KinCore

PDB: 2ZM3 — TYR IGF1R_HUMAN

Total number of chains: 4

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	ABAminus	4	100.0%	2ZM3A

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	IGF1R	IGF1R_HUMAN	2ZM3A	P08069	981	1285	1367.0	575:60001	Type1	Inactive	DFGin	6.789	15.505	ABAminus	-126.6, 3.02	-143.72, 130.04	-129.16, 19.26	296.34, 90.11	-55.9, -25.14	in-out	in	9.527	Saltbr-out	4.852	HRD-in	-72.76, -50.33	77.45, -5.62	out-in-out	SNCoio	in-out	ActLoopNT-in	3.048	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-118.76, 9.6	APE9-dihe-in	-63.6, 138.6	APE8-dihe-in	-67.76, 134.68	APE8-rot-na	23.16	APE67-dihe-in	-69.69, -0.78	-61.9, -34.84	APE12-dist-na	13.645	APE11-dist-na	9.848	APE10-dist-na	9.225	APE9-dist-in	5.645	None	PTR1161,PTR1165,PTR1166	PTR1161,PTR1165,PTR1166	XRAY	2.5	0.204	0.257	A	308	302	3	0	0	0	[[999, 1268]]	1.0	2zm3	TYR_IGF1R_HUMAN	TYR	1.9e-95	325.0	1	260	260	1152	1153	1154	1156	1158	1033	1050	1054	1132	1134	1133	1135	1194	1182	1177	1176	1175	1174	1173	1172	1171	1080	Insulin-like growth factor 1 receptor
TYR	IGF1R	IGF1R_HUMAN	2ZM3B	P08069	981	1285	1367.0	575:60001	Type1	Inactive	DFGin	6.898	15.542	ABAminus	-122.17, -30.49	-117.45, 117.57	-113.54, 25.96	293.65, 87.06	-63.47, -21.66	in-out	in	9.271	Saltbr-out	4.722	HRD-in	-70.83, -52.07	75.8, -5.9	out-in-out	SNCoio	in-out	ActLoopNT-in	2.903	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-116.67, 22.47	APE9-dihe-in	-72.91, 143.81	APE8-dihe-in	-66.5, 133.93	APE8-rot-na	346.04	APE67-dihe-in	-76.24, -7.5	-59.54, -34.53	APE12-dist-na	13.473	APE11-dist-na	9.742	APE10-dist-na	9.363	APE9-dist-in	5.867	None	PTR1161,PTR1165,PTR1166	PTR1161,PTR1165,PTR1166	XRAY	2.5	0.204	0.257	B	308	298	7	0	0	0	[[999, 1268]]	1.0	2zm3	TYR_IGF1R_HUMAN	TYR	1.9e-95	325.0	1	260	260	1152	1153	1154	1156	1158	1033	1050	1054	1132	1134	1133	1135	1194	1182	1177	1176	1175	1174	1173	1172	1171	1080	Insulin-like growth factor 1 receptor
TYR	IGF1R	IGF1R_HUMAN	2ZM3C	P08069	981	1285	1367.0	575:60001	Type1	Inactive	DFGin	6.947	15.802	ABAminus	-152.06, 34.97	-157.73, 111.59	-117.56, 21.8	294.76, 97.45	-67.22, -1.53	in-out	in	9.294	Saltbr-out	4.566	HRD-in	-77.37, -44.24	69.01, -4.52	out-in-out	SNCoio	in-out	ActLoopNT-in	2.914	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-140.21, 38.41	APE9-dihe-in	-71.06, 141.9	APE8-dihe-in	-59.24, 134.31	APE8-rot-na	17.13	APE67-dihe-in	-70.15, -0.4	-63.02, -34.83	APE12-dist-na	13.912	APE11-dist-na	9.841	APE10-dist-na	10.352	APE9-dist-in	5.839	None	PTR1161,PTR1165,PTR1166	PTR1161,PTR1165,PTR1166	XRAY	2.5	0.204	0.257	C	308	298	7	0	0	0	[[999, 1268]]	1.0	2zm3	TYR_IGF1R_HUMAN	TYR	1.9e-95	325.0	1	260	260	1152	1153	1154	1156	1158	1033	1050	1054	1132	1134	1133	1135	1194	1182	1177	1176	1175	1174	1173	1172	1171	1080	Insulin-like growth factor 1 receptor
TYR	IGF1R	IGF1R_HUMAN	2ZM3D	P08069	981	1285	1367.0	575:60001	Type1	Inactive	DFGin	6.824	15.051	ABAminus	-111.39, -39.63	-105.46, 131.68	-127.13, 27.77	299.55, 96.91	-65.49, -19.62	in-out	in	9.687	Saltbr-out	5.274	HRD-in	-74.05, -49.11	76.32, -10.43	out-in-out	SNCoio	in-out	ActLoopNT-in	2.901	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-119.17, 22.3	APE9-dihe-in	-75.96, 143.16	APE8-dihe-in	-66.16, 129.67	APE8-rot-na	349.87	APE67-dihe-in	-74.71, -7.32	-58.83, -32.73	APE12-dist-na	13.653	APE11-dist-na	9.739	APE10-dist-na	9.3	APE9-dist-in	5.836	None	PTR1161,PTR1165,PTR1166	PTR1161,PTR1165,PTR1166	XRAY	2.5	0.204	0.257	D	308	295	10	0	0	0	[[999, 1268]]	1.0	2zm3	TYR_IGF1R_HUMAN	TYR	1.9e-95	325.0	1	260	260	1152	1153	1154	1156	1158	1033	1050	1054	1132	1134	1133	1135	1194	1182	1177	1176	1175	1174	1173	1172	1171	1080	Insulin-like growth factor 1 receptor

