Ligand: TAK

Total number of chains: 9
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 66.7% 3Q4TA
DFGin None 2 22.2% 7JHGA
None None 1 11.1% 3AQVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK MELK MELK_HUMAN 6GVXA Q14680 1 333 651.0 TAK:60402 Type1 None DFGin 6.711 15.2598 BLAminus -125.4, 178.58 58.73, 78.31 -98.95, 27.88 285.76, 76.62 -69.49, -24.6 in-in in 9.0037 Saltbr-in 2.9077 HRD-in -62.31, -45.72 65.24, 14.32 in-in-none SNCiin in-none ActLoopNT-in 2.8688 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -86.88 APE9-dihe-na -85.92, -154.54 APE8-dihe-in -73.43, 134.24 APE8-rot-in 297.0 APE67-dihe-in -62.55, -20.46 -61.75, -38.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.5188 APE9-dist-in 4.4863 None None None XRAY 2.24 0.205 0.24 A 344.0 311.0 15 29 22 7 [[11, 263]] 1.0 6gvx CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 6GVXB Q14680 1 335 651.0 TAK:60402 Type1 Inactive DFGin 6.7539 15.4942 BLAminus -124.69, 179.93 57.83, 81.5 -101.39, 28.11 283.05, 78.99 -70.11, -31.83 in-in in 9.0647 Saltbr-in 2.472 HRD-in -64.06, -46.18 61.47, 17.03 in-in-out SNCiio in-out ActLoopNT-in 2.8564 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -127.94 APE8-dihe-in -66.05, 131.75 APE8-rot-out 178.58 APE67-dihe-in -65.84, -20.47 -62.83, -40.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.407 None None None XRAY 2.24 0.205 0.24 B 344.0 315.0 20 29 17 12 [[11, 263]] 1.0 6gvx CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PRKAA1 AAPK1_HUMAN 7JHGA Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 3.9583 12.3851 None -75.55, -57.95 -128.11, 115.65 -75.63, -58.59 53.99, 94.22 -113.12, -1.21 out-out out 12.413 Saltbr-out 12.2756 HRD-out -118.93, 87.19 -68.87, -35.95 out-out-out SNCooo out-out ActLoopNT-out 5.7547 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.04, -42.27 APE9-dihe-na -68.52, -40.55 APE8-dihe-in -128.24, 81.11 APE8-rot-out 178.77 APE67-dihe-in -67.22, -49.66 -68.38, -37.04 APE12-dist-in 12.5847 APE11-dist-out 17.7613 APE10-dist-out 17.9846 APE9-dist-out 11.2385 None None None EM 3.47 999.0 999.0 A 484.0 380.0 0 27 27 0 [[27, 279]] 1.0 7jhg CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 7M74A Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 4.8105 13.2336 None -76.76, -62.2 -122.49, 107.13 -85.46, -38.34 61.13, 92.05 -117.4, -4.69 out-out out 13.6955 Saltbr-out 11.2388 HRD-out -115.45, 89.03 -69.29, -34.6 out-out-out SNCooo out-out ActLoopNT-out 5.6069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -77.56, -39.26 APE9-dihe-na -72.79, -36.52 APE8-dihe-in -124.27, 83.8 APE8-rot-out 178.33 APE67-dihe-in -73.53, -46.6 -74.47, -34.26 APE12-dist-in 12.8577 APE11-dist-out 17.936 APE10-dist-out 18.1451 APE9-dist-out 11.1081 None None None EM 3.93 999.0 999.0 A 484.0 380.0 0 27 27 0 [[27, 279]] 1.0 7m74 CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 3AQVA P54646 7 279 552.0 TAK:1 Type1 Inactive None 11.4178 16.606 None -77.64, 137.51 -58.36, 143.4 -127.83, 21.4 46.24, 88.73 -78.74, -145.72 out-out out 11.2516 Saltbr-out 5.1804 HRD-out -77.57, 129.2 -132.8, 160.46 out-out-none SNCoon out-none ActLoopNT-out 11.2812 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.84, 102.31 999.0, -56.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T172D None None XRAY 2.08 0.224 0.281 A 276.0 267.0 6 27 21 6 [[16, 268]] 1.0 3aqv CAMK_PRKAA2_HUMAN CAMK 3.3e-90 307.8 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
