PDB: 6UIP — CMGC DYR1A_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 6UIPB
DFGin None 1 33.3% 6UIPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6UIPB Q13627 136 478 763.0 Q8J:501 Type1 Inactive DFGin 6.8948 14.9297 ABAminus -128.46, -42.33 -94.91, 127.61 -132.24, 12.58 285.14, 81.63 -56.41, -45.59 in-in in 9.0869 Saltbr-in 2.8984 HRD-in -67.7, -47.87 68.18, -0.51 in-in-in SNCiii in-in ActLoopNT-in 3.0911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.31, 177.75 APE9-dihe-na 64.01, 150.34 APE8-dihe-in -71.42, 137.1 APE8-rot-in 300.33 APE67-dihe-in -57.48, -29.96 -50.84, -45.43 APE12-dist-in 12.84 APE11-dist-in 11.176 APE10-dist-in 7.1503 APE9-dist-in 2.9743 None PTR321 PTR321 XRAY 3.7 0.272 0.29 B 361.0 338.0 6 25 25 0 [[159, 479]] 1.0 6uip CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UIPC Q13627 131 477 763.0 Q8J:501 Type1 Inactive DFGin 6.9566 14.5835 ABAminus -128.48, -41.69 -94.89, 138.63 -139.05, 93.64 283.54, 77.23 -157.81, 999.0 in-in in 8.6955 Saltbr-in 2.6597 HRD-in -68.31, -47.09 68.76, -0.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -122.81, -42.23 APE9-dihe-na -85.49, 157.66 APE8-dihe-in -67.92, 135.09 APE8-rot-out 172.73 APE67-dihe-in -59.1, -31.97 -53.15, -45.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.0463 None PTR321 PTR321 XRAY 3.7 0.272 0.29 C 361.0 306.0 39 25 16 9 [[159, 479]] 1.0 6uip CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UIPA Q13627 131 479 763.0 Q8J:501 Type1 Inactive DFGin 7.3285 15.2923 None -128.98, -33.2 -83.24, -86.92 68.74, 42.73 287.01, 105.17 -106.11, -43.86 in-in in 8.6072 Saltbr-in 2.4441 HRD-in -69.31, -45.72 68.49, 1.14 in-in-in SNCiii in-in ActLoopNT-in 3.0339 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.27, -51.33 APE9-dihe-na -84.83, 157.96 APE8-dihe-in -67.65, 136.35 APE8-rot-in 301.98 APE67-dihe-in -59.01, -29.0 -52.09, -48.51 APE12-dist-in 12.5097 APE11-dist-in 10.8491 APE10-dist-in 6.989 APE9-dist-in 3.2296 None PTR321 PTR321 XRAY 3.7 0.272 0.29 A 361.0 345.0 4 25 25 0 [[159, 479]] 1.0 6uip CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 6UIP — CMGC DYR1A_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 6UIPB
DFGin None 1 33.3% 6UIPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6UIPB Q13627 136 478 763.0 Q8J:501 Type1 Inactive DFGin 6.8948 14.9297 ABAminus -128.46, -42.33 -94.91, 127.61 -132.24, 12.58 285.14, 81.63 -56.41, -45.59 in-in in 9.0869 Saltbr-in 2.8984 HRD-in -67.7, -47.87 68.18, -0.51 in-in-in SNCiii in-in ActLoopNT-in 3.0911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.31, 177.75 APE9-dihe-na 64.01, 150.34 APE8-dihe-in -71.42, 137.1 APE8-rot-in 300.33 APE67-dihe-in -57.48, -29.96 -50.84, -45.43 APE12-dist-in 12.84 APE11-dist-in 11.176 APE10-dist-in 7.1503 APE9-dist-in 2.9743 None PTR321 PTR321 XRAY 3.7 0.272 0.29 B 361.0 338.0 6 25 25 0 [[159, 479]] 1.0 6uip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UIPC Q13627 131 477 763.0 Q8J:501 Type1 Inactive DFGin 6.9566 14.5835 ABAminus -128.48, -41.69 -94.89, 138.63 -139.05, 93.64 283.54, 77.23 -157.81, 999.0 in-in in 8.6955 Saltbr-in 2.6597 HRD-in -68.31, -47.09 68.76, -0.11 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na -122.81, -42.23 APE9-dihe-na -85.49, 157.66 APE8-dihe-in -67.92, 135.09 APE8-rot-out 172.73 APE67-dihe-in -59.1, -31.97 -53.15, -45.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.0463 None PTR321 PTR321 XRAY 3.7 0.272 0.29 C 361.0 306.0 39 25 16 9 [[159, 479]] 1.0 6uip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6UIPA Q13627 131 479 763.0 Q8J:501 Type1 Inactive DFGin 7.3285 15.2923 None -128.98, -33.2 -83.24, -86.92 68.74, 42.73 287.01, 105.17 -106.11, -43.86 in-in in 8.6072 Saltbr-in 2.4441 HRD-in -69.31, -45.72 68.49, 1.14 in-in-in SNCiii in-in ActLoopNT-in 3.0339 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.27, -51.33 APE9-dihe-na -84.83, 157.96 APE8-dihe-in -67.65, 136.35 APE8-rot-in 301.98 APE67-dihe-in -59.01, -29.0 -52.09, -48.51 APE12-dist-in 12.5097 APE11-dist-in 10.8491 APE10-dist-in 6.989 APE9-dist-in 3.2296 None PTR321 PTR321 XRAY 3.7 0.272 0.29 A 361.0 345.0 4 25 25 0 [[159, 479]] 1.0 6uip Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 6UIP — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name