Ligand: XA4

Total number of chains: 5
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 2 40.0% 7KY0D
DFGin BLAminus 1 20.0% 7KXZA
DFGin BLBplus 1 20.0% 7KY0A
DFGin None 1 20.0% 7KY0C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 7KXZA P00533 696 1017 1210.0 XA4:1102 Type1 Active DFGin 5.9204 14.5875 BLAminus -136.31, -168.83 60.33, 83.14 -97.98, 27.21 293.22, 85.75 -65.75, -18.76 in-in in 8.5433 Saltbr-in 2.4743 HRD-in -75.7, -47.88 69.93, 6.54 in-in-in SNCiii in-in ActLoopNT-in 2.9286 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.33, 134.32 APE9-dihe-in -142.53, 141.1 APE8-dihe-in -75.24, 95.2 APE8-rot-na 20.58 APE67-dihe-in -77.94, 1.68 -59.99, -41.31 APE12-dist-na 12.2524 APE11-dist-na 10.145 APE10-dist-na 10.5334 APE9-dist-in 6.6494 None None None XRAY 2.4 0.191 0.219 A 331.0 299.0 4 30 30 0 [[712, 970]] 1.0 7kxz TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0A P00533 701 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.9335 13.7201 BLBplus -141.11, -177.29 64.89, 51.57 -115.71, 120.75 54.84, 96.01 152.25, 35.37 out-out out 13.4852 Saltbr-out 12.2123 HRD-in -66.11, -56.54 81.78, -10.06 out-out-none SNCoon out-none ActLoopNT-out 8.6441 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.15 APE8-dihe-in -82.92, 73.8 APE8-rot-na 32.47 APE67-dihe-in -76.16, -2.99 -59.22, -41.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7332 T790M,V948R None None XRAY 3.1 0.24 0.292 A 331.0 288.0 14 30 16 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0B P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.2439 15.4394 BLBtrans -160.57, 176.1 77.66, 59.27 -115.51, 105.39 132.91, 62.63 158.65, 57.76 out-out out 13.2955 Saltbr-out 10.451 HRD-in -69.02, -53.59 81.26, -3.78 out-out-out SNCooo out-out ActLoopNT-out 9.2811 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.26 APE8-dihe-in -79.51, 75.82 APE8-rot-na 31.83 APE67-dihe-in -75.32, -0.28 -59.99, -39.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2692 T790M,V948R None None XRAY 3.1 0.24 0.292 B 331.0 285.0 20 30 16 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0D P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.302 15.4796 BLBtrans -138.98, -176.35 58.31, 55.74 -112.38, 119.92 126.22, 87.9 141.73, 45.73 out-out out 13.3418 Saltbr-out 11.5543 HRD-in -67.33, -55.84 83.95, -5.94 out-out-none SNCoon out-none ActLoopNT-out 9.1009 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.65 APE8-dihe-in -83.77, 71.98 APE8-rot-na 32.22 APE67-dihe-in -72.87, -2.69 -55.69, -38.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5111 T790M,V948R None None XRAY 3.1 0.24 0.292 D 331.0 294.0 14 30 16 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0C P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 5.7951 16.2132 None -140.43, -171.69 57.16, 56.26 -102.57, 14.47 175.77, 70.43 -64.23, -166.18 out-out out 13.304 Saltbr-out 13.7106 HRD-in -68.5, -58.2 83.04, -5.79 out-out-none SNCoon out-none ActLoopNT-out 7.9551 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.7 APE8-dihe-in -78.4, 79.01 APE8-rot-na 31.55 APE67-dihe-in -75.24, -1.85 -59.7, -43.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5896 T790M,V948R None None XRAY 3.1 0.24 0.292 C 331.0 289.0 19 30 16 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: XA4

Total number of chains: 5
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBtrans 2 40.0% 7KY0D
DFGin BLAminus 1 20.0% 7KXZA
DFGin BLBplus 1 20.0% 7KY0A
DFGin None 1 20.0% 7KY0C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 7KXZA P00533 696 1017 1210.0 XA4:1102 Type1 Active DFGin 5.9204 14.5875 BLAminus -136.31, -168.83 60.33, 83.14 -97.98, 27.21 293.22, 85.75 -65.75, -18.76 in-in in 8.5433 Saltbr-in 2.4743 HRD-in -75.7, -47.88 69.93, 6.54 in-in-in SNCiii in-in ActLoopNT-in 2.9286 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.33, 134.32 APE9-dihe-in -142.53, 141.1 APE8-dihe-in -75.24, 95.2 APE8-rot-na 20.58 APE67-dihe-in -77.94, 1.68 -59.99, -41.31 APE12-dist-na 12.2524 APE11-dist-na 10.145 APE10-dist-na 10.5334 APE9-dist-in 6.6494 None None None XRAY 2.4 0.191 0.219 A 331.0 299.0 4 30 30 0 [[712, 970]] 1.0 7kxz Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0A P00533 701 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.9335 13.7201 BLBplus -141.11, -177.29 64.89, 51.57 -115.71, 120.75 54.84, 96.01 152.25, 35.37 out-out out 13.4852 Saltbr-out 12.2123 HRD-in -66.11, -56.54 81.78, -10.06 out-out-none SNCoon out-none ActLoopNT-out 8.6441 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.15 APE8-dihe-in -82.92, 73.8 APE8-rot-na 32.47 APE67-dihe-in -76.16, -2.99 -59.22, -41.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7332 T790M,V948R None None XRAY 3.1 0.24 0.292 A 331.0 288.0 14 30 16 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0B P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.2439 15.4394 BLBtrans -160.57, 176.1 77.66, 59.27 -115.51, 105.39 132.91, 62.63 158.65, 57.76 out-out out 13.2955 Saltbr-out 10.451 HRD-in -69.02, -53.59 81.26, -3.78 out-out-out SNCooo out-out ActLoopNT-out 9.2811 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.26 APE8-dihe-in -79.51, 75.82 APE8-rot-na 31.83 APE67-dihe-in -75.32, -0.28 -59.99, -39.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2692 T790M,V948R None None XRAY 3.1 0.24 0.292 B 331.0 285.0 20 30 16 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0D P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.302 15.4796 BLBtrans -138.98, -176.35 58.31, 55.74 -112.38, 119.92 126.22, 87.9 141.73, 45.73 out-out out 13.3418 Saltbr-out 11.5543 HRD-in -67.33, -55.84 83.95, -5.94 out-out-none SNCoon out-none ActLoopNT-out 9.1009 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.65 APE8-dihe-in -83.77, 71.98 APE8-rot-na 32.22 APE67-dihe-in -72.87, -2.69 -55.69, -38.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5111 T790M,V948R None None XRAY 3.1 0.24 0.292 D 331.0 294.0 14 30 16 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0C P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 5.7951 16.2132 None -140.43, -171.69 57.16, 56.26 -102.57, 14.47 175.77, 70.43 -64.23, -166.18 out-out out 13.304 Saltbr-out 13.7106 HRD-in -68.5, -58.2 83.04, -5.79 out-out-none SNCoon out-none ActLoopNT-out 7.9551 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.7 APE8-dihe-in -78.4, 79.01 APE8-rot-na 31.55 APE67-dihe-in -75.24, -1.85 -59.7, -43.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5896 T790M,V948R None None XRAY 3.1 0.24 0.292 C 331.0 289.0 19 30 16 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: XA4

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name