TKL ACVR1 ACVR1_HUMAN 3H9RA Q04771 172 499 509.0 TAK:1 Type1 Inactive DFGin 7.5175 13.0138 BLAminus -122.25, 172.9 70.66, 76.36 -93.47, 23.87 309.45, 171.73 -63.2, -18.75 in-out in 8.4509 Saltbr-out 4.4252 HRD-in -86.19, -50.58 71.93, 4.62 out-in-out SNCoio in-out ActLoopNT-in 2.9547 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -141.78, 171.85 APE9-dihe-na -47.59, 161.63 APE8-dihe-in -64.93, 129.41 APE8-rot-in 303.28 APE67-dihe-in -52.25, -29.45 -62.04, -44.48 APE12-dist-none 999.0 APE11-dist-out 6.9532 APE10-dist-out 8.6688 APE9-dist-in 3.7133 None None None XRAY 2.35 0.187 0.256 A 330.0 312.0 16 32 19 13 [[207, 497]] 1.0 3h9r TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 4C02A Q04771 178 499 509.0 TAK:1507 Type1 Inactive DFGin 7.5278 12.9432 BLAminus -123.21, 176.23 69.71, 70.69 -93.29, 15.04 304.56, 179.92 -66.52, -15.92 in-out in 8.6896 Saltbr-out 4.6675 HRD-in -78.82, -50.72 79.56, 2.7 out-in-in SNCoii in-in ActLoopNT-in 2.9175 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.38, -27.16 APE9-dihe-na -78.85, -155.95 APE8-dihe-in -85.96, 128.83 APE8-rot-in 303.97 APE67-dihe-in -57.18, -27.24 -62.7, -42.91 APE12-dist-in 12.2934 APE11-dist-in 12.1337 APE10-dist-in 6.1885 APE9-dist-in 3.5972 None None None XRAY 2.17 0.178 0.198 A 330.0 313.0 5 32 29 3 [[207, 497]] 1.0 4c02 TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR2A AVR2A_HUMAN 3Q4TA P27037 191 484 513.0 TAK:60002 Type1 Inactive DFGin 7.5736 14.0966 BLAminus -123.56, 165.6 68.53, 85.67 -104.01, 23.68 300.6, 98.11 -61.19, -27.21 in-in in 8.2168 Saltbr-in 2.797 HRD-in -88.26, -44.7 74.99, 6.75 in-in-out SNCiio in-out ActLoopNT-in 2.8743 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.25, 165.71 APE9-dihe-na -78.55, -169.19 APE8-dihe-in -70.65, 121.11 APE8-rot-in 308.48 APE67-dihe-in -46.78, -36.2 -40.9, -55.96 APE12-dist-in 10.3422 APE11-dist-out 6.2827 APE10-dist-out 8.8817 APE9-dist-in 3.5295 None None None XRAY 1.96 0.171 0.223 A 322.0 294.0 0 30 30 0 [[192, 481]] 1.0 3q4t TKL_ACVR2A_HUMAN TKL 3.5e-83 285.1 2.0 266.0 265.0 339 340 341 343 345 219 232 236 319 321 320 322.0 386 369 364 363 362 361 360 359 358 268 Activin receptor type-2A
TKL ACVR2A AVR2A_HUMAN 3Q4TB P27037 191 485 513.0 TAK:60001 Type1 Active DFGin 7.5844 13.7734 BLAminus -128.74, 167.36 69.0, 93.18 -108.05, 19.83 304.44, 108.16 -60.68, -27.36 in-in in 8.091 Saltbr-in 2.7887 HRD-in -87.27, -46.41 76.78, -1.51 in-in-in SNCiii in-in ActLoopNT-in 2.8357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.89, -26.02 APE9-dihe-na -85.65, -161.16 APE8-dihe-in -82.47, 131.09 APE8-rot-in 297.46 APE67-dihe-in -64.09, -26.22 -62.33, -41.13 APE12-dist-in 10.9477 APE11-dist-in 12.4473 APE10-dist-in 6.4709 APE9-dist-in 3.4539 None None None XRAY 1.96 0.171 0.223 B 322.0 293.0 2 30 28 2 [[192, 481]] 1.0 3q4t TKL_ACVR2A_HUMAN TKL 3.5e-83 285.1 2.0 266.0 265.0 339 340 341 343 345 219 232 236 319 321 320 322.0 386 369 364 363 362 361 360 359 358 268 Activin receptor type-2A

Ligand: TAK

Total number of chains: 9
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 66.7% 3Q4TA
DFGin None 2 22.2% 7JHGA
