PDB: 2OIC — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2OICD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 2OICA Q9NWZ3 163 458 460.0 STU:1 Type1 Active DFGin 7.5415 14.5501 BLAminus -120.17, -157.79 43.1, 78.64 -95.77, 16.12 291.84, 81.73 -52.42, -46.68 in-in in 9.1643 Saltbr-in 2.7447 HRD-in -70.7, -51.8 81.1, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.8301 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 162.72 APE9-dihe-na 127.09, -176.82 APE8-dihe-in -109.75, 123.25 APE8-rot-in 303.17 APE67-dihe-in -63.31, -16.61 -48.06, -48.45 APE12-dist-in 10.1333 APE11-dist-in 11.7238 APE10-dist-in 6.3469 APE9-dist-in 3.4459 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 A 301.0 279.0 17 30 24 6 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICB Q9NWZ3 164 459 460.0 STU:2 Type1 Active DFGin 7.3007 14.318 BLAminus -135.72, -165.01 43.24, 86.39 -100.56, 27.64 301.91, 89.45 -68.65, -40.8 in-in in 8.997 Saltbr-in 3.0216 HRD-in -70.79, -51.12 80.52, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.8485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.84, 167.54 APE9-dihe-na 125.4, -168.64 APE8-dihe-in -121.45, 120.26 APE8-rot-in 302.84 APE67-dihe-in -66.81, -13.26 -49.44, -48.37 APE12-dist-in 10.0934 APE11-dist-in 11.7177 APE10-dist-in 6.031 APE9-dist-in 3.6867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 B 301.0 278.0 18 30 24 6 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.6419 14.5124 BLAminus -134.38, -175.33 55.45, 88.83 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.1756 Saltbr-in 3.2966 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5672 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301.0 280.0 18 30 20 10 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICD Q9NWZ3 161 459 460.0 STU:4 Type1 Active DFGin 6.9643 14.7946 BLAminus -128.12, -176.74 47.11, 78.66 -89.74, 11.31 298.87, 93.52 -54.67, -36.62 in-in in 8.7014 Saltbr-in 2.6141 HRD-in -65.25, -53.17 80.56, 0.44 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 151.9 APE9-dihe-na 143.33, 177.59 APE8-dihe-in -104.02, 127.84 APE8-rot-in 302.2 APE67-dihe-in -61.5, -18.42 -54.54, -50.36 APE12-dist-in 10.5716 APE11-dist-in 11.6739 APE10-dist-in 6.1102 APE9-dist-in 3.4836 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 D 301.0 287.0 12 30 28 2 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 2OIC — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2OICD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 2OICA Q9NWZ3 163 458 460.0 STU:1 Type1 Active DFGin 7.5415 14.5501 BLAminus -120.17, -157.79 43.1, 78.64 -95.77, 16.12 291.84, 81.73 -52.42, -46.68 in-in in 9.1643 Saltbr-in 2.7447 HRD-in -70.7, -51.8 81.1, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.8301 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 162.72 APE9-dihe-na 127.09, -176.82 APE8-dihe-in -109.75, 123.25 APE8-rot-in 303.17 APE67-dihe-in -63.31, -16.61 -48.06, -48.45 APE12-dist-in 10.1333 APE11-dist-in 11.7238 APE10-dist-in 6.3469 APE9-dist-in 3.4459 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 A 301.0 279.0 17 30 24 6 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICB Q9NWZ3 164 459 460.0 STU:2 Type1 Active DFGin 7.3007 14.318 BLAminus -135.72, -165.01 43.24, 86.39 -100.56, 27.64 301.91, 89.45 -68.65, -40.8 in-in in 8.997 Saltbr-in 3.0216 HRD-in -70.79, -51.12 80.52, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.8485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.84, 167.54 APE9-dihe-na 125.4, -168.64 APE8-dihe-in -121.45, 120.26 APE8-rot-in 302.84 APE67-dihe-in -66.81, -13.26 -49.44, -48.37 APE12-dist-in 10.0934 APE11-dist-in 11.7177 APE10-dist-in 6.031 APE9-dist-in 3.6867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 B 301.0 278.0 18 30 24 6 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.6419 14.5124 BLAminus -134.38, -175.33 55.45, 88.83 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.1756 Saltbr-in 3.2966 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.5672 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301.0 280.0 18 30 20 10 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OICD Q9NWZ3 161 459 460.0 STU:4 Type1 Active DFGin 6.9643 14.7946 BLAminus -128.12, -176.74 47.11, 78.66 -89.74, 11.31 298.87, 93.52 -54.67, -36.62 in-in in 8.7014 Saltbr-in 2.6141 HRD-in -65.25, -53.17 80.56, 0.44 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.06, 151.9 APE9-dihe-na 143.33, 177.59 APE8-dihe-in -104.02, 127.84 APE8-rot-in 302.2 APE67-dihe-in -61.5, -18.42 -54.54, -50.36 APE12-dist-in 10.5716 APE11-dist-in 11.6739 APE10-dist-in 6.1102 APE9-dist-in 3.4836 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 D 301.0 287.0 12 30 28 2 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 2OIC — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name