PDB: 2ZM3 — TYR IGF1R_HUMAN

Total number of chains: 4

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	ABAminus	4	100.0%	2ZM3A

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	IGF1R	IGF1R_HUMAN	2ZM3A	P08069	981	1285	1367.0	575:60001	Type1	Inactive	DFGin	6.789	15.505	ABAminus	-126.6, 3.02	-143.72, 130.04	-129.16, 19.26	296.34, 90.11	-55.9, -25.14	in-out	in	9.527	Saltbr-out	4.852	HRD-in	-72.76, -50.33	77.45, -5.62	out-in-out	SNCoio	in-out	ActLoopNT-in	3.048	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-118.76, 9.6	APE9-dihe-in	-63.6, 138.6	APE8-dihe-in	-67.76, 134.68	APE8-rot-na	23.16	APE67-dihe-in	-69.69, -0.78	-61.9, -34.84	APE12-dist-na	13.645	APE11-dist-na	9.848	APE10-dist-na	9.225	APE9-dist-in	5.645	None	PTR1161,PTR1165,PTR1166	PTR1161,PTR1165,PTR1166	XRAY	2.5	0.204	0.257	A	308	302	3	0	0	0	[[999, 1268]]	1.0	2zm3	Homo sapiens	TYR_IGF1R_HUMAN	TYR	1.9e-95	325.0	1	260	260	1152	1153	1154	1156	1158	1033	1050	1054	1132	1134	1133	1135	1194	1182	1177	1176	1175	1174	1173	1172	1171	1080	Insulin-like growth factor 1 receptor
TYR	IGF1R	IGF1R_HUMAN	2ZM3B	P08069	981	1285	1367.0	575:60001	Type1	Inactive	DFGin	6.898	15.542	ABAminus	-122.17, -30.49	-117.45, 117.57	-113.54, 25.96	293.65, 87.06	-63.47, -21.66	in-out	in	9.271	Saltbr-out	4.722	HRD-in	-70.83, -52.07	75.8, -5.9	out-in-out	SNCoio	in-out	ActLoopNT-in	2.903	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-116.67, 22.47	APE9-dihe-in	-72.91, 143.81	APE8-dihe-in	-66.5, 133.93	APE8-rot-na	346.04	APE67-dihe-in	-76.24, -7.5	-59.54, -34.53	APE12-dist-na	13.473	APE11-dist-na	9.742	APE10-dist-na	9.363	APE9-dist-in	5.867	None	PTR1161,PTR1165,PTR1166	PTR1161,PTR1165,PTR1166	XRAY	2.5	0.204	0.257	B	308	298	7	0	0	0	[[999, 1268]]	1.0	2zm3	Homo sapiens	TYR_IGF1R_HUMAN	TYR	1.9e-95	325.0	1	260	260	1152	1153	1154	1156	1158	1033	1050	1054	1132	1134	1133	1135	1194	1182	1177	1176	1175	1174	1173	1172	1171	1080	Insulin-like growth factor 1 receptor
