Type1 Inactive DFGin 6.885 15.532 None -132.35, -51.84 -89.28, 88.82 -91.59, 19.28 282.49, 80.64 -62.07, -38.03 in-in in 8.0337 Saltbr-in 2.912 HRD-in -62.84, -54.31 70.37, 7.41 in-in-out SNCiio in-out ActLoopNT-in 3.0011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -68.25, -47.63 APE9-dihe-na -75.15, 151.02 APE8-dihe-in -63.11, 148.71 APE8-rot-out 182.54 APE67-dihe-in -62.59, -33.17 -53.62, -43.42 APE12-dist-in 12.5031 APE11-dist-in 11.8127 APE10-dist-in 6.379 APE9-dist-in 3.619 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bug CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUG — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 2 66.7% 8BUGH
DFGin BLAminus 1 33.3% 8BUGE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUGE Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 7.5082 15.7435 BLAminus -142.95, -165.93 46.31, 64.06 -92.32, 17.1 280.22, 84.99 -61.9, -35.84 in-in in 8.2122 Saltbr-in 3.1127 HRD-in -63.09, -51.61 71.91, 6.47 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -74.97, -44.52 APE9-dihe-na -69.42, 151.3 APE8-dihe-in -61.28, 146.55 APE8-rot-out 168.8 APE67-dihe-in -63.35, -29.72 -54.01, -46.01 APE12-dist-in 13.2222 APE11-dist-in 12.7218 APE10-dist-in 6.9462 APE9-dist-in 3.4313 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUGH Q9NYV4 715 1039 1490.0 No_ligand No_ligand Inactive DFGin 6.8959 15.5984 None -126.85, -81.65 -69.29, 99.31 -95.06, 17.81 283.55, 80.77 -62.15, -37.73 in-out in 8.4976 Saltbr-out 4.2388 HRD-in -64.31, -53.09 70.58, 6.39 out-in-out SNCoio in-out ActLoopNT-in 3.0823 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -77.05, -49.38 APE9-dihe-na -69.37, 152.54 APE8-dihe-in -59.34, 145.1 APE8-rot-out 62.3 APE67-dihe-in -62.01, -33.03 -53.97, -44.11 APE12-dist-in 12.9733 APE11-dist-in 12.4826 APE10-dist-in 6.5883 APE9-dist-in 3.6522 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUGB Q9NYV4 715 1041 1490.0 RPW:61101 Type1 Inactive DFGin 6.885 15.532 None -132.35, -51.84 -89.28, 88.82 -91.59, 19.28 282.49, 80.64 -62.07, -38.03 in-in in 8.0337 Saltbr-in 2.912 HRD-in -62.84, -54.31 70.37, 7.41 in-in-out SNCiio in-out ActLoopNT-in 3.0011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -68.25, -47.63 APE9-dihe-na -75.15, 151.02 APE8-dihe-in -63.11, 148.71 APE8-rot-out 182.54 APE67-dihe-in -62.59, -33.17 -53.62, -43.42 APE12-dist-in 12.5031 APE11-dist-in 11.8127 APE10-dist-in 6.379 APE9-dist-in 3.619 K965R TPO893 TPO893 XRAY 3.53 0.19 0.231 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bug Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUG — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name