PDB: 8BR5 — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 8BR5DDD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 8BR5AAA Q9NWZ3 163 459 460.0 R73:501 Type1 Inactive DFGin 6.8909 13.5487 BLAminus -135.64, 166.52 72.95, 87.11 -114.61, 20.95 314.97, 96.05 -63.79, -34.13 in-out in 8.5773 Saltbr-out 5.1263 HRD-in -65.01, -58.54 82.12, 4.04 out-in-in SNCoii in-in ActLoopNT-in 2.6426 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.82, 159.99 APE9-dihe-na 128.75, -171.24 APE8-dihe-in -115.19, 111.48 APE8-rot-in 311.1 APE67-dihe-in -62.63, -23.51 -40.08, -50.26 APE12-dist-in 9.8978 APE11-dist-in 11.8187 APE10-dist-in 6.2927 APE9-dist-in 3.5113 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 AAA 299.0 285.0 12 30 26 4 [[183, 456]] 1.0 8br5 TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 8BR5BBB Q9NWZ3 162 459 460.0 R73:501 Type1 Inactive DFGin 6.8575 13.7617 BLAminus -136.08, 166.61 73.3, 87.27 -114.6, 19.85 314.86, 95.64 -65.31, -30.39 in-out in 8.5226 Saltbr-out 3.7294 HRD-in -65.19, -58.29 82.32, 3.9 out-in-in SNCoii in-in ActLoopNT-in 3.1133 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.6, 159.09 APE9-dihe-na 128.61, -173.24 APE8-dihe-in -115.27, 111.19 APE8-rot-in 312.87 APE67-dihe-in -62.24, -23.3 -41.16, -49.65 APE12-dist-in 10.2149 APE11-dist-in 11.8096 APE10-dist-in 6.2677 APE9-dist-in 3.5494 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 BBB 299.0 286.0 12 30 25 5 [[183, 456]] 1.0 8br5 TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 8BR5CCC Q9NWZ3 163 459 460.0 R73:501 Type1 Inactive DFGin 6.708 13.7926 BLAminus -136.19, 166.86 72.98, 86.7 -114.08, 20.57 315.82, 89.7 -62.71, -31.97 in-out in 8.6814 Saltbr-out 3.7563 HRD-in -65.25, -58.07 82.96, 3.39 out-in-in SNCoii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.36, 158.08 APE9-dihe-na 127.09, -172.58 APE8-dihe-in -114.98, 111.31 APE8-rot-in 311.74 APE67-dihe-in -61.49, -24.18 -41.35, -49.9 APE12-dist-in 10.074 APE11-dist-in 11.8248 APE10-dist-in 6.1654 APE9-dist-in 3.5104 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 CCC 299.0 284.0 13 30 24 6 [[183, 456]] 1.0 8br5 TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 8BR5DDD Q9NWZ3 164 459 460.0 R73:501 Type1 Inactive DFGin 6.9291 13.6331 BLAminus -135.77, 166.02 73.96, 87.25 -114.76, 19.82 314.36, 95.52 -65.27, -32.15 in-out in 8.387 Saltbr-out 3.6821 HRD-in -64.82, -58.41 82.56, 3.65 out-in-in SNCoii in-in ActLoopNT-in 2.6458 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.87, 159.3 APE9-dihe-na 128.38, -172.65 APE8-dihe-in -115.23, 111.34 APE8-rot-in 311.38 APE67-dihe-in -63.77, -22.78 -39.6, -50.55 APE12-dist-in 9.8784 APE11-dist-in 11.8965 APE10-dist-in 6.3607 APE9-dist-in 3.5306 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 DDD 299.0 285.0 11 30 26 4 [[183, 456]] 1.0 8br5 TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 8BR5 — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 8BR5DDD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 8BR5AAA Q9NWZ3 163 459 460.0 R73:501 Type1 Inactive DFGin 6.8909 13.5487 BLAminus -135.64, 166.52 72.95, 87.11 -114.61, 20.95 314.97, 96.05 -63.79, -34.13 in-out in 8.5773 Saltbr-out 5.1263 HRD-in -65.01, -58.54 82.12, 4.04 out-in-in SNCoii in-in ActLoopNT-in 2.6426 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.82, 159.99 APE9-dihe-na 128.75, -171.24 APE8-dihe-in -115.19, 111.48 APE8-rot-in 311.1 APE67-dihe-in -62.63, -23.51 -40.08, -50.26 APE12-dist-in 9.8978 APE11-dist-in 11.8187 APE10-dist-in 6.2927 APE9-dist-in 3.5113 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 AAA 299.0 285.0 12 30 26 4 [[183, 456]] 1.0 8br5 Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 8BR5BBB Q9NWZ3 162 459 460.0 R73:501 Type1 Inactive DFGin 6.8575 13.7617 BLAminus -136.08, 166.61 73.3, 87.27 -114.6, 19.85 314.86, 95.64 -65.31, -30.39 in-out in 8.5226 Saltbr-out 3.7294 HRD-in -65.19, -58.29 82.32, 3.9 out-in-in SNCoii in-in ActLoopNT-in 3.1133 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.6, 159.09 APE9-dihe-na 128.61, -173.24 APE8-dihe-in -115.27, 111.19 APE8-rot-in 312.87 APE67-dihe-in -62.24, -23.3 -41.16, -49.65 APE12-dist-in 10.2149 APE11-dist-in 11.8096 APE10-dist-in 6.2677 APE9-dist-in 3.5494 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 BBB 299.0 286.0 12 30 25 5 [[183, 456]] 1.0 8br5 Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 8BR5CCC Q9NWZ3 163 459 460.0 R73:501 Type1 Inactive DFGin 6.708 13.7926 BLAminus -136.19, 166.86 72.98, 86.7 -114.08, 20.57 315.82, 89.7 -62.71, -31.97 in-out in 8.6814 Saltbr-out 3.7563 HRD-in -65.25, -58.07 82.96, 3.39 out-in-in SNCoii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.36, 158.08 APE9-dihe-na 127.09, -172.58 APE8-dihe-in -114.98, 111.31 APE8-rot-in 311.74 APE67-dihe-in -61.49, -24.18 -41.35, -49.9 APE12-dist-in 10.074 APE11-dist-in 11.8248 APE10-dist-in 6.1654 APE9-dist-in 3.5104 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 CCC 299.0 284.0 13 30 24 6 [[183, 456]] 1.0 8br5 Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 8BR5DDD Q9NWZ3 164 459 460.0 R73:501 Type1 Inactive DFGin 6.9291 13.6331 BLAminus -135.77, 166.02 73.96, 87.25 -114.76, 19.82 314.36, 95.52 -65.27, -32.15 in-out in 8.387 Saltbr-out 3.6821 HRD-in -64.82, -58.41 82.56, 3.65 out-in-in SNCoii in-in ActLoopNT-in 2.6458 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.87, 159.3 APE9-dihe-na 128.38, -172.65 APE8-dihe-in -115.23, 111.34 APE8-rot-in 311.38 APE67-dihe-in -63.77, -22.78 -39.6, -50.55 APE12-dist-in 9.8784 APE11-dist-in 11.8965 APE10-dist-in 6.3607 APE9-dist-in 3.5306 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.7 0.215 0.254 DDD 299.0 285.0 11 30 26 4 [[183, 456]] 1.0 8br5 Homo sapiens TKL_IRAK4_HUMAN TKL 4e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 8BR5 — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name