TYR	IGF1R	IGF1R_HUMAN	2ZM3C	P08069	981	1285	1367.0	575:60001	Type1	Inactive	DFGin	6.947	15.802	ABAminus	-152.06, 34.97	-157.73, 111.59	-117.56, 21.8	294.76, 97.45	-67.22, -1.53	in-out	in	9.294	Saltbr-out	4.566	HRD-in	-77.37, -44.24	69.01, -4.52	out-in-out	SNCoio	in-out	ActLoopNT-in	2.914	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-140.21, 38.41	APE9-dihe-in	-71.06, 141.9	APE8-dihe-in	-59.24, 134.31	APE8-rot-na	17.13	APE67-dihe-in	-70.15, -0.4	-63.02, -34.83	APE12-dist-na	13.912	APE11-dist-na	9.841	APE10-dist-na	10.352	APE9-dist-in	5.839	None	PTR1161,PTR1165,PTR1166	PTR1161,PTR1165,PTR1166	XRAY	2.5	0.204	0.257	C	308	298	7	0	0	0	[[999, 1268]]	1.0	2zm3	Homo sapiens	TYR_IGF1R_HUMAN	TYR	1.9e-95	325.0	1	260	260	1152	1153	1154	1156	1158	1033	1050	1054	1132	1134	1133	1135	1194	1182	1177	1176	1175	1174	1173	1172	1171	1080	Insulin-like growth factor 1 receptor
TYR	IGF1R	IGF1R_HUMAN	2ZM3D	P08069	981	1285	1367.0	575:60001	Type1	Inactive	DFGin	6.824	15.051	ABAminus	-111.39, -39.63	-105.46, 131.68	-127.13, 27.77	299.55, 96.91	-65.49, -19.62	in-out	in	9.687	Saltbr-out	5.274	HRD-in	-74.05, -49.11	76.32, -10.43	out-in-out	SNCoio	in-out	ActLoopNT-in	2.901	ActLoopCT-out	TYR	APEdihe_oiiai	APEdist_aaai	APE10-dihe-out	-119.17, 22.3	APE9-dihe-in	-75.96, 143.16	APE8-dihe-in	-66.16, 129.67	APE8-rot-na	349.87	APE67-dihe-in	-74.71, -7.32	-58.83, -32.73	APE12-dist-na	13.653	APE11-dist-na	9.739	APE10-dist-na	9.3	APE9-dist-in	5.836	None	PTR1161,PTR1165,PTR1166	PTR1161,PTR1165,PTR1166	XRAY	2.5	0.204	0.257	D	308	295	10	0	0	0	[[999, 1268]]	1.0	2zm3	Homo sapiens	TYR_IGF1R_HUMAN	TYR	1.9e-95	325.0	1	260	260	1152	1153	1154	1156	1158	1033	1050	1054	1132	1134	1133	1135	1194	1182	1177	1176	1175	1174	1173	1172	1171	1080	Insulin-like growth factor 1 receptor

PDB: 2ZM3 — TYR IGF1R_HUMAN

Total number of chains: 0

Active chains: 0

Total number of genes: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name