Ligand: XA4

Total number of chains: 6
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% 9GHTA
DFGin BLBtrans 2 33.3% 7KY0D
DFGin BLBplus 1 16.7% 7KY0A
DFGin None 1 16.7% 7KY0C
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 7KXZA P00533 696 1017 1210.0 XA4:1102 Type1 Active DFGin 5.92 14.588 BLAminus DFGAsp-rot-in -136.31, -168.83 60.33, 83.14 195.64, -15.93 -97.98, 27.21 293.22, 85.75 -65.75, -18.76 in-in in 8.543 Saltbr-in 2.474 HRD-in -75.7, -47.88 69.93, 6.54 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -55.33, 134.32 APE9-dihe-in -142.53, 141.1 APE8-dihe-in -75.24, 95.2 APE8-rot-na 20.58 APE67-dihe-in -77.94, 1.68 -59.99, -41.31 APE12-dist-na 12.252 APE11-dist-na 10.145 APE10-dist-na 10.533 APE9-dist-na 6.649 None None None XRAY 2.4 0.191 0.219 A 331 299 4 0 0 0 [[712, 970]] 1.0 7kxz TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9GHTA P00533 697 1019 1210.0 XA4:1101 Type1 Active DFGin 5.754 14.138 BLAminus DFGAsp-rot-in -148.6072, -166.4841 59.6524, 84.1142 196.6498, -21.0078 -100.3379, 30.2422 294.6079, 94.0275 -65.1607, -28.1663 in-in in 8.325 Saltbr-in 2.568 HRD-in -71.1198, -49.8305 69.3307, 3.3075 in-in-in SNCiii in-in ActLoopNT-in 3.016 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -62.9009, 128.9331 APE9-dihe-in -155.2994, 137.627 APE8-dihe-in -72.992, 117.3146 APE8-rot-na 347.9419 APE67-dihe-in -72.6169, -6.7971 -69.3657, -41.8045 APE12-dist-na 12.238 APE11-dist-na 9.926 APE10-dist-na 10.381 APE9-dist-na 6.344 None None None XRAY 2.6 0.2 0.237 A 333 300 3 0 0 0 [[712, 970]] 1.0 9ght TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0A P00533 701 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.934 13.72 BLBplus DFGAsp-rot-in -141.11, -177.29 64.89, 51.57 201.59, 25.05 -115.71, 120.75 54.84, 96.01 152.25, 35.37 out-out out 13.485 Saltbr-out 12.212 HRD-in -66.11, -56.54 81.78, -10.06 out-out-none SNCoon out-none ActLoopNT-out 8.644 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.15 APE8-dihe-in -82.92, 73.8 APE8-rot-na 32.47 APE67-dihe-in -76.16, -2.99 -59.22, -41.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.733 T790M,V948R None None XRAY 3.1 0.24 0.292 A 331 288 14 0 0 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0B P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.244 15.439 BLBtrans DFGAsp-rot-in -160.57, 176.1 77.66, 59.27 199.12, 2.09 -115.51, 105.39 132.91, 62.63 158.65, 57.76 out-out out 13.296 Saltbr-out 10.451 HRD-in -69.02, -53.59 81.26, -3.78 out-out-none SNCoon out-none ActLoopNT-out 9.281 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.26 APE8-dihe-in -79.51, 75.82 APE8-rot-na 31.83 APE67-dihe-in -75.32, -0.28 -59.99, -39.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.269 T790M,V948R None None XRAY 3.1 0.24 0.292 B 331 285 20 0 0 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0D P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.302 15.48 BLBtrans DFGAsp-rot-in -138.98, -176.35 58.31, 55.74 200.52, 71.4 -112.38, 119.92 126.22, 87.9 141.73, 45.73 out-out out 13.342 Saltbr-out 11.554 HRD-in -67.33, -55.84 83.95, -5.94 out-out-none SNCoon out-none ActLoopNT-out 9.101 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.65 APE8-dihe-in -83.77, 71.98 APE8-rot-na 32.22 APE67-dihe-in -72.87, -2.69 -55.69, -38.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.511 T790M,V948R None None XRAY 3.1 0.24 0.292 D 331 294 14 0 0 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0C P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 5.795 16.213 None DFGAsp-rot-in -140.43, -171.69 57.16, 56.26 202.9, 15.53 -102.57, 14.47 175.77, 70.43 -64.23, -166.18 out-out out 13.304 Saltbr-out 13.711 HRD-in -68.5, -58.2 83.04, -5.79 out-out-none SNCoon out-none ActLoopNT-out 7.955 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.7 APE8-dihe-in -78.4, 79.01 APE8-rot-na 31.55 APE67-dihe-in -75.24, -1.85 -59.7, -43.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.59 T790M,V948R None None XRAY 3.1 0.24 0.292 C 331 289 19 0 0 14 [[712, 970]] 1.0 7ky0 TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: XA4

