PDB: 8BU1 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 2 66.7% 8BU1B
DFGin BLAminus 1 33.3% 8BU1E
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU1E Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.0678 15.2145 BLAminus -136.12, -177.54 44.75, 87.14 -99.51, 30.27 285.35, 73.68 -68.31, -25.33 in-in in 7.7936 Saltbr-in 3.0999 HRD-in -77.94, -49.77 74.02, -0.64 in-in-out SNCiio in-out ActLoopNT-in 2.6913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.97, -45.94 APE9-dihe-na -80.52, 149.74 APE8-dihe-in -60.97, 145.17 APE8-rot-out 178.02 APE67-dihe-in -66.77, -27.56 -51.22, -43.09 APE12-dist-in 13.0179 APE11-dist-in 12.2266 APE10-dist-in 6.9915 APE9-dist-in 3.5494 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 E 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1B Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.8884 15.2984 None -128.47, -62.59 -80.73, 98.22 -97.65, 30.1 286.08, 74.34 -69.36, -27.39 in-in in 7.8207 Saltbr-in 3.2637 HRD-in -79.79, -51.42 72.8, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.7133 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.4, -55.58 APE9-dihe-na -85.22, 150.62 APE8-dihe-in -62.26, 144.21 APE8-rot-out 179.44 APE67-dihe-in -65.72, -30.15 -51.5, -38.4 APE12-dist-in 13.2818 APE11-dist-in 11.6162 APE10-dist-in 6.9008 APE9-dist-in 3.7142 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 B 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.9866 15.4035 None -124.14, -66.45 -82.78, 98.54 -96.09, 28.76 284.79, 71.99 -70.28, -26.46 in-in in 7.8662 Saltbr-in 3.166 HRD-in -79.63, -53.16 73.52, -1.03 in-in-out SNCiio in-out ActLoopNT-in 2.7593 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.57, -50.83 APE9-dihe-na -86.52, 154.66 APE8-dihe-in -59.58, 143.86 APE8-rot-out 8.75 APE67-dihe-in -65.52, -30.46 -51.58, -39.94 APE12-dist-in 13.8095 APE11-dist-in 12.2137 APE10-dist-in 7.2362 APE9-dist-in 3.5954 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU1 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 2 66.7% 8BU1B
DFGin BLAminus 1 33.3% 8BU1E
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU1E Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 7.0678 15.2145 BLAminus -136.12, -177.54 44.75, 87.14 -99.51, 30.27 285.35, 73.68 -68.31, -25.33 in-in in 7.7936 Saltbr-in 3.0999 HRD-in -77.94, -49.77 74.02, -0.64 in-in-out SNCiio in-out ActLoopNT-in 2.6913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.97, -45.94 APE9-dihe-na -80.52, 149.74 APE8-dihe-in -60.97, 145.17 APE8-rot-out 178.02 APE67-dihe-in -66.77, -27.56 -51.22, -43.09 APE12-dist-in 13.0179 APE11-dist-in 12.2266 APE10-dist-in 6.9915 APE9-dist-in 3.5494 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 E 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1B Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.8884 15.2984 None -128.47, -62.59 -80.73, 98.22 -97.65, 30.1 286.08, 74.34 -69.36, -27.39 in-in in 7.8207 Saltbr-in 3.2637 HRD-in -79.79, -51.42 72.8, -1.21 in-in-out SNCiio in-out ActLoopNT-in 2.7133 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -112.4, -55.58 APE9-dihe-na -85.22, 150.62 APE8-dihe-in -62.26, 144.21 APE8-rot-out 179.44 APE67-dihe-in -65.72, -30.15 -51.5, -38.4 APE12-dist-in 13.2818 APE11-dist-in 11.6162 APE10-dist-in 6.9008 APE9-dist-in 3.7142 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 B 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU1H Q9NYV4 715 1044 1490.0 RQL:61101 Type1 Inactive DFGin 6.9866 15.4035 None -124.14, -66.45 -82.78, 98.54 -96.09, 28.76 284.79, 71.99 -70.28, -26.46 in-in in 7.8662 Saltbr-in 3.166 HRD-in -79.63, -53.16 73.52, -1.03 in-in-out SNCiio in-out ActLoopNT-in 2.7593 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -109.57, -50.83 APE9-dihe-na -86.52, 154.66 APE8-dihe-in -59.58, 143.86 APE8-rot-out 8.75 APE67-dihe-in -65.52, -30.46 -51.58, -39.94 APE12-dist-in 13.8095 APE11-dist-in 12.2137 APE10-dist-in 7.2362 APE9-dist-in 3.5954 K965R TPO893 TPO893 XRAY 2.98 0.195 0.218 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bu1 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU1 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name