None None 1 11.1% 3AQVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK MELK MELK_HUMAN 6GVXA Q14680 1 333 651.0 TAK:60402 Type1 None DFGin 6.711 15.2598 BLAminus -125.4, 178.58 58.73, 78.31 -98.95, 27.88 285.76, 76.62 -69.49, -24.6 in-in in 9.0037 Saltbr-in 2.9077 HRD-in -62.31, -45.72 65.24, 14.32 in-in-none SNCiin in-none ActLoopNT-in 2.8688 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -86.88 APE9-dihe-na -85.92, -154.54 APE8-dihe-in -73.43, 134.24 APE8-rot-in 297.0 APE67-dihe-in -62.55, -20.46 -61.75, -38.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.5188 APE9-dist-in 4.4863 None None None XRAY 2.24 0.205 0.24 A 344.0 311.0 15 29 22 7 [[11, 263]] 1.0 6gvx Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 6GVXB Q14680 1 335 651.0 TAK:60402 Type1 Inactive DFGin 6.7539 15.4942 BLAminus -124.69, 179.93 57.83, 81.5 -101.39, 28.11 283.05, 78.99 -70.11, -31.83 in-in in 9.0647 Saltbr-in 2.472 HRD-in -64.06, -46.18 61.47, 17.03 in-in-out SNCiio in-out ActLoopNT-in 2.8564 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -127.94 APE8-dihe-in -66.05, 131.75 APE8-rot-out 178.58 APE67-dihe-in -65.84, -20.47 -62.83, -40.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.407 None None None XRAY 2.24 0.205 0.24 B 344.0 315.0 20 29 17 12 [[11, 263]] 1.0 6gvx Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PRKAA1 AAPK1_HUMAN 7JHGA Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 3.9583 12.3851 None -75.55, -57.95 -128.11, 115.65 -75.63, -58.59 53.99, 94.22 -113.12, -1.21 out-out out 12.413 Saltbr-out 12.2756 HRD-out -118.93, 87.19 -68.87, -35.95 out-out-out SNCooo out-out ActLoopNT-out 5.7547 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -71.04, -42.27 APE9-dihe-na -68.52, -40.55 APE8-dihe-in -128.24, 81.11 APE8-rot-out 178.77 APE67-dihe-in -67.22, -49.66 -68.38, -37.04 APE12-dist-in 12.5847 APE11-dist-out 17.7613 APE10-dist-out 17.9846 APE9-dist-out 11.2385 None None None EM 3.47 999.0 999.0 A 484.0 380.0 0 27 27 0 [[27, 279]] 1.0 7jhg Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 7M74A Q13131 22 559 559.0 TAK:60601 Type1 Inactive DFGin 4.8105 13.2336 None -76.76, -62.2 -122.49, 107.13 -85.46, -38.34 61.13, 92.05 -117.4, -4.69 out-out out 13.6955 Saltbr-out 11.2388 HRD-out -115.45, 89.03 -69.29, -34.6 out-out-out SNCooo out-out ActLoopNT-out 5.6069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -77.56, -39.26 APE9-dihe-na -72.79, -36.52 APE8-dihe-in -124.27, 83.8 APE8-rot-out 178.33 APE67-dihe-in -73.53, -46.6 -74.47, -34.26 APE12-dist-in 12.8577 APE11-dist-out 17.936 APE10-dist-out 18.1451 APE9-dist-out 11.1081 None None None EM 3.93 999.0 999.0 A 484.0 380.0 0 27 27 0 [[27, 279]] 1.0 7m74 Homo sapiens CAMK_PRKAA1_HUMAN CAMK 3.5e-89 304.7 1.0 256.0 256.0 167 168 169 171 173 56 75 79 147 149 148 150.0 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA2 AAPK2_HUMAN 3AQVA P54646 7 279 552.0 TAK:1 Type1 Inactive None 11.4178 16.606 None -77.64, 137.51 -58.36, 143.4 -127.83, 21.4 46.24, 88.73 -78.74, -145.72 out-out out 11.2516 Saltbr-out 5.1804 HRD-out -77.57, 129.2 -132.8, 160.46 out-out-none SNCoon out-none ActLoopNT-out 11.2812 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.84, 102.31 999.0, -56.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T172D None None XRAY 2.08 0.224 0.281 A 276.0 267.0 6 27 21 6 [[16, 268]] 1.0 3aqv Homo sapiens CAMK_PRKAA2_HUMAN CAMK 3.3e-90 307.8 1.0 256.0 256.0 156 157 158 160 162 45 64 68 136 138 137 139.0 196 183 178 177 176 175 174 173 172 94 5'-AMP-activated protein kinase catalytic subunit alpha-2
TKL ACVR1 ACVR1_HUMAN 3H9RA Q04771 172 499 509.0 TAK:1 Type1 Inactive DFGin 7.5175 13.0138 BLAminus -122.25, 172.9 70.66, 76.36 -93.47, 23.87 309.45, 171.73 -63.2, -18.75 in-out in 8.4509 Saltbr-out 4.4252 HRD-in -86.19, -50.58 71.93, 4.62 out-in-out SNCoio in-out ActLoopNT-in 2.9547 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -141.78, 171.85 APE9-dihe-na -47.59, 161.63 APE8-dihe-in -64.93, 129.41 APE8-rot-in 303.28 APE67-dihe-in -52.25, -29.45 -62.04, -44.48 APE12-dist-none 999.0 APE11-dist-out 6.9532 APE10-dist-out 8.6688 APE9-dist-in 3.7133 None None None XRAY 2.35 0.187 0.256 A 330.0 312.0 16 32 19 13 [[207, 497]] 1.0 3h9r Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 4C02A Q04771 178 499 509.0 TAK:1507 Type1 Inactive DFGin 7.5278 12.9432 BLAminus -123.21, 176.23 69.71, 70.69 -93.29, 15.04 304.56, 179.92 -66.52, -15.92 in-out in 8.6896 Saltbr-out 4.6675 HRD-in -78.82, -50.72 79.56, 2.7 out-in-in SNCoii in-in ActLoopNT-in 2.9175 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.38, -27.16 APE9-dihe-na -78.85, -155.95 APE8-dihe-in -85.96, 128.83 APE8-rot-in 303.97 APE67-dihe-in -57.18, -27.24 -62.7, -42.91 APE12-dist-in 12.2934 APE11-dist-in 12.1337 APE10-dist-in 6.1885 APE9-dist-in 3.5972 None None None XRAY 2.17 0.178 0.198 A 330.0 313.0 5 32 29 3 [[207, 497]] 1.0 4c02 Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR2A AVR2A_HUMAN 3Q4TA P27037 191 484 513.0 TAK:60002 Type1 Inactive DFGin 7.5736 14.0966 BLAminus -123.56, 165.6 68.53, 85.67 -104.01, 23.68 300.6, 98.11 -61.19, -27.21 in-in in 8.2168 Saltbr-in 2.797 HRD-in -88.26, -44.7 74.99, 6.75 in-in-out SNCiio in-out ActLoopNT-in 2.8743 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -135.25, 165.71 APE9-dihe-na -78.55, -169.19 APE8-dihe-in -70.65, 121.11 APE8-rot-in 308.48 APE67-dihe-in -46.78, -36.2 -40.9, -55.96 APE12-dist-in 10.3422 APE11-dist-out 6.2827 APE10-dist-out 8.8817 APE9-dist-in 3.5295 None None None XRAY 1.96 0.171 0.223 A 322.0 294.0 0 30 30 0 [[192, 481]] 1.0 3q4t Homo sapiens TKL_ACVR2A_HUMAN TKL 3.5e-83 285.1 2.0 266.0 265.0 339 340 341 343 345 219 232 236 319 321 320 322.0 386 369 364 363 362 361 360 359 358 268 Activin receptor type-2A
TKL ACVR2A AVR2A_HUMAN 3Q4TB P27037 191 485 513.0 TAK:60001 Type1 Active DFGin 7.5844 13.7734 BLAminus -128.74, 167.36 69.0, 93.18 -108.05, 19.83 304.44, 108.16 -60.68, -27.36 in-in in 8.091 Saltbr-in 2.7887 HRD-in -87.27, -46.41 76.78, -1.51 in-in-in SNCiii in-in ActLoopNT-in 2.8357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.89, -26.02 APE9-dihe-na -85.65, -161.16 APE8-dihe-in -82.47, 131.09 APE8-rot-in 297.46 APE67-dihe-in -64.09, -26.22 -62.33, -41.13 APE12-dist-in 10.9477 APE11-dist-in 12.4473 APE10-dist-in 6.4709 APE9-dist-in 3.4539 None None None XRAY 1.96 0.171 0.223 B 322.0 293.0 2 30 28 2 [[192, 481]] 1.0 3q4t Homo sapiens TKL_ACVR2A_HUMAN TKL 3.5e-83 285.1 2.0 266.0 265.0 339 340 341 343 345 219 232 236 319 321 320 322.0 386 369 364 363 362 361 360 359 358 268 Activin receptor type-2A

Ligand: TAK

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name