Total number of chains: 6
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% 9GHTA
DFGin BLBtrans 2 33.3% 7KY0D
DFGin BLBplus 1 16.7% 7KY0A
DFGin None 1 16.7% 7KY0C
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 7KXZA P00533 696 1017 1210.0 XA4:1102 Type1 Active DFGin 5.92 14.588 BLAminus DFGAsp-rot-in -136.31, -168.83 60.33, 83.14 195.64, -15.93 -97.98, 27.21 293.22, 85.75 -65.75, -18.76 in-in in 8.543 Saltbr-in 2.474 HRD-in -75.7, -47.88 69.93, 6.54 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -55.33, 134.32 APE9-dihe-in -142.53, 141.1 APE8-dihe-in -75.24, 95.2 APE8-rot-na 20.58 APE67-dihe-in -77.94, 1.68 -59.99, -41.31 APE12-dist-na 12.252 APE11-dist-na 10.145 APE10-dist-na 10.533 APE9-dist-na 6.649 None None None XRAY 2.4 0.191 0.219 A 331 299 4 0 0 0 [[712, 970]] 1.0 7kxz Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9GHTA P00533 697 1019 1210.0 XA4:1101 Type1 Active DFGin 5.754 14.138 BLAminus DFGAsp-rot-in -148.6072, -166.4841 59.6524, 84.1142 196.6498, -21.0078 -100.3379, 30.2422 294.6079, 94.0275 -65.1607, -28.1663 in-in in 8.325 Saltbr-in 2.568 HRD-in -71.1198, -49.8305 69.3307, 3.3075 in-in-in SNCiii in-in ActLoopNT-in 3.016 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -62.9009, 128.9331 APE9-dihe-in -155.2994, 137.627 APE8-dihe-in -72.992, 117.3146 APE8-rot-na 347.9419 APE67-dihe-in -72.6169, -6.7971 -69.3657, -41.8045 APE12-dist-na 12.238 APE11-dist-na 9.926 APE10-dist-na 10.381 APE9-dist-na 6.344 None None None XRAY 2.6 0.2 0.237 A 333 300 3 0 0 0 [[712, 970]] 1.0 9ght Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0A P00533 701 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.934 13.72 BLBplus DFGAsp-rot-in -141.11, -177.29 64.89, 51.57 201.59, 25.05 -115.71, 120.75 54.84, 96.01 152.25, 35.37 out-out out 13.485 Saltbr-out 12.212 HRD-in -66.11, -56.54 81.78, -10.06 out-out-none SNCoon out-none ActLoopNT-out 8.644 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.15 APE8-dihe-in -82.92, 73.8 APE8-rot-na 32.47 APE67-dihe-in -76.16, -2.99 -59.22, -41.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.733 T790M,V948R None None XRAY 3.1 0.24 0.292 A 331 288 14 0 0 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0B P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.244 15.439 BLBtrans DFGAsp-rot-in -160.57, 176.1 77.66, 59.27 199.12, 2.09 -115.51, 105.39 132.91, 62.63 158.65, 57.76 out-out out 13.296 Saltbr-out 10.451 HRD-in -69.02, -53.59 81.26, -3.78 out-out-none SNCoon out-none ActLoopNT-out 9.281 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.26 APE8-dihe-in -79.51, 75.82 APE8-rot-na 31.83 APE67-dihe-in -75.32, -0.28 -59.99, -39.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.269 T790M,V948R None None XRAY 3.1 0.24 0.292 B 331 285 20 0 0 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0D P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 4.302 15.48 BLBtrans DFGAsp-rot-in -138.98, -176.35 58.31, 55.74 200.52, 71.4 -112.38, 119.92 126.22, 87.9 141.73, 45.73 out-out out 13.342 Saltbr-out 11.554 HRD-in -67.33, -55.84 83.95, -5.94 out-out-none SNCoon out-none ActLoopNT-out 9.101 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.65 APE8-dihe-in -83.77, 71.98 APE8-rot-na 32.22 APE67-dihe-in -72.87, -2.69 -55.69, -38.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.511 T790M,V948R None None XRAY 3.1 0.24 0.292 D 331 294 14 0 0 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7KY0C P00533 700 1007 1210.0 XA4:1101 Type1 Inactive DFGin 5.795 16.213 None DFGAsp-rot-in -140.43, -171.69 57.16, 56.26 202.9, 15.53 -102.57, 14.47 175.77, 70.43 -64.23, -166.18 out-out out 13.304 Saltbr-out 13.711 HRD-in -68.5, -58.2 83.04, -5.79 out-out-none SNCoon out-none ActLoopNT-out 7.955 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.7 APE8-dihe-in -78.4, 79.01 APE8-rot-na 31.55 APE67-dihe-in -75.24, -1.85 -59.7, -43.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.59 T790M,V948R None None XRAY 3.1 0.24 0.292 C 331 289 19 0 0 14 [[712, 970]] 1.0 7ky0 Homo sapiens TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: XA4

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name