PDB: 4Y73 — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4Y73C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 4Y73A Q9NWZ3 163 459 460.0 XPY:1000 Type1 Inactive DFGin 6.7939 13.8816 BLAminus -135.22, 179.14 58.81, 74.84 -95.42, 16.11 309.59, 98.19 -56.86, -31.3 in-out in 8.6719 Saltbr-out 4.1966 HRD-in -65.11, -54.01 76.65, -4.03 out-in-in SNCoii in-in ActLoopNT-in 2.7411 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.98, 155.58 APE9-dihe-na 135.26, -172.46 APE8-dihe-in -110.18, 112.73 APE8-rot-in 310.78 APE67-dihe-in -61.03, -19.56 -40.26, -54.06 APE12-dist-in 10.1174 APE11-dist-in 11.6957 APE10-dist-in 6.3615 APE9-dist-in 4.0109 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 A 302.0 292.0 5 30 25 5 [[183, 456]] 1.0 4y73 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4Y73B Q9NWZ3 161 459 460.0 XPY:1000 Type1 Inactive DFGin 6.9031 13.8994 BLAminus -134.53, 179.53 58.2, 75.65 -95.32, 17.24 309.95, 97.89 -59.17, -23.79 in-out in 8.3394 Saltbr-out 3.7399 HRD-in -64.75, -51.42 74.08, -3.62 out-in-in SNCoii in-in ActLoopNT-in 2.8588 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.97, 155.19 APE9-dihe-na 135.01, -173.41 APE8-dihe-in -108.72, 112.77 APE8-rot-in 310.3 APE67-dihe-in -60.51, -19.8 -41.06, -53.91 APE12-dist-in 10.1439 APE11-dist-in 11.7409 APE10-dist-in 6.3534 APE9-dist-in 3.9692 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 B 302.0 292.0 7 30 23 7 [[183, 456]] 1.0 4y73 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4Y73C Q9NWZ3 164 460 460.0 XPY:1000 Type1 Inactive DFGin 6.9893 13.7959 BLAminus -135.91, 178.91 60.18, 74.45 -95.65, 17.31 309.71, 99.32 -57.1, -32.23 in-out in 8.4949 Saltbr-out 4.0135 HRD-in -67.33, -52.41 76.27, -4.09 out-in-in SNCoii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 155.49 APE9-dihe-na 134.48, -173.93 APE8-dihe-in -109.04, 112.55 APE8-rot-in 310.08 APE67-dihe-in -60.39, -19.29 -39.87, -53.77 APE12-dist-in 10.0164 APE11-dist-in 11.817 APE10-dist-in 6.4291 APE9-dist-in 3.9704 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 C 302.0 293.0 4 30 26 4 [[183, 456]] 1.0 4y73 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4Y73D Q9NWZ3 164 459 460.0 XPY:1000 Type1 Active DFGin 6.9462 13.9421 BLAminus -134.48, 179.63 58.03, 76.69 -96.29, 18.79 309.44, 97.62 -57.19, -32.63 in-in in 8.8874 Saltbr-in 3.1833 HRD-in -69.87, -49.37 75.0, -4.9 in-in-in SNCiii in-in ActLoopNT-in 2.7499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.55, 154.63 APE9-dihe-na 135.98, -173.49 APE8-dihe-in -109.02, 111.96 APE8-rot-in 310.2 APE67-dihe-in -59.31, -19.91 -40.37, -53.91 APE12-dist-in 10.0238 APE11-dist-in 11.7099 APE10-dist-in 6.3725 APE9-dist-in 4.0774 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 D 302.0 291.0 5 30 25 5 [[183, 456]] 1.0 4y73 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 4Y73 — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4Y73C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 4Y73A Q9NWZ3 163 459 460.0 XPY:1000 Type1 Inactive DFGin 6.7939 13.8816 BLAminus -135.22, 179.14 58.81, 74.84 -95.42, 16.11 309.59, 98.19 -56.86, -31.3 in-out in 8.6719 Saltbr-out 4.1966 HRD-in -65.11, -54.01 76.65, -4.03 out-in-in SNCoii in-in ActLoopNT-in 2.7411 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.98, 155.58 APE9-dihe-na 135.26, -172.46 APE8-dihe-in -110.18, 112.73 APE8-rot-in 310.78 APE67-dihe-in -61.03, -19.56 -40.26, -54.06 APE12-dist-in 10.1174 APE11-dist-in 11.6957 APE10-dist-in 6.3615 APE9-dist-in 4.0109 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 A 302.0 292.0 5 30 25 5 [[183, 456]] 1.0 4y73 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4Y73B Q9NWZ3 161 459 460.0 XPY:1000 Type1 Inactive DFGin 6.9031 13.8994 BLAminus -134.53, 179.53 58.2, 75.65 -95.32, 17.24 309.95, 97.89 -59.17, -23.79 in-out in 8.3394 Saltbr-out 3.7399 HRD-in -64.75, -51.42 74.08, -3.62 out-in-in SNCoii in-in ActLoopNT-in 2.8588 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.97, 155.19 APE9-dihe-na 135.01, -173.41 APE8-dihe-in -108.72, 112.77 APE8-rot-in 310.3 APE67-dihe-in -60.51, -19.8 -41.06, -53.91 APE12-dist-in 10.1439 APE11-dist-in 11.7409 APE10-dist-in 6.3534 APE9-dist-in 3.9692 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 B 302.0 292.0 7 30 23 7 [[183, 456]] 1.0 4y73 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4Y73C Q9NWZ3 164 460 460.0 XPY:1000 Type1 Inactive DFGin 6.9893 13.7959 BLAminus -135.91, 178.91 60.18, 74.45 -95.65, 17.31 309.71, 99.32 -57.1, -32.23 in-out in 8.4949 Saltbr-out 4.0135 HRD-in -67.33, -52.41 76.27, -4.09 out-in-in SNCoii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 155.49 APE9-dihe-na 134.48, -173.93 APE8-dihe-in -109.04, 112.55 APE8-rot-in 310.08 APE67-dihe-in -60.39, -19.29 -39.87, -53.77 APE12-dist-in 10.0164 APE11-dist-in 11.817 APE10-dist-in 6.4291 APE9-dist-in 3.9704 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 C 302.0 293.0 4 30 26 4 [[183, 456]] 1.0 4y73 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4Y73D Q9NWZ3 164 459 460.0 XPY:1000 Type1 Active DFGin 6.9462 13.9421 BLAminus -134.48, 179.63 58.03, 76.69 -96.29, 18.79 309.44, 97.62 -57.19, -32.63 in-in in 8.8874 Saltbr-in 3.1833 HRD-in -69.87, -49.37 75.0, -4.9 in-in-in SNCiii in-in ActLoopNT-in 2.7499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.55, 154.63 APE9-dihe-na 135.98, -173.49 APE8-dihe-in -109.02, 111.96 APE8-rot-in 310.2 APE67-dihe-in -59.31, -19.91 -40.37, -53.91 APE12-dist-in 10.0238 APE11-dist-in 11.7099 APE10-dist-in 6.3725 APE9-dist-in 4.0774 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.14 0.196 0.217 D 302.0 291.0 5 30 25 5 [[183, 456]] 1.0 4y73 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 4Y73 — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name