PDB: 5JSM — TKL BRAF_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 4 100.0% 5JSMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRAF BRAF_HUMAN 5JSMA P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 6.3913 13.0389 BLAplus -138.4, -174.44 69.43, 19.37 -96.67, -11.2 60.48, 90.73 -70.16, 170.4 out-out out 12.5188 Saltbr-out 11.8479 HRD-in -67.42, -52.76 81.37, -8.85 out-out-out SNCooo out-out ActLoopNT-out 7.3704 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -126.49 APE9-dihe-na -72.61, -3.43 APE8-dihe-out -78.38, -5.15 APE8-rot-in 323.72 APE67-dihe-in -63.19, -24.3 -66.02, -22.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.0208 APE9-dist-out 11.7508 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 A 280.0 262.0 12 30 18 12 [[457, 716]] 1.0 5jsm TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5JSMD P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 6.1228 13.0315 BLAplus -131.14, -174.1 61.1, 20.52 -90.6, -7.92 60.52, 88.06 -77.98, 170.41 out-out out 12.2319 Saltbr-out 11.4685 HRD-in -70.97, -49.77 79.36, -15.05 out-out-out SNCooo out-out ActLoopNT-out 6.931 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -122.39 APE9-dihe-na -69.86, -160.53 APE8-dihe-out 66.03, 26.93 APE8-rot-out 79.84 APE67-dihe-in -63.53, -17.75 -74.4, -20.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.2857 APE9-dist-out 11.4992 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 D 280.0 255.0 19 30 19 11 [[457, 716]] 1.0 5jsm TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5JSMB P15056 448 721 766.0 6NB:60801 Type1.5_Back Inactive DFGin 6.0624 13.1149 BLAplus -131.27, -176.98 63.39, 23.33 -93.63, -10.63 60.2, 91.2 -76.07, 171.28 out-out out 12.2257 Saltbr-out 11.0758 HRD-in -71.71, -49.86 78.57, -16.34 out-out-none SNCoon out-none ActLoopNT-out 6.8658 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 9.89 APE8-rot-in 315.15 APE67-dihe-in -61.71, -26.31 -77.16, -23.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 B 280.0 259.0 15 30 18 12 [[457, 716]] 1.0 5jsm TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5JSMC P15056 448 722 766.0 6NB:60801 Type1.5_Back Inactive DFGin 6.3825 13.1095 BLAplus -129.7, -173.18 63.38, 21.31 -96.67, -12.5 57.76, 93.77 -77.13, 167.54 out-out out 12.6372 Saltbr-out 11.8496 HRD-in -70.95, -49.33 78.01, -16.99 out-out-out SNCooo out-out ActLoopNT-out 6.8539 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 9.67 APE8-rot-out 63.05 APE67-dihe-in -58.68, -22.16 -80.83, -26.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 C 280.0 259.0 16 30 15 15 [[457, 716]] 1.0 5jsm TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

PDB: 5JSM — TKL BRAF_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 4 100.0% 5JSMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRAF BRAF_HUMAN 5JSMA P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 6.3913 13.0389 BLAplus -138.4, -174.44 69.43, 19.37 -96.67, -11.2 60.48, 90.73 -70.16, 170.4 out-out out 12.5188 Saltbr-out 11.8479 HRD-in -67.42, -52.76 81.37, -8.85 out-out-out SNCooo out-out ActLoopNT-out 7.3704 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -126.49 APE9-dihe-na -72.61, -3.43 APE8-dihe-out -78.38, -5.15 APE8-rot-in 323.72 APE67-dihe-in -63.19, -24.3 -66.02, -22.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.0208 APE9-dist-out 11.7508 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 A 280.0 262.0 12 30 18 12 [[457, 716]] 1.0 5jsm Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5JSMD P15056 448 721 766.0 No_ligand No_ligand Inactive DFGin 6.1228 13.0315 BLAplus -131.14, -174.1 61.1, 20.52 -90.6, -7.92 60.52, 88.06 -77.98, 170.41 out-out out 12.2319 Saltbr-out 11.4685 HRD-in -70.97, -49.77 79.36, -15.05 out-out-out SNCooo out-out ActLoopNT-out 6.931 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -122.39 APE9-dihe-na -69.86, -160.53 APE8-dihe-out 66.03, 26.93 APE8-rot-out 79.84 APE67-dihe-in -63.53, -17.75 -74.4, -20.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.2857 APE9-dist-out 11.4992 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 D 280.0 255.0 19 30 19 11 [[457, 716]] 1.0 5jsm Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5JSMB P15056 448 721 766.0 6NB:60801 Type1.5_Back Inactive DFGin 6.0624 13.1149 BLAplus -131.27, -176.98 63.39, 23.33 -93.63, -10.63 60.2, 91.2 -76.07, 171.28 out-out out 12.2257 Saltbr-out 11.0758 HRD-in -71.71, -49.86 78.57, -16.34 out-out-none SNCoon out-none ActLoopNT-out 6.8658 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 9.89 APE8-rot-in 315.15 APE67-dihe-in -61.71, -26.31 -77.16, -23.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 B 280.0 259.0 15 30 18 12 [[457, 716]] 1.0 5jsm Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5JSMC P15056 448 722 766.0 6NB:60801 Type1.5_Back Inactive DFGin 6.3825 13.1095 BLAplus -129.7, -173.18 63.38, 21.31 -96.67, -12.5 57.76, 93.77 -77.13, 167.54 out-out out 12.6372 Saltbr-out 11.8496 HRD-in -70.95, -49.33 78.01, -16.99 out-out-out SNCooo out-out ActLoopNT-out 6.8539 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 9.67 APE8-rot-out 63.05 APE67-dihe-in -58.68, -22.16 -80.83, -26.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.19 0.209 0.26 C 280.0 259.0 16 30 15 15 [[457, 716]] 1.0 5jsm Homo sapiens TKL_BRAF_HUMAN TKL 4.7e-84 288.0 4.0 267.0 264.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

PDB: 5JSM — TKL BRAF_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name