Ligand: T12

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2NRUA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 2NRUA Q9NWZ3 164 458 460.0 T12:600 Type1 Inactive DFGin 6.81 14.207 BLAminus -144.52, 176.61 61.01, 85.78 -109.02, 12.36 305.24, 99.64 -69.12, -13.83 in-out in 8.945 Saltbr-out 4.713 HRD-in -72.42, -46.16 74.2, -6.12 out-in-in SNCoii in-in ActLoopNT-in 2.729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.65, 155.19 APE9-dihe-na 137.29, -171.31 APE8-dihe-in -118.15, 118.79 APE8-rot-in 298.95 APE67-dihe-in -68.17, -16.18 -56.18, -39.45 APE12-dist-in 9.982 APE11-dist-in 12.025 APE10-dist-in 6.356 APE9-dist-in 3.687 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 A 307 295 0 0 0 0 [[183, 456]] 1.0 2nru TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRUB Q9NWZ3 163 458 460.0 T12:601 Type1 Inactive DFGin 6.96 14.211 BLAminus -137.22, 177.45 63.67, 76.5 -99.31, 24.17 313.64, 91.89 -66.38, -18.79 in-out in 8.961 Saltbr-out 4.848 HRD-in -79.32, -50.69 82.23, -1.29 out-in-in SNCoii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.97, 154.3 APE9-dihe-na 141.66, -169.29 APE8-dihe-in -112.44, 117.57 APE8-rot-in 305.42 APE67-dihe-in -56.19, -21.78 -44.47, -53.99 APE12-dist-in 10.087 APE11-dist-in 11.874 APE10-dist-in 6.257 APE9-dist-in 3.788 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 B 307 296 0 0 0 0 [[183, 456]] 1.0 2nru TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRUC Q9NWZ3 164 458 460.0 T12:602 Type1 Inactive DFGin 6.862 14.044 BLAminus -133.27, -178.43 54.04, 81.31 -99.32, 21.09 309.78, 92.94 -44.33, -46.49 in-out in 9.178 Saltbr-out 6.049 HRD-in -65.42, -50.47 80.21, -0.92 out-in-in SNCoii in-in ActLoopNT-in 2.684 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.9, 149.98 APE9-dihe-na 140.03, -170.94 APE8-dihe-in -117.58, 117.62 APE8-rot-in 307.34 APE67-dihe-in -53.9, -13.95 -48.73, -50.48 APE12-dist-in 9.989 APE11-dist-in 11.979 APE10-dist-in 6.176 APE9-dist-in 3.651 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 C 307 295 0 0 0 0 [[183, 456]] 1.0 2nru TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRUD Q9NWZ3 164 458 460.0 T12:603 Type1 Inactive DFGin 6.947 14.098 BLAminus -135.72, 173.17 70.19, 87.19 -107.97, 13.86 307.81, 96.43 -64.39, -20.58 in-out in 9.107 Saltbr-out 4.489 HRD-in -69.73, -51.3 77.25, -2.09 out-in-in SNCoii in-in ActLoopNT-in 2.662 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.08, 159.59 APE9-dihe-na 136.7, -170.84 APE8-dihe-in -116.97, 119.52 APE8-rot-in 299.39 APE67-dihe-in -65.53, -15.07 -56.41, -37.98 APE12-dist-in 9.92 APE11-dist-in 11.855 APE10-dist-in 6.269 APE9-dist-in 3.606 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 D 307 295 0 0 0 0 [[183, 456]] 1.0 2nru TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: T12

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2NRUA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 2NRUA Q9NWZ3 164 458 460.0 T12:600 Type1 Inactive DFGin 6.81 14.207 BLAminus -144.52, 176.61 61.01, 85.78 -109.02, 12.36 305.24, 99.64 -69.12, -13.83 in-out in 8.945 Saltbr-out 4.713 HRD-in -72.42, -46.16 74.2, -6.12 out-in-in SNCoii in-in ActLoopNT-in 2.729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.65, 155.19 APE9-dihe-na 137.29, -171.31 APE8-dihe-in -118.15, 118.79 APE8-rot-in 298.95 APE67-dihe-in -68.17, -16.18 -56.18, -39.45 APE12-dist-in 9.982 APE11-dist-in 12.025 APE10-dist-in 6.356 APE9-dist-in 3.687 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 A 307 295 0 0 0 0 [[183, 456]] 1.0 2nru Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRUB Q9NWZ3 163 458 460.0 T12:601 Type1 Inactive DFGin 6.96 14.211 BLAminus -137.22, 177.45 63.67, 76.5 -99.31, 24.17 313.64, 91.89 -66.38, -18.79 in-out in 8.961 Saltbr-out 4.848 HRD-in -79.32, -50.69 82.23, -1.29 out-in-in SNCoii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.97, 154.3 APE9-dihe-na 141.66, -169.29 APE8-dihe-in -112.44, 117.57 APE8-rot-in 305.42 APE67-dihe-in -56.19, -21.78 -44.47, -53.99 APE12-dist-in 10.087 APE11-dist-in 11.874 APE10-dist-in 6.257 APE9-dist-in 3.788 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 B 307 296 0 0 0 0 [[183, 456]] 1.0 2nru Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRUC Q9NWZ3 164 458 460.0 T12:602 Type1 Inactive DFGin 6.862 14.044 BLAminus -133.27, -178.43 54.04, 81.31 -99.32, 21.09 309.78, 92.94 -44.33, -46.49 in-out in 9.178 Saltbr-out 6.049 HRD-in -65.42, -50.47 80.21, -0.92 out-in-in SNCoii in-in ActLoopNT-in 2.684 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.9, 149.98 APE9-dihe-na 140.03, -170.94 APE8-dihe-in -117.58, 117.62 APE8-rot-in 307.34 APE67-dihe-in -53.9, -13.95 -48.73, -50.48 APE12-dist-in 9.989 APE11-dist-in 11.979 APE10-dist-in 6.176 APE9-dist-in 3.651 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 C 307 295 0 0 0 0 [[183, 456]] 1.0 2nru Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2NRUD Q9NWZ3 164 458 460.0 T12:603 Type1 Inactive DFGin 6.947 14.098 BLAminus -135.72, 173.17 70.19, 87.19 -107.97, 13.86 307.81, 96.43 -64.39, -20.58 in-out in 9.107 Saltbr-out 4.489 HRD-in -69.73, -51.3 77.25, -2.09 out-in-in SNCoii in-in ActLoopNT-in 2.662 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.08, 159.59 APE9-dihe-na 136.7, -170.84 APE8-dihe-in -116.97, 119.52 APE8-rot-in 299.39 APE67-dihe-in -65.53, -15.07 -56.41, -37.98 APE12-dist-in 9.92 APE11-dist-in 11.855 APE10-dist-in 6.269 APE9-dist-in 3.606 None TPO345,SEP346 TPO345,SEP346 XRAY 2.0 0.237 0.299 D 307 295 0 0 0 0 [[183, 456]] 1.0 2nru Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: T12

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name