PDB: 8BU9 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BU9H
DFGin BLAminus 1 33.3% 8BU9E
DFGin None 1 33.3% 8BU9B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU9H Q9NYV4 715 1038 1490.0 RRC:61101 Type1 Inactive DFGin 6.8966 15.0279 ABAminus -130.72, -61.46 -86.64, 101.77 -100.72, 17.49 288.44, 80.02 -65.69, -13.23 in-in in 8.1483 Saltbr-in 3.5944 HRD-in -73.34, -52.41 71.89, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.7833 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.4, -56.59 APE9-dihe-na -80.8, 152.68 APE8-dihe-in -61.03, 143.88 APE8-rot-out 47.91 APE67-dihe-in -59.68, -32.23 -55.45, -41.09 APE12-dist-in 13.7228 APE11-dist-in 11.9439 APE10-dist-in 7.0071 APE9-dist-in 3.5232 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9E Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.9943 15.2956 BLAminus -144.01, 174.3 58.02, 76.59 -92.29, 23.22 284.15, 79.53 -66.56, -16.01 in-in in 7.9265 Saltbr-in 2.9785 HRD-in -72.29, -52.87 75.22, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.9527 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -79.11, -41.8 APE9-dihe-na -74.19, 150.88 APE8-dihe-in -62.82, 143.67 APE8-rot-out 166.93 APE67-dihe-in -61.65, -28.3 -55.31, -42.74 APE12-dist-in 13.0026 APE11-dist-in 12.7132 APE10-dist-in 6.8922 APE9-dist-in 3.4751 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.8954 15.5504 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.0334 Saltbr-in 3.4619 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.0383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.2624 APE11-dist-in 11.7849 APE10-dist-in 6.4997 APE9-dist-in 3.5775 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU9 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 8BU9H
DFGin BLAminus 1 33.3% 8BU9E
DFGin None 1 33.3% 8BU9B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU9H Q9NYV4 715 1038 1490.0 RRC:61101 Type1 Inactive DFGin 6.8966 15.0279 ABAminus -130.72, -61.46 -86.64, 101.77 -100.72, 17.49 288.44, 80.02 -65.69, -13.23 in-in in 8.1483 Saltbr-in 3.5944 HRD-in -73.34, -52.41 71.89, 3.55 in-in-out SNCiio in-out ActLoopNT-in 2.7833 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.4, -56.59 APE9-dihe-na -80.8, 152.68 APE8-dihe-in -61.03, 143.88 APE8-rot-out 47.91 APE67-dihe-in -59.68, -32.23 -55.45, -41.09 APE12-dist-in 13.7228 APE11-dist-in 11.9439 APE10-dist-in 7.0071 APE9-dist-in 3.5232 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9E Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.9943 15.2956 BLAminus -144.01, 174.3 58.02, 76.59 -92.29, 23.22 284.15, 79.53 -66.56, -16.01 in-in in 7.9265 Saltbr-in 2.9785 HRD-in -72.29, -52.87 75.22, 4.09 in-in-out SNCiio in-out ActLoopNT-in 2.9527 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -79.11, -41.8 APE9-dihe-na -74.19, 150.88 APE8-dihe-in -62.82, 143.67 APE8-rot-out 166.93 APE67-dihe-in -61.65, -28.3 -55.31, -42.74 APE12-dist-in 13.0026 APE11-dist-in 12.7132 APE10-dist-in 6.8922 APE9-dist-in 3.4751 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU9B Q9NYV4 715 1039 1490.0 RRC:61101 Type1 Inactive DFGin 6.8954 15.5504 None -126.5, -98.68 -52.95, 118.93 -112.03, 20.69 280.85, 78.53 -65.13, -14.55 in-in in 8.0334 Saltbr-in 3.4619 HRD-in -71.08, -52.06 74.5, 2.49 in-in-out SNCiio in-out ActLoopNT-in 3.0383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.03, -51.01 APE9-dihe-na -76.4, 148.49 APE8-dihe-in -61.77, 145.89 APE8-rot-out 190.86 APE67-dihe-in -62.1, -33.32 -50.51, -38.53 APE12-dist-in 13.2624 APE11-dist-in 11.7849 APE10-dist-in 6.4997 APE9-dist-in 3.5775 K965R TPO893 TPO893 XRAY 3.51 0.181 0.223 B 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu9 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU9 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name