Ligand: ZSB (Zasocitinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 3 100.0% 8S9AA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR TYK2-1 TYK2_HUMAN 8S9AA P29597 577 868 1187.0 ZSB:901 Type1 Pseudo DFGin 7.465 12.783 None -59.49, 156.87 -53.44, 145.49 -73.94, -3.93 28.08, 142.08 71.29, -152.49 in-na in 9.645 Saltbr-na 999.0 HRD-in -80.97, -57.69 81.03, 6.24 na-out-out SNCaoo out-out ActLoopNT-out 8.468 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.12, -39.62 APE9-dihe-out -57.45, -31.53 APE8-dihe-out -85.9, -0.44 APE8-rot-na 294.43 APE67-dihe-out -98.22, 12.4 -65.02, 133.34 APE12-dist-na 9.967 APE11-dist-na 12.285 APE10-dist-na 16.605 APE9-dist-out 11.838 None None None XRAY 1.83 0.186 0.224 A 295 264 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AB P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.549 12.607 None -55.02, 155.39 -55.48, 149.15 -78.11, 1.0 33.17, 138.7 68.16, -152.66 in-na in 9.568 Saltbr-na 999.0 HRD-in -83.23, -60.75 91.28, -0.48 na-out-out SNCaoo out-out ActLoopNT-out 8.591 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.5, -42.74 APE9-dihe-out -57.15, -27.18 APE8-dihe-out -83.95, -1.9 APE8-rot-na 289.14 APE67-dihe-out -98.17, 15.26 -66.86, 137.45 APE12-dist-na 9.96 APE11-dist-na 12.078 APE10-dist-na 16.412 APE9-dist-out 11.895 None None None XRAY 1.83 0.186 0.224 B 295 263 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AC P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.452 12.668 None -61.15, 155.8 -50.19, 148.71 -74.89, -0.44 30.12, 140.82 66.87, -150.05 in-na in 9.655 Saltbr-na 999.0 HRD-in -81.68, -62.05 88.29, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.26 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.23, -43.49 APE9-dihe-out -60.0, -25.56 APE8-dihe-out -89.19, -0.15 APE8-rot-na 289.26 APE67-dihe-out -98.71, 15.21 -67.33, 135.82 APE12-dist-na 9.697 APE11-dist-na 12.309 APE10-dist-na 16.494 APE9-dist-out 11.766 None None None XRAY 1.83 0.186 0.224 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2

Ligand: ZSB (Zasocitinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 3 100.0% 8S9AA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR TYK2-1 TYK2_HUMAN 8S9AA P29597 577 868 1187.0 ZSB:901 Type1 Pseudo DFGin 7.465 12.783 None -59.49, 156.87 -53.44, 145.49 -73.94, -3.93 28.08, 142.08 71.29, -152.49 in-na in 9.645 Saltbr-na 999.0 HRD-in -80.97, -57.69 81.03, 6.24 na-out-out SNCaoo out-out ActLoopNT-out 8.468 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.12, -39.62 APE9-dihe-out -57.45, -31.53 APE8-dihe-out -85.9, -0.44 APE8-rot-na 294.43 APE67-dihe-out -98.22, 12.4 -65.02, 133.34 APE12-dist-na 9.967 APE11-dist-na 12.285 APE10-dist-na 16.605 APE9-dist-out 11.838 None None None XRAY 1.83 0.186 0.224 A 295 264 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AB P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.549 12.607 None -55.02, 155.39 -55.48, 149.15 -78.11, 1.0 33.17, 138.7 68.16, -152.66 in-na in 9.568 Saltbr-na 999.0 HRD-in -83.23, -60.75 91.28, -0.48 na-out-out SNCaoo out-out ActLoopNT-out 8.591 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.5, -42.74 APE9-dihe-out -57.15, -27.18 APE8-dihe-out -83.95, -1.9 APE8-rot-na 289.14 APE67-dihe-out -98.17, 15.26 -66.86, 137.45 APE12-dist-na 9.96 APE11-dist-na 12.078 APE10-dist-na 16.412 APE9-dist-out 11.895 None None None XRAY 1.83 0.186 0.224 B 295 263 28 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S9AC P29597 578 867 1187.0 ZSB:901 Type1 Pseudo DFGin 7.452 12.668 None -61.15, 155.8 -50.19, 148.71 -74.89, -0.44 30.12, 140.82 66.87, -150.05 in-na in 9.655 Saltbr-na 999.0 HRD-in -81.68, -62.05 88.29, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.26 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.23, -43.49 APE9-dihe-out -60.0, -25.56 APE8-dihe-out -89.19, -0.15 APE8-rot-na 289.26 APE67-dihe-out -98.71, 15.21 -67.33, 135.82 APE12-dist-na 9.697 APE11-dist-na 12.309 APE10-dist-na 16.494 APE9-dist-out 11.766 None None None XRAY 1.83 0.186 0.224 C 295 261 30 0 0 0 [[589, 868], [897, 1171]] 2.0 8s9a Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2 260 259 758 759 760 762 764 642 658 662 731 733 732 734 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2

Ligand: ZSB (Zasocitinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name