PDB: 4ZTL — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4ZTLD

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL IRAK4 IRAK4_HUMAN 4ZTLA 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTLB 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTLC 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTLD 2.39 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4

PDB: 4ZTL — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4ZTLD

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL IRAK4 IRAK4_HUMAN 4ZTLA 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4ZTLB 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 165 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4ZTLC 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4ZTLD 2.39 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4S1 Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens

PDB: 4ZTL — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism