PDB: 8BU4 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BU4B
DFGin BLAminus 1 33.3% 8BU4E
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU4B Q9NYV4 715 1043 1490.0 RQL:61101 Type1 Inactive DFGin 6.85 15.4476 ABAminus -129.55, -62.28 -85.09, 103.01 -99.2, 24.51 288.36, 76.72 -66.96, -36.21 in-in in 8.3567 Saltbr-in 2.9754 HRD-in -68.4, -61.77 77.35, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.9924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.64, -39.36 APE9-dihe-na -92.3, 149.92 APE8-dihe-in -61.52, 149.36 APE8-rot-out 186.04 APE67-dihe-in -64.54, -31.54 -56.18, -38.32 APE12-dist-in 13.385 APE11-dist-in 11.5066 APE10-dist-in 6.6111 APE9-dist-in 3.4581 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU4H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.0469 15.5284 ABAminus -118.75, -57.9 -97.23, 97.83 -98.97, 29.55 288.47, 78.73 -75.71, -15.5 in-out in 8.2875 Saltbr-out 3.9063 HRD-in -79.59, -55.06 74.66, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.8791 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.0, -34.01 APE9-dihe-na -98.0, 156.31 APE8-dihe-in -61.54, 149.21 APE8-rot-out 67.45 APE67-dihe-in -64.95, -40.0 -58.15, -33.89 APE12-dist-in 13.8217 APE11-dist-in 12.0458 APE10-dist-in 7.1648 APE9-dist-in 3.5506 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU4E Q9NYV4 715 1039 1490.0 RQL:61101 Type1 Inactive DFGin 7.468 15.54 BLAminus -141.1, 177.81 60.96, 67.17 -93.67, 20.14 286.75, 91.51 -68.13, -33.02 in-out in 8.589 Saltbr-out 5.3781 HRD-in -65.76, -60.59 77.41, 5.82 out-in-out SNCoio in-out ActLoopNT-in 3.0295 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.44, -31.45 APE9-dihe-na -85.2, 150.66 APE8-dihe-in -60.73, 147.65 APE8-rot-out 173.82 APE67-dihe-in -63.61, -27.41 -58.33, -41.33 APE12-dist-in 13.0819 APE11-dist-in 12.5962 APE10-dist-in 6.8982 APE9-dist-in 3.368 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU4 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BU4B
DFGin BLAminus 1 33.3% 8BU4E
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU4B Q9NYV4 715 1043 1490.0 RQL:61101 Type1 Inactive DFGin 6.85 15.4476 ABAminus -129.55, -62.28 -85.09, 103.01 -99.2, 24.51 288.36, 76.72 -66.96, -36.21 in-in in 8.3567 Saltbr-in 2.9754 HRD-in -68.4, -61.77 77.35, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.9924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.64, -39.36 APE9-dihe-na -92.3, 149.92 APE8-dihe-in -61.52, 149.36 APE8-rot-out 186.04 APE67-dihe-in -64.54, -31.54 -56.18, -38.32 APE12-dist-in 13.385 APE11-dist-in 11.5066 APE10-dist-in 6.6111 APE9-dist-in 3.4581 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU4H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.0469 15.5284 ABAminus -118.75, -57.9 -97.23, 97.83 -98.97, 29.55 288.47, 78.73 -75.71, -15.5 in-out in 8.2875 Saltbr-out 3.9063 HRD-in -79.59, -55.06 74.66, 4.8 out-in-out SNCoio in-out ActLoopNT-in 2.8791 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -121.0, -34.01 APE9-dihe-na -98.0, 156.31 APE8-dihe-in -61.54, 149.21 APE8-rot-out 67.45 APE67-dihe-in -64.95, -40.0 -58.15, -33.89 APE12-dist-in 13.8217 APE11-dist-in 12.0458 APE10-dist-in 7.1648 APE9-dist-in 3.5506 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU4E Q9NYV4 715 1039 1490.0 RQL:61101 Type1 Inactive DFGin 7.468 15.54 BLAminus -141.1, 177.81 60.96, 67.17 -93.67, 20.14 286.75, 91.51 -68.13, -33.02 in-out in 8.589 Saltbr-out 5.3781 HRD-in -65.76, -60.59 77.41, 5.82 out-in-out SNCoio in-out ActLoopNT-in 3.0295 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -92.44, -31.45 APE9-dihe-na -85.2, 150.66 APE8-dihe-in -60.73, 147.65 APE8-rot-out 173.82 APE67-dihe-in -63.61, -27.41 -58.33, -41.33 APE12-dist-in 13.0819 APE11-dist-in 12.5962 APE10-dist-in 6.8982 APE9-dist-in 3.368 K965R TPO893 TPO893 XRAY 3.09 0.205 0.223 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bu4 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